UniProtKB - P05177 (CP1A2_HUMAN)
Protein
Cytochrome P450 1A2
Gene
CYP1A2
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).1 Publication8 Publications
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]3 PublicationsEC:1.14.14.13 PublicationsThis reaction proceeds in the forward3 Publications direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 4-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 4-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- cholesterol + O2 + reduced [NADPH—hemoprotein reductase] = 25-hydroxycholesterol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- all-trans-retinol + O2 + reduced [NADPH—hemoprotein reductase] = all-trans-retinal + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- all-trans-retinal + O2 + reduced [NADPH—hemoprotein reductase] = all-trans-retinoate + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O1 PublicationEC:4.2.1.1521 PublicationThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH—hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Kineticsi
- KM=19 µM for 17beta-estradiol (2-hydroxylation)1 Publication
- KM=9 µM for all-trans retinol1 Publication
- KM=4 µM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole1 Publication
- KM=21 µM for 2-amino-3-methylimidazo[4,5-f]quinoline1 Publication
- KM=26 µM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline1 Publication
- KM=27 µM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline1 Publication
- KM=71 µM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine1 Publication
- KM=25 µM for phenacetin1 Publication
- Vmax=9.2 nmol/min/nmol enzyme toward 17beta-estradiol (2-hydroxylation)1 Publication
- Vmax=491 pmol/min/nmol enzyme toward all-trans retinol1 Publication
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Pathwayi: cholesterol metabolism
This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.
Pathwayi: arachidonate metabolism
This protein is involved in the pathway arachidonate metabolism, which is part of Lipid metabolism.3 PublicationsView all proteins of this organism that are known to be involved in the pathway arachidonate metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 226 | SubstrateCurated | 1 | |
Metal bindingi | 458 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- caffeine oxidase activity Source: BHF-UCL
- demethylase activity Source: UniProtKB
- electron transfer activity Source: UniProtKB
- enzyme binding Source: BHF-UCL
- estrogen 16-alpha-hydroxylase activity Source: UniProtKB
- estrogen 2-hydroxylase activity Source: UniProtKB
- heme binding Source: UniProtKB
- hydroperoxy icosatetraenoate dehydratase activity Source: UniProtKB-EC
- iron ion binding Source: InterPro
- monooxygenase activity Source: BHF-UCL
- oxidoreductase activity Source: BHF-UCL
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: UniProtKB
GO - Biological processi
- alkaloid metabolic process Source: BHF-UCL
- cellular respiration Source: Ensembl
- cellular response to cadmium ion Source: Ensembl
- cellular response to copper ion Source: Ensembl
- cholesterol metabolic process Source: UniProtKB-UniPathway
- dibenzo-p-dioxin metabolic process Source: Ensembl
- drug catabolic process Source: BHF-UCL
- drug metabolic process Source: BHF-UCL
- epoxygenase P450 pathway Source: Reactome
- estrogen metabolic process Source: UniProtKB
- exogenous drug catabolic process Source: BHF-UCL
- heterocycle metabolic process Source: BHF-UCL
- hydrogen peroxide biosynthetic process Source: Ensembl
- long-chain fatty acid biosynthetic process Source: Reactome
- lung development Source: Ensembl
- methylation Source: Reactome
- monocarboxylic acid metabolic process Source: BHF-UCL
- monoterpenoid metabolic process Source: BHF-UCL
- omega-hydroxylase P450 pathway Source: Reactome
- oxidation-reduction process Source: BHF-UCL
