EDN1

Functionⁱ

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19767294
endothelin A receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
endothelin B receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
hormone activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
- 2649896

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
artery smooth muscle contraction
Source: BHF-UCL
Inferred from direct assayⁱ
- 8982507
body fluid secretion Source: Ensembl
branching involved in blood vessel morphogenesis Source: Ensembl
calcium-mediated signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
- 1917960
cartilage development Source: Ensembl
cell-cell signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 12379507
cell surface receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 1713452
cellular response to calcium ion Source: Ensembl
cellular response to drug Source: Ensembl
cellular response to fatty acid Source: Ensembl
cellular response to glucocorticoid stimulus Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to interferon-gamma Source: Ensembl
cellular response to interleukin-1 Source: Ensembl
cellular response to mineralocorticoid stimulus Source: Ensembl
cellular response to peptide hormone stimulus Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
cellular response to tumor necrosis factor Source: Ensembl
dorsal/ventral pattern formation Source: Ensembl
epithelial fluid transport Source: Ensembl
G-protein coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 17078114
heart development Source: Ensembl
histamine secretion Source: Ensembl
inositol phosphate-mediated signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 1917960
in utero embryonic development Source: Ensembl
leukocyte activation
Source: BHF-UCL
Traceable author statementⁱ
- 16820593
maternal process involved in parturition Source: Ensembl
membrane depolarization Source: Ensembl
middle ear morphogenesis Source: Ensembl
multicellular organism aging Source: Ensembl
negative regulation of blood coagulation
Source: BHF-UCL
Traceable author statementⁱ
- 16820593
negative regulation of cellular protein metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19767294
negative regulation of hormone secretion Source: Ensembl
negative regulation of nitric-oxide synthase biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 16820593
negative regulation of smooth muscle cell apoptotic process Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 19767294
neural crest cell development Source: Ensembl
nitric oxide transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 16820593
peptide hormone secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
phosphatidylinositol 3-kinase signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 17078114
phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
positive regulation of cardiac muscle hypertrophy
Source: BHF-UCL
Inferred from direct assayⁱ
- 12847114
positive regulation of cell growth involved in cardiac muscle cell development
Source: BHF-UCL
Inferred from direct assayⁱ
- 24117217
positive regulation of cell migration
Source: BHF-UCL
Inferred from direct assayⁱ
- 9696419
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17078114
- 1917960
positive regulation of cell size
Source: BHF-UCL
Inferred from direct assayⁱ
- 12847114
positive regulation of chemokine-mediated signaling pathway
Source: BHF-UCL
Inferred by curatorⁱ
- 17178876
positive regulation of cytosolic calcium ion concentration
Source: BHF-UCL
Inferred from direct assayⁱ
- 1917960
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
positive regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 24117217
positive regulation of endothelial cell migration
Source: BHF-UCL
Traceable author statementⁱ
- 8999856
positive regulation of heart rate
Source: BHF-UCL
Inferred from direct assayⁱ
- 2649896
positive regulation of hormone secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
positive regulation of JUN kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 12847114
positive regulation of MAP kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
- 12847114
positive regulation of mitotic nuclear division
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
positive regulation of neutrophil chemotaxis Source: Ensembl
positive regulation of NIK/NF-kappaB signaling Source: Ensembl
positive regulation of nitric oxide biosynthetic process
Source: BHF-UCL
Traceable author statementⁱ
- 8999856
positive regulation of odontogenesis Source: Ensembl
positive regulation of prostaglandin-endoperoxide synthase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 9492062
positive regulation of prostaglandin secretion Source: Ensembl
positive regulation of receptor biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 17178876
positive regulation of renal sodium excretion Source: Ensembl
positive regulation of sarcomere organization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12847114
positive regulation of smooth muscle cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10393673
positive regulation of smooth muscle contraction Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 24117217
positive regulation of urine volume Source: Ensembl
positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
prostaglandin biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 9492062
protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
protein kinase C deactivation
Source: BHF-UCL
Inferred from direct assayⁱ
- 16820593
regulation of glucose transmembrane transport Source: Ensembl
regulation of pH Source: Ensembl
regulation of sensory perception of pain Source: Ensembl
regulation of systemic arterial blood pressure by endothelin
Source: BHF-UCL
Inferred from direct assayⁱ
- 2649896
regulation of vasoconstriction Source: InterPro
respiratory gaseous exchange Source: Ensembl
response to activity Source: Ensembl
response to amino acid Source: Ensembl
response to dexamethasone Source: Ensembl
response to leptin Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to muscle stretch Source: Ensembl
response to nicotine Source: Ensembl
response to ozone Source: Ensembl
response to prostaglandin F Source: Ensembl
response to salt Source: Ensembl
response to testosterone Source: Ensembl
rhythmic excitation Source: Ensembl
sensory perception of pain Source: Ensembl
superoxide anion generation Source: Ensembl
vasoconstriction
Source: BHF-UCL
Inferred from direct assayⁱ
- 11410113
- 2649896
vein smooth muscle contraction
Source: BHF-UCL
Inferred from direct assayⁱ
- 9422810

