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UniProtKB - P05305 (EDN1_HUMAN)
Protein
Endothelin-1
Gene
EDN1
Organism
Homo sapiens (Human)
Status
Functioni
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).
Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031).
Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437).
By similarity2 PublicationsGO - Molecular functioni
- cytokine activity Source: BHF-UCL
- endothelin A receptor binding Source: BHF-UCL
- endothelin B receptor binding Source: BHF-UCL
- hormone activity Source: BHF-UCL
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
- artery smooth muscle contraction Source: BHF-UCL
- axon extension Source: Ensembl
- axonogenesis involved in innervation Source: Ensembl
- body fluid secretion Source: Ensembl
- branching involved in blood vessel morphogenesis Source: Ensembl
- calcium ion transmembrane transport Source: Ensembl
- calcium-mediated signaling Source: BHF-UCL
- canonical Wnt signaling pathway Source: Ensembl
- cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
- cartilage development Source: Ensembl
- cell-cell signaling Source: BHF-UCL
- cell surface receptor signaling pathway Source: BHF-UCL
- cellular calcium ion homeostasis Source: MGI
- cellular response to calcium ion Source: Ensembl
- cellular response to fatty acid Source: Ensembl
- cellular response to follicle-stimulating hormone stimulus Source: Ensembl
- cellular response to glucocorticoid stimulus Source: Ensembl
- cellular response to human chorionic gonadotropin stimulus Source: Ensembl
- cellular response to hydrogen peroxide Source: MGI
- cellular response to hypoxia Source: Ensembl
- cellular response to interferon-gamma Source: Ensembl
- cellular response to interleukin-1 Source: Ensembl
- cellular response to luteinizing hormone stimulus Source: Ensembl
- cellular response to mineralocorticoid stimulus Source: Ensembl
- cellular response to organic substance Source: MGI
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- cellular response to tumor necrosis factor Source: Ensembl
- cellular response to xenobiotic stimulus Source: Ensembl
- dorsal/ventral pattern formation Source: Ensembl
- embryonic heart tube development Source: Ensembl
- endothelin receptor signaling pathway Source: UniProtKB
- endothelin receptor signaling pathway involved in heart process Source: Ensembl
- epithelial fluid transport Source: Ensembl
- ERK1 and ERK2 cascade Source: Ensembl
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- histamine secretion Source: Ensembl
- I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- inositol phosphate-mediated signaling Source: BHF-UCL
- in utero embryonic development Source: Ensembl
- leukocyte activation Source: BHF-UCL
- maternal process involved in parturition Source: Ensembl
- meiotic cell cycle process involved in oocyte maturation Source: Ensembl
- membrane depolarization Source: Ensembl
- middle ear morphogenesis Source: Ensembl
- mitochondrion organization Source: Ensembl
- multicellular organism aging Source: Ensembl
- negative regulation of blood coagulation Source: BHF-UCL
- negative regulation of cellular protein metabolic process Source: BHF-UCL
- negative regulation of gene expression Source: Ensembl
- negative regulation of hormone secretion Source: Ensembl
- negative regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
- negative regulation of smooth muscle cell apoptotic process Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- neural crest cell fate commitment Source: Ensembl
- nitric oxide transport Source: BHF-UCL
- noradrenergic neuron differentiation Source: Ensembl
- peptide hormone secretion Source: BHF-UCL
- pharyngeal arch artery morphogenesis Source: Ensembl
- phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- phospholipase D-activating G protein-coupled receptor signaling pathway Source: Ensembl
- positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
- positive regulation of cation channel activity Source: MGI
- positive regulation of cell growth involved in cardiac muscle cell development Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of cell size Source: BHF-UCL
