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Entry version 180 (18 Sep 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Non-histone chromosomal protein HMG-17

Gene

HMGN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05204

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMGN2
Synonyms:HMG17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4986 HMGN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
163910 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05204

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3151

Open Targets

More...
OpenTargetsi
ENSG00000198830

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35089

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HMGN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
123106

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002066972 – 90Non-histone chromosomal protein HMG-17Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25Phosphoserine1 Publication1
Modified residuei29ADP-ribosylserine; alternate1 Publication1
Modified residuei29Phosphoserine; alternate1 Publication1
Modified residuei82N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation favors cytoplasmic localization.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P05204

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P05204

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P05204

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P05204

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05204

PeptideAtlas

More...
PeptideAtlasi
P05204

PRoteomics IDEntifications database

More...
PRIDEi
P05204

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51825

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P05204

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05204

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05204

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P05204

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198830 Expressed in 91 organ(s), highest expression level in pituitary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05204 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018371
HPA077364

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2Q155542EBI-1758689,EBI-706637

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109394, 25 interactors

Protein interaction database and analysis system

More...
IntActi
P05204, 90 interactors

Molecular INTeraction database

More...
MINTi
P05204

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355228

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1B8 Eukaryota
ENOG410Z0UC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116395

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05204

KEGG Orthology (KO)

More...
KOi
K11300

Identification of Orthologs from Complete Genome Data

More...
OMAi
SARLSAX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05204

Family and domain databases

Database of protein disorder

More...
DisProti
DP00039

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000079 HMGN_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01101 HMG14_17, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00925 NONHISHMG17

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00527 HMG17, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00355 HMG14_17, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P05204-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,393
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1C58E52200422C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5K → N (PubMed:3754870).Curated1
Sequence conflicti26 – 27AR → SA AA sequence (PubMed:2040281).Curated2

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 9261.5 Da from positions 2 - 90. Determined by ESI. 1 Publication
Molecular mass is 9341.3±1.9 Da from positions 2 - 90. Determined by ESI. 1 Publication
Molecular mass is 9421.5 Da from positions 2 - 90. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0037167E → K in variant H17. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M12623 mRNA Translation: AAA52678.1
X13546 Genomic DNA Translation: CAA31898.1
CR542122 mRNA Translation: CAG46919.1
AL513365 Genomic DNA No translation available.
BC000378 mRNA Translation: AAH00378.1
BC003050 mRNA Translation: AAH03050.1
BC014644 mRNA Translation: AAH14644.2
BC032140 mRNA Translation: AAH32140.2
BC070297 mRNA Translation: AAH70297.1
BC071707 mRNA Translation: AAH71707.1
BC072010 mRNA Translation: AAH72010.1
BC072011 mRNA Translation: AAH72011.1
BC075837 mRNA Translation: AAH75837.1
BC081567 mRNA Translation: AAH81567.1
BC110390 mRNA Translation: AAI10391.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS283.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S03700

NCBI Reference Sequences

More...
RefSeqi
NP_005508.1, NM_005517.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361427; ENSP00000355228; ENSG00000198830
ENST00000619352; ENSP00000481160; ENSG00000198830

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3151

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3151

UCSC genome browser

More...
UCSCi
uc001bmp.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12623 mRNA Translation: AAA52678.1
X13546 Genomic DNA Translation: CAA31898.1
CR542122 mRNA Translation: CAG46919.1
AL513365 Genomic DNA No translation available.
BC000378 mRNA Translation: AAH00378.1
BC003050 mRNA Translation: AAH03050.1
BC014644 mRNA Translation: AAH14644.2
BC032140 mRNA Translation: AAH32140.2
BC070297 mRNA Translation: AAH70297.1
BC071707 mRNA Translation: AAH71707.1
BC072010 mRNA Translation: AAH72010.1
BC072011 mRNA Translation: AAH72011.1
BC075837 mRNA Translation: AAH75837.1
BC081567 mRNA Translation: AAH81567.1
BC110390 mRNA Translation: AAI10391.1
CCDSiCCDS283.1
PIRiS03700
RefSeqiNP_005508.1, NM_005517.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi109394, 25 interactors
IntActiP05204, 90 interactors
MINTiP05204
STRINGi9606.ENSP00000355228

PTM databases

iPTMnetiP05204
PhosphoSitePlusiP05204
SwissPalmiP05204

Polymorphism and mutation databases

BioMutaiHMGN2
DMDMi123106

Proteomic databases

EPDiP05204
jPOSTiP05204
MassIVEiP05204
MaxQBiP05204
PaxDbiP05204
PeptideAtlasiP05204
PRIDEiP05204
ProteomicsDBi51825
TopDownProteomicsiP05204

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3151
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361427; ENSP00000355228; ENSG00000198830
ENST00000619352; ENSP00000481160; ENSG00000198830
GeneIDi3151
KEGGihsa:3151
UCSCiuc001bmp.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3151
DisGeNETi3151

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HMGN2
HGNCiHGNC:4986 HMGN2
HPAiCAB018371
HPA077364
MIMi163910 gene
neXtProtiNX_P05204
OpenTargetsiENSG00000198830
PharmGKBiPA35089

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J1B8 Eukaryota
ENOG410Z0UC LUCA
GeneTreeiENSGT00950000182802
HOGENOMiHOG000116395
InParanoidiP05204
KOiK11300
OMAiSARLSAX
PhylomeDBiP05204

Enzyme and pathway databases

SIGNORiP05204

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HMGN2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HMGN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3151

Pharos

More...
Pharosi
P05204

Protein Ontology

More...
PROi
PR:P05204

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198830 Expressed in 91 organ(s), highest expression level in pituitary gland
GenevisibleiP05204 HS

Family and domain databases

DisProtiDP00039
InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMGN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05204
Secondary accession number(s): Q0VGD5, Q6FGI5, Q96C64
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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