- oxidative deethylation Source: BHF-UCL
- oxidative demethylation Source: BHF-UCL
- porphyrin-containing compound metabolic process Source: Ensembl
- post-embryonic development Source: Ensembl
- regulation of gene expression Source: Ensembl
- response to estradiol Source: Ensembl
- response to immobilization stress Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- retinol metabolic process Source: UniProtKB
- steroid catabolic process Source: BHF-UCL
- toxin biosynthetic process Source: BHF-UCL
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Lyase, Monooxygenase, Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS06728-MONOMER |
BRENDAi | 1.14.14.1, 2681 1.14.99.38, 2681 |
PathwayCommonsi | P05177 |
Reactomei | R-HSA-156581, Methylation R-HSA-211957, Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-5423646, Aflatoxin activation and detoxification R-HSA-9018681, Biosynthesis of protectins R-HSA-9027307, Biosynthesis of maresin-like SPMs |
SABIO-RKi | P05177 |
UniPathwayi | UPA00296 UPA00383 UPA00912 |
Chemistry databases
SwissLipidsi | SLP:000001202 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000140505.6 |
HGNCi | HGNC:2596, CYP1A2 |
MIMi | 108330, gene 124060, gene+phenotype |
neXtProti | NX_P05177 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- intracellular membrane-bounded organelle Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1544 |
MIMi | 124060, gene+phenotype |
OpenTargetsi | ENSG00000140505 |
Orphaneti | 284121, Toxicity or absent response to clozapine |
PharmGKBi | PA27093 |
Miscellaneous databases
Pharosi | P05177, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3356 |
DrugBanki | DB08496, (R)-warfarin DB01667, 8-azaguanine DB14132, 8-chlorotheophylline DB04356, 9-Deazaguanine DB02489, 9-Methylguanine DB12001, Abemaciclib DB05812, Abiraterone DB13573, Acefylline DB01418, Acenocoumarol DB00316, Acetaminophen DB06594, Agomelatine DB00518, Albendazole DB05396, Albinterferon Alfa-2B DB00969, Alosetron DB07453, alpha-Naphthoflavone DB01424, Aminophenazone DB01223, Aminophylline DB01118, Amiodarone DB00321, Amitriptyline DB00261, Anagrelide DB01217, Anastrozole DB01435, Antipyrine DB06605, Apixaban DB05676, Apremilast DB06413, Armodafinil DB06216, Asenapine DB01072, Atazanavir DB06442, Avasimibe DB06626, Axitinib DB00993, Azathioprine DB00972, Azelastine DB13203, Bamifylline DB05015, Belinostat DB06769, Bendamustine DB06770, Benzyl alcohol DB06771, Besifloxacin DB06732, beta-Naphthoflavone DB00195, Betaxolol DB04889, Bicifadine DB11967, Binimetinib DB13975, Black cohosh DB00188, Bortezomib DB01558, Bromazepam DB14018, Bromotheophylline DB13812, Bufylline DB00201, Caffeine DB09061, Cannabidiol DB11791, Capmatinib DB06774, Capsaicin DB00564, Carbamazepine DB01136, Carvedilol DB12814, Cepeginterferon alfa-2B DB00477, Chlorpromazine DB00356, Chlorzoxazone DB01166, Cilostazol DB00501, Cimetidine DB01012, Cinacalcet DB00568, Cinnarizine DB00827, Cinoxacin DB00537, Ciprofloxacin DB00215, Citalopram DB14025, Clinafloxacin DB01242, Clomipramine DB00575, Clonidine DB00758, Clopidogrel DB00363, Clozapine DB00286, Conjugated estrogens DB11672, Curcumin DB14635, Curcumin sulfate DB00924, Cyclobenzaprine DB00851, Dacarbazine DB06292, Dapagliflozin DB01254, Dasatinib DB01609, Deferasirox DB01151, Desipramine DB12161, Deutetrabenazine DB01191, Dexfenfluramine DB00633, Dexmedetomidine DB11994, Diacerein DB00586, Diclofenac DB11511, Difloxacin DB12945, Dihydralazine DB00280, Disopyramide DB01184, Domperidone DB09167, Dosulepin DB05928, Dovitinib DB01142, Doxepin DB09273, Doxofylline DB00476, Duloxetine DB00625, Efavirenz DB15444, Elexacaftor DB06210, Eltrombopag DB13874, Enasidenib DB00467, Enoxacin DB11404, Enrofloxacin DB00530, Erlotinib DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00655, Estrone