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UniProtKB - P05187 (PPB1_HUMAN)

Entry version 226 (25 May 2022)
Sequence version 2 (01 Jul 1989)
Previous versions | rss
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Protein

Alkaline phosphatase, placental type

Gene

ALPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alkaline phosphatase that can hydrolyze various phosphate compounds.

2 Publications

Miscellaneous

In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi64Magnesium4 Publications1
Metal bindingi64Zinc 14 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei114Phosphoserine intermediatePROSITE-ProRule annotation1
Metal bindingi114Zinc 14 Publications1
Metal bindingi177Magnesium4 Publications1
Metal bindingi238CalciumBy similarity1
Metal bindingi291Calcium; via carbonyl oxygenBy similarity1
Metal bindingi292CalciumBy similarity1
Metal bindingi307CalciumBy similarity1
Metal bindingi333Magnesium4 Publications1
Metal bindingi338Zinc 24 Publications1
Metal bindingi342Zinc 2; via tele nitrogen4 Publications1
Metal bindingi379Zinc 14 Publications1
Metal bindingi380Zinc 1; via tele nitrogen4 Publications1
Metal bindingi454Zinc 2; via tele nitrogen4 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • dephosphorylation Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05187

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811438, Intra-Golgi traffic

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P05187

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P05187

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alkaline phosphatase, placental type (EC:3.1.3.1)
Alternative name(s):
Alkaline phosphatase Regan isozyme
Placental alkaline phosphatase 11 Publication
Short name:
PLAP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALPPImported
Synonyms:PLAP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:439, ALPP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		171800, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05187

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei513 – 529HelicalAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		250

Open Targets

More...OpenTargetsi		ENSG00000163283

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24730

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05187, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4458

Drug and drug target database

More...DrugBanki		DB01373, Calcium
DB08413, METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALPP

Domain mapping of disease mutations (DMDM)

More...DMDMi		130737

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002403123 – 506Alkaline phosphatase, placental typeAdd BLAST484
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000024032507 – 535Removed in mature formAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi143 ↔ 2055 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi144N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi271N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi489 ↔ 4965 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi506GPI-anchor amidated aspartate1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05187

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05187

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05187

MaxQB - The MaxQuant DataBase

More...MaxQBi		P05187

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05187

PeptideAtlas

More...PeptideAtlasi		P05187

PRoteomics IDEntifications database

More...PRIDEi		P05187

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51823

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		ALPP

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05187, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05187

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P05187

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05187

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in placenta (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163283, Expressed in placenta and 60 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05187, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163283, Group enriched (cervix, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106751, 129 interactors

Protein interaction database and analysis system

More...IntActi		P05187, 50 interactors

Molecular INTeraction database

More...MINTi		P05187

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000375881

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P05187

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05187, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1535
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P05187

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05187

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P05187

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 449DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alkaline phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4126, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008539_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05187

Identification of Orthologs from Complete Genome Data

More...OMAi		MFRMGTP

Database of Orthologous Groups

More...OrthoDBi		454880at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05187

TreeFam database of animal gene trees

More...TreeFami		TF323513

Family and domain databases

Conserved Domains Database

More...CDDi		cd16012, ALP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001952, Alkaline_phosphatase
IPR018299, Alkaline_phosphatase_AS
IPR017850, Alkaline_phosphatase_core_sf

The PANTHER Classification System

More...PANTHERi		PTHR11596, PTHR11596, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00245, Alk_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00113, ALKPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00098, alkPPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53649, SSF53649, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00123, ALKALINE_PHOSPHATASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P05187-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGPCMLLLL LLLGLRLQLS LGIIPVEEEN PDFWNREAAE ALGAAKKLQP 
        60         70         80         90        100
AQTAAKNLII FLGDGMGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA 
       110        120        130        140        150
LSKTYNVDKH VPDSGATATA YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE 
       160        170        180        190        200
VISVMNRAKK AGKSVGVVTT TRVQHASPAG TYAHTVNRNW YSDADVPASA 
       210        220        230        240        250
RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP DDYSQGGTRL 
       260        270        280        290        300
DGKNLVQEWL AKRQGARYVW NRTELMQASL DPSVTHLMGL FEPGDMKYEI 
       310        320        330        340        350
HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYRAL 
       360        370        380        390        400
TETIMFDDAI ERAGQLTSEE DTLSLVTADH SHVFSFGGYP LRGSSIFGLA 
       410        420        430        440        450
PGKARDRKAY TVLLYGNGPG YVLKDGARPD VTESESGSPE YRQQSAVPLD 
       460        470        480        490        500
EETHAGEDVA VFARGPQAHL VHGVQEQTFI AHVMAFAACL EPYTACDLAP 
       510        520        530 
PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP
Length:535
Mass (Da):57,954
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13C136679A70C76B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA51708 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66M → V in AAA51709 (PubMed:3461452).Curated1
Sequence conflicti261 – 262AK → GE in AAA51706 (PubMed:3001717).Curated2
Sequence conflicti277Q → R in AAA51709 (PubMed:3461452).Curated1
Sequence conflicti285T → A in AAA51709 (PubMed:3461452).Curated1
Sequence conflicti324N → H in AAA51706 (PubMed:3001717).Curated1
Sequence conflicti389Y → C in AAA51709 (PubMed:3461452).Curated1
Sequence conflicti394S → G in AAA51709 (PubMed:3461452).Curated1
Sequence conflicti396 – 397IF → FI in AAA51706 (PubMed:3001717).Curated2
Sequence conflicti401P → A in AAA51706 (PubMed:3001717).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Placental ALP is highly polymorphic, there are at least three common alleles.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01741925P → L2 PublicationsCorresponds to variant dbSNP:rs1130335EnsemblClinVar.1
Natural variantiVAR_05052089I → L1 PublicationCorresponds to variant dbSNP:rs13026692Ensembl.1
Natural variantiVAR_050521231R → P1 PublicationCorresponds to variant dbSNP:rs1048988EnsemblClinVar.1
Natural variantiVAR_050522263R → H1 PublicationCorresponds to variant dbSNP:rs2853378Ensembl.1
Natural variantiVAR_050523451E → G. Corresponds to variant dbSNP:rs1048994Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M19159 Genomic DNA Translation: AAA51710.1
M13077 mRNA Translation: AAC97139.1
M14169 mRNA Translation: AAA51708.1 Different initiation.
M14170 mRNA Translation: AAA51709.1
AC068134 Genomic DNA Translation: AAY24087.1
BC009647 mRNA Translation: AAH09647.1
BC068501 mRNA Translation: AAH68501.1
BC094743 mRNA Translation: AAH94743.1
M12551 mRNA Translation: AAA51706.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2490.1

