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Protein

Heterochromatin protein 1

Gene

Su(var)205

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24Histone H3K9me21
Binding sitei45Histone H3K9me21
Binding sitei48Histone H3K9me21

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • histone binding Source: FlyBase
  • Hsp70 protein binding Source: CAFA
  • methylated histone binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • protein binding, bridging Source: CAFA
  • protein-containing complex binding Source: CAFA
  • rDNA binding Source: FlyBase
  • RNA binding Source: FlyBase
  • RNA polymerase binding Source: CAFA
  • RNA polymerase II C-terminal domain binding Source: CAFA
  • satellite DNA binding Source: FlyBase

GO - Biological processi

  • chromatin silencing Source: FlyBase
  • chromatin silencing at centromere Source: FlyBase
  • chromosome organization Source: FlyBase
  • establishment of chromatin silencing Source: FlyBase
  • gene silencing Source: FlyBase
  • heterochromatin assembly Source: FlyBase
  • histone H4-K20 trimethylation Source: FlyBase
  • mitotic cell cycle Source: CACAO
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • positive regulation of extent of heterochromatin assembly Source: FlyBase
  • positive regulation of FACT complex assembly Source: CAFA
  • positive regulation of histone H3-K9 dimethylation Source: FlyBase
  • positive regulation of methylation-dependent chromatin silencing Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: CAFA
  • protein localization to euchromatin Source: CAFA
  • regulation of apoptotic process Source: FlyBase
  • regulation of histone methylation Source: FlyBase
  • regulation of protein localization to chromatin Source: CAFA
  • regulation of transcription, DNA-templated Source: FlyBase
  • telomere maintenance Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-73777 RNA Polymerase I Chain Elongation
R-DME-8953750 Transcriptional Regulation by E2F6
R-DME-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP05205

Names & Taxonomyi

Protein namesi
Recommended name:
Heterochromatin protein 1
Short name:
HP1
Alternative name(s):
Non-histone chromosomal protein C1A9 antigen
Gene namesi
Name:Su(var)205
Synonyms:HP1
ORF Names:CG8409
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003607 Su(var)205

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26V → M: Impairs chromo domain folding and histone H3 binding. Does not affect piwi binding. 2 Publications1
Mutagenesisi191I → E: Abolishes piwi binding. 1 Publication1
Mutagenesisi200W → A: Abolishes piwi binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801971 – 206Heterochromatin protein 1Add BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11Phosphoserine1 Publication1
Modified residuei15Phosphoserine2 Publications1
Modified residuei102Phosphoserine1 Publication1
Modified residuei103Phosphoserine1 Publication1
Modified residuei113Phosphoserine1 Publication1
Modified residuei127Phosphothreonine1 Publication1
Modified residuei128Phosphothreonine2 Publications1
Modified residuei134Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05205
PRIDEiP05205

PTM databases

iPTMnetiP05205

Expressioni

Gene expression databases

BgeeiFBgn0003607
GenevisibleiP05205 DM

Interactioni

Subunit structurei

Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone binding Source: FlyBase
  • Hsp70 protein binding Source: CAFA
  • methylated histone binding Source: FlyBase
  • protein binding, bridging Source: CAFA
  • RNA polymerase binding Source: CAFA
  • RNA polymerase II C-terminal domain binding Source: CAFA

Protein-protein interaction databases

BioGridi60248, 94 interactors
DIPiDIP-21869N
ELMiP05205
IntActiP05205, 43 interactors
MINTiP05205
STRINGi7227.FBpp0079251

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 35Combined sources13
Beta strandi38 – 45Combined sources8
Helixi50 – 52Combined sources3
Beta strandi54 – 57Combined sources4
Helixi58 – 60Combined sources3
Helixi64 – 73Combined sources10
Turni142 – 146Combined sources5
Beta strandi149 – 158Combined sources10
Beta strandi161 – 168Combined sources8
Beta strandi175 – 178Combined sources4
Helixi179 – 185Combined sources7
Helixi187 – 196Combined sources10

3D structure databases

ProteinModelPortaliP05205
SMRiP05205
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05205

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 82Chromo 1PROSITE-ProRule annotationAdd BLAST59
Domaini147 – 205Chromo 2PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 206Binds to Su(var)39Add BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 23Poly-Glu6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1911 Eukaryota
ENOG4111JKD LUCA
GeneTreeiENSGT00510000046310
InParanoidiP05205
KOiK11587
OMAiPETENTW
OrthoDBiEOG091G0RBS
PhylomeDBiP05205

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR017984 Chromo_dom_subgr
IPR023780 Chromo_domain
IPR008251 Chromo_shadow_dom
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF00385 Chromo, 1 hit
PF01393 Chromo_shadow, 1 hit
PRINTSiPR00504 CHROMODOMAIN
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00300 ChSh, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 2 hits

Sequencei

Sequence statusi: Complete.

