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Entry version 198 (13 Feb 2019)
Sequence version 1 (01 Apr 1988)
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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi437Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS05414-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-9027307 Biosynthesis of maresin-like SPMs

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P05181

SIGNOR Signaling Network Open Resource

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SIGNORi
P05181

Chemistry databases

SwissLipids knowledge resource for lipid biology

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SwissLipidsi
SLP:000001596

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Cytochrome P450-J
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2E1
Synonyms:CYP2E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130649.9

Human Gene Nomenclature Database

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HGNCi
HGNC:2631 CYP2E1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
124040 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P05181

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1571

Open Targets

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OpenTargetsi
ENSG00000130649

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA129

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5281

Drug and drug target database

More...
DrugBanki
DB00316 Acetaminophen
DB00041 Aldesleukin
DB00918 Almotriptan
DB00969 Alosetron
DB01223 Aminophylline
DB00321 Amitriptyline
DB06728 Aniline
DB01435 Antipyrine
DB00972 Azelastine
DB06770 Benzyl alcohol
DB04794 Bifonazole
DB01558 Bromazepam
DB00835 Brompheniramine
DB01156 Bupropion
DB00201 Caffeine
DB06774 Capsaicin
DB00748 Carbinoxamine
DB01136 Carvedilol
DB00477 Chlorpromazine
DB00356 Chlorzoxazone
DB00501 Cimetidine
DB00215 Citalopram
DB04920 Clevidipine
DB00636 Clofibrate
DB00882 Clomifene
DB01068 Clonazepam
DB00257 Clotrimazole
DB00363 Clozapine
DB01394 Colchicine
DB00851 Dacarbazine
DB06637 Dalfampridine
DB00250 Dapsone
DB01151 Desipramine
DB01234 Dexamethasone
DB01191 Dexfenfluramine
DB00633 Dexmedetomidine
DB00514 Dextromethorphan
DB00829 Diazepam
DB00586 Diclofenac
DB00255 Diethylstilbestrol
DB00822 Disulfiram
DB01127 Econazole
DB08846 Ellagic Acid
DB00228 Enflurane
DB00109 Enfuvirtide
DB00655 Estrone
DB00898 Ethanol
DB06689 Ethanolamine Oleate
DB00593 Ethosuximide
DB00773 Etoposide
DB01628 Etoricoxib
DB00949 Felbamate
DB08868 Fingolimod
DB01544 Flunitrazepam
DB00623 Fluphenazine
DB00690 Flurazepam
DB00176 Fluvoxamine
DB00158 Folic Acid
DB01213 Fomepizole
DB01296 Glucosamine
DB04077 Glycerol
DB05708 GTS-21
DB01159 Halothane
DB01355 Hexobarbital
DB04946 Iloperidone
DB00458 Imipramine
DB00753 Isoflurane
DB00951 Isoniazid
DB00883 Isosorbide Dinitrate
DB01167 Itraconazole
DB00170 Menadione
DB00371 Meprobamate
DB00703 Methazolamide
DB00763 Methimazole
DB01403 Methotrimeprazine
DB01028 Methoxyflurane
DB01011 Metyrapone
DB00379 Mexiletine
DB01110 Miconazole
DB00683 Midazolam
DB01204 Mitoxantrone
DB00622 Nicardipine
DB02701 Nicotinamide
DB00184 Nicotine
DB01115 Nifedipine
DB06712 Nilvadipine
DB01595 Nitrazepam
DB00540 Nortriptyline
DB00904 Ondansetron
DB01173 Orphenadrine
DB00526 Oxaliplatin
DB00617 Paramethadione
DB03783 Phenacetin
DB00780 Phenelzine
DB01174 Phenobarbital
DB01085 Pilocarpine
DB01100 Pimozide
DB04977 Plitidepsin
DB01131 Proguanil
DB00818 Propofol
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB00503 Ritonavir
DB06201 Rufinamide
DB00118 S-Adenosylmethionine
DB01037 Selegiline
DB01236 Sevoflurane
DB00203 Sildenafil
DB00428 Streptozocin
DB00359 Sulfadiazine
DB00259 Sulfanilamide
DB00675 Tamoxifen
DB01079 Tegaserod
DB01041 Thalidomide
DB01412 Theobromine
DB00277 Theophylline
DB00599 Thiopental
DB00679 Thioridazine
DB00208 Ticlopidine
DB01007 Tioconazole
DB04858 Tirapazamine
DB05109 Trabectedin
DB00752 Tranylcypromine
DB00347 Trimethadione
DB01586 Ursodeoxycholic acid
DB00549 Zafirlukast
DB01198 Zopiclone

