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Protein

Cytochrome P450 3A2

Gene

Cyp3a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi443Iron (heme axial ligand)1

GO - Molecular functioni

  • aromatase activity Source: UniProtKB-EC
  • demethylase activity Source: RGD
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: RGD
  • testosterone 6-beta-hydroxylase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKiP05183

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A2 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA2
Cytochrome P450-PCN2
Cytochrome P450/6-beta-A
Testosterone 6-beta-hydroxylase
Gene namesi
Name:Cyp3a2
Synonyms:Cyp3a-2, Cyp3a11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708379 Cyp3a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3324
DrugBankiDB08834 Tauroursodeoxycholic acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517841 – 504Cytochrome P450 3A2Add BLAST504

Proteomic databases

PaxDbiP05183
PRIDEiP05183

PTM databases

iPTMnetiP05183
PhosphoSitePlusiP05183

Expressioni

Tissue specificityi

Expressed in liver.2 Publications

Inductioni

By pregnenolone 16-alpha-carbonitrile (PNCN) and dexamethasone.3 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001291

Chemistry databases

BindingDBiP05183

Structurei

3D structure databases

ProteinModelPortaliP05183
SMRiP05183
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiP05183
KOiK07424
PhylomeDBiP05183

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P05183-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLLSALTLE TWVLLAVILV LLYRLGTHRH GIFKKQGIPG PKPLPFLGTV
60 70 80 90 100
LNYYKGLGRF DMECYKKYGK IWGLFDGQTP VFAIMDTEMI KNVLVKECFS
110 120 130 140 150
VFTNRRDFGP VGIMGKAVSV AKDEEWKRYR ALLSPTFTSG RLKEMFPIIE
160 170 180 190 200
QYGDILVKYL KQEAETGKPV TMKKVFGAYS MDVITSTSFG VNVDSLNNPK
210 220 230 240 250
DPFVEKTKKL LRFDFFDPLF LSVVLFPFLT PIYEMLNICM FPKDSIAFFQ
260 270 280 290 300
KFVHRIKETR LDSKHKHRVD FLQLMLNAHN NSKDEVSHKA LSDVEIIAQS
310 320 330 340 350
VIFIFAGYET TSSTLSFVLY FLATHPDIQK KLQEEIDGAL PSKAPPTYDI
360 370 380 390 400
VMEMEYLDMV LNETLRLYPI GNRLERVCKK DIELDGLFIP KGSVVTIPTY
410 420 430 440 450
ALHHDPQHWP KPEEFHPERF SKENKGSIDP YVYLPFGNGP RNCIGMRFAL
460 470 480 490 500
MNMKLALTKV LQNFSFQPCK ETQIPLKLSR QAILEPEKPI VLKVLPRDAV

INGA
Length:504
Mass (Da):57,732
Last modified:July 15, 1999 - v2
Checksum:iC2C84AF736035AB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56 – 57GL → AV in CAA55887 (PubMed:2043144).Curated2
Sequence conflicti429D → H in AAA41051 (PubMed:3785219).Curated1
Sequence conflicti445G → D in AAA41051 (PubMed:3785219).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13646 mRNA Translation: AAA41051.1
X79319 Genomic DNA Translation: CAA55887.1
X79320 mRNA Translation: CAA55888.1
U09742 mRNA Translation: AAA82168.1
U09734
, U09725, U09726, U09727, U09728, U09729, U09730, U09731, U09732, U09733 Genomic DNA Translation: AAB60492.1
BC089765 mRNA Translation: AAH89765.1
PIRiA25222
RefSeqiNP_695224.2, NM_153312.2
UniGeneiRn.225885

Genome annotation databases

GeneIDi266682
KEGGirno:266682

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13646 mRNA Translation: AAA41051.1
X79319 Genomic DNA Translation: CAA55887.1
X79320 mRNA Translation: CAA55888.1
U09742 mRNA Translation: AAA82168.1
U09734
, U09725, U09726, U09727, U09728, U09729, U09730, U09731, U09732, U09733 Genomic DNA Translation: AAB60492.1
BC089765 mRNA Translation: AAH89765.1
PIRiA25222
RefSeqiNP_695224.2, NM_153312.2
UniGeneiRn.225885

3D structure databases

ProteinModelPortaliP05183
SMRiP05183
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001291

Chemistry databases

BindingDBiP05183
ChEMBLiCHEMBL3324
DrugBankiDB08834 Tauroursodeoxycholic acid

PTM databases

iPTMnetiP05183
PhosphoSitePlusiP05183

Proteomic databases

PaxDbiP05183
PRIDEiP05183

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266682
KEGGirno:266682

Organism-specific databases

CTDi266682
RGDi708379 Cyp3a2

Phylogenomic databases

HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiP05183
KOiK07424
PhylomeDBiP05183

Enzyme and pathway databases

SABIO-RKiP05183

Miscellaneous databases

PROiPR:P05183

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP3A2_RAT
AccessioniPrimary (citable) accession number: P05183
Secondary accession number(s): Q5FVU5, Q64629, Q64672
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 15, 1999
Last modified: January 31, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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