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Vasoactive, Vasoconstrictor

Molecular function

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P05305

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endothelin-1 Alternative name(s): Preproendothelin-1 Short name: PPET1 Cleaved into the following 2 chains: Endothelin-1 Short name: ET-1 Big endothelin-1
Gene namesⁱ	Name:EDN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000078401.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3176 EDN1
MIMⁱ	131240 gene
neXtProtⁱ	NX_P05305

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Question mark ears, isolated (QME)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.

Auriculocondylar syndrome 3 (ARCND3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071153	77	P → H in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777232EnsemblClinVar.		1
Natural variantⁱVAR_071154	91	K → E in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777231EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1906
MalaCards human disease database More...MalaCardsⁱ	EDN1
MIMⁱ	612798 phenotype 615706 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000078401
Orphanetⁱ	137888 Auriculocondylar syndrome
PharmGKBⁱ	PA27614

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB05407 TBC-3711

DrugBankⁱ

DB05407 TBC-3711

Polymorphism and mutation databases

BioMutaⁱ	EDN1
DMDMⁱ	119610

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 17	1 PublicationAdd BLAST	17
PropeptideⁱPRO_0000008058	18 – 50	Add BLAST	33
PeptideⁱPRO_0000008059	53 – 90	Big endothelin-11 PublicationAdd BLAST	38
PeptideⁱPRO_0000008060	53 – 73	Endothelin-11 PublicationAdd BLAST	21
PropeptideⁱPRO_0000008061	74 – 212	Add BLAST	139

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	53 ↔ 67	1 Publication
Disulfide bondⁱ	55 ↔ 63	1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	73 – 74	Cleavage; by KEL1 Publication		2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	P05305
PeptideAtlas More...PeptideAtlasⁱ	P05305
PRIDEⁱ	P05305
ProteomicsDBⁱ	51829
TopDownProteomicsⁱ	P05305

PTM databases

iPTMnetⁱ	P05305
PhosphoSitePlusⁱ	P05305

Miscellaneous databases

PMAP-CutDBⁱ	P05305

PMAP-CutDBⁱ

P05305

Expressionⁱ

Tissue specificityⁱ

Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000078401 Expressed in 198 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_EDN1
ExpressionAtlasⁱ	P05305 baseline and differential
Genevisibleⁱ	P05305 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB032500 CAB037291 HPA031976

HPAⁱ

CAB032500
CAB037291
HPA031976

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EDNRA	P25101	2	EBI-715181,EBI-6624559
EDNRB	P24530	2	EBI-715181,EBI-6624656

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19767294
endothelin A receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
endothelin B receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
hormone activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10770212
- 2649896

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108228, 5 interactors
IntActⁱ	P05305, 5 interactors
STRINGⁱ	9606.ENSP00000368683