DB04574, Estrone sulfate DB13592, Etamiphylline DB00898, Ethanol DB00977, Ethinylestradiol DB00773, Etoposide DB01628, Etoricoxib DB00927, Famotidine DB01482, Fenethylline DB01195, Flecainide DB08972, Flumequine DB04841, Flunarizine DB00544, Fluorouracil DB00472, Fluoxetine DB00499, Flutamide DB00176, Fluvoxamine DB01320, Fosphenytoin DB00998, Frovatriptan DB14029, Furafylline DB06160, Garenoxacin DB01044, Gatifloxacin DB01241, Gemfibrozil DB01155, Gemifloxacin DB01645, Genistein DB00365, Grepafloxacin DB00400, Griseofulvin DB05708, GTS-21 DB00629, Guanabenz DB00502, Haloperidol DB01094, Hesperetin DB14999, Human interferon beta DB04076, Hypoxanthine DB11737, Icotinib DB00619, Imatinib DB00458, Imipramine DB01306, Insulin aspart DB09456, Insulin beef DB09564, Insulin degludec DB01307, Insulin detemir DB00047, Insulin glargine DB01309, Insulin glulisine DB00030, Insulin human DB00046, Insulin lispro DB11567, Insulin peglispro DB00071, Insulin pork DB11568, Insulin tregopil DB05258, Interferon alfa DB00034, Interferon alfa-2a, Recombinant DB00105, Interferon alfa-2b DB15131, Interferon alfa-2c DB00011, Interferon alfa-n1 DB00018, Interferon alfa-n3 DB00069, Interferon alfacon-1 DB00060, Interferon beta-1a DB00068, Interferon beta-1b DB00033, Interferon gamma-1b DB00951, Isoniazid DB11757, Istradefylline DB09570, Ixazomib DB01026, Ketoconazole DB01097, Leflunomide DB09078, Lenvatinib DB01002, Levobupivacaine DB01137, Levofloxacin DB00281, Lidocaine DB12406, Lisofylline DB09198, Lobeglitazone DB04948, Lofexidine DB00978, Lomefloxacin DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB06077, Lumateperone DB01283, Lumiracoxib DB00772, Malathion DB00934, Maprotiline DB14009, Medical Cannabis DB01065, Melatonin DB00170, Menadione DB00454, Meperidine DB00532, Mephenytoin DB00333, Methadone DB00763, Methimazole DB00553, Methoxsalen DB01028, Methoxyflurane DB09241, Methylene blue DB01233, Metoclopramide DB00379, Mexiletine DB06148, Mianserin DB01388, Mibefradil DB06595, Midostaurin DB00370, Mirtazapine DB00745, Modafinil DB00218, Moxifloxacin DB06510, Muraglitazar DB14011, Nabiximols DB00461, Nabumetone DB00607, Nafcillin DB00779, Nalidixic acid DB00788, Naproxen DB06600, Nemonoxacin DB00238, Nevirapine DB06803, Niclosamide DB00184, Nicotine DB01115, Nifedipine DB00435, Nitric Oxide DB05115, NN344 DB00717, Norethisterone DB01059, Norfloxacin DB00540, Nortriptyline DB05990, Obeticholic acid DB01165, Ofloxacin DB00334, Olanzapine DB00338, Omeprazole DB00904, Ondansetron DB11443, Orbifloxacin DB01173, Orphenadrine DB11837, Osilodrostat DB09330, Osimertinib DB13627, Oxolinic acid DB01303, Oxtriphylline DB00377, Palonosetron DB00715, Paroxetine DB06589, Pazopanib DB11774, Pazufloxacin DB00487, Pefloxacin DB00008, Peginterferon alfa-2a DB00022, Peginterferon alfa-2b DB09122, Peginterferon beta-1a DB13634, Pentifylline DB00806, Pentoxifylline DB11198, Peppermint oil DB08883, Perampanel DB00850, Perphenazine DB03783, Phenacetin DB01174, Phenobarbital DB00388, Phenylephrine DB00252, Phenytoin DB11450, Pimobendan DB01100, Pimozide DB13823, Pipemidic acid DB04951, Pirfenidone DB11642, Pitolisant DB08910, Pomalidomide DB01058, Praziquantel DB01087, Primaquine DB00794, Primidone DB00420, Promazine DB09288, Propacetamol DB01182, Propafenone DB06479, Propentofylline DB00818, Propofol DB00571, Propranolol DB13449, Proxyphylline DB11892, Prulifloxacin DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB00980, Ramelteon DB09290, Ramosetron DB00863, Ranitidine DB01367, Rasagiline DB02709, Resveratrol DB13174, Rhein DB01045, Rifampicin DB11753, Rifamycin DB00740, Riluzole DB00503, Ritonavir DB00533, Rofecoxib DB15119, Ropeginterferon alfa-2b DB00268, Ropinirole DB00296, Ropivacaine DB00412, Rosiglitazone DB00817, Rosoxacin DB12332, Rucaparib DB13772, Rufloxacin DB06654, Safinamide