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1330

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP2E1

Domain mapping of disease mutations (DMDM)

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DMDMi
117250

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000517511 – 493Cytochrome P450 2E1Add BLAST493

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P05181

PeptideAtlas

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PeptideAtlasi
P05181

PRoteomics IDEntifications database

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PRIDEi
P05181

ProteomicsDB human proteome resource

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ProteomicsDBi
51820

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P05181

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P05181

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By ethanol and isoniazid.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000130649 Expressed in 171 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P05181 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P05181 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA009128
HPA029564

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107944, 18 interactors

Protein interaction database and analysis system

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IntActi
P05181, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000252945

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P05181

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E4EX-ray2.60A/B32-493[»]
3E6IX-ray2.20A/B32-493[»]
3GPHX-ray2.70A/B32-493[»]
3KOHX-ray2.90A/B32-493[»]
3LC4X-ray3.10A/B32-493[»]
3T3ZX-ray2.35A/B/C/D32-493[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P05181

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05181

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P05181

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni298 – 303Substrate bindingCurated6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0156 Eukaryota
COG2124 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000036992

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG015789

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05181

KEGG Orthology (KO)

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KOi
K07415

Identification of Orthologs from Complete Genome Data

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OMAi
FKYSDHF

Database of Orthologous Groups

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OrthoDBi
702827at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P05181

TreeFam database of animal gene trees

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TreeFami
TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008070 Cyt_P450_E_grp-I_CYP2E-like
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00463 EP450I
PR01687 EP450ICYP2E
PR00385 P450

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P05181-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL
60 70 80 90 100
KNIPKSFTRL AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR
110 120 130 140 150
GDLPAFHAHR DRGIIFNNGP TWKDIRRFSL TTLRNYGMGK QGNESRIQRE
160 170 180 190 200
AHFLLEALRK TQGQPFDPTF LIGCAPCNVI ADILFRKHFD YNDEKFLRLM
210 220 230 240 250
YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA EVKEYVSERV
260 270 280 290 300
KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM
360 370 380 390 400
DAVVHEIQRF ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN
410 420 430 440 450
QEFPDPEKFK PEHFLNENGK FKYSDYFKPF STGKRVCAGE GLARMELFLL
460 470 480 490
LCAILQHFNL KPLVDPKDID LSPIHIGFGC IPPRYKLCVI PRS
Length:493
Mass (Da):56,849
Last modified:April 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED0399E32A005644
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7H4H0Y7H4_HUMAN
Cytochrome P450 2E1
CYP2E1
356Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y593H0Y593_HUMAN
Cytochrome P450 2E1
CYP2E1
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H694F5H694_HUMAN
Cytochrome P450 2E1
CYP2E1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGV5H0YGV5_HUMAN
Cytochrome P450 2E1
CYP2E1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2Missing AA sequence (PubMed:3675576).Curated1
Sequence conflicti23W → A AA sequence (PubMed:8031147).Curated1
Sequence conflicti32L → N AA sequence (PubMed:8031147).Curated1
Sequence conflicti71Y → C in AAH67433 (PubMed:15489334).Curated1
Sequence conflicti235V → A in AAF13601 (Ref. 3) Curated1
Sequence conflicti355H → R in AAH67433 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00836076R → H in allele CYP2E1*2; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs72559710Ensembl.1
Natural variantiVAR_008361179V → I in allele CYP2E1*4. 2 PublicationsCorresponds to variant dbSNP:rs6413419Ensembl.1
Natural variantiVAR_055382219N → D1 PublicationCorresponds to variant dbSNP:rs41299426Ensembl.1
Natural variantiVAR_055383366S → C1 PublicationCorresponds to variant dbSNP:rs41299434Ensembl.1
Natural variantiVAR_008362389V → I in allele CYP2E1*3. 1 PublicationCorresponds to variant dbSNP:rs55897648Ensembl.1
Natural variantiVAR_024727457H → L2 PublicationsCorresponds to variant dbSNP:rs28969387Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02625 mRNA Translation: AAA35743.1
J02843 Genomic DNA Translation: AAA52155.1
AF182276 mRNA Translation: AAF13601.1
DQ515958 Genomic DNA Translation: ABF47105.1
AL161645 Genomic DNA No translation available.
CH471211 Genomic DNA Translation: EAW61357.1
BC067433 mRNA Translation: AAH67433.1
AF084225 mRNA Translation: AAD13753.1
D50111 Genomic DNA Translation: BAA08796.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7686.1

