UniProtKB - P05231 (IL6_HUMAN)
Interleukin-6
IL6
Functioni
GO - Molecular functioni
- cytokine activity Source: BHF-UCL
- growth factor activity Source: BHF-UCL
- interleukin-6 receptor binding Source: BHF-UCL
GO - Biological processi
- acute-phase response Source: BHF-UCL
- cellular protein metabolic process Source: Reactome
- cellular response to hydrogen peroxide Source: BHF-UCL
- cellular response to lipopolysaccharide Source: MGI
- cellular response to virus Source: UniProtKB
- cytokine-mediated signaling pathway Source: BHF-UCL
- defense response to Gram-negative bacterium Source: BHF-UCL
- defense response to Gram-positive bacterium Source: BHF-UCL
- defense response to virus Source: BHF-UCL
- endocrine pancreas development Source: BHF-UCL
- germinal center B cell differentiation Source: UniProtKB
- glucagon secretion Source: BHF-UCL
- glucose homeostasis Source: UniProtKB
- hepatic immune response Source: BHF-UCL
- hepatocyte proliferation Source: UniProtKB
- humoral immune response Source: BHF-UCL
- inflammatory response Source: BHF-UCL
- interleukin-6-mediated signaling pathway Source: BHF-UCL
- liver regeneration Source: UniProtKB
- maintenance of blood-brain barrier Source: ARUK-UCL
- monocyte chemotaxis Source: BHF-UCL
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of bone resorption Source: BHF-UCL
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of chemokine production Source: UniProtKB
- negative regulation of collagen biosynthetic process Source: BHF-UCL
- negative regulation of fat cell differentiation Source: BHF-UCL
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
- negative regulation of interleukin-1-mediated signaling pathway Source: BHF-UCL
- negative regulation of lipid storage Source: BHF-UCL
- negative regulation of neurogenesis Source: ARUK-UCL
- negative regulation of primary miRNA processing Source: ARUK-UCL
- neuron cellular homeostasis Source: ARUK-UCL
- neuron projection development Source: BHF-UCL
- neutrophil apoptotic process Source: UniProtKB
- neutrophil mediated immunity Source: BHF-UCL
- platelet activation Source: BHF-UCL
- positive regulation of acute inflammatory response Source: BHF-UCL
- positive regulation of apoptotic DNA fragmentation Source: ARUK-UCL
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of B cell activation Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of chemokine production Source: BHF-UCL
- positive regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
- positive regulation of DNA-binding transcription factor activity Source: ARUK-UCL
- positive regulation of epithelial to mesenchymal transition Source: ARUK-UCL
- positive regulation of extracellular matrix disassembly Source: ARUK-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of glial cell proliferation Source: ARUK-UCL
- positive regulation of immunoglobulin production Source: BHF-UCL
- positive regulation of interleukin-10 production Source: ARUK-UCL
- positive regulation of interleukin-17 production Source: ARUK-UCL
- positive regulation of interleukin-1 beta production Source: ARUK-UCL
- positive regulation of interleukin-21 production Source: UniProtKB
- positive regulation of interleukin-6 production Source: BHF-UCL
- positive regulation of interleukin-8 production Source: ARUK-UCL
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: ARUK-UCL
- positive regulation of leukocyte chemotaxis Source: BHF-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of neuroinflammatory response Source: ARUK-UCL
- positive regulation of osteoblast differentiation Source: ARUK-UCL
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of production of miRNAs involved in gene silencing by miRNA Source: ARUK-UCL
- positive regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
- positive regulation of receptor signaling pathway via STAT Source: ARUK-UCL
- positive regulation of smooth muscle cell proliferation Source: BHF-UCL
- positive regulation of T cell proliferation Source: BHF-UCL
- positive regulation of T-helper 2 cell cytokine production Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of translation Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: ARUK-UCL