DB11491, Sarafloxacin DB00418, Secobarbital DB01037, Selegiline DB11689, Selumetinib DB06290, Simeprevir DB13261, Sitafloxacin DB00398, Sorafenib DB01208, Sparfloxacin DB09118, Stiripentol DB00428, Streptozocin DB06820, Sulconazole DB00382, Tacrine DB00675, Tamoxifen DB09071, Tasimelteon DB05488, Technetium Tc-99m ciprofloxacin DB09256, Tegafur DB01079, Tegaserod DB01405, Temafloxacin DB00857, Terbinafine DB08880, Teriflunomide DB01412, Theobromine DB00277, Theophylline DB00730, Thiabendazole DB01623, Thiothixene DB00208, Ticlopidine DB00697, Tizanidine DB01056, Tocainide DB06264, Tolperisone DB00752, Tranylcypromine DB00384, Triamterene DB12245, Triclabendazole DB00831, Trifluoperazine DB00440, Trimethoprim DB00685, Trovafloxacin DB08867, Ulipristal DB13609, Umifenovir DB06235, Vadimezan DB00313, Valproic acid DB08881, Vemurafenib DB00661, Verapamil DB09185, Viloxazine DB12026, Voxilaprevir DB00682, Warfarin DB02134, Xanthine DB00549, Zafirlukast DB00744, Zileuton DB00315, Zolmitriptan DB00425, Zolpidem DB09225, Zotepine DB09120, Zucapsaicin |
DrugCentrali | P05177 |
GuidetoPHARMACOLOGYi | 1319 |
Polymorphism and mutation databases
BioMutai | CYP1A2 |
DMDMi | 117144 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000051651 | 2 – 516 | Cytochrome P450 1A2Add BLAST | 515 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 69 | O-linked (GlcNAc) serineBy similarity | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | P05177 |
PaxDbi | P05177 |
PeptideAtlasi | P05177 |
PRIDEi | P05177 |
PTM databases
GlyGeni | P05177, 1 site |
iPTMneti | P05177 |
PhosphoSitePlusi | P05177 |
Expressioni
Tissue specificityi
Liver.
Inductioni
By nicotine, omeprazole, phenobarbital, primidone and rifampicin.
Gene expression databases
Bgeei | ENSG00000140505, Expressed in liver and 165 other tissues |
Genevisiblei | P05177, HS |
Organism-specific databases
HPAi | ENSG00000140505, Tissue enriched (liver) |
Interactioni
Subunit structurei
Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.
1 PublicationBinary interactionsi
P05177
With | #Exp. | IntAct |
---|---|---|
ABHD16A [O95870] | 3 | EBI-17183330,EBI-348517 |
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107924, 8 interactors |
IntActi | P05177, 6 interactors |
STRINGi | 9606.ENSP00000342007 |
Chemistry databases
BindingDBi | P05177 |
Miscellaneous databases
RNActi | P05177, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P05177 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05177 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00950000183037 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | P05177 |
OMAi | AKWEVFL |
OrthoDBi | 702827at2759 |
PhylomeDBi | P05177 |
TreeFami | TF105095 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008066, Cyt_P450_E_grp-I_CYP1 IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01683, EP450ICYP1A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P05177-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL
60 70 80 90 100
LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA
160 170 180 190 200
SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI
210 220 230 240 250
GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL
260 270 280 290 300
QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN
310 320 330 340 350
LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV
360 370 380 390 400
IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY
410 420 430 440 450
IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML
460 470 480 490 500
FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK
510
HARCEHVQAR LRFSIN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 79 | R → S in AAA35738 (PubMed:3462722).Curated | 1 | |
Sequence conflicti | 81 | G → D in AAH67427 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 170 | K → M in AAF13599 (Ref. 5) Curated | 1 | |