- positive regulation of chemokine-mediated signaling pathway Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of endothelial cell migration Source: BHF-UCL
- positive regulation of heart rate Source: BHF-UCL
- positive regulation of hormone secretion Source: BHF-UCL
- positive regulation of JUN kinase activity Source: BHF-UCL
- positive regulation of MAP kinase activity Source: BHF-UCL
- positive regulation of mitotic nuclear division Source: BHF-UCL
- positive regulation of neutrophil chemotaxis Source: Ensembl
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
- positive regulation of odontogenesis Source: Ensembl
- positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
- positive regulation of prostaglandin secretion Source: Ensembl
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of sarcomere organization Source: BHF-UCL
- positive regulation of signaling receptor activity Source: BHF-UCL
- positive regulation of smooth muscle cell proliferation Source: BHF-UCL
- positive regulation of smooth muscle contraction Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of urine volume Source: Ensembl
- positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- prostaglandin biosynthetic process Source: BHF-UCL
- protein kinase A signaling Source: MGI
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- protein kinase C deactivation Source: BHF-UCL
- protein phosphorylation Source: Ensembl
- regulation of glucose transmembrane transport Source: Ensembl
- regulation of pH Source: Ensembl
- regulation of sensory perception of pain Source: Ensembl
- regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
- regulation of vasoconstriction Source: InterPro
- renal sodium ion absorption Source: Ensembl
- respiratory gaseous exchange by respiratory system Source: Ensembl
- response to activity Source: Ensembl
- response to amino acid Source: Ensembl
- response to amphetamine Source: Ensembl
- response to dexamethasone Source: Ensembl
- response to leptin Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to muscle stretch Source: Ensembl
- response to nicotine Source: Ensembl
- response to ozone Source: Ensembl
- response to prostaglandin F Source: Ensembl
- response to salt Source: Ensembl
- response to testosterone Source: Ensembl
- rhythmic excitation Source: Ensembl
- semaphorin-plexin signaling pathway involved in axon guidance Source: Ensembl
- sensory perception of pain Source: Ensembl
- superoxide anion generation Source: Ensembl
- sympathetic neuron axon guidance Source: Ensembl
- thyroid gland development Source: Ensembl
- transcription by RNA polymerase II Source: Ensembl
- vasoconstriction Source: BHF-UCL
- vein smooth muscle contraction Source: BHF-UCL
Keywordsi
Molecular function | Vasoactive, Vasoconstrictor |
Enzyme and pathway databases
PathwayCommonsi | P05305 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P05305 |
SIGNORi | P05305 |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin-1Alternative name(s): Preproendothelin-1 Short name: PPET1 Cleaved into the following 2 chains: |
Gene namesi | Name:EDN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3176, EDN1 |
MIMi | 131240, gene |
neXtProti | NX_P05305 |
VEuPathDBi | HostDB:ENSG00000078401 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- rough endoplasmic reticulum lumen Source: Ensembl
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Other locations
- basal part of cell Source: Ensembl
- cytoplasm Source: BHF-UCL
- transport vesicle Source: Reactome
- Weibel-Palade body Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Question mark ears, isolated (QME)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071152 | 64 | V → D in QME. 1 PublicationCorresponds to variant dbSNP:rs587777233EnsemblClinVar. | 1 |
Auriculocondylar syndrome 3 (ARCND3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071153 | 77 | P → H in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777232EnsemblClinVar. | 1 | |
Natural variantiVAR_071154 | 91 | K → E in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777231EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1906 |
MalaCardsi | EDN1 |
MIMi | 612798, phenotype 615706, phenotype 618979, phenotype |
OpenTargetsi | ENSG00000078401 |
