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UniProtKB - P05198 (IF2A_HUMAN)

Entry version 220 (25 May 2022)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Eukaryotic translation initiation factor 2 subunit 1

Gene

EIF2S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705).

This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (PubMed:16289705).

Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex (PubMed:16289705).

In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (PubMed:16289705).

EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352).

3 Publications

Caution

This gene should not be confused with EIF2A, with which it shares the alias EIF2A. Although both of these proteins function in binding initiator tRNA to the 40S ribosomal subunit, the eIF2 complex requires GTP, whereas the EIF2A protein does so in a codon-dependent manner.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is regulated by phosphorylation at Ser-49 and Ser-52, which stabilizes the eIF-2/GDP/eIF-2B complex and prevents the eIF-2B-mediated exchange of GDP for GTP, thereby preventing the formation of the 43S pre-initiation complex (PIC) (PubMed:15207627, PubMed:18032499). This results in the global attenuation of 5' cap-dependent protein synthesis and concomitant translation of ISR-specific mRNAs that contain a short upstream open reading frame (uORF) in their 5' UTR, such as ATF4, ATF5, DDIT3/CHOP and PPP1R15A/GADD34 (PubMed:19131336).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.5.3, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05198

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-381042, PERK regulates gene expression
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-72649, Translation initiation complex formation
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72731, Recycling of eIF2:GDP
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P05198

SIGNOR Signaling Network Open Resource

More...SIGNORi		P05198

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2 subunit 1
Alternative name(s):
Eukaryotic translation initiation factor 2 subunit alpha
Short name:
eIF-2-alpha
Short name:
eIF-2A
Short name:
eIF-2alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF2S1Imported
Synonyms:EIF2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3265, EIF2S1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603907, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05198

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134001

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1965

Open Targets

More...OpenTargetsi		ENSG00000134001

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27695

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05198, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1255131

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EIF2S1

Domain mapping of disease mutations (DMDM)

More...DMDMi		124200

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001373821 – 315Eukaryotic translation initiation factor 2 subunit 1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49Phosphoserine; by HRIBy similarity1
Modified residuei52PhosphoserineCombined sources1
Modified residuei141N6-acetyllysineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei279PhosphothreonineCombined sources1
Modified residuei281PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-49 and Ser-52 stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation, while concomitantly initiating the preferential translation of integrated stress response (ISR)-specific mRNAs (PubMed:15207627, PubMed:18032499, PubMed:19131336). Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2 (By similarity). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity).By similarity3 Publications
(Microbial infection) Phosphorylation by vaccinia virus protein E3 and rotavirus A stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05198

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05198

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05198

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05198

PeptideAtlas

More...PeptideAtlasi		P05198

PRoteomics IDEntifications database

More...PRIDEi		P05198

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51824

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P05198

2D gel databases

USC-OGP 2-DE database

More...OGPi		P05198

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00219678

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05198, 5 sites, 1 O-linked glycan (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05198

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P05198

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05198

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P05198

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated upon endoplasmic reticulum stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134001, Expressed in testis and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P05198, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05198, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134001, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain (PubMed:23063529).

Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation (By similarity).

Interacts with ABCF1 isoform 2 (PubMed:17894550). Associates with ribosomes (PubMed:17894550).

Interacts with DDX3X in an RNA-independent manner (PubMed:18596238).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108285, 170 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P05198

Database of interacting proteins

More...DIPi		DIP-39418N

Protein interaction database and analysis system

More...IntActi		P05198, 57 interactors

Molecular INTeraction database

More...MINTi		P05198

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256383

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05198, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P05198

Biological Magnetic Resonance Data Bank

More...BMRBi		P05198

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05198

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P05198

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 88S1 motifPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni293 – 315DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi300 – 315Acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-2-alpha family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2916, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007015

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05198

Identification of Orthologs from Complete Genome Data

More...OMAi		DVNEHQR

Database of Orthologous Groups

More...OrthoDBi		1093186at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05198

TreeFam database of animal gene trees

More...TreeFami		TF101502

Family and domain databases

Conserved Domains Database

More...CDDi		cd04452, S1_IF2_alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.190, 1 hit
2.40.50.140, 1 hit
3.30.70.1130, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00508

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012340, NA-bd_OB-fold
IPR022967, S1_dom
IPR003029, S1_domain
IPR044126, S1_IF2_alpha
IPR024055, TIF2_asu_C
IPR024054, TIF2_asu_middle_sf
IPR011488, TIF_2_asu

The PANTHER Classification System

More...PANTHERi		PTHR10602, PTHR10602, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07541, EIF_2_alpha, 1 hit
PF00575, S1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00316, S1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF110993, SSF110993, 1 hit
SSF116742, SSF116742, 1 hit
SSF50249, SSF50249, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50126, S1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P05198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE 
        60         70         80         90        100
LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED 
       110        120        130        140        150
KFTKSKTVYS ILRHVAEVLE YTKDEQLESL FQRTAWVFDD KYKRPGYGAY 
       160        170        180        190        200
DAFKHAVSDP SILDSLDLNE DEREVLINNI NRRLTPQAVK IRADIEVACY 
       210        220        230        240        250
GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT TLERTEGLSV 
       260        270        280        290        300
LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV 
       310 
DGDDDAEEME AKAED
Length:315
Mass (Da):36,112
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF3E75E3816E6B1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4T5G3V4T5_HUMAN
Eukaryotic translation initiation f...
EIF2S1
273Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJS4H0YJS4_HUMAN
Eukaryotic translation initiation f...
EIF2S1
252Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J02645 mRNA Translation: AAA52373.1
BC002513 mRNA Translation: AAH02513.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9781.1