Sequence conflicti | 311 | V → L in AAA52154 (PubMed:3462722).Curated | 1 | |
Sequence conflicti | 380 | S → P in AAH67429 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 450 – 451 | LF → MLV in AAA52154 (PubMed:3462722).Curated | 2 | |
Sequence conflicti | 492 | T → I in AAF13599 (Ref. 5) Curated | 1 | |
Sequence conflicti | 511 | Missing in CAA77335 (PubMed:3755823).Curated | 1 | |
Sequence conflicti | 511 | Missing in AAA52146 (PubMed:2575218).Curated | 1 | |
Sequence conflicti | 511 | Missing in AAA52163 (PubMed:2575218).Curated | 1 | |
Sequence conflicti | 512 | R → P in AAA35738 (PubMed:3462722).Curated | 1 |
Polymorphismi
The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023196 | 18 | S → C2 PublicationsCorresponds to variant dbSNP:rs17861152Ensembl. | 1 | |
Natural variantiVAR_008349 | 21 | F → L in allele CYP1A2*2. 1 PublicationCorresponds to variant dbSNP:rs56160784Ensembl. | 1 | |
Natural variantiVAR_025182 | 42 | P → R in allele CYP1A2*15. 1 PublicationCorresponds to variant dbSNP:rs72547511Ensembl. | 1 | |
Natural variantiVAR_025183 | 73 | G → R1 PublicationCorresponds to variant dbSNP:rs45565238Ensembl. | 1 | |
Natural variantiVAR_020848 | 83 | T → M in allele CYP1A2*9. 1 PublicationCorresponds to variant dbSNP:rs138652540Ensembl. | 1 | |
Natural variantiVAR_025184 | 104 | D → N1 PublicationCorresponds to variant dbSNP:rs34067076Ensembl. | 1 | |
Natural variantiVAR_025185 | 111 | L → F1 PublicationCorresponds to variant dbSNP:rs45442197Ensembl. | 1 | |
Natural variantiVAR_020849 | 168 | E → Q in allele CYP1A2*10. 1 PublicationCorresponds to variant dbSNP:rs72547512Ensembl. | 1 | |
Natural variantiVAR_020850 | 186 | F → L in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value. 1 PublicationCorresponds to variant dbSNP:rs72547513Ensembl. | 1 | |
Natural variantiVAR_025186 | 205 | F → V1 PublicationCorresponds to variant dbSNP:rs45540640Ensembl. | 1 | |
Natural variantiVAR_020851 | 212 | S → C in allele CYP1A2*12. 1 PublicationCorresponds to variant dbSNP:rs758748797Ensembl. | 1 | |
Natural variantiVAR_025187 | 281 | R → W1 PublicationCorresponds to variant dbSNP:rs45468096EnsemblClinVar. | 1 | |
Natural variantiVAR_024709 | 298 | S → R1 PublicationCorresponds to variant dbSNP:rs17861157Ensembl. | 1 | |
Natural variantiVAR_020852 | 299 | G → S in allele CYP1A2*13. 1 PublicationCorresponds to variant dbSNP:rs35796837Ensembl. | 1 | |
Natural variantiVAR_024710 | 314 | I → V2 PublicationsCorresponds to variant dbSNP:rs28399418Ensembl. | 1 | |
Natural variantiVAR_020793 | 348 | D → N in allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity. 2 PublicationsCorresponds to variant dbSNP:rs56276455Ensembl. | 1 | |
Natural variantiVAR_025188 | 377 | R → Q in allele CYP1A2*16. 1 PublicationCorresponds to variant dbSNP:rs72547515Ensembl. | 1 | |
Natural variantiVAR_020794 | 386 | I → F in allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin. 2 PublicationsCorresponds to variant dbSNP:rs72547516Ensembl. | 1 | |
Natural variantiVAR_020795 | 406 | C → Y in allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation. 2 PublicationsCorresponds to variant dbSNP:rs55889066Ensembl. | 1 | |
Natural variantiVAR_020796 | 431 | R → W in allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure. 3 PublicationsCorresponds to variant dbSNP:rs28399424Ensembl. | 1 | |
Natural variantiVAR_020853 | 438 | T → I in allele CYP1A2*14. 2 PublicationsCorresponds to variant dbSNP:rs45486893Ensembl. | 1 | |
Natural variantiVAR_025189 | 456 | R → H in allele CYP1A2*8. 1 PublicationCorresponds to variant dbSNP:rs72547517Ensembl. | 1 | |
