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Protein

Non-histone chromosomal protein HMG-17

Gene

HMGN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

SIGNORiP05204

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:HMGN2
Synonyms:HMG17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198830.10
HGNCiHGNC:4986 HMGN2
MIMi163910 gene
neXtProtiNX_P05204

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3151
OpenTargetsiENSG00000198830
PharmGKBiPA35089

Polymorphism and mutation databases

BioMutaiHMGN2
DMDMi123106

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066972 – 90Non-histone chromosomal protein HMG-17Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Phosphoserine1 Publication1
Modified residuei29ADP-ribosylserine; alternate1 Publication1
Modified residuei29Phosphoserine; alternate1 Publication1
Modified residuei82N6-acetyllysine; alternateCombined sources1
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationi

Phosphorylation favors cytoplasmic localization.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP05204
MaxQBiP05204
PaxDbiP05204
PeptideAtlasiP05204
PRIDEiP05204
ProteomicsDBi51825
TopDownProteomicsiP05204

PTM databases

iPTMnetiP05204
PhosphoSitePlusiP05204

Expressioni

Gene expression databases

BgeeiENSG00000198830 Expressed in 91 organ(s), highest expression level in pituitary gland
CleanExiHS_HMGN2
GenevisibleiP05204 HS

Organism-specific databases

HPAiCAB018371
HPA077364

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2Q155542EBI-1758689,EBI-706637

Protein-protein interaction databases

BioGridi109394, 22 interactors
IntActiP05204, 10 interactors
MINTiP05204
STRINGi9606.ENSP00000355228

Structurei

3D structure databases

DisProtiDP00039
ProteinModelPortaliP05204
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J1B8 Eukaryota
ENOG410Z0UC LUCA
GeneTreeiENSGT00730000110660
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiP05204
KOiK11300
OMAiSARLSAX
PhylomeDBiP05204

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05204-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,393
Last modified:January 23, 2007 - v3
Checksum:iB1C58E52200422C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → N (PubMed:3754870).Curated1
Sequence conflicti26 – 27AR → SA AA sequence (PubMed:2040281).Curated2

Mass spectrometryi

Molecular mass is 9261.5 Da from positions 2 - 90. Determined by ESI. 1 Publication
Molecular mass is 9341.3±1.9 Da from positions 2 - 90. Determined by ESI. 1 Publication
Molecular mass is 9421.5 Da from positions 2 - 90. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0037167E → K in variant H17. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12623 mRNA Translation: AAA52678.1
X13546 Genomic DNA Translation: CAA31898.1
CR542122 mRNA Translation: CAG46919.1
AL513365 Genomic DNA No translation available.
BC000378 mRNA Translation: AAH00378.1
BC003050 mRNA Translation: AAH03050.1
BC014644 mRNA Translation: AAH14644.2
BC032140 mRNA Translation: AAH32140.2
BC070297 mRNA Translation: AAH70297.1
BC071707 mRNA Translation: AAH71707.1
BC072010 mRNA Translation: AAH72010.1
BC072011 mRNA Translation: AAH72011.1
BC075837 mRNA Translation: AAH75837.1
BC081567 mRNA Translation: AAH81567.1
BC110390 mRNA Translation: AAI10391.1
CCDSiCCDS283.1
PIRiS03700
RefSeqiNP_005508.1, NM_005517.3
UniGeneiHs.181163

Genome annotation databases

EnsembliENST00000361427; ENSP00000355228; ENSG00000198830
ENST00000619352; ENSP00000481160; ENSG00000198830
GeneIDi3151
KEGGihsa:3151
UCSCiuc001bmp.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12623 mRNA Translation: AAA52678.1
X13546 Genomic DNA Translation: CAA31898.1
CR542122 mRNA Translation: CAG46919.1
AL513365 Genomic DNA No translation available.
BC000378 mRNA Translation: AAH00378.1
BC003050 mRNA Translation: AAH03050.1
BC014644 mRNA Translation: AAH14644.2
BC032140 mRNA Translation: AAH32140.2
BC070297 mRNA Translation: AAH70297.1
BC071707 mRNA Translation: AAH71707.1
BC072010 mRNA Translation: AAH72010.1
BC072011 mRNA Translation: AAH72011.1
BC075837 mRNA Translation: AAH75837.1
BC081567 mRNA Translation: AAH81567.1
BC110390 mRNA Translation: AAI10391.1
CCDSiCCDS283.1
PIRiS03700
RefSeqiNP_005508.1, NM_005517.3
UniGeneiHs.181163

3D structure databases

DisProtiDP00039
ProteinModelPortaliP05204
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109394, 22 interactors
IntActiP05204, 10 interactors
MINTiP05204
STRINGi9606.ENSP00000355228

PTM databases

iPTMnetiP05204
PhosphoSitePlusiP05204

Polymorphism and mutation databases

BioMutaiHMGN2
DMDMi123106

Proteomic databases

EPDiP05204
MaxQBiP05204
PaxDbiP05204
PeptideAtlasiP05204
PRIDEiP05204
ProteomicsDBi51825
TopDownProteomicsiP05204

Protocols and materials databases

DNASUi3151
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361427; ENSP00000355228; ENSG00000198830
ENST00000619352; ENSP00000481160; ENSG00000198830
GeneIDi3151
KEGGihsa:3151
UCSCiuc001bmp.5 human

Organism-specific databases

CTDi3151
DisGeNETi3151
EuPathDBiHostDB:ENSG00000198830.10
GeneCardsiHMGN2
HGNCiHGNC:4986 HMGN2
HPAiCAB018371
HPA077364
MIMi163910 gene
neXtProtiNX_P05204
OpenTargetsiENSG00000198830
PharmGKBiPA35089
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1B8 Eukaryota
ENOG410Z0UC LUCA
GeneTreeiENSGT00730000110660
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiP05204
KOiK11300
OMAiSARLSAX
PhylomeDBiP05204

Enzyme and pathway databases

SIGNORiP05204

Miscellaneous databases

ChiTaRSiHMGN2 human
GeneWikiiHMGN2
GenomeRNAii3151
PROiPR:P05204
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198830 Expressed in 91 organ(s), highest expression level in pituitary gland
CleanExiHS_HMGN2
GenevisibleiP05204 HS

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN2_HUMAN
AccessioniPrimary (citable) accession number: P05204
Secondary accession number(s): Q0VGD5, Q6FGI5, Q96C64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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