- positive regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- positive regulation of vascular endothelial growth factor production Source: ARUK-UCL
- post-translational protein modification Source: Reactome
- regulation of angiogenesis Source: BHF-UCL
- regulation of astrocyte activation Source: ARUK-UCL
- regulation of glucagon secretion Source: UniProtKB
- regulation of insulin secretion Source: UniProtKB
- regulation of microglial cell activation Source: ARUK-UCL
- regulation of neuroinflammatory response Source: ARUK-UCL
- regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
- regulation of vascular endothelial growth factor production Source: BHF-UCL
- response to activity Source: UniProtKB
- response to glucocorticoid Source: BHF-UCL
- response to peptidoglycan Source: BHF-UCL
- T follicular helper cell differentiation Source: UniProtKB
- T-helper 17 cell lineage commitment Source: UniProtKB
- vascular endothelial growth factor production Source: UniProtKB
Keywordsi
Molecular function | Cytokine, Growth factor |
Biological process | Acute phase |
Enzyme and pathway databases
PathwayCommonsi | P05231 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9662834, CD163 mediating an anti-inflammatory response |
SignaLinki | P05231 |
SIGNORi | P05231 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-6CuratedShort name: IL-6 Alternative name(s): B-cell stimulatory factor 2 Short name: BSF-2 CTL differentiation factor Short name: CDF Hybridoma growth factor Interferon beta-2 Short name: IFN-beta-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6018, IL6 |
MIMi | 147620, gene |
neXtProti | NX_P05231 |
VEuPathDBi | HostDB:ENSG00000136244.11 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Plasma Membrane
- interleukin-6 receptor complex Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Rheumatoid arthritis systemic juvenile (RASJ)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 173 | A → V: Almost no loss of activity. 1 Publication | 1 | |
Mutagenesisi | 185 | W → R: No loss of activity. 1 Publication | 1 | |
Mutagenesisi | 204 | S → P: 87% loss of activity. 1 Publication | 1 | |
Mutagenesisi | 210 | R → K, E, Q, T, A or P: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 212 | M → T, N, S or R: Loss of activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3569 |
MalaCardsi | IL6 |
MIMi | 148000, phenotype 604302, phenotype |
OpenTargetsi | ENSG00000136244 |
Orphaneti | 206, NON RARE IN EUROPE: Crohn disease 85414, Systemic-onset juvenile idiopathic arthritis |
PharmGKBi | PA198 |
Miscellaneous databases
Pharosi | P05231, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1795129 |
DrugBanki | DB05767, Andrographolide DB05513, Atiprimod DB11967, Binimetinib DB05744, CRx-139 DB12140, Dilmapimod DB10770, Foreskin fibroblast (neonatal) DB10772, Foreskin keratinocyte (neonatal) DB01404, Ginseng DB09221, Polaprezinc DB09036, Siltuximab DB06083, Tapinarof DB05470, VX-702 DB05017, YSIL6 |
DrugCentrali | P05231 |
Genetic variation databases
BioMutai | IL6 |
DMDMi | 124347 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 3 PublicationsAdd BLAST | 29 | |
ChainiPRO_0000015582 | 30 – 212 | Interleukin-6Add BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 72 ↔ 78 | 1 Publication | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 81 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 101 ↔ 111 | 1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P05231 |
PaxDbi | P05231 |
PeptideAtlasi | P05231 |
PRIDEi | P05231 |
ProteomicsDBi | 51828 |
PTM databases
GlyGeni | P05231, 1 site |
iPTMneti | P05231 |
MetOSitei | P05231 |
PhosphoSitePlusi | P05231 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000136244, Expressed in left coronary artery and 159 other tissues |
ExpressionAtlasi | P05231, baseline and differential |
Genevisiblei | P05231, HS |
Organism-specific databases
HPAi | ENSG00000136244, Tissue enhanced (adipose tissue, lymphoid tissue) |
Interactioni
Subunit structurei
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:12829785).
Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003).
Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003).