Protein sequence database of the Protein Information Resource

More...PIRi		A31074, PAHUA

NCBI Reference Sequences

More...RefSeqi		NP_001623.3, NM_001632.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000392027.3; ENSP00000375881.2; ENSG00000163283.7

Database of genes from NCBI RefSeq genomes

More...GeneIDi		250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:250

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000392027.3; ENSP00000375881.2; NM_001632.5; NP_001623.3

UCSC genome browser

More...UCSCi		uc002vsq.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Alkaline phosphatase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19159 Genomic DNA Translation: AAA51710.1
M13077 mRNA Translation: AAC97139.1
M14169 mRNA Translation: AAA51708.1 Different initiation.
M14170 mRNA Translation: AAA51709.1
AC068134 Genomic DNA Translation: AAY24087.1
BC009647 mRNA Translation: AAH09647.1
BC068501 mRNA Translation: AAH68501.1
BC094743 mRNA Translation: AAH94743.1
M12551 mRNA Translation: AAA51706.1
CCDSiCCDS2490.1
PIRiA31074, PAHUA
RefSeqiNP_001623.3, NM_001632.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EW2X-ray1.82A23-535[»]
1ZEBX-ray1.90A23-506[»]
1ZEDX-ray1.57A23-506[»]
1ZEFX-ray1.90A23-506[»]
2GLQX-ray1.60A23-506[»]
3MK0X-ray1.90A23-506[»]
3MK1X-ray1.57A23-506[»]
3MK2X-ray1.89A23-503[»]
AlphaFoldDBiP05187
SMRiP05187
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106751, 129 interactors
IntActiP05187, 50 interactors
MINTiP05187
STRINGi9606.ENSP00000375881

Chemistry databases

BindingDBiP05187
ChEMBLiCHEMBL4458
DrugBankiDB01373, Calcium
DB08413, METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER

PTM databases

DEPODiALPP
GlyGeniP05187, 2 sites
iPTMnetiP05187
MetOSiteiP05187
PhosphoSitePlusiP05187

Genetic variation databases

BioMutaiALPP
DMDMi130737

Proteomic databases

EPDiP05187
jPOSTiP05187
MassIVEiP05187
MaxQBiP05187
PaxDbiP05187
PeptideAtlasiP05187
PRIDEiP05187
ProteomicsDBi51823

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P05187, 14 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3515, 1774 antibodies from 45 providers

The DNASU plasmid repository

More...DNASUi		250

Genome annotation databases

EnsembliENST00000392027.3; ENSP00000375881.2; ENSG00000163283.7
GeneIDi250
KEGGihsa:250
MANE-SelectiENST00000392027.3; ENSP00000375881.2; NM_001632.5; NP_001623.3
UCSCiuc002vsq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		250
DisGeNETi250

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALPP
HGNCiHGNC:439, ALPP
HPAiENSG00000163283, Group enriched (cervix, placenta)
MIMi171800, gene
neXtProtiNX_P05187
OpenTargetsiENSG00000163283
PharmGKBiPA24730
VEuPathDBiHostDB:ENSG00000163283

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4126, Eukaryota
GeneTreeiENSGT00950000183063
HOGENOMiCLU_008539_4_0_1
InParanoidiP05187
OMAiMFRMGTP
OrthoDBi454880at2759
PhylomeDBiP05187
TreeFamiTF323513

Enzyme and pathway databases

BRENDAi3.1.3.1, 2681
PathwayCommonsiP05187
ReactomeiR-HSA-6811438, Intra-Golgi traffic
SABIO-RKiP05187
SignaLinkiP05187

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		250, 11 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALPP, human
EvolutionaryTraceiP05187

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Placental_alkaline_phosphatase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		250
PharosiP05187, Tbio

Protein Ontology

More...PROi		PR:P05187
RNActiP05187, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163283, Expressed in placenta and 60 other tissues
GenevisibleiP05187, HS

Family and domain databases

CDDicd16012, ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR001952, Alkaline_phosphatase
IPR018299, Alkaline_phosphatase_AS
IPR017850, Alkaline_phosphatase_core_sf
PANTHERiPTHR11596, PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245, Alk_phosphatase, 1 hit
PRINTSiPR00113, ALKPHPHTASE
SMARTiView protein in SMART
SM00098, alkPPc, 1 hit
SUPFAMiSSF53649, SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123, ALKALINE_PHOSPHATASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05187
Secondary accession number(s): P05188
, P06861, Q53S78, Q96DB7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 1, 1989
Last modified: May 25, 2022
This is version 226 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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