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	53 – 56	Combined sources	4
Beta strandⁱ	57 – 59	Combined sources	3
Helixⁱ	61 – 67	Combined sources	7
Turnⁱ	68 – 70	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P05305
SMRⁱ	P05305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P05305

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	109 – 123	Endothelin-likeAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWVG Eukaryota ENOG4111WED LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063310
HOGENOMⁱ	HOG000231110
HOVERGENⁱ	HBG051441
InParanoidⁱ	P05305
KEGG Orthology (KO) More...KOⁱ	K16366
OMAⁱ	WVNTPEH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LEL
PhylomeDBⁱ	P05305
TreeFamⁱ	TF333184

Family and domain databases

InterProⁱ	View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00322 Endothelin, 1 hit
PRINTSⁱ	PR00365 ENDOTHELIN
SMARTⁱ	View protein in SMART SM00272 END, 2 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P05305-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS 
        60         70         80         90        100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT 
       110        120        130        140        150
KATDRENRCQ CASQKDKKCW NFCQAGKELR AEDIMEKDWN NHKKGKDCSK 
       160        170        180        190        200
LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE TMRNSVKSSF HDPKLKGKPS 
       210 
RERYVTHNRA HW

Length:212

Mass (Da):24,425

Last modified:November 1, 1988 - v1

Checksum:ⁱE2DA0EB86755BC3D

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071152	64	V → D in QME. 1 PublicationCorresponds to variant dbSNP:rs587777233EnsemblClinVar.	1
Natural variantⁱVAR_071153	77	P → H in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777232EnsemblClinVar.	1
Natural variantⁱVAR_071154	91	K → E in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777231EnsemblClinVar.	1
Natural variantⁱVAR_048933	186	V → I. Corresponds to variant dbSNP:rs6413478Ensembl.	1
Natural variantⁱVAR_014188	198	K → N Polymorphism associated with HDL cholesterol levels is some populations and in a sex-specific manner. 6 PublicationsCorresponds to variant dbSNP:rs5370EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00749 mRNA Translation: CAA68718.1 M25380 , M25377, M25378, M25379 Genomic DNA Translation: AAA52407.1 J05008 Genomic DNA Translation: AAA52339.1 S56805 mRNA Translation: AAB25760.1 AY434104 Genomic DNA Translation: AAQ96600.1 Z98050 Genomic DNA No translation available. BC009720 mRNA Translation: AAH09720.1 M25549 Genomic DNA Translation: AAA52338.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4522.1
PIRⁱ	A36517 ANHU1
NCBI Reference Sequences More...RefSeqⁱ	NP_001161791.1, NM_001168319.1 NP_001946.3, NM_001955.4 XP_011512632.1, XM_011514330.2 XP_011512633.1, XM_011514331.2 XP_016865820.1, XM_017010331.1
UniGeneⁱ	Hs.511899 Hs.713645

Genome annotation databases

Ensemblⁱ	ENST00000379375; ENSP00000368683; ENSG00000078401
GeneIDⁱ	1906
KEGGⁱ	hsa:1906

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P05305	EDN1 protein		HUMAN		212	UniRef100_P05305
Endothelin-1 (Fragment)		BOSMU		55

Protein	Similar proteins		Species	Score	Length	Source
P05305	EDN1 protein		HUMAN		212	UniRef90_P05305
Endothelin-1 (Fragment)		BOSMU		55
EDN1 isoform 1		PANTR		212
Endothelin 1		PONAB		212
Endothelin 1		PANPA		212
+22

Protein	Similar proteins		Species	Score	Length	Source
P05305	Endothelin-1		PIG		203	UniRef50_P05305
Endothelin-1		BOVIN		202
Endothelin-1		SHEEP		202
Endothelin-1		RABIT		202
Endothelin-1		CANLF		202
+146