Natural variantiVAR_055563 | 457 | R → W. Corresponds to variant dbSNP:rs34151816Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z00036 mRNA Translation: CAA77335.1 M55053 mRNA Translation: AAA52146.1 M12078 mRNA Translation: AAA52154.1 L00389 , L00384, L00385, L00386, L00388, L00387 Genomic DNA Translation: AAA35738.1 M31667 , M31664, M31665, M31666 Genomic DNA Translation: AAA52163.1 AF182274 mRNA Translation: AAF13599.1 AF253322 Genomic DNA Translation: AAK25728.1 DQ022432 Genomic DNA Translation: AAY26399.1 BC067424 mRNA Translation: AAH67424.1 BC067425 mRNA Translation: AAH67425.1 BC067426 mRNA Translation: AAH67426.1 BC067427 mRNA Translation: AAH67427.1 BC067428 mRNA Translation: AAH67428.1 BC067429 mRNA Translation: AAH67429.1 |
CCDSi | CCDS32293.1 |
PIRi | S16718, O4HU4 |
RefSeqi | NP_000752.2, NM_000761.4 |
Genome annotation databases
Ensembli | ENST00000343932; ENSP00000342007; ENSG00000140505 |
GeneIDi | 1544 |
KEGGi | hsa:1544 |
UCSCi | uc002ayr.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP1A2 alleles |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z00036 mRNA Translation: CAA77335.1 M55053 mRNA Translation: AAA52146.1 M12078 mRNA Translation: AAA52154.1 L00389 , L00384, L00385, L00386, L00388, L00387 Genomic DNA Translation: AAA35738.1 M31667 , M31664, M31665, M31666 Genomic DNA Translation: AAA52163.1 AF182274 mRNA Translation: AAF13599.1 AF253322 Genomic DNA Translation: AAK25728.1 DQ022432 Genomic DNA Translation: AAY26399.1 BC067424 mRNA Translation: AAH67424.1 BC067425 mRNA Translation: AAH67425.1 BC067426 mRNA Translation: AAH67426.1 BC067427 mRNA Translation: AAH67427.1 BC067428 mRNA Translation: AAH67428.1 BC067429 mRNA Translation: AAH67429.1 |
CCDSi | CCDS32293.1 |
PIRi | S16718, O4HU4 |
RefSeqi | NP_000752.2, NM_000761.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HI4 | X-ray | 1.95 | A | 27-516 | [»] | |
SMRi | P05177 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107924, 8 interactors |
IntActi | P05177, 6 interactors |
STRINGi | 9606.ENSP00000342007 |
Chemistry databases
BindingDBi | P05177 |
ChEMBLi | CHEMBL3356 |
DrugBanki | DB08496, (R)-warfarin DB01667, 8-azaguanine DB14132, 8-chlorotheophylline DB04356, 9-Deazaguanine DB02489, 9-Methylguanine DB12001, Abemaciclib DB05812, Abiraterone DB13573, Acefylline DB01418, Acenocoumarol DB00316, Acetaminophen DB06594, Agomelatine DB00518, Albendazole DB05396, Albinterferon Alfa-2B DB00969, Alosetron DB07453, alpha-Naphthoflavone DB01424, Aminophenazone DB01223, Aminophylline DB01118, Amiodarone DB00321, Amitriptyline DB00261, Anagrelide DB01217, Anastrozole DB01435, Antipyrine DB06605, Apixaban DB05676, Apremilast DB06413, Armodafinil DB06216, Asenapine DB01072, Atazanavir DB06442, Avasimibe DB06626, Axitinib DB00993, Azathioprine DB00972, Azelastine DB13203, Bamifylline DB05015, Belinostat DB06769, Bendamustine DB06770, Benzyl alcohol DB06771, Besifloxacin DB06732, beta-Naphthoflavone DB00195, Betaxolol DB04889, Bicifadine DB11967, Binimetinib DB13975, Black cohosh DB00188, Bortezomib DB01558, Bromazepam DB14018, Bromotheophylline DB13812, Bufylline DB00201, Caffeine DB09061, Cannabidiol DB11791, Capmatinib DB06774, Capsaicin DB00564, Carbamazepine DB01136, Carvedilol DB12814, Cepeginterferon alfa-2B DB00477, Chlorpromazine DB00356, Chlorzoxazone DB01166, Cilostazol DB00501, Cimetidine DB01012, Cinacalcet DB00568, Cinnarizine DB00827, Cinoxacin DB00537, Ciprofloxacin DB00215, Citalopram DB14025, Clinafloxacin DB01242, Clomipramine DB00575, Clonidine DB00758, Clopidogrel DB00363, Clozapine DB00286, Conjugated estrogens DB11672, Curcumin DB14635, Curcumin sulfate DB00924, Cyclobenzaprine DB00851, Dacarbazine DB06292, Dapagliflozin DB01254, Dasatinib DB01609, Deferasirox DB01151, Desipramine DB12161, Deutetrabenazine DB01191, Dexfenfluramine DB00633, Dexmedetomidine DB11994, Diacerein DB00586, Diclofenac DB11511, Difloxacin DB12945, Dihydralazine DB00280, Disopyramide DB01184, Domperidone DB09167, Dosulepin DB05928, Dovitinib