Orphaneti | 137888, Auriculocondylar syndrome |
PharmGKBi | PA27614 |
Miscellaneous databases
Pharosi | P05305, Tbio |
Chemistry databases
DrugBanki | DB05407, TBC-3711 |
Genetic variation databases
BioMutai | EDN1 |
DMDMi | 119610 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | 1 PublicationAdd BLAST | 17 | |
PropeptideiPRO_0000008058 | 18 – 50 | Add BLAST | 33 | |
PeptideiPRO_0000008059 | 53 – 90 | Big endothelin-11 PublicationAdd BLAST | 38 | |
PeptideiPRO_0000008060 | 53 – 73 | Endothelin-11 PublicationAdd BLAST | 21 | |
PropeptideiPRO_0000008061 | 74 – 212 | Add BLAST | 139 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 67 | 1 Publication | ||
Disulfide bondi | 55 ↔ 63 | 1 Publication |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 73 – 74 | Cleavage; by KEL1 Publication | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
MassIVEi | P05305 |
PaxDbi | P05305 |
PeptideAtlasi | P05305 |
PRIDEi | P05305 |
ProteomicsDBi | 51829 |
TopDownProteomicsi | P05305 |
PTM databases
iPTMneti | P05305 |
PhosphoSitePlusi | P05305 |
Expressioni
Tissue specificityi
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.1 Publication
Gene expression databases
Bgeei | ENSG00000078401, Expressed in upper lobe of lung and 210 other tissues |
ExpressionAtlasi | P05305, baseline and differential |
Genevisiblei | P05305, HS |
Organism-specific databases
HPAi | ENSG00000078401, Low tissue specificity |
Interactioni
Binary interactionsi
GO - Molecular functioni
- cytokine activity Source: BHF-UCL
- endothelin A receptor binding Source: BHF-UCL
- endothelin B receptor binding Source: BHF-UCL
- hormone activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 108228, 5 interactors |
CORUMi | P05305 |
IntActi | P05305, 7 interactors |
STRINGi | 9606.ENSP00000368683 |
Chemistry databases
BindingDBi | P05305 |
Miscellaneous databases
RNActi | P05305, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P05305 |
BMRBi | P05305 |
SMRi | P05305 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05305 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 109 – 123 | Endothelin-likeAdd BLAST | 15 | |
Regioni | 168 – 212 | DisorderedSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the endothelin/sarafotoxin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S1NV, Eukaryota |
GeneTreei | ENSGT00950000183053 |
HOGENOMi | CLU_090013_1_0_1 |
InParanoidi | P05305 |
OMAi | RCQCANQ |
OrthoDBi | 1264335at2759 |
PhylomeDBi | P05305 |
TreeFami | TF333184 |
Family and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin |
PANTHERi | PTHR13874, PTHR13874, 1 hit |
Pfami | View protein in Pfam PF00322, Endothelin, 1 hit |
PRINTSi | PR00365, ENDOTHELIN |
SMARTi | View protein in SMART SM00272, END, 2 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P05305-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT
110 120 130 140 150
KATDRENRCQ CASQKDKKCW NFCQAGKELR AEDIMEKDWN NHKKGKDCSK
160 170 180 190 200
LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE TMRNSVKSSF HDPKLKGKPS
210
RERYVTHNRA HW
Polymorphismi
EDN1 genetic variants may influence high density lipoprotein cholesterol (HDLC) levels in some populations and in a sex-specific manner, defining the high density lipoprotein cholesterol level quantitative trait locus 7 (HDLCQ7) [MIMi:618979].1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071152 | 64 | V → D in QME. 1 PublicationCorresponds to variant dbSNP:rs587777233EnsemblClinVar. | 1 | |
Natural variantiVAR_071153 | 77 | P → H in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777232EnsemblClinVar. | 1 | |
Natural variantiVAR_071154 | 91 | K → E in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777231EnsemblClinVar. | 1 | |
Natural variantiVAR_048933 | 186 | V → I. Corresponds to variant dbSNP:rs6413478Ensembl. | 1 | |
Natural variantiVAR_014188 | 198 | K → N Associated with HDL cholesterol levels is some populations and in a sex-specific manner. 6 PublicationsCorresponds to variant dbSNP:rs5370EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00749 mRNA Translation: CAA68718.1 M25380 , M25377, M25378, M25379 Genomic DNA Translation: AAA52407.1 J05008 Genomic DNA Translation: AAA52339.1 S56805 mRNA Translation: AAB25760.1 AY434104 Genomic DNA Translation: AAQ96600.1 Z98050 Genomic DNA No translation available. BC009720 mRNA Translation: AAH09720.1 M25549 Genomic DNA Translation: AAA52338.1 |