P05205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKIDNPES SAKVSDAEEE EEEYAVEKII DRRVRKGKVE YYLKWKGYPE
60 70 80 90 100
TENTWEPENN LDCQDLIQQY EASRKDEEKS AASKKDRPSS SAKAKETQGR
110 120 130 140 150
ASSSTSTASK RKSEEPTAPS GNKSKRTTDA EQDTIPVSGS TGFDRGLEAE
160 170 180 190 200
KILGASDNNG RLTFLIQFKG VDQAEMVPSS VANEKIPRMV IHFYEERLSW

YSDNED
Length:206
Mass (Da):23,185
Last modified:November 1, 1995 - v2
Checksum:i6A5B204C487526B7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti105T → A in strain: NC322, NC358 and NC359. 1 Publication1
Natural varianti126R → C in strain: NC390. 1 Publication1
Natural varianti134T → S in strain: MW25. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57574 Genomic DNA Translation: AAA28620.1
M14131 mRNA Translation: AAA28402.1 Sequence problems.
FJ218607 Genomic DNA Translation: ACI96755.1
FJ218612 Genomic DNA Translation: ACI96760.1
FJ218613 Genomic DNA Translation: ACI96761.1
FJ218614 Genomic DNA Translation: ACI96762.1
FJ218615 Genomic DNA Translation: ACI96763.1
FJ218616 Genomic DNA Translation: ACI96764.1
FJ218617 Genomic DNA Translation: ACI96765.1
FJ218618 Genomic DNA Translation: ACI96766.1
FJ218619 Genomic DNA Translation: ACI96767.1
FJ218620 Genomic DNA Translation: ACI96768.1
FJ218621 Genomic DNA Translation: ACI96769.1
FJ218622 Genomic DNA Translation: ACI96770.1
FJ218623 Genomic DNA Translation: ACI96771.1
FJ218624 Genomic DNA Translation: ACI96772.1
FJ218625 Genomic DNA Translation: ACI96773.1
FJ218626 Genomic DNA Translation: ACI96774.1
FJ218627 Genomic DNA Translation: ACI96775.1
FJ218628 Genomic DNA Translation: ACI96776.1
FJ218629 Genomic DNA Translation: ACI96777.1
FJ218630 Genomic DNA Translation: ACI96778.1
FJ218631 Genomic DNA Translation: ACI96779.1
FJ218632 Genomic DNA Translation: ACI96780.1
FJ218633 Genomic DNA Translation: ACI96781.1
FJ218634 Genomic DNA Translation: ACI96782.1
FJ218635 Genomic DNA Translation: ACI96783.1
FJ218636 Genomic DNA Translation: ACI96784.1
FJ218637 Genomic DNA Translation: ACI96785.1
FJ218638 Genomic DNA Translation: ACI96786.1
FJ218639 Genomic DNA Translation: ACI96787.1
AE014134 Genomic DNA Translation: AAF52618.1
AE014134 Genomic DNA Translation: AAN11156.1
AY061119 mRNA Translation: AAL28667.1
PIRiA39268
RefSeqiNP_476755.1, NM_057407.4
NP_723361.1, NM_164799.2
UniGeneiDm.3713

Genome annotation databases

EnsemblMetazoaiFBtr0079635; FBpp0079251; FBgn0003607
FBtr0079636; FBpp0079252; FBgn0003607
GeneIDi34119
KEGGidme:Dmel_CG8409
UCSCiCG8409-RB d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiHP1_DROME
AccessioniPrimary (citable) accession number: P05205
Secondary accession number(s): A4V0F1
, B6UVR4, B6UVS1, B6UVS2, B6UVS3, B6UVT2, B6UVT6, B6UVT7, Q9VLR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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