EIF2S1

Functionⁱ

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

GO - Molecular functionⁱ

ribosome binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17894550
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
translation initiation factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16289705

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cellular response to amino acid starvation Source: UniProtKB
cellular response to heat Source: Ensembl
cellular response to oxidative stress Source: ARUK-UCL
cellular response to UV Source: UniProtKB
negative regulation of guanyl-nucleotide exchange factor activity Source: Ensembl
negative regulation of translational initiation in response to stress Source: UniProtKB
PERK-mediated unfolded protein response
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 22934019
positive regulation of neuron death
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 18508033
positive regulation of type B pancreatic cell apoptotic process Source: Ensembl
protein autophosphorylation Source: Ensembl
response to endoplasmic reticulum stress
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 18508033
response to manganese-induced endoplasmic reticulum stress Source: Ensembl
stress granule assembly Source: ARUK-UCL
translational initiation Source: Reactome
transmembrane transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor, RNA-binding
Biological process	Protein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-381042 PERK regulates gene expression R-HSA-382556 ABC-family proteins mediated transport R-HSA-72649 Translation initiation complex formation R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72731 Recycling of eIF2:GDP
SIGNORⁱ	P05198

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-381042 PERK regulates gene expression
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-72649 Translation initiation complex formation
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72731 Recycling of eIF2:GDP

SIGNORⁱ

P05198

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 2 subunit 1 Alternative name(s): Eukaryotic translation initiation factor 2 subunit alpha Short name: eIF-2-alpha Short name: eIF-2A Short name: eIF-2alpha
Gene namesⁱ	Name:EIF2S1 Synonyms:EIF2A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134001.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3265 EIF2S1
MIMⁱ	603907 gene
neXtProtⁱ	NX_P05198

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1965
Open Targets More...OpenTargetsⁱ	ENSG00000134001
PharmGKBⁱ	PA27695

Chemistry databases

ChEMBLⁱ	CHEMBL1255131

ChEMBLⁱ

CHEMBL1255131

Polymorphism and mutation databases

BioMutaⁱ	EIF2S1
DMDMⁱ	124200

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000137382	1 – 315	Eukaryotic translation initiation factor 2 subunit 1Add BLAST		315

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	49	Phosphoserine; by HRIBy similarity	1
Modified residueⁱ	52	PhosphoserineCombined sources	1
Modified residueⁱ	141	N6-acetyllysineCombined sources	1
Modified residueⁱ	158	PhosphoserineCombined sources	1
Modified residueⁱ	279	PhosphothreonineCombined sources	1
Modified residueⁱ	281	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation (PubMed:15207627, PubMed:18032499). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity).By similarity2 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P05198
PaxDbⁱ	P05198
PeptideAtlas More...PeptideAtlasⁱ	P05198
PRIDEⁱ	P05198
ProteomicsDBⁱ	51824
TopDownProteomicsⁱ	P05198

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P05198
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00219678

PTM databases

iPTMnetⁱ	P05198
PhosphoSitePlusⁱ	P05198
SwissPalmⁱ	P05198

Miscellaneous databases

PMAP-CutDBⁱ	P05198

PMAP-CutDBⁱ

P05198

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134001 Expressed in 233 organ(s), highest expression level in testis
CleanExⁱ	HS_EIF2A HS_EIF2S1
ExpressionAtlasⁱ	P05198 baseline and differential
Genevisibleⁱ	P05198 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011663 HPA064885

HPAⁱ

CAB011663
HPA064885

Interactionⁱ

Subunit structureⁱ

Heterotrimer composed of an alpha, a beta and a gamma chain (PubMed:23063529). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation (By similarity). Interacts with ABCF1 isoform 2 (PubMed:17894550). Associates with ribosomes (PubMed:17894550).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ACTN1	P12814	4	EBI-1056162,EBI-351710
DDX3X	O00571	3	EBI-1056162,EBI-353779
EIF2AK2	P19525	5	EBI-1056162,EBI-640775
Eif2ak3	Q9Z2B5	4	EBI-1056162,EBI-1226344	From Mus musculus.
EIF2S2	P20042	6	EBI-1056162,EBI-711977
EIF2S3	P41091	4	EBI-1056162,EBI-1054228

Protein-protein interaction databases

BioGridⁱ	108285, 78 interactors
CORUMⁱ	P05198
Database of interacting proteins More...DIPⁱ	DIP-39418N
IntActⁱ	P05198, 37 interactors
Molecular INTeraction database More...MINTⁱ	P05198
STRINGⁱ	9606.ENSP00000256383