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Endothelin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00749 mRNA Translation: CAA68718.1 M25380 , M25377, M25378, M25379 Genomic DNA Translation: AAA52407.1 J05008 Genomic DNA Translation: AAA52339.1 S56805 mRNA Translation: AAB25760.1 AY434104 Genomic DNA Translation: AAQ96600.1 Z98050 Genomic DNA No translation available. BC009720 mRNA Translation: AAH09720.1 M25549 Genomic DNA Translation: AAA52338.1
CCDSⁱ	CCDS4522.1
PIRⁱ	A36517 ANHU1
RefSeqⁱ	NP_001161791.1, NM_001168319.1 NP_001946.3, NM_001955.4 XP_011512632.1, XM_011514330.2 XP_011512633.1, XM_011514331.2 XP_016865820.1, XM_017010331.1
UniGeneⁱ	Hs.511899 Hs.713645

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1EDN	X-ray	2.18	A	53-73	[»]
	1EDP	NMR	-	A	53-69	[»]
	1T7H	X-ray	1.13	A/B	51-68	[»]
	1V6R	NMR	-	A	53-73	[»]
	5GLH	X-ray	2.80	B	53-73	[»]
ProteinModelPortalⁱ	P05305
SMRⁱ	P05305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108228, 5 interactors
IntActⁱ	P05305, 5 interactors
STRINGⁱ	9606.ENSP00000368683

Chemistry databases

DrugBankⁱ	DB05407 TBC-3711

DrugBankⁱ

DB05407 TBC-3711

PTM databases

iPTMnetⁱ	P05305
PhosphoSitePlusⁱ	P05305

Polymorphism and mutation databases

BioMutaⁱ	EDN1
DMDMⁱ	119610

Proteomic databases

PaxDbⁱ	P05305
PeptideAtlasⁱ	P05305
PRIDEⁱ	P05305
ProteomicsDBⁱ	51829
TopDownProteomicsⁱ	P05305

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1906
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379375; ENSP00000368683; ENSG00000078401
GeneIDⁱ	1906
KEGGⁱ	hsa:1906

Organism-specific databases

CTDⁱ	1906
DisGeNETⁱ	1906
EuPathDBⁱ	HostDB:ENSG00000078401.6
GeneCardsⁱ	EDN1
H-InvDBⁱ	HIX0033211
HGNCⁱ	HGNC:3176 EDN1
HPAⁱ	CAB032500 CAB037291 HPA031976
MalaCardsⁱ	EDN1
MIMⁱ	131240 gene 612798 phenotype 615706 phenotype
neXtProtⁱ	NX_P05305
OpenTargetsⁱ	ENSG00000078401
Orphanetⁱ	137888 Auriculocondylar syndrome
PharmGKBⁱ	PA27614
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWVG Eukaryota ENOG4111WED LUCA
GeneTreeⁱ	ENSGT00530000063310
HOGENOMⁱ	HOG000231110
HOVERGENⁱ	HBG051441
InParanoidⁱ	P05305
KOⁱ	K16366
OMAⁱ	WVNTPEH
OrthoDBⁱ	EOG091G0LEL
PhylomeDBⁱ	P05305
TreeFamⁱ	TF333184

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P05305

Miscellaneous databases

EvolutionaryTraceⁱ	P05305
GeneWikiⁱ	Endothelin_1
GenomeRNAiⁱ	1906
PMAP-CutDBⁱ	P05305
Protein Ontology More...PROⁱ	PR:P05305
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000078401 Expressed in 198 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_EDN1
ExpressionAtlasⁱ	P05305 baseline and differential
Genevisibleⁱ	P05305 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin
Pfamⁱ	View protein in Pfam PF00322 Endothelin, 1 hit
PRINTSⁱ	PR00365 ENDOTHELIN
SMARTⁱ	View protein in SMART SM00272 END, 2 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EDN1_HUMAN
Accessionⁱ	P05305Primary (citable) accession number: P05305 Secondary accession number(s): Q96DA1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	November 1, 1988
	Last modified:	September 12, 2018
	This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P05305 (EDN1_HUMAN)

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Endothelin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