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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxyprogesterone + [reduced NADPH--hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxypregnenolone + [reduced NADPH--hemoprotein reductase] + O2 = 3-beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.19By similarity, EC:1.14.14.32By similarity)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519261 – 509Steroid 17-alpha-hydroxylase/17,20 lyaseAdd BLAST509

Proteomic databases

PaxDbiP05185
PRIDEiP05185

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019061

Structurei

3D structure databases

ProteinModelPortaliP05185
SMRiP05185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000036991
HOVERGENiHBG106944
InParanoidiP05185
KOiK00512

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P05185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLAVFLL TLAYLFWPKT KHSGAKYPRS LPSLPLVGSL PFLPRRGQQH
60 70 80 90 100
KNFFKLQEKY GPIYSFRLGS KTTVMIGHHQ LAREVLLKKG KEFSGRPKVA
110 120 130 140 150
TLDILSDNQK GIAFADHGAH WQLHRKLALN AFALFKDGNL KLEKIINQEA
160 170 180 190 200
NVLCDFLATQ HGEAIDLSEP LSLAVTNIIS FICFNFSFKN EDPALKAIQN
210 220 230 240 250
VNDGILEVLS KEVLLDIFPV LKIFPSKAME KMKGCVQTRN ELLNEILEKC
260 270 280 290 300
QENFSSDSIT NLLHILIQAK VNADNNNAGP DQDSKLLSNR HMLATIGDIF
310 320 330 340 350
GAGVETTTSV IKWIVAYLLH HPSLKKRIQD DIDQIIGFNR TPTISDRNRL
360 370 380 390 400
VLLEATIREV LRIRPVAPTL IPHKAVIDSS IGDLTIDKGT DVVVNLWALH
410 420 430 440 450
HSEKEWQHPD LFMPERFLDP TGTQLISPSL SYLPFGAGPR SCVGEMLARQ
460 470 480 490 500
ELFLFMSRLL QRFNLEIPDD GKLPSLEGHA SLVLQIKPFK VKIEVRQAWK

EAQAEGSTP
Length:509
Mass (Da):57,244
Last modified:August 13, 1987 - v1
Checksum:i64B0E5537A474BB7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240N → K in AAI10170 (Ref. 3) Curated1
Sequence conflicti423T → A no nucleotide entry (PubMed:2543297).Curated1
Sequence conflicti458R → W no nucleotide entry (PubMed:2543297).Curated1
Sequence conflicti509P → S no nucleotide entry (PubMed:2543297).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12547 mRNA Translation: AAA30485.1
BC110169 mRNA Translation: AAI10170.1
PIRiS04346
RefSeqiNP_776729.1, NM_174304.2
UniGeneiBt.89153

Genome annotation databases

GeneIDi281739
KEGGibta:281739

Similar proteinsi

Entry informationi

Entry nameiCP17A_BOVIN
AccessioniPrimary (citable) accession number: P05185
Secondary accession number(s): Q2YDL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 25, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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