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	8 – 13	Combined sources	6
Beta strandⁱ	19 – 27	Combined sources	9
Beta strandⁱ	29 – 36	Combined sources	8
Turnⁱ	37 – 41	Combined sources	5
Beta strandⁱ	43 – 47	Combined sources	5
Helixⁱ	48 – 50	Combined sources	3
Turnⁱ	60 – 62	Combined sources	3
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	68 – 77	Combined sources	10
Turnⁱ	78 – 81	Combined sources	4
Beta strandⁱ	82 – 87	Combined sources	6
Helixⁱ	92 – 118	Combined sources	27
Helixⁱ	124 – 133	Combined sources	10
Helixⁱ	135 – 142	Combined sources	8
Helixⁱ	147 – 158	Combined sources	12
Helixⁱ	160 – 163	Combined sources	4
Helixⁱ	170 – 182	Combined sources	13
Beta strandⁱ	190 – 193	Combined sources	4
Turnⁱ	202 – 204	Combined sources	3
Helixⁱ	205 – 217	Combined sources	13
Beta strandⁱ	218 – 220	Combined sources	3
Beta strandⁱ	225 – 231	Combined sources	7
Beta strandⁱ	234 – 240	Combined sources	7
Helixⁱ	244 – 263	Combined sources	20
Helixⁱ	282 – 289	Combined sources	8
Helixⁱ	293 – 295	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P05198
SMRⁱ	P05198
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P05198

EvolutionaryTraceⁱ

P05198

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 88	S1 motifPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the eIF-2-alpha family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2916 Eukaryota COG1093 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007015
HOGENOMⁱ	HOG000199476
HOVERGENⁱ	HBG001910
InParanoidⁱ	P05198
KEGG Orthology (KO) More...KOⁱ	K03237
OMAⁱ	KDVNEHQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07NN
PhylomeDBⁱ	P05198
TreeFamⁱ	TF101502

Family and domain databases

Gene3Dⁱ	1.10.150.190, 1 hit 3.30.70.1130, 1 hit
InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR022967 S1_dom IPR003029 S1_domain IPR024055 TIF2_asu_C IPR024054 TIF2_asu_middle_sf IPR011488 TIF_2_asu
PANTHERⁱ	PTHR10602 PTHR10602, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07541 EIF_2_alpha, 1 hit PF00575 S1, 1 hit
SMARTⁱ	View protein in SMART SM00316 S1, 1 hit
SUPFAMⁱ	SSF110993 SSF110993, 1 hit SSF116742 SSF116742, 1 hit SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS50126 S1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P05198-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE 
        60         70         80         90        100
LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED 
       110        120        130        140        150
KFTKSKTVYS ILRHVAEVLE YTKDEQLESL FQRTAWVFDD KYKRPGYGAY 
       160        170        180        190        200
DAFKHAVSDP SILDSLDLNE DEREVLINNI NRRLTPQAVK IRADIEVACY 
       210        220        230        240        250
GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT TLERTEGLSV 
       260        270        280        290        300
LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV 
       310 
DGDDDAEEME AKAED

Length:315

Mass (Da):36,112

Last modified:January 23, 2007 - v3

Checksum:ⁱFF3E75E3816E6B1E

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V4T5	G3V4T5_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 2 subunit 1	EIF2S1	273	Annotation score:
H0YJS4	H0YJS4_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 2 subunit 1	EIF2S1	252	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02645 mRNA Translation: AAA52373.1 BC002513 mRNA Translation: AAH02513.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9781.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004085.1, NM_004094.4
UniGeneⁱ	Hs.151777

Genome annotation databases

Ensemblⁱ	ENST00000256383; ENSP00000256383; ENSG00000134001 ENST00000466499; ENSP00000425299; ENSG00000134001
GeneIDⁱ	1965
KEGGⁱ	hsa:1965

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P05198	Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, isoform CRA_a		HUMAN		315	UniRef100_P05198
EIF2S1 isoform 1		PANTR		315
Eukaryotic translation initiation factor 2 subunit 1		MACMU		315
Eukaryotic translation initiation factor 2 subunit alpha		RHIBE		315
Macaca fascicularis brain cDNA clone: QflA-19301, similar to human eukaryotic translation initiation factor 2, subunit 1alpha, 35kDa (EIF2S1), mRNA, RefSeq: NM_004094.3		MACFA		315
+14

Protein	Similar proteins		Species	Score	Length	Source
P05198	Eukaryotic translation initiation factor 2 subunit 1		CHICK		315	UniRef90_P05198
Eukaryotic translation initiation factor 2 subunit 1		PONAB		315
Eukaryotic translation initiation factor 2 subunit 1		XENLA		315
Eukaryotic translation initiation factor 2 subunit 1		XENTR		315
Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, isoform CRA_a		HUMAN		315
+204