NCBI Reference Sequences

More...RefSeqi		NP_004085.1, NM_004094.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256383.11; ENSP00000256383.4; ENSG00000134001.15
ENST00000466499.6; ENSP00000425299.1; ENSG00000134001.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1965

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1965

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000256383.11; ENSP00000256383.4; NM_004094.5; NP_004085.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02645 mRNA Translation: AAA52373.1
BC002513 mRNA Translation: AAH02513.1
CCDSiCCDS9781.1
RefSeqiNP_004085.1, NM_004094.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KL9X-ray1.90A2-183[»]
1Q8KNMR-A5-303[»]
6K71electron microscopy4.30K1-315[»]
6K72electron microscopy4.60K/L1-315[»]
6O81electron microscopy3.21L/M1-315[»]
6O85electron microscopy3.03L2-315[»]
6O9Zelectron microscopy3.03L/M2-315[»]
6YBVelectron microscopy3.80r1-315[»]
6ZMWelectron microscopy3.70r1-315[»]
6ZP4electron microscopy2.90O1-315[»]
7A09electron microscopy3.50O1-315[»]
7D43electron microscopy4.30K/L1-315[»]
7D44electron microscopy4.00K/L1-315[»]
7D45electron microscopy3.80K1-315[»]
7F66electron microscopy2.76N1-315[»]
7F67electron microscopy3.59N/Q1-315[»]
7NZMelectron microscopy3.96E2-187[»]
AlphaFoldDBiP05198
BMRBiP05198
SMRiP05198
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108285, 170 interactors
CORUMiP05198
DIPiDIP-39418N
IntActiP05198, 57 interactors
MINTiP05198
STRINGi9606.ENSP00000256383

Chemistry databases

ChEMBLiCHEMBL1255131

PTM databases

GlyGeniP05198, 5 sites, 1 O-linked glycan (4 sites)
iPTMnetiP05198
MetOSiteiP05198
PhosphoSitePlusiP05198
SwissPalmiP05198

Genetic variation databases

BioMutaiEIF2S1
DMDMi124200

2D gel databases

OGPiP05198
REPRODUCTION-2DPAGEiIPI00219678

Proteomic databases

EPDiP05198
jPOSTiP05198
MassIVEiP05198
PaxDbiP05198
PeptideAtlasiP05198
PRIDEiP05198
ProteomicsDBi51824
TopDownProteomicsiP05198

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3181, 896 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		1965

Genome annotation databases

EnsembliENST00000256383.11; ENSP00000256383.4; ENSG00000134001.15
ENST00000466499.6; ENSP00000425299.1; ENSG00000134001.15
GeneIDi1965
KEGGihsa:1965
MANE-SelectiENST00000256383.11; ENSP00000256383.4; NM_004094.5; NP_004085.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1965
DisGeNETi1965

GeneCards: human genes, protein and diseases

More...GeneCardsi		EIF2S1
HGNCiHGNC:3265, EIF2S1
HPAiENSG00000134001, Low tissue specificity
MIMi603907, gene
neXtProtiNX_P05198
OpenTargetsiENSG00000134001
PharmGKBiPA27695
VEuPathDBiHostDB:ENSG00000134001

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2916, Eukaryota
GeneTreeiENSGT00390000007015
InParanoidiP05198
OMAiDVNEHQR
OrthoDBi1093186at2759
PhylomeDBiP05198
TreeFamiTF101502

Enzyme and pathway databases

BRENDAi3.6.5.3, 2681
PathwayCommonsiP05198
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-381042, PERK regulates gene expression
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-72649, Translation initiation complex formation
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72731, Recycling of eIF2:GDP
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency
SignaLinkiP05198
SIGNORiP05198

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1965, 794 hits in 1055 CRISPR screens
EvolutionaryTraceiP05198

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EIF2S1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1965
PharosiP05198, Tbio

Protein Ontology

More...PROi		PR:P05198
RNActiP05198, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134001, Expressed in testis and 245 other tissues
ExpressionAtlasiP05198, baseline and differential
GenevisibleiP05198, HS

Family and domain databases

CDDicd04452, S1_IF2_alpha, 1 hit
Gene3Di1.10.150.190, 1 hit
2.40.50.140, 1 hit
3.30.70.1130, 1 hit
IDEALiIID00508
InterProiView protein in InterPro
IPR012340, NA-bd_OB-fold
IPR022967, S1_dom
IPR003029, S1_domain
IPR044126, S1_IF2_alpha
IPR024055, TIF2_asu_C
IPR024054, TIF2_asu_middle_sf
IPR011488, TIF_2_asu
PANTHERiPTHR10602, PTHR10602, 1 hit
PfamiView protein in Pfam
PF07541, EIF_2_alpha, 1 hit
PF00575, S1, 1 hit
SMARTiView protein in SMART
SM00316, S1, 1 hit
SUPFAMiSSF110993, SSF110993, 1 hit
SSF116742, SSF116742, 1 hit
SSF50249, SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50126, S1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05198
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 220 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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