Protein sequence database of the Protein Information Resource

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PIRi
A31949

NCBI Reference Sequences

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RefSeqi
NP_000764.1, NM_000773.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.12907

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252945; ENSP00000252945; ENSG00000130649
ENST00000463117; ENSP00000440689; ENSG00000130649

Database of genes from NCBI RefSeq genomes

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GeneIDi
1571

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1571

UCSC genome browser

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UCSCi
uc001lnj.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2E1 alleles

Wikipedia

CYP2E1 entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02625 mRNA Translation: AAA35743.1
J02843 Genomic DNA Translation: AAA52155.1
AF182276 mRNA Translation: AAF13601.1
DQ515958 Genomic DNA Translation: ABF47105.1
AL161645 Genomic DNA No translation available.
CH471211 Genomic DNA Translation: EAW61357.1
BC067433 mRNA Translation: AAH67433.1
AF084225 mRNA Translation: AAD13753.1
D50111 Genomic DNA Translation: BAA08796.1
CCDSiCCDS7686.1
PIRiA31949
RefSeqiNP_000764.1, NM_000773.3
UniGeneiHs.12907

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E4EX-ray2.60A/B32-493[»]
3E6IX-ray2.20A/B32-493[»]
3GPHX-ray2.70A/B32-493[»]
3KOHX-ray2.90A/B32-493[»]
3LC4X-ray3.10A/B32-493[»]
3T3ZX-ray2.35A/B/C/D32-493[»]
ProteinModelPortaliP05181
SMRiP05181
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107944, 18 interactors
IntActiP05181, 10 interactors
STRINGi9606.ENSP00000252945

