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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH1
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606991 – 379Alcohol dehydrogenase 1Add BLAST379

Expressioni

Gene expression databases

ExpressionAtlasiP05336 baseline and differential

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP05336
SMRiP05336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P05336-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAGKVIKC KAAVAWEAGK PLTMEEVEVA PPQAMEVRVK ILFTSLCHTD
60 70 80 90 100
VYFWEAKGQI PMFPRIFGHE AGGIVESVGE GVTDVAPGDH VLPVFTGECK
110 120 130 140 150
ECPHCKSAES NMCDLLRINT DRGVMIGDGK SRFSIGGKPI YHFVGTSTFS
160 170 180 190 200
EYTVMHVGCV AKINPEAPLD KVCVLSCGIS TGLGASINVA KPPKGSTVAI
210 220 230 240 250
FGLGAVGLAA AEGARIAGAS RIIGVDLNAV RFEEARKFGC TEFVNPKDHT
260 270 280 290 300
KPVQQVLADM TNGGVDRSVE CTGNVNAMIQ AFECVHDGWG VAVLVGVPHK
310 320 330 340 350
DAEFKTHPMN FLNERTLKGT FFGNFKPRTD LPNVVEMYMK KELEVEKFIT
360 370
HSVPFSEINT AFDLMAKGEG IRCIIRMDN
Length:379
Mass (Da):40,884
Last modified:November 1, 1988 - v1
Checksum:i3A94ABDD2967FCB7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74I → T in CAB51640 (Ref. 2) Curated1
Sequence conflicti93P → A in CAB51640 (Ref. 2) Curated1
Sequence conflicti126 – 127IG → NR in CAB51640 (Ref. 2) Curated2
Sequence conflicti134S → F in CAB51640 (Ref. 2) Curated1
Sequence conflicti205A → S in CAB51640 (Ref. 2) Curated1
Sequence conflicti210A → T in CAB51640 (Ref. 2) Curated1
Sequence conflicti225V → I in CAB51640 (Ref. 2) Curated1
Sequence conflicti230V → F in CAB51640 (Ref. 2) Curated1
Sequence conflicti248D → A in CAB51640 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07774 mRNA Translation: CAA30600.1
X12732 Genomic DNA Translation: CAB51640.1
PIRiS01893
UniGeneiHv.22954

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07774 mRNA Translation: CAA30600.1
X12732 Genomic DNA Translation: CAB51640.1
PIRiS01893
UniGeneiHv.22954

3D structure databases

ProteinModelPortaliP05336
SMRiP05336
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

ExpressionAtlasiP05336 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_HORVU
AccessioniPrimary (citable) accession number: P05336
Secondary accession number(s): Q40011
, Q40012, Q40013, Q40014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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