CCDSi | CCDS4522.1 |
PIRi | A36517, ANHU1 |
RefSeqi | NP_001161791.1, NM_001168319.1 NP_001946.3, NM_001955.4 XP_011512632.1, XM_011514330.2 XP_011512633.1, XM_011514331.2 XP_016865820.1, XM_017010331.1 |
Genome annotation databases
Ensembli | ENST00000379375.6; ENSP00000368683.5; ENSG00000078401.7 |
GeneIDi | 1906 |
KEGGi | hsa:1906 |
MANE-Selecti | ENST00000379375.6; ENSP00000368683.5; NM_001955.5; NP_001946.3 |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Endothelin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00749 mRNA Translation: CAA68718.1 M25380 , M25377, M25378, M25379 Genomic DNA Translation: AAA52407.1 J05008 Genomic DNA Translation: AAA52339.1 S56805 mRNA Translation: AAB25760.1 AY434104 Genomic DNA Translation: AAQ96600.1 Z98050 Genomic DNA No translation available. BC009720 mRNA Translation: AAH09720.1 M25549 Genomic DNA Translation: AAA52338.1 |
CCDSi | CCDS4522.1 |
PIRi | A36517, ANHU1 |
RefSeqi | NP_001161791.1, NM_001168319.1 NP_001946.3, NM_001955.4 XP_011512632.1, XM_011514330.2 XP_011512633.1, XM_011514331.2 XP_016865820.1, XM_017010331.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EDN | X-ray | 2.18 | A | 53-73 | [»] | |
1EDP | NMR | - | A | 53-69 | [»] | |
1T7H | X-ray | 1.13 | A/B | 51-68 | [»] | |
1V6R | NMR | - | A | 53-73 | [»] | |
5GLH | X-ray | 2.80 | B | 53-73 | [»] | |
6DK5 | X-ray | 1.85 | A/B | 53-73 | [»] | |
AlphaFoldDBi | P05305 | |||||
BMRBi | P05305 | |||||
SMRi | P05305 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108228, 5 interactors |
CORUMi | P05305 |
IntActi | P05305, 7 interactors |
STRINGi | 9606.ENSP00000368683 |
Chemistry databases
BindingDBi | P05305 |
DrugBanki | DB05407, TBC-3711 |
PTM databases
iPTMneti | P05305 |
PhosphoSitePlusi | P05305 |
Genetic variation databases
BioMutai | EDN1 |
DMDMi | 119610 |
Proteomic databases
MassIVEi | P05305 |
PaxDbi | P05305 |
PeptideAtlasi | P05305 |
PRIDEi | P05305 |
ProteomicsDBi | 51829 |
TopDownProteomicsi | P05305 |
Protocols and materials databases
Antibodypediai | 10136, 793 antibodies from 37 providers |
DNASUi | 1906 |
Genome annotation databases
Ensembli | ENST00000379375.6; ENSP00000368683.5; ENSG00000078401.7 |
GeneIDi | 1906 |
KEGGi | hsa:1906 |
MANE-Selecti | ENST00000379375.6; ENSP00000368683.5; NM_001955.5; NP_001946.3 |
Organism-specific databases
CTDi | 1906 |
DisGeNETi | 1906 |
GeneCardsi | EDN1 |
HGNCi | HGNC:3176, EDN1 |
HPAi | ENSG00000078401, Low tissue specificity |
MalaCardsi | EDN1 |
MIMi | 131240, gene 612798, phenotype 615706, phenotype 618979, phenotype |
neXtProti | NX_P05305 |
OpenTargetsi | ENSG00000078401 |
Orphaneti | 137888, Auriculocondylar syndrome |
PharmGKBi | PA27614 |
VEuPathDBi | HostDB:ENSG00000078401 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1NV, Eukaryota |
GeneTreei | ENSGT00950000183053 |
HOGENOMi | CLU_090013_1_0_1 |
InParanoidi | P05305 |
OMAi | RCQCANQ |
OrthoDBi | 1264335at2759 |
PhylomeDBi | P05305 |
TreeFami | TF333184 |
Enzyme and pathway databases
PathwayCommonsi | P05305 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P05305 |
SIGNORi | P05305 |
Miscellaneous databases
BioGRID-ORCSi | 1906, 9 hits in 1072 CRISPR screens |
EvolutionaryTracei | P05305 |
GeneWikii | Endothelin_1 |
GenomeRNAii | 1906 |
Pharosi | P05305, Tbio |
PROi | PR:P05305 |
RNActi | P05305, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000078401, Expressed in upper lobe of lung and 210 other tissues |
ExpressionAtlasi | P05305, baseline and differential |
Genevisiblei | P05305, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin |
PANTHERi | PTHR13874, PTHR13874, 1 hit |
Pfami | View protein in Pfam PF00322, Endothelin, 1 hit |
PRINTSi | PR00365, ENDOTHELIN |
SMARTi | View protein in SMART SM00272, END, 2 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | EDN1_HUMAN | |
Accessioni | P05305Primary (citable) accession number: P05305 Secondary accession number(s): Q96DA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | May 25, 2022 | |
This is version 221 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families