2 PublicationsBinary interactionsi
Hide detailsP05231
With | #Exp. | IntAct |
---|---|---|
IL6R [P08887] | 7 | EBI-720533,EBI-299383 |
SORL1 [Q92673] | 4 | EBI-720533,EBI-1171329 |
SORT1 [Q99523] | 4 | EBI-720533,EBI-1057058 |
GO - Molecular functioni
- cytokine activity Source: BHF-UCL
- growth factor activity Source: BHF-UCL
- interleukin-6 receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109783, 9 interactors |
DIPi | DIP-482N |
IntActi | P05231, 8 interactors |
STRINGi | 9606.ENSP00000385675 |
Chemistry databases
BindingDBi | P05231 |
Miscellaneous databases
RNActi | P05231, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P05231 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05231 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7Q4, Eukaryota |
GeneTreei | ENSGT00390000000878 |
InParanoidi | P05231 |
OMAi | YDKCENS |
PhylomeDBi | P05231 |
TreeFami | TF335984 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR003574, IL-6 IPR030474, IL-6/GCSF/MGF IPR030473, IL6/GCSF/MGF_CS |
PANTHERi | PTHR10511, PTHR10511, 1 hit PTHR10511:SF3, PTHR10511:SF3, 1 hit |
Pfami | View protein in Pfam PF00489, IL6, 1 hit |
PIRSFi | PIRSF001935, IL6_MGF_GCSF, 1 hit |
PRINTSi | PR00433, IL6GCSFMGF |
SMARTi | View protein in SMART SM00126, IL6, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00254, INTERLEUKIN_6, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS
60 70 80 90 100
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL
160 170 180 190 200
IQFLQKKAKN LDAITTPDPT TNASLLTKLQ AQNQWLQDMT THLILRSFKE
210
FLQSSLRALR QM
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MCZ3 | B5MCZ3_HUMAN | Interleukin-6 | IL6 | 189 | Annotation score: | ||
B5MC14 | B5MC14_HUMAN | Interleukin-6 | IL6 | 198 | Annotation score: | ||
C9J5B0 | C9J5B0_HUMAN | Interleukin-6 | IL6 | 152 | Annotation score: | ||
B5MC21 | B5MC21_HUMAN | Interleukin-6 | IL6 | 136 | Annotation score: | ||
B4DNV3 | B4DNV3_HUMAN | Interleukin-6 | IL6 | 122 | Annotation score: |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013075 | 32 | P → S1 PublicationCorresponds to variant dbSNP:rs2069830EnsemblClinVar. | 1 | |
Natural variantiVAR_029266 | 162 | D → E. Corresponds to variant dbSNP:rs13306435Ensembl. | 1 | |
Natural variantiVAR_013076 | 162 | D → V1 PublicationCorresponds to variant dbSNP:rs2069860EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04430 mRNA Translation: CAA28026.1 M14584 mRNA Translation: AAA52728.1 X04602 mRNA Translation: CAA28268.1 Y00081 Genomic DNA Translation: CAA68278.1 M18403 mRNA Translation: AAA52729.1 M29150 mRNA Translation: AAA59154.1 X04402 Genomic DNA Translation: CAA27990.1 X04403 mRNA Translation: CAA27991.1 M54894 mRNA Translation: AAC41704.1 S56892 mRNA Translation: AAD13886.1 AF372214 Genomic DNA Translation: AAK48987.1 BC015511 mRNA Translation: AAH15511.1 |
CCDSi | CCDS5375.1 |
PIRi | A32648, IVHUB2 |
RefSeqi | NP_000591.1, NM_000600.4 XP_011513692.1, XM_011515390.2 |
Genome annotation databases
Ensembli | ENST00000258743; ENSP00000258743; ENSG00000136244 ENST00000404625; ENSP00000385675; ENSG00000136244 |
GeneIDi | 3569 |
KEGGi | hsa:3569 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Interleukin-6 entry |
SeattleSNPs |
SHMPD The Singapore human mutation and polymorphism database |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04430 mRNA Translation: CAA28026.1 M14584 mRNA Translation: AAA52728.1 X04602 mRNA Translation: CAA28268.1 Y00081 Genomic DNA Translation: CAA68278.1 M18403 mRNA Translation: AAA52729.1 M29150 mRNA Translation: AAA59154.1 X04402 Genomic DNA Translation: CAA27990.1 X04403 mRNA Translation: CAA27991.1 M54894 mRNA Translation: AAC41704.1 S56892 mRNA Translation: AAD13886.1 AF372214 Genomic DNA Translation: AAK48987.1 BC015511 mRNA Translation: AAH15511.1 |
CCDSi | CCDS5375.1 |
PIRi | A32648, IVHUB2 |
