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UniProtKB - P05300 (LAMP1_CHICK)
Protein
Lysosome-associated membrane glycoprotein 1
Gene
LAMP1
Organism
Gallus gallus (Chicken)
Status
Functioni
Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis. Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
By similarity(Microbial infection) Plays an essential role in efficient replication and spread of Marek's disease virus, by facilitating viral cell-to-cell spread.
1 PublicationGO - Biological processi
- establishment of protein localization to organelle Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Lysosome-associated membrane glycoprotein 1Short name: LAMP-1 Short name: Lysosome-associated membrane protein 1 Alternative name(s): Lysosome membrane glycoprotein LEP100 |
Gene namesi | Name:LAMP1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Endosome
- Endosome membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
- Late endosome membrane By similarity; Single-pass type I membrane protein Sequence analysis
Lysosome
- Lysosome membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
- Cytolytic granule membrane By similarity; Single-pass type I membrane protein Sequence analysis
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane (PubMed:2871029, PubMed:3107839). Colocalizes with OSBPL1A at the late endosome (PubMed:3107839).2 Publications
Endosome
- endosome membrane Source: UniProtKB
- late endosome membrane Source: GO_Central
Lysosome
- cytolytic granule membrane Source: UniProtKB
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: AgBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 379 | LumenalSequence analysisAdd BLAST | 361 | |
Transmembranei | 380 – 403 | HelicalPROSITE-ProRule annotationAdd BLAST | 24 | |
Topological domaini | 404 – 414 | CytoplasmicPROSITE-ProRule annotationAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Add BLAST | 18 | |
ChainiPRO_0000017109 | 19 – 414 | Lysosome-associated membrane glycoprotein 1Add BLAST | 396 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 67 | PROSITE-ProRule annotation | ||
Glycosylationi | 33 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 58 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 142 ↔ 178 | PROSITE-ProRule annotation | ||
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 168 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 225 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 228 ↔ 266 | PROSITE-ProRule annotation | ||
Glycosylationi | 238 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 259 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 289 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 319 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 335 ↔ 372 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P05300 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 181 | First lumenal domainAdd BLAST | 163 | |
Regioni | 182 – 224 | HingeAdd BLAST | 43 | |
Regioni | 186 – 213 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 225 – 379 | Second lumenal domainAdd BLAST | 155 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 186 – 210 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the LAMP family.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4818, Eukaryota |
InParanoidi | P05300 |
OrthoDBi | 1042920at2759 |
PhylomeDBi | P05300 |
Family and domain databases
InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
PANTHERi | PTHR11506, PTHR11506, 1 hit |
Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
PRINTSi | PR00336, LYSASSOCTDMP |
PROSITEi | View protein in PROSITE PS00310, LAMP_1, 1 hit PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P05300-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGAARAVLL GFLQASSSFD VRDSTGKVCI IANLTVAFSV EYKSSGQKQF
60 70 80 90 100
AHFFLPQNAT SQSHSSCGEG NTSHPILALS FGAGHLISLN FSKTLDKYQV
110 120 130 140 150
EELTFHYNLS DETLFPNATE GKVMVATQKS VIQARIGTEY RCINSKYVRM
160 170 180 190 200
KHVNITFSNV TLEAYPTNDT FSANKTECRE DMVSTTTVAP TTPKHATSQV
210 220 230 240 250
PTTSPAPTAA PSSPAVGKYN VTGANGTCVL ASMGLQLNIT YVKKDEKMGL
260 270 280 290 300
DLLNFIPHNT SASGMCESTS AFLNLAFEKT KITFHFVLNA SSEKFFLQGV
310 320 330 340 350
NVSTTLPSEA KAPTFEASND SMSESRATVG NSYKCSAEEN FQVTDKALVN
360 370 380 390 400
VFNVQVQAFK VDGDKFGAME ECQLDENNML IPIIVGAALA GLVLIVLIAY
410
LIGRKRSHAG YQTI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | G → R in AAA65947 (PubMed:2250003).Curated | 1 | |
Sequence conflicti | 148 | V → I in AAA65947 (PubMed:2250003).Curated | 1 | |
Sequence conflicti | 325 | S → L in AAA65947 (PubMed:2250003).Curated | 1 | |
Sequence conflicti | 369 | M → V in AAA65947 (PubMed:2250003).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07775 mRNA Translation: CAA30601.1 M59365 , M59361, M59362, M59363, M59364 Genomic DNA Translation: AAA65947.1 |
PIRi | A38331 |
RefSeqi | NP_990614.2, NM_205283.2 |
Genome annotation databases
GeneIDi | 396220 |
KEGGi | gga:396220 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07775 mRNA Translation: CAA30601.1 M59365 , M59361, M59362, M59363, M59364 Genomic DNA Translation: AAA65947.1 |
PIRi | A38331 |
RefSeqi | NP_990614.2, NM_205283.2 |
3D structure databases
SMRi | P05300 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000027119 |
Proteomic databases
PaxDbi | P05300 |
Genome annotation databases
GeneIDi | 396220 |
KEGGi | gga:396220 |
Organism-specific databases
CTDi | 3916 |
Phylogenomic databases
eggNOGi | KOG4818, Eukaryota |
InParanoidi | P05300 |
OrthoDBi | 1042920at2759 |
PhylomeDBi | P05300 |
Miscellaneous databases
PROi | PR:P05300 |
Family and domain databases
InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
PANTHERi | PTHR11506, PTHR11506, 1 hit |
Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
PRINTSi | PR00336, LYSASSOCTDMP |
PROSITEi | View protein in PROSITE PS00310, LAMP_1, 1 hit PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LAMP1_CHICK | |
Accessioni | P05300Primary (citable) accession number: P05300 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families