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Protein

Chymotrypsin-like elastase family member 2A

Gene

Cela2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei123Charge relay systemBy similarity1
Active sitei218Charge relay systemBy similarity1

GO - Molecular functioni

  • serine hydrolase activity Source: MGI
  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.155

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 2A (EC:3.4.21.71)
Alternative name(s):
Elastase-2
Elastase-2A
Gene namesi
Name:Cela2a
Synonyms:Ela-2, Ela2, Ela2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95316 Cela2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000002768717 – 30Activation peptideAdd BLAST14
ChainiPRO_000002768831 – 271Chymotrypsin-like elastase family member 2AAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi157 ↔ 224PROSITE-ProRule annotation
Disulfide bondi188 ↔ 204PROSITE-ProRule annotation
Disulfide bondi214 ↔ 245PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiP05208
PaxDbiP05208
PeptideAtlasiP05208
PRIDEiP05208

PTM databases

PhosphoSitePlusiP05208

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSMUSG00000058579 Expressed in 61 organ(s), highest expression level in pancreas
CleanExiMM_ELA2
GenevisibleiP05208 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099539

Structurei

3D structure databases

ProteinModelPortaliP05208
SMRiP05208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 269Peptidase S1PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiP05208
KOiK01346
OMAiSSNTACY
OrthoDBiEOG091G0DF7
PhylomeDBiP05208
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05208-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRTLLLSAL VAGALSCGYP TYEVEDDVSR VVGGQEATPN TWPWQVSLQV
60 70 80 90 100
LSSGRWRHNC GGSLVANNWV LTAAHCLSNY QTYRVLLGAH SLSNPGAGSA
110 120 130 140 150
AVQVSKLVVH QRWNSQNVGN GYDIALIKLA SPVTLSKNIQ TACLPPAGTI
160 170 180 190 200
LPRNYVCYVT GWGLLQTNGN SPDTLRQGRL LVVDYATCSS ASWWGSSVKS
210 220 230 240 250
SMVCAGGDGV TSSCNGDSGG PLNCRASNGQ WQVHGIVSFG SSLGCNYPRK
260 270
PSVFTRVSNY IDWINSVMAR N
Length:271
Mass (Da):28,914
Last modified:August 13, 1987 - v1
Checksum:iFA542AE38FED3B4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04573 mRNA Translation: CAA28242.1
X04576 Genomic DNA Translation: CAA28244.1
BC026552 mRNA Translation: AAH26552.1
CCDSiCCDS18884.1
PIRiA25528
RefSeqiNP_031945.1, NM_007919.3
UniGeneiMm.45316

Genome annotation databases

EnsembliENSMUST00000102481; ENSMUSP00000099539; ENSMUSG00000058579
GeneIDi13706
KEGGimmu:13706
UCSCiuc008vpj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04573 mRNA Translation: CAA28242.1
X04576 Genomic DNA Translation: CAA28244.1
BC026552 mRNA Translation: AAH26552.1
CCDSiCCDS18884.1
PIRiA25528
RefSeqiNP_031945.1, NM_007919.3
UniGeneiMm.45316

3D structure databases

ProteinModelPortaliP05208
SMRiP05208
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099539

Protein family/group databases

MEROPSiS01.155

PTM databases

PhosphoSitePlusiP05208

Proteomic databases

MaxQBiP05208
PaxDbiP05208
PeptideAtlasiP05208
PRIDEiP05208

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102481; ENSMUSP00000099539; ENSMUSG00000058579
GeneIDi13706
KEGGimmu:13706
UCSCiuc008vpj.1 mouse

Organism-specific databases

CTDi63036
MGIiMGI:95316 Cela2a

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiP05208
KOiK01346
OMAiSSNTACY
OrthoDBiEOG091G0DF7
PhylomeDBiP05208
TreeFamiTF330455

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiCela2a mouse
PROiPR:P05208
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058579 Expressed in 61 organ(s), highest expression level in pancreas
CleanExiMM_ELA2
GenevisibleiP05208 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEL2A_MOUSE
AccessioniPrimary (citable) accession number: P05208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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