RefSeqi | NP_000591.1, NM_000600.4 XP_011513692.1, XM_011515390.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ALU | X-ray | 1.90 | A | 28-212 | [»] | |
1IL6 | NMR | - | A | 28-212 | [»] | |
1N2Q | model | - | E/F | 30-212 | [»] | |
1P9M | X-ray | 3.65 | B | 29-212 | [»] | |
2IL6 | NMR | - | A | 28-212 | [»] | |
4CNI | X-ray | 2.20 | C/D | 42-212 | [»] | |
4J4L | X-ray | 2.30 | C/D | 47-212 | [»] | |
4NI7 | X-ray | 2.40 | A | 28-212 | [»] | |
4NI9 | X-ray | 2.55 | A/C | 28-212 | [»] | |
4O9H | X-ray | 2.42 | A | 28-212 | [»] | |
4ZS7 | X-ray | 2.93 | A | 42-212 | [»] | |
5FUC | X-ray | 2.70 | A/B | 49-212 | [»] | |
SMRi | P05231 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109783, 9 interactors |
DIPi | DIP-482N |
IntActi | P05231, 8 interactors |
STRINGi | 9606.ENSP00000385675 |
Chemistry databases
BindingDBi | P05231 |
ChEMBLi | CHEMBL1795129 |
DrugBanki | DB05767, Andrographolide DB05513, Atiprimod DB11967, Binimetinib DB05744, CRx-139 DB12140, Dilmapimod DB10770, Foreskin fibroblast (neonatal) DB10772, Foreskin keratinocyte (neonatal) DB01404, Ginseng DB09221, Polaprezinc DB09036, Siltuximab DB06083, Tapinarof DB05470, VX-702 DB05017, YSIL6 |
DrugCentrali | P05231 |
PTM databases
GlyGeni | P05231, 1 site |
iPTMneti | P05231 |
MetOSitei | P05231 |
PhosphoSitePlusi | P05231 |
Genetic variation databases
BioMutai | IL6 |
DMDMi | 124347 |
Proteomic databases
MassIVEi | P05231 |
PaxDbi | P05231 |
PeptideAtlasi | P05231 |
PRIDEi | P05231 |
ProteomicsDBi | 51828 |
Protocols and materials databases
ABCDi | P05231, 186 sequenced antibodies |
Antibodypediai | 12025, 2808 antibodies |
CPTCi | P05231, 3 antibodies |
DNASUi | 3569 |
Genome annotation databases
Ensembli | ENST00000258743; ENSP00000258743; ENSG00000136244 ENST00000404625; ENSP00000385675; ENSG00000136244 |
GeneIDi | 3569 |
KEGGi | hsa:3569 |
Organism-specific databases
CTDi | 3569 |
DisGeNETi | 3569 |
GeneCardsi | IL6 |
HGNCi | HGNC:6018, IL6 |
HPAi | ENSG00000136244, Tissue enhanced (adipose tissue, lymphoid tissue) |
MalaCardsi | IL6 |
MIMi | 147620, gene 148000, phenotype 604302, phenotype |
neXtProti | NX_P05231 |
OpenTargetsi | ENSG00000136244 |
Orphaneti | 206, NON RARE IN EUROPE: Crohn disease 85414, Systemic-onset juvenile idiopathic arthritis |
PharmGKBi | PA198 |
VEuPathDBi | HostDB:ENSG00000136244.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S7Q4, Eukaryota |
GeneTreei | ENSGT00390000000878 |
InParanoidi | P05231 |
OMAi | YDKCENS |
PhylomeDBi | P05231 |
TreeFami | TF335984 |
Enzyme and pathway databases
PathwayCommonsi | P05231 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9662834, CD163 mediating an anti-inflammatory response |
SignaLinki | P05231 |
SIGNORi | P05231 |
Miscellaneous databases
BioGRID-ORCSi | 3569, 5 hits in 995 CRISPR screens |
ChiTaRSi | IL6, human |
EvolutionaryTracei | P05231 |
GeneWikii | Interleukin_6 |
GenomeRNAii | 3569 |
Pharosi | P05231, Tclin |
PROi | PR:P05231 |
RNActi | P05231, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136244, Expressed in left coronary artery and 159 other tissues |
ExpressionAtlasi | P05231, baseline and differential |
Genevisiblei | P05231, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR003574, IL-6 IPR030474, IL-6/GCSF/MGF IPR030473, IL6/GCSF/MGF_CS |
PANTHERi | PTHR10511, PTHR10511, 1 hit PTHR10511:SF3, PTHR10511:SF3, 1 hit |
Pfami | View protein in Pfam PF00489, IL6, 1 hit |
PIRSFi | PIRSF001935, IL6_MGF_GCSF, 1 hit |
PRINTSi | PR00433, IL6GCSFMGF |
SMARTi | View protein in SMART SM00126, IL6, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00254, INTERLEUKIN_6, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL6_HUMAN | |
Accessioni | P05231Primary (citable) accession number: P05231 Secondary accession number(s): Q9UCU2, Q9UCU3, Q9UCU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | August 13, 1987 | |
Last modified: | April 7, 2021 | |
This is version 235 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families