Protein	Similar proteins		Species	Score	Length	Source
P05198	Eukaryotic translation initiation factor 2 subunit 1		XENLA		315	UniRef50_P05198
Eukaryotic translation initiation factor 2 subunit 1		XENTR		315
Eukaryotic translation initiation factor 2 subunit 1		PONAB		315
Eukaryotic translation initiation factor 2 subunit 1		CHICK		315
Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, isoform CRA_a		HUMAN		315
+242

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02645 mRNA Translation: AAA52373.1 BC002513 mRNA Translation: AAH02513.1
CCDSⁱ	CCDS9781.1
RefSeqⁱ	NP_004085.1, NM_004094.4
UniGeneⁱ	Hs.151777

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KL9	X-ray	1.90	A	2-183	[»]
	1Q8K	NMR	-	A	5-303	[»]
ProteinModelPortalⁱ	P05198
SMRⁱ	P05198
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108285, 78 interactors
CORUMⁱ	P05198
DIPⁱ	DIP-39418N
IntActⁱ	P05198, 37 interactors
MINTⁱ	P05198
STRINGⁱ	9606.ENSP00000256383

Chemistry databases

ChEMBLⁱ	CHEMBL1255131

ChEMBLⁱ

CHEMBL1255131

PTM databases

iPTMnetⁱ	P05198
PhosphoSitePlusⁱ	P05198
SwissPalmⁱ	P05198

Polymorphism and mutation databases

BioMutaⁱ	EIF2S1
DMDMⁱ	124200

2D gel databases

OGPⁱ	P05198
REPRODUCTION-2DPAGEⁱ	IPI00219678

Proteomic databases

EPDⁱ	P05198
PaxDbⁱ	P05198
PeptideAtlasⁱ	P05198
PRIDEⁱ	P05198
ProteomicsDBⁱ	51824
TopDownProteomicsⁱ	P05198

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1965
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000256383; ENSP00000256383; ENSG00000134001 ENST00000466499; ENSP00000425299; ENSG00000134001
GeneIDⁱ	1965
KEGGⁱ	hsa:1965

Organism-specific databases

CTDⁱ	1965
DisGeNETⁱ	1965
EuPathDBⁱ	HostDB:ENSG00000134001.12
GeneCardsⁱ	EIF2S1
HGNCⁱ	HGNC:3265 EIF2S1
HPAⁱ	CAB011663 HPA064885
MIMⁱ	603907 gene
neXtProtⁱ	NX_P05198
OpenTargetsⁱ	ENSG00000134001
PharmGKBⁱ	PA27695
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2916 Eukaryota COG1093 LUCA
GeneTreeⁱ	ENSGT00390000007015
HOGENOMⁱ	HOG000199476
HOVERGENⁱ	HBG001910
InParanoidⁱ	P05198
KOⁱ	K03237
OMAⁱ	KDVNEHQ
OrthoDBⁱ	EOG091G07NN
PhylomeDBⁱ	P05198
TreeFamⁱ	TF101502

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-381042 PERK regulates gene expression R-HSA-382556 ABC-family proteins mediated transport R-HSA-72649 Translation initiation complex formation R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72731 Recycling of eIF2:GDP
SIGNORⁱ	P05198

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-381042 PERK regulates gene expression
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-72649 Translation initiation complex formation
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72731 Recycling of eIF2:GDP

SIGNORⁱ

P05198

Miscellaneous databases

ChiTaRSⁱ	EIF2S1 human
EvolutionaryTraceⁱ	P05198
GeneWikiⁱ	EIF2S1
GenomeRNAiⁱ	1965
PMAP-CutDBⁱ	P05198
Protein Ontology More...PROⁱ	PR:P05198
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134001 Expressed in 233 organ(s), highest expression level in testis
CleanExⁱ	HS_EIF2A HS_EIF2S1
ExpressionAtlasⁱ	P05198 baseline and differential
Genevisibleⁱ	P05198 HS

Family and domain databases

Gene3Dⁱ	1.10.150.190, 1 hit 3.30.70.1130, 1 hit
InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR022967 S1_dom IPR003029 S1_domain IPR024055 TIF2_asu_C IPR024054 TIF2_asu_middle_sf IPR011488 TIF_2_asu
PANTHERⁱ	PTHR10602 PTHR10602, 1 hit
Pfamⁱ	View protein in Pfam PF07541 EIF_2_alpha, 1 hit PF00575 S1, 1 hit
SMARTⁱ	View protein in SMART SM00316 S1, 1 hit
SUPFAMⁱ	SSF110993 SSF110993, 1 hit SSF116742 SSF116742, 1 hit SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS50126 S1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IF2A_HUMAN
Accessionⁱ	P05198Primary (citable) accession number: P05198
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 198 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Translation initiation factors
List of translation initiation factor entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - P05198 (IF2A_HUMAN)

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Eukaryotic translation initiation factor 2 subunit 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