Chemistry databases

BindingDBiP05181
ChEMBLiCHEMBL5281
DrugBankiDB00316 Acetaminophen
DB00041 Aldesleukin
DB00918 Almotriptan
DB00969 Alosetron
DB01223 Aminophylline
DB00321 Amitriptyline
DB06728 Aniline
DB01435 Antipyrine
DB00972 Azelastine
DB06770 Benzyl alcohol
DB04794 Bifonazole
DB01558 Bromazepam
DB00835 Brompheniramine
DB01156 Bupropion
DB00201 Caffeine
DB06774 Capsaicin
DB00748 Carbinoxamine
DB01136 Carvedilol
DB00477 Chlorpromazine
DB00356 Chlorzoxazone
DB00501 Cimetidine
DB00215 Citalopram
DB04920 Clevidipine
DB00636 Clofibrate
DB00882 Clomifene
DB01068 Clonazepam
DB00257 Clotrimazole
DB00363 Clozapine
DB01394 Colchicine
DB00851 Dacarbazine
DB06637 Dalfampridine
DB00250 Dapsone
DB01151 Desipramine
DB01234 Dexamethasone
DB01191 Dexfenfluramine
DB00633 Dexmedetomidine
DB00514 Dextromethorphan
DB00829 Diazepam
DB00586 Diclofenac
DB00255 Diethylstilbestrol
DB00822 Disulfiram
DB01127 Econazole
DB08846 Ellagic Acid
DB00228 Enflurane
DB00109 Enfuvirtide
DB00655 Estrone
DB00898 Ethanol
DB06689 Ethanolamine Oleate
DB00593 Ethosuximide
DB00773 Etoposide
DB01628 Etoricoxib
DB00949 Felbamate
DB08868 Fingolimod
DB01544 Flunitrazepam
DB00623 Fluphenazine
DB00690 Flurazepam
DB00176 Fluvoxamine
DB00158 Folic Acid
DB01213 Fomepizole
DB01296 Glucosamine
DB04077 Glycerol
DB05708 GTS-21
DB01159 Halothane
DB01355 Hexobarbital
DB04946 Iloperidone
DB00458 Imipramine
DB00753 Isoflurane
DB00951 Isoniazid
DB00883 Isosorbide Dinitrate
DB01167 Itraconazole
DB00170 Menadione
DB00371 Meprobamate
DB00703 Methazolamide
DB00763 Methimazole
DB01403 Methotrimeprazine
DB01028 Methoxyflurane
DB01011 Metyrapone
DB00379 Mexiletine
DB01110 Miconazole
DB00683 Midazolam
DB01204 Mitoxantrone
DB00622 Nicardipine
DB02701 Nicotinamide
DB00184 Nicotine
DB01115 Nifedipine
DB06712 Nilvadipine
DB01595 Nitrazepam
DB00540 Nortriptyline
DB00904 Ondansetron
DB01173 Orphenadrine
DB00526 Oxaliplatin
DB00617 Paramethadione
DB03783 Phenacetin
DB00780 Phenelzine
DB01174 Phenobarbital
DB01085 Pilocarpine
DB01100 Pimozide
DB04977 Plitidepsin
DB01131 Proguanil
DB00818 Propofol
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB00503 Ritonavir
DB06201 Rufinamide
DB00118 S-Adenosylmethionine
DB01037 Selegiline
DB01236 Sevoflurane
DB00203 Sildenafil
DB00428 Streptozocin
DB00359 Sulfadiazine
DB00259 Sulfanilamide
DB00675 Tamoxifen
DB01079 Tegaserod
DB01041 Thalidomide
DB01412 Theobromine
DB00277 Theophylline
DB00599 Thiopental
DB00679 Thioridazine
DB00208 Ticlopidine
DB01007 Tioconazole
DB04858 Tirapazamine
DB05109 Trabectedin
DB00752 Tranylcypromine
DB00347 Trimethadione
DB01586 Ursodeoxycholic acid
DB00549 Zafirlukast
DB01198 Zopiclone
GuidetoPHARMACOLOGYi1330
SwissLipidsiSLP:000001596

PTM databases

iPTMnetiP05181
PhosphoSitePlusiP05181

Polymorphism and mutation databases

BioMutaiCYP2E1
DMDMi117250

Proteomic databases

PaxDbiP05181
PeptideAtlasiP05181
PRIDEiP05181
ProteomicsDBi51820

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252945; ENSP00000252945; ENSG00000130649
ENST00000463117; ENSP00000440689; ENSG00000130649
GeneIDi1571
KEGGihsa:1571
UCSCiuc001lnj.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1571
DisGeNETi1571
EuPathDBiHostDB:ENSG00000130649.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP2E1
HGNCiHGNC:2631 CYP2E1
HPAiHPA009128
HPA029564
MIMi124040 gene
neXtProtiNX_P05181
OpenTargetsiENSG00000130649
PharmGKBiPA129

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00940000161594
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP05181
KOiK07415
OMAiFKYSDHF
OrthoDBi702827at2759
PhylomeDBiP05181
TreeFamiTF352043

Enzyme and pathway databases

BioCyciMetaCyc:HS05414-MONOMER
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiP05181
SIGNORiP05181

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP2E1 human
EvolutionaryTraceiP05181

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYP2E1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1571

Protein Ontology

More...
PROi
PR:P05181

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130649 Expressed in 171 organ(s), highest expression level in liver
ExpressionAtlasiP05181 baseline and differential
GenevisibleiP05181 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008070 Cyt_P450_E_grp-I_CYP2E-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01687 EP450ICYP2E
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2E1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05181
Secondary accession number(s): Q5VZD5, Q6NWT9, Q9UK47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 1, 1988
Last modified: February 13, 2019
This is version 198 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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