DB01142, Doxepin DB09273, Doxofylline DB00476, Duloxetine DB00625, Efavirenz DB15444, Elexacaftor DB06210, Eltrombopag DB13874, Enasidenib DB00467, Enoxacin DB11404, Enrofloxacin DB00530, Erlotinib DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00655, Estrone DB04574, Estrone sulfate DB13592, Etamiphylline DB00898, Ethanol DB00977, Ethinylestradiol DB00773, Etoposide DB01628, Etoricoxib DB00927, Famotidine DB01482, Fenethylline DB01195, Flecainide DB08972, Flumequine DB04841, Flunarizine DB00544, Fluorouracil DB00472, Fluoxetine DB00499, Flutamide DB00176, Fluvoxamine DB01320, Fosphenytoin DB00998, Frovatriptan DB14029, Furafylline DB06160, Garenoxacin DB01044, Gatifloxacin DB01241, Gemfibrozil DB01155, Gemifloxacin DB01645, Genistein DB00365, Grepafloxacin DB00400, Griseofulvin DB05708, GTS-21 DB00629, Guanabenz DB00502, Haloperidol DB01094, Hesperetin DB14999, Human interferon beta DB04076, Hypoxanthine DB11737, Icotinib DB00619, Imatinib DB00458, Imipramine DB01306, Insulin aspart DB09456, Insulin beef DB09564, Insulin degludec DB01307, Insulin detemir DB00047, Insulin glargine DB01309, Insulin glulisine DB00030, Insulin human DB00046, Insulin lispro DB11567, Insulin peglispro DB00071, Insulin pork DB11568, Insulin tregopil DB05258, Interferon alfa DB00034, Interferon alfa-2a, Recombinant DB00105, Interferon alfa-2b DB15131, Interferon alfa-2c DB00011, Interferon alfa-n1 DB00018, Interferon alfa-n3 DB00069, Interferon alfacon-1 DB00060, Interferon beta-1a DB00068, Interferon beta-1b DB00033, Interferon gamma-1b DB00951, Isoniazid DB11757, Istradefylline DB09570, Ixazomib DB01026, Ketoconazole DB01097, Leflunomide DB09078, Lenvatinib DB01002, Levobupivacaine DB01137, Levofloxacin DB00281, Lidocaine DB12406, Lisofylline DB09198, Lobeglitazone DB04948, Lofexidine DB00978, Lomefloxacin DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB06077, Lumateperone DB01283, Lumiracoxib DB00772, Malathion DB00934, Maprotiline DB14009, Medical Cannabis DB01065, Melatonin DB00170, Menadione DB00454, Meperidine DB00532, Mephenytoin DB00333, Methadone DB00763, Methimazole DB00553, Methoxsalen DB01028, Methoxyflurane DB09241, Methylene blue DB01233, Metoclopramide DB00379, Mexiletine DB06148, Mianserin DB01388, Mibefradil DB06595, Midostaurin DB00370, Mirtazapine DB00745, Modafinil DB00218, Moxifloxacin DB06510, Muraglitazar DB14011, Nabiximols DB00461, Nabumetone DB00607, Nafcillin DB00779, Nalidixic acid DB00788, Naproxen DB06600, Nemonoxacin DB00238, Nevirapine DB06803, Niclosamide DB00184, Nicotine DB01115, Nifedipine DB00435, Nitric Oxide DB05115, NN344 DB00717, Norethisterone DB01059, Norfloxacin DB00540, Nortriptyline DB05990, Obeticholic acid DB01165, Ofloxacin DB00334, Olanzapine DB00338, Omeprazole DB00904, Ondansetron DB11443, Orbifloxacin DB01173, Orphenadrine DB11837, Osilodrostat DB09330, Osimertinib DB13627, Oxolinic acid DB01303, Oxtriphylline DB00377, Palonosetron DB00715, Paroxetine DB06589, Pazopanib DB11774, Pazufloxacin DB00487, Pefloxacin DB00008, Peginterferon alfa-2a DB00022, Peginterferon alfa-2b DB09122, Peginterferon beta-1a DB13634, Pentifylline DB00806, Pentoxifylline DB11198, Peppermint oil DB08883, Perampanel DB00850, Perphenazine DB03783, Phenacetin DB01174, Phenobarbital DB00388, Phenylephrine DB00252, Phenytoin DB11450, Pimobendan DB01100, Pimozide DB13823, Pipemidic acid DB04951, Pirfenidone DB11642, Pitolisant DB08910, Pomalidomide DB01058, Praziquantel DB01087, Primaquine DB00794, Primidone DB00420, Promazine DB09288, Propacetamol DB01182, Propafenone DB06479, Propentofylline DB00818, Propofol DB00571, Propranolol DB13449, Proxyphylline DB11892, Prulifloxacin DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB00980, Ramelteon DB09290, Ramosetron DB00863, Ranitidine DB01367, Rasagiline DB02709, Resveratrol DB13174, Rhein