Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endothelin-1

Gene

EDN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05305

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endothelin-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EDN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078401.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3176 EDN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131240 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05305

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Question mark ears, isolated (QME)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.
See also OMIM:612798
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07115264V → D in QME. 1 PublicationCorresponds to variant dbSNP:rs587777233EnsemblClinVar.1
Auriculocondylar syndrome 3 (ARCND3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.
See also OMIM:615706
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07115377P → H in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777232EnsemblClinVar.1
Natural variantiVAR_07115491K → E in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777231EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1906

MalaCards human disease database

More...
MalaCardsi
EDN1
MIMi612798 phenotype
615706 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000078401

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
137888 Auriculocondylar syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27614

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB05407 TBC-3711

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EDN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119610

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 171 PublicationAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000805818 – 50Add BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000805953 – 90Big endothelin-11 PublicationAdd BLAST38
PeptideiPRO_000000806053 – 73Endothelin-11 PublicationAdd BLAST21
PropeptideiPRO_000000806174 – 212Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 671 Publication
Disulfide bondi55 ↔ 631 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei73 – 74Cleavage; by KEL1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05305

PeptideAtlas

More...
PeptideAtlasi
P05305

PRoteomics IDEntifications database

More...
PRIDEi
P05305

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51829

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P05305

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05305

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05305

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P05305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078401 Expressed in 198 organ(s), highest expression level in upper lobe of lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_EDN1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05305 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05305 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032500
CAB037291
HPA031976

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108228, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P05305

Protein interaction database and analysis system

More...
IntActi
P05305, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368683

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EDNX-ray2.18A53-73[»]
1EDPNMR-A53-69[»]
1T7HX-ray1.13A/B51-68[»]
1V6RNMR-A53-73[»]
5GLHX-ray2.80B53-73[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P05305

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P05305

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05305

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni109 – 123Endothelin-likeAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWVG Eukaryota
ENOG4111WED LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063310

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231110

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051441

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05305

KEGG Orthology (KO)

More...
KOi
K16366

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCQCASQ

Database of Orthologous Groups

More...
OrthoDBi
1264335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05305

TreeFam database of animal gene trees

More...
TreeFami
TF333184

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00322 Endothelin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00365 ENDOTHELIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00272 END, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P05305-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT
110 120 130 140 150
KATDRENRCQ CASQKDKKCW NFCQAGKELR AEDIMEKDWN NHKKGKDCSK
160 170 180 190 200
LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE TMRNSVKSSF HDPKLKGKPS
210
RERYVTHNRA HW
Length:212
Mass (Da):24,425
Last modified:November 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2DA0EB86755BC3D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07115264V → D in QME. 1 PublicationCorresponds to variant dbSNP:rs587777233EnsemblClinVar.1
Natural variantiVAR_07115377P → H in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777232EnsemblClinVar.1
Natural variantiVAR_07115491K → E in ARCND3. 1 PublicationCorresponds to variant dbSNP:rs587777231EnsemblClinVar.1
Natural variantiVAR_048933186V → I. Corresponds to variant dbSNP:rs6413478Ensembl.1
Natural variantiVAR_014188198K → N Polymorphism associated with HDL cholesterol levels is some populations and in a sex-specific manner. 6 PublicationsCorresponds to variant dbSNP:rs5370EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00749 mRNA Translation: CAA68718.1
M25380
, M25377, M25378, M25379 Genomic DNA Translation: AAA52407.1
J05008 Genomic DNA Translation: AAA52339.1
S56805 mRNA Translation: AAB25760.1
AY434104 Genomic DNA Translation: AAQ96600.1
Z98050 Genomic DNA No translation available.
BC009720 mRNA Translation: AAH09720.1
M25549 Genomic DNA Translation: AAA52338.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4522.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A36517 ANHU1

NCBI Reference Sequences

More...
RefSeqi
NP_001161791.1, NM_001168319.1
NP_001946.3, NM_001955.4
XP_011512632.1, XM_011514330.2
XP_011512633.1, XM_011514331.2
XP_016865820.1, XM_017010331.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.511899
Hs.713645

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379375; ENSP00000368683; ENSG00000078401

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1906

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Endothelin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00749 mRNA Translation: CAA68718.1
M25380
, M25377, M25378, M25379 Genomic DNA Translation: AAA52407.1
J05008 Genomic DNA Translation: AAA52339.1
S56805 mRNA Translation: AAB25760.1
AY434104 Genomic DNA Translation: AAQ96600.1
Z98050 Genomic DNA No translation available.
BC009720 mRNA Translation: AAH09720.1
M25549 Genomic DNA Translation: AAA52338.1
CCDSiCCDS4522.1
PIRiA36517 ANHU1
RefSeqiNP_001161791.1, NM_001168319.1
NP_001946.3, NM_001955.4
XP_011512632.1, XM_011514330.2
XP_011512633.1, XM_011514331.2
XP_016865820.1, XM_017010331.1
UniGeneiHs.511899
Hs.713645

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EDNX-ray2.18A53-73[»]
1EDPNMR-A53-69[»]
1T7HX-ray1.13A/B51-68[»]
1V6RNMR-A53-73[»]
5GLHX-ray2.80B53-73[»]
ProteinModelPortaliP05305
SMRiP05305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108228, 5 interactors
CORUMiP05305
IntActiP05305, 5 interactors
STRINGi9606.ENSP00000368683

Chemistry databases

DrugBankiDB05407 TBC-3711

PTM databases

iPTMnetiP05305
PhosphoSitePlusiP05305

Polymorphism and mutation databases

BioMutaiEDN1
DMDMi119610

Proteomic databases

PaxDbiP05305
PeptideAtlasiP05305
PRIDEiP05305
ProteomicsDBi51829
TopDownProteomicsiP05305

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1906
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379375; ENSP00000368683; ENSG00000078401
GeneIDi1906
KEGGihsa:1906

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1906
DisGeNETi1906
EuPathDBiHostDB:ENSG00000078401.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EDN1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0033211
HGNCiHGNC:3176 EDN1
HPAiCAB032500
CAB037291
HPA031976
MalaCardsiEDN1
MIMi131240 gene
612798 phenotype
615706 phenotype
neXtProtiNX_P05305
OpenTargetsiENSG00000078401
Orphaneti137888 Auriculocondylar syndrome
PharmGKBiPA27614

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWVG Eukaryota
ENOG4111WED LUCA
GeneTreeiENSGT00530000063310
HOGENOMiHOG000231110
HOVERGENiHBG051441
InParanoidiP05305
KOiK16366
OMAiRCQCASQ
OrthoDBi1264335at2759
PhylomeDBiP05305
TreeFamiTF333184

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP05305

Miscellaneous databases

EvolutionaryTraceiP05305

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Endothelin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1906
PMAP-CutDBiP05305

Protein Ontology

More...
PROi
PR:P05305

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078401 Expressed in 198 organ(s), highest expression level in upper lobe of lung
CleanExiHS_EDN1
ExpressionAtlasiP05305 baseline and differential
GenevisibleiP05305 HS

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEDN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05305
Secondary accession number(s): Q96DA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: January 16, 2019
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again