DB01045, Rifampicin DB11753, Rifamycin DB00740, Riluzole DB00503, Ritonavir DB00533, Rofecoxib DB15119, Ropeginterferon alfa-2b DB00268, Ropinirole DB00296, Ropivacaine DB00412, Rosiglitazone DB00817, Rosoxacin DB12332, Rucaparib DB13772, Rufloxacin DB06654, Safinamide DB11491, Sarafloxacin DB00418, Secobarbital DB01037, Selegiline DB11689, Selumetinib DB06290, Simeprevir DB13261, Sitafloxacin DB00398, Sorafenib DB01208, Sparfloxacin DB09118, Stiripentol DB00428, Streptozocin DB06820, Sulconazole DB00382, Tacrine DB00675, Tamoxifen DB09071, Tasimelteon DB05488, Technetium Tc-99m ciprofloxacin DB09256, Tegafur DB01079, Tegaserod DB01405, Temafloxacin DB00857, Terbinafine DB08880, Teriflunomide DB01412, Theobromine DB00277, Theophylline DB00730, Thiabendazole DB01623, Thiothixene DB00208, Ticlopidine DB00697, Tizanidine DB01056, Tocainide DB06264, Tolperisone DB00752, Tranylcypromine DB00384, Triamterene DB12245, Triclabendazole DB00831, Trifluoperazine DB00440, Trimethoprim DB00685, Trovafloxacin DB08867, Ulipristal DB13609, Umifenovir DB06235, Vadimezan DB00313, Valproic acid DB08881, Vemurafenib DB00661, Verapamil DB09185, Viloxazine DB12026, Voxilaprevir DB00682, Warfarin DB02134, Xanthine DB00549, Zafirlukast DB00744, Zileuton DB00315, Zolmitriptan DB00425, Zolpidem DB09225, Zotepine DB09120, Zucapsaicin |
DrugCentrali | P05177 |
GuidetoPHARMACOLOGYi | 1319 |
SwissLipidsi | SLP:000001202 |
PTM databases
GlyGeni | P05177, 1 site |
iPTMneti | P05177 |
PhosphoSitePlusi | P05177 |
Polymorphism and mutation databases
BioMutai | CYP1A2 |
DMDMi | 117144 |
Proteomic databases
MassIVEi | P05177 |
PaxDbi | P05177 |
PeptideAtlasi | P05177 |
PRIDEi | P05177 |
Protocols and materials databases
Antibodypediai | 4221, 718 antibodies |
Genome annotation databases
Ensembli | ENST00000343932; ENSP00000342007; ENSG00000140505 |
GeneIDi | 1544 |
KEGGi | hsa:1544 |
UCSCi | uc002ayr.2, human |
Organism-specific databases
CTDi | 1544 |
DisGeNETi | 1544 |
EuPathDBi | HostDB:ENSG00000140505.6 |
GeneCardsi | CYP1A2 |
HGNCi | HGNC:2596, CYP1A2 |
HPAi | ENSG00000140505, Tissue enriched (liver) |
MIMi | 108330, gene 124060, gene+phenotype |
neXtProti | NX_P05177 |
OpenTargetsi | ENSG00000140505 |
Orphaneti | 284121, Toxicity or absent response to clozapine |
PharmGKBi | PA27093 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00950000183037 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | P05177 |
OMAi | AKWEVFL |
OrthoDBi | 702827at2759 |
PhylomeDBi | P05177 |
TreeFami | TF105095 |
Enzyme and pathway databases
UniPathwayi | UPA00296 UPA00383 UPA00912 |
BioCyci | MetaCyc:HS06728-MONOMER |
BRENDAi | 1.14.14.1, 2681 1.14.99.38, 2681 |
PathwayCommonsi | P05177 |
Reactomei | R-HSA-156581, Methylation R-HSA-211957, Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-5423646, Aflatoxin activation and detoxification R-HSA-9018681, Biosynthesis of protectins R-HSA-9027307, Biosynthesis of maresin-like SPMs |
SABIO-RKi | P05177 |
Miscellaneous databases
BioGRID-ORCSi | 1544, 5 hits in 843 CRISPR screens |
EvolutionaryTracei | P05177 |
GeneWikii | CYP1A2 |
GenomeRNAii | 1544 |
Pharosi | P05177, Tchem |
PROi | PR:P05177 |
RNActi | P05177, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140505, Expressed in liver and 165 other tissues |
Genevisiblei | P05177, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008066, Cyt_P450_E_grp-I_CYP1 IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01683, EP450ICYP1A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP1A2_HUMAN | |
Accessioni | P05177Primary (citable) accession number: P05177 Secondary accession number(s): Q16754 Q9UK49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | September 12, 2018 | |
Last modified: | December 2, 2020 | |
This is version 212 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations