CYP1A2

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.1 Publication

Catalytic activityⁱ

an alkane
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O₂
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
reduced [NADPH—hemoprotein reductase]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
a primary alcohol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
oxidized [NADPH—hemoprotein reductase]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.12
  "Cholesterol 25-hydroxylation activity of CYP3A."
  Honda A., Miyazaki T., Ikegami T., Iwamoto J., Maeda T., Hirayama T., Saito Y., Teramoto T., Matsuzaki Y.
  J. Lipid Res. 52:1509-1516(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
EC:1.14.14.1
1 Publication
Manual assertion based on experiment inⁱ
- Ref.12
  "Cholesterol 25-hydroxylation activity of CYP3A."
  Honda A., Miyazaki T., Ikegami T., Iwamoto J., Maeda T., Hirayama T., Saito Y., Teramoto T., Matsuzaki Y.
  J. Lipid Res. 52:1509-1516(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
an alkane
zoom
+
O₂
zoom
+
reduced [NADPH—hemoprotein reductase]
FMNH₂
zoom
=
a primary alcohol
zoom
+
H⁺
zoom
+
H₂O
zoom
+
oxidized [NADPH—hemoprotein reductase]
FMN
zoom

Cofactorⁱ

heme

Kineticsⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	226	SubstrateCurated		1
Metal bindingⁱ	458	Iron (heme axial ligand)		1

GO - Molecular functionⁱ

aromatase activity Source: UniProtKB-EC
caffeine oxidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18619574
demethylase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 2813353
electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 2813353
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15680923
heme binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17311915
iron ion binding Source: InterPro
monooxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15327587
- 19651758
oxidoreductase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16401082
- 19219744
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2813353

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

alkaloid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11511187
cellular respiration Source: Ensembl
cellular response to cadmium ion Source: Ensembl
cellular response to copper ion Source: Ensembl
dibenzo-p-dioxin metabolic process Source: Ensembl
drug catabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18356043
drug metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 15327587
- 19219744
epoxygenase P450 pathway Source: Reactome
exogenous drug catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18619574
heterocycle metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 15327587
hydrogen peroxide biosynthetic process Source: Ensembl
long-chain fatty acid biosynthetic process Source: Reactome
lung development Source: Ensembl
methylation Source: Reactome
monocarboxylic acid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19651758
monoterpenoid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 16401082
omega-hydroxylase P450 pathway Source: Reactome
oxidation-reduction process
Source: BHF-UCL
Inferred from direct assayⁱ
- 16401082
- 19219744
oxidative deethylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19029318
oxidative demethylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 18619574
porphyrin-containing compound metabolic process Source: Ensembl
post-embryonic development Source: Ensembl
regulation of gene expression Source: Ensembl
response to estradiol Source: Ensembl
response to immobilization stress Source: Ensembl
response to lipopolysaccharide Source: Ensembl
steroid catabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18356043
toxin biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11511187
xenobiotic metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Biological process	Lipid metabolism, Steroid metabolism, Sterol metabolism
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06728-MONOMER
BRENDAⁱ	1.14.14.1 2681 1.14.99.38 2681
Reactomeⁱ	R-HSA-156581 Methylation R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-5423646 Aflatoxin activation and detoxification R-HSA-9018681 Biosynthesis of protectins R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKⁱ	P05177

Chemistry databases

SwissLipidsⁱ	SLP:000001202

SwissLipidsⁱ

SLP:000001202

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 1A2 (EC:1.14.14.11 Publication) Alternative name(s): CYPIA2 Cholesterol 25-hydroxylase1 Publication Cytochrome P(3)450 Cytochrome P450 4 Cytochrome P450-P3
Gene namesⁱ	Name:CYP1A2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140505.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2596 CYP1A2
MIMⁱ	108330 gene 124060 gene+phenotype
neXtProtⁱ	NX_P05177

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1544
MalaCards human disease database More...MalaCardsⁱ	CYP1A2
MIMⁱ	124060 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000140505
Orphanetⁱ	284121 Toxicity or absent response to clozapine
PharmGKBⁱ	PA27093

Chemistry databases

ChEMBLⁱ	CHEMBL3356
Drug and drug target database More...DrugBankⁱ	DB07453 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE DB05812 Abiraterone DB01418 Acenocoumarol DB00316 Acetaminophen DB00787 Aciclovir DB06594 Agomelatine DB00518 Albendazole DB00523 Alitretinoin DB00918 Almotriptan DB00969 Alosetron DB00357 Aminoglutethimide DB01424 Aminophenazone DB01223 Aminophylline DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00261 Anagrelide DB01217 Anastrozole DB01435 Antipyrine DB06605 Apixaban DB00714 Apomorphine DB00673 Aprepitant DB06413 Armodafinil DB06216 Asenapine DB01072 Atazanavir DB00572 Atropine DB06626 Axitinib DB00972 Azelastine DB00207 Azithromycin DB06769 Bendamustine DB06770 Benzyl alcohol DB06732 beta-Naphthoflavone DB00195 Betaxolol DB00188 Bortezomib DB01558 Bromazepam DB01200 Bromocriptine DB00297 Bupivacaine DB00921 Buprenorphine DB01156 Bupropion DB00201 Caffeine DB06774 Capsaicin DB00564 Carbamazepine DB00389 Carbimazole DB00262 Carmustine DB01136 Carvedilol DB00477 Chlorpromazine DB00356 Chlorzoxazone DB01166 Cilostazol DB00501 Cimetidine DB01012 Cinacalcet DB00568 Cinnarizine DB00537 Ciprofloxacin DB00604 Cisapride DB00215 Citalopram DB01211 Clarithromycin DB01407 Clenbuterol DB04920 Clevidipine DB01013 Clobetasol propionate DB00882 Clomifene DB01242 Clomipramine DB00575 Clonidine DB00758 Clopidogrel DB00257 Clotrimazole DB00363 Clozapine DB00286 Conjugated Equine Estrogens DB05219 Crisaborole DB00924 Cyclobenzaprine DB00851 Dacarbazine DB04816 Dantron DB06292 Dapagliflozin DB01254 Dasatinib DB00694 Daunorubicin DB00705 Delavirdine DB01151 Desipramine DB00967 Desloratadine DB01191 Dexfenfluramine DB00633 Dexmedetomidine DB00829 Diazepam DB00586 Diclofenac DB00917 Dinoprostone DB01075 Diphenhydramine DB00822 Disulfiram DB01184 Domperidone DB00988 Dopamine DB01142 Doxepin DB00476 Duloxetine DB00974 Edetic Acid DB00625 Efavirenz DB06210 Eltrombopag DB00467 Enoxacin DB00494 Entacapone DB00668 Epinephrine DB00696 Ergotamine DB00530 Erlotinib DB00199 Erythromycin DB00783 Estradiol DB00655 Estrone DB04574 Estrone sulfate DB00898 Ethanol DB00773 Etoposide DB01628 Etoricoxib DB00196 Fluconazole DB04841 Flunarizine DB01544 Flunitrazepam DB00544 Fluorouracil DB00472 Fluoxetine DB00623 Fluphenazine DB00499 Flutamide DB01095 Fluvastatin DB00176 Fluvoxamine DB00998 Frovatriptan DB01241 Gemfibrozil DB01645 Genistein DB08909 Glycerol Phenylbutyrate DB00365 Grepafloxacin DB00400 Griseofulvin DB05708 GTS-21 DB00629 Guanabenz DB00502 Haloperidol DB01094 Hesperetin DB01355 Hexobarbital DB11737 Icotinib DB04946 Iloperidone DB00619 Imatinib DB00458 Imipramine DB00724 Imiquimod DB01306 Insulin Aspart DB09456 Insulin Beef DB01307 Insulin Detemir DB00047 Insulin Glargine DB01309 Insulin Glulisine DB00030 Insulin Human DB00046 Insulin Lispro DB00071 Insulin Pork DB00033 Interferon gamma-1b DB01029 Irbesartan DB00951 Isoniazid DB09570 Ixazomib DB01026 Ketoconazole DB00448 Lansoprazole DB01097 Leflunomide DB01002 Levobupivacaine DB01137 Levofloxacin DB00281 Lidocaine DB00978 Lomefloxacin DB01601 Lopinavir DB04871 Lorcaserin DB00678 Losartan DB01283 Lumiracoxib DB00772 Malathion DB00934 Maprotiline DB00737 Meclizine DB01065 Melatonin DB00170 Menadione DB00532 Mephenytoin DB01357 Mestranol DB00333 Methadone DB00763 Methimazole DB01403 Methotrimeprazine DB00553 Methoxsalen DB01028 Methoxyflurane DB00379 Mexiletine DB06148 Mianserin DB01388 Mibefradil DB01110 Miconazole DB00834 Mifepristone DB00370 Mirtazapine DB01171 Moclobemide DB00745 Modafinil DB00461 Nabumetone DB00607 Nafcillin DB00788 Naproxen DB01149 Nefazodone DB00220 Nelfinavir DB00238 Nevirapine DB06803 Niclosamide DB00184 Nicotine DB01115 Nifedipine DB06712 Nilvadipine DB00401 Nisoldipine DB00435 Nitric Oxide DB00325 Nitroprusside DB00368 Norepinephrine DB01059 Norfloxacin DB00540 Nortriptyline DB05990 Obeticholic acid DB01165 Ofloxacin DB00334 Olanzapine DB00338 Omeprazole DB00904 Ondansetron DB01173 Orphenadrine DB09330 Osimertinib DB00526 Oxaliplatin DB01303 Oxtriphylline DB06412 Oxymetholone DB00377 Palonosetron DB00213 Pantoprazole DB00715 Paroxetine DB06589 Pazopanib DB00487 Pefloxacin DB00008 Peginterferon alfa-2a DB00022 Peginterferon alfa-2b DB00738 Pentamidine DB00806 Pentoxifylline DB00850 Perphenazine DB03783 Phenacetin DB01174 Phenobarbital DB00191 Phentermine DB00388 Phenylephrine DB00397 Phenylpropanolamine DB01100 Pimozide DB01621 Pipotiazine DB08910 Pomalidomide DB01058 Praziquantel DB01087 Primaquine DB00794 Primidone DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB01182 Propafenone DB00818 Propofol DB00571 Propranolol DB00339 Pyrazinamide DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB00980 Ramelteon DB00863 Ranitidine DB01367 Rasagiline DB02709 Resveratrol DB00615 Rifabutin DB01045 Rifampicin DB08864 Rilpivirine DB00740 Riluzole DB00503 Ritonavir DB00953 Rizatriptan DB00533 Rofecoxib DB00268 Ropinirole DB00296 Ropivacaine DB00412 Rosiglitazone DB05271 Rotigotine DB00778 Roxithromycin DB12332 Rucaparib DB00418 Secobarbital DB01037 Selegiline DB01104 Sertraline DB06290 Simeprevir DB06819 Sodium phenylbutyrate DB00398 Sorafenib DB00428 Streptozocin DB06820 Sulconazole DB00605 Sulindac DB00382 Tacrine DB00675 Tamoxifen DB01079 Tegaserod DB00976 Telithromycin DB01405 Temafloxacin DB00300 Tenofovir DB00857 Terbinafine DB01041 Thalidomide DB01412 Theobromine DB00277 Theophylline DB00730 Thiabendazole DB00679 Thioridazine DB01623 Thiothixene DB00208 Ticlopidine DB01007 Tioconazole DB00697 Tizanidine DB01056 Tocainide DB00539 Toremifene DB00752 Tranylcypromine DB00384 Triamterene DB00831 Trifluoperazine DB08867 Ulipristal DB00577 Valaciclovir DB00313 Valproic Acid DB08881 Vemurafenib DB00661 Verapamil DB00682 Warfarin DB00549 Zafirlukast DB00744 Zileuton DB00246 Ziprasidone DB00315 Zolmitriptan DB00425 Zolpidem
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1319

Polymorphism and mutation databases

BioMutaⁱ	CYP1A2
DMDMⁱ	117144

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000051651	2 – 516	Cytochrome P450 1A2Add BLAST		515

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	69	O-linked (GlcNAc) serineBy similarity		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P05177
PaxDbⁱ	P05177
PeptideAtlas More...PeptideAtlasⁱ	P05177
PRIDEⁱ	P05177
ProteomicsDBⁱ	51818 51819

PTM databases

iPTMnetⁱ	P05177
PhosphoSitePlusⁱ	P05177

Expressionⁱ

Tissue specificityⁱ

Liver.

Inductionⁱ

By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

Gene expression databases

Bgeeⁱ	ENSG00000140505 Expressed in 164 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP1A2
Genevisibleⁱ	P05177 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016531

HPAⁱ

CAB016531

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15680923

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107924, 7 interactors
IntActⁱ	P05177, 1 interactor
STRINGⁱ	9606.ENSP00000342007

Chemistry databases

BindingDBⁱ

P05177

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	49 – 51	Combined sources	3
Helixⁱ	54 – 57	Combined sources	4
Helixⁱ	61 – 72	Combined sources	12
Beta strandⁱ	74 – 80	Combined sources	7
Beta strandⁱ	83 – 88	Combined sources	6
Helixⁱ	91 – 98	Combined sources	8
Turnⁱ	99 – 101	Combined sources	3
Helixⁱ	102 – 104	Combined sources	3
Helixⁱ	112 – 115	Combined sources	4
Turnⁱ	123 – 125	Combined sources	3
Helixⁱ	131 – 146	Combined sources	16
Turnⁱ	147 – 149	Combined sources	3
Helixⁱ	160 – 181	Combined sources	22
Helixⁱ	188 – 205	Combined sources	18
Helixⁱ	206 – 208	Combined sources	3
Helixⁱ	214 – 220	Combined sources	7
Helixⁱ	221 – 223	Combined sources	3
Helixⁱ	224 – 227	Combined sources	4
Helixⁱ	235 – 237	Combined sources	3
Helixⁱ	240 – 244	Combined sources	5
Helixⁱ	248 – 273	Combined sources	26
Helixⁱ	283 – 293	Combined sources	11
Helixⁱ	305 – 308	Combined sources	4
Helixⁱ	310 – 335	Combined sources	26
Helixⁱ	337 – 350	Combined sources	14
Turnⁱ	351 – 353	Combined sources	3
Helixⁱ	359 – 361	Combined sources	3
Helixⁱ	366 – 379	Combined sources	14
Beta strandⁱ	394 – 396	Combined sources	3
Beta strandⁱ	399 – 401	Combined sources	3
Beta strandⁱ	406 – 410	Combined sources	5
Helixⁱ	411 – 416	Combined sources	6
Turnⁱ	418 – 420	Combined sources	3
Helixⁱ	429 – 432	Combined sources	4
Beta strandⁱ	437 – 440	Combined sources	4
Helixⁱ	442 – 445	Combined sources	4
Helixⁱ	454 – 456	Combined sources	3
Helixⁱ	461 – 478	Combined sources	18
Beta strandⁱ	480 – 482	Combined sources	3
Beta strandⁱ	496 – 498	Combined sources	3
Beta strandⁱ	507 – 510	Combined sources	4

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HI4	X-ray	1.95	A	27-516	[»]
ProteinModelPortalⁱ	P05177
SMRⁱ	P05177
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P05177

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153539
HOGENOMⁱ	HOG000036991
HOVERGENⁱ	HBG106944
InParanoidⁱ	P05177
OMAⁱ	VIGAMCF
Database of Orthologous Groups More...OrthoDBⁱ	920162at2759
PhylomeDBⁱ	P05177
TreeFamⁱ	TF105095

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P05177-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL 
        60         70         80         90        100
LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR 
       110        120        130        140        150
QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA 
       160        170        180        190        200
SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI 
       210        220        230        240        250
GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL 
       260        270        280        290        300
QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN 
       310        320        330        340        350
LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV 
       360        370        380        390        400
IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY 
       410        420        430        440        450
IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML 
       460        470        480        490        500
FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK 
       510 
HARCEHVQAR LRFSIN

Length:516

Mass (Da):58,407

Last modified:September 12, 2018 - v4

Checksum:ⁱ8557AB02860C4806

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	79	R → S in AAA35738 (PubMed:3462722).Curated	1
Sequence conflictⁱ	81	G → D in AAH67427 (PubMed:15489334).Curated	1
Sequence conflictⁱ	170	K → M in AAF13599 (Ref. 5) Curated	1
Sequence conflictⁱ	311	V → L in AAA52154 (PubMed:3462722).Curated	1
Sequence conflictⁱ	380	S → P in AAH67429 (PubMed:15489334).Curated	1
Sequence conflictⁱ	450 – 451	LF → MLV in AAA52154 (PubMed:3462722).Curated	2
Sequence conflictⁱ	492	T → I in AAF13599 (Ref. 5) Curated	1
Sequence conflictⁱ	511	Missing in CAA77335 (PubMed:3755823).Curated	1
Sequence conflictⁱ	511	Missing in AAA52146 (PubMed:2575218).Curated	1
Sequence conflictⁱ	511	Missing in AAA52163 (PubMed:2575218).Curated	1
Sequence conflictⁱ	512	R → P in AAA35738 (PubMed:3462722).Curated	1

Polymorphismⁱ

The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023196	18	S → C2 PublicationsCorresponds to variant dbSNP:rs17861152Ensembl.	1
Natural variantⁱVAR_008349	21	F → L in allele CYP1A2*2. 1 PublicationCorresponds to variant dbSNP:rs56160784Ensembl.	1
Natural variantⁱVAR_025182	42	P → R in allele CYP1A2*15. 1 PublicationCorresponds to variant dbSNP:rs72547511Ensembl.	1
Natural variantⁱVAR_025183	73	G → R1 PublicationCorresponds to variant dbSNP:rs45565238Ensembl.	1
Natural variantⁱVAR_020848	83	T → M in allele CYP1A2*9. 1 PublicationCorresponds to variant dbSNP:rs138652540Ensembl.	1
Natural variantⁱVAR_025184	104	D → N1 PublicationCorresponds to variant dbSNP:rs34067076Ensembl.	1
Natural variantⁱVAR_025185	111	L → F1 PublicationCorresponds to variant dbSNP:rs45442197Ensembl.	1
Natural variantⁱVAR_020849	168	E → Q in allele CYP1A2*10. 1 PublicationCorresponds to variant dbSNP:rs72547512Ensembl.	1
Natural variantⁱVAR_020850	186	F → L in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value. 1 PublicationCorresponds to variant dbSNP:rs72547513Ensembl.	1
Natural variantⁱVAR_025186	205	F → V1 PublicationCorresponds to variant dbSNP:rs45540640Ensembl.	1
Natural variantⁱVAR_020851	212	S → C in allele CYP1A2*12. 1 PublicationCorresponds to variant dbSNP:rs758748797Ensembl.	1
Natural variantⁱVAR_025187	281	R → W1 PublicationCorresponds to variant dbSNP:rs45468096Ensembl.	1
Natural variantⁱVAR_024709	298	S → R1 PublicationCorresponds to variant dbSNP:rs17861157Ensembl.	1
Natural variantⁱVAR_020852	299	G → S in allele CYP1A2*13. 1 PublicationCorresponds to variant dbSNP:rs35796837Ensembl.	1
Natural variantⁱVAR_024710	314	I → V2 PublicationsCorresponds to variant dbSNP:rs28399418Ensembl.	1
Natural variantⁱVAR_020793	348	D → N in allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity. 2 PublicationsCorresponds to variant dbSNP:rs56276455Ensembl.	1
Natural variantⁱVAR_025188	377	R → Q in allele CYP1A2*16. 1 PublicationCorresponds to variant dbSNP:rs72547515Ensembl.	1
Natural variantⁱVAR_020794	386	I → F in allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin. 2 PublicationsCorresponds to variant dbSNP:rs72547516Ensembl.	1
Natural variantⁱVAR_020795	406	C → Y in allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation. 2 PublicationsCorresponds to variant dbSNP:rs55889066Ensembl.	1
Natural variantⁱVAR_020796	431	R → W in allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure. 3 PublicationsCorresponds to variant dbSNP:rs28399424Ensembl.	1
Natural variantⁱVAR_020853	438	T → I in allele CYP1A2*14. 2 PublicationsCorresponds to variant dbSNP:rs45486893Ensembl.	1
Natural variantⁱVAR_025189	456	R → H in allele CYP1A2*8. 1 PublicationCorresponds to variant dbSNP:rs72547517Ensembl.	1
Natural variantⁱVAR_055563	457	R → W. Corresponds to variant dbSNP:rs34151816Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z00036 mRNA Translation: CAA77335.1 M55053 mRNA Translation: AAA52146.1 M12078 mRNA Translation: AAA52154.1 L00389 L00387 Genomic DNA Translation: AAA35738.1 M31667 , M31664, M31665, M31666 Genomic DNA Translation: AAA52163.1 AF182274 mRNA Translation: AAF13599.1 AF253322 Genomic DNA Translation: AAK25728.1 DQ022432 Genomic DNA Translation: AAY26399.1 BC067424 mRNA Translation: AAH67424.1 BC067425 mRNA Translation: AAH67425.1 BC067426 mRNA Translation: AAH67426.1 BC067427 mRNA Translation: AAH67427.1 BC067428 mRNA Translation: AAH67428.1 BC067429 mRNA Translation: AAH67429.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32293.1
PIRⁱ	S16718 O4HU4
NCBI Reference Sequences More...RefSeqⁱ	NP_000752.2, NM_000761.4
UniGeneⁱ	Hs.1361

Genome annotation databases

Ensemblⁱ	ENST00000343932; ENSP00000342007; ENSG00000140505
GeneIDⁱ	1544
UCSC genome browser More...UCSCⁱ	uc002ayr.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P05177	Cytochrome P450		PANTR		517	UniRef90_P05177
Cytochrome P450		PANPA		517
Cytochrome P450 1A2		PONAB		516
Cytochrome P450		GORGO		516
UPI0000F23D49		HUMAN		495
+1

Protein	Similar proteins		Species	Score	Length	Source
P05177	Cytochrome P450		PANPA		517	UniRef50_P05177
Cytochrome P450		PANTR		517
Cytochrome P450 1A2		PONAB		516
Cytochrome P450		GORGO		516
Cytochrome P450		NEOLE		543
+756

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP1A2 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z00036 mRNA Translation: CAA77335.1 M55053 mRNA Translation: AAA52146.1 M12078 mRNA Translation: AAA52154.1 L00389 L00387 Genomic DNA Translation: AAA35738.1 M31667 , M31664, M31665, M31666 Genomic DNA Translation: AAA52163.1 AF182274 mRNA Translation: AAF13599.1 AF253322 Genomic DNA Translation: AAK25728.1 DQ022432 Genomic DNA Translation: AAY26399.1 BC067424 mRNA Translation: AAH67424.1 BC067425 mRNA Translation: AAH67425.1 BC067426 mRNA Translation: AAH67426.1 BC067427 mRNA Translation: AAH67427.1 BC067428 mRNA Translation: AAH67428.1 BC067429 mRNA Translation: AAH67429.1
CCDSⁱ	CCDS32293.1
PIRⁱ	S16718 O4HU4
RefSeqⁱ	NP_000752.2, NM_000761.4
UniGeneⁱ	Hs.1361

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HI4	X-ray	1.95	A	27-516	[»]
ProteinModelPortalⁱ	P05177
SMRⁱ	P05177
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107924, 7 interactors
IntActⁱ	P05177, 1 interactor
STRINGⁱ	9606.ENSP00000342007

Chemistry databases

BindingDBⁱ	P05177
ChEMBLⁱ	CHEMBL3356
DrugBankⁱ	DB07453 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE DB05812 Abiraterone DB01418 Acenocoumarol DB00316 Acetaminophen DB00787 Aciclovir DB06594 Agomelatine DB00518 Albendazole DB00523 Alitretinoin DB00918 Almotriptan DB00969 Alosetron DB00357 Aminoglutethimide DB01424 Aminophenazone DB01223 Aminophylline DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00261 Anagrelide DB01217 Anastrozole DB01435 Antipyrine DB06605 Apixaban DB00714 Apomorphine DB00673 Aprepitant DB06413 Armodafinil DB06216 Asenapine DB01072 Atazanavir DB00572 Atropine DB06626 Axitinib DB00972 Azelastine DB00207 Azithromycin DB06769 Bendamustine DB06770 Benzyl alcohol DB06732 beta-Naphthoflavone DB00195 Betaxolol DB00188 Bortezomib DB01558 Bromazepam DB01200 Bromocriptine DB00297 Bupivacaine DB00921 Buprenorphine DB01156 Bupropion DB00201 Caffeine DB06774 Capsaicin DB00564 Carbamazepine DB00389 Carbimazole DB00262 Carmustine DB01136 Carvedilol DB00477 Chlorpromazine DB00356 Chlorzoxazone DB01166 Cilostazol DB00501 Cimetidine DB01012 Cinacalcet DB00568 Cinnarizine DB00537 Ciprofloxacin DB00604 Cisapride DB00215 Citalopram DB01211 Clarithromycin DB01407 Clenbuterol DB04920 Clevidipine DB01013 Clobetasol propionate DB00882 Clomifene DB01242 Clomipramine DB00575 Clonidine DB00758 Clopidogrel DB00257 Clotrimazole DB00363 Clozapine DB00286 Conjugated Equine Estrogens DB05219 Crisaborole DB00924 Cyclobenzaprine DB00851 Dacarbazine DB04816 Dantron DB06292 Dapagliflozin DB01254 Dasatinib DB00694 Daunorubicin DB00705 Delavirdine DB01151 Desipramine DB00967 Desloratadine DB01191 Dexfenfluramine DB00633 Dexmedetomidine DB00829 Diazepam DB00586 Diclofenac DB00917 Dinoprostone DB01075 Diphenhydramine DB00822 Disulfiram DB01184 Domperidone DB00988 Dopamine DB01142 Doxepin DB00476 Duloxetine DB00974 Edetic Acid DB00625 Efavirenz DB06210 Eltrombopag DB00467 Enoxacin DB00494 Entacapone DB00668 Epinephrine DB00696 Ergotamine DB00530 Erlotinib DB00199 Erythromycin DB00783 Estradiol DB00655 Estrone DB04574 Estrone sulfate DB00898 Ethanol DB00773 Etoposide DB01628 Etoricoxib DB00196 Fluconazole DB04841 Flunarizine DB01544 Flunitrazepam DB00544 Fluorouracil DB00472 Fluoxetine DB00623 Fluphenazine DB00499 Flutamide DB01095 Fluvastatin DB00176 Fluvoxamine DB00998 Frovatriptan DB01241 Gemfibrozil DB01645 Genistein DB08909 Glycerol Phenylbutyrate DB00365 Grepafloxacin DB00400 Griseofulvin DB05708 GTS-21 DB00629 Guanabenz DB00502 Haloperidol DB01094 Hesperetin DB01355 Hexobarbital DB11737 Icotinib DB04946 Iloperidone DB00619 Imatinib DB00458 Imipramine DB00724 Imiquimod DB01306 Insulin Aspart DB09456 Insulin Beef DB01307 Insulin Detemir DB00047 Insulin Glargine DB01309 Insulin Glulisine DB00030 Insulin Human DB00046 Insulin Lispro DB00071 Insulin Pork DB00033 Interferon gamma-1b DB01029 Irbesartan DB00951 Isoniazid DB09570 Ixazomib DB01026 Ketoconazole DB00448 Lansoprazole DB01097 Leflunomide DB01002 Levobupivacaine DB01137 Levofloxacin DB00281 Lidocaine DB00978 Lomefloxacin DB01601 Lopinavir DB04871 Lorcaserin DB00678 Losartan DB01283 Lumiracoxib DB00772 Malathion DB00934 Maprotiline DB00737 Meclizine DB01065 Melatonin DB00170 Menadione DB00532 Mephenytoin DB01357 Mestranol DB00333 Methadone DB00763 Methimazole DB01403 Methotrimeprazine DB00553 Methoxsalen DB01028 Methoxyflurane DB00379 Mexiletine DB06148 Mianserin DB01388 Mibefradil DB01110 Miconazole DB00834 Mifepristone DB00370 Mirtazapine DB01171 Moclobemide DB00745 Modafinil DB00461 Nabumetone DB00607 Nafcillin DB00788 Naproxen DB01149 Nefazodone DB00220 Nelfinavir DB00238 Nevirapine DB06803 Niclosamide DB00184 Nicotine DB01115 Nifedipine DB06712 Nilvadipine DB00401 Nisoldipine DB00435 Nitric Oxide DB00325 Nitroprusside DB00368 Norepinephrine DB01059 Norfloxacin DB00540 Nortriptyline DB05990 Obeticholic acid DB01165 Ofloxacin DB00334 Olanzapine DB00338 Omeprazole DB00904 Ondansetron DB01173 Orphenadrine DB09330 Osimertinib DB00526 Oxaliplatin DB01303 Oxtriphylline DB06412 Oxymetholone DB00377 Palonosetron DB00213 Pantoprazole DB00715 Paroxetine DB06589 Pazopanib DB00487 Pefloxacin DB00008 Peginterferon alfa-2a DB00022 Peginterferon alfa-2b DB00738 Pentamidine DB00806 Pentoxifylline DB00850 Perphenazine DB03783 Phenacetin DB01174 Phenobarbital DB00191 Phentermine DB00388 Phenylephrine DB00397 Phenylpropanolamine DB01100 Pimozide DB01621 Pipotiazine DB08910 Pomalidomide DB01058 Praziquantel DB01087 Primaquine DB00794 Primidone DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB01182 Propafenone DB00818 Propofol DB00571 Propranolol DB00339 Pyrazinamide DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB00980 Ramelteon DB00863 Ranitidine DB01367 Rasagiline DB02709 Resveratrol DB00615 Rifabutin DB01045 Rifampicin DB08864 Rilpivirine DB00740 Riluzole DB00503 Ritonavir DB00953 Rizatriptan DB00533 Rofecoxib DB00268 Ropinirole DB00296 Ropivacaine DB00412 Rosiglitazone DB05271 Rotigotine DB00778 Roxithromycin DB12332 Rucaparib DB00418 Secobarbital DB01037 Selegiline DB01104 Sertraline DB06290 Simeprevir DB06819 Sodium phenylbutyrate DB00398 Sorafenib DB00428 Streptozocin DB06820 Sulconazole DB00605 Sulindac DB00382 Tacrine DB00675 Tamoxifen DB01079 Tegaserod DB00976 Telithromycin DB01405 Temafloxacin DB00300 Tenofovir DB00857 Terbinafine DB01041 Thalidomide DB01412 Theobromine DB00277 Theophylline DB00730 Thiabendazole DB00679 Thioridazine DB01623 Thiothixene DB00208 Ticlopidine DB01007 Tioconazole DB00697 Tizanidine DB01056 Tocainide DB00539 Toremifene DB00752 Tranylcypromine DB00384 Triamterene DB00831 Trifluoperazine DB08867 Ulipristal DB00577 Valaciclovir DB00313 Valproic Acid DB08881 Vemurafenib DB00661 Verapamil DB00682 Warfarin DB00549 Zafirlukast DB00744 Zileuton DB00246 Ziprasidone DB00315 Zolmitriptan DB00425 Zolpidem
GuidetoPHARMACOLOGYⁱ	1319
SwissLipidsⁱ	SLP:000001202

PTM databases

iPTMnetⁱ	P05177
PhosphoSitePlusⁱ	P05177

Polymorphism and mutation databases

BioMutaⁱ	CYP1A2
DMDMⁱ	117144

Proteomic databases

MaxQBⁱ	P05177
PaxDbⁱ	P05177
PeptideAtlasⁱ	P05177
PRIDEⁱ	P05177
ProteomicsDBⁱ	51818 51819

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000343932; ENSP00000342007; ENSG00000140505
GeneIDⁱ	1544
UCSCⁱ	uc002ayr.2 human

Organism-specific databases

CTDⁱ	1544
DisGeNETⁱ	1544
EuPathDBⁱ	HostDB:ENSG00000140505.6
GeneCardsⁱ	CYP1A2
HGNCⁱ	HGNC:2596 CYP1A2
HPAⁱ	CAB016531
MalaCardsⁱ	CYP1A2
MIMⁱ	108330 gene 124060 gene+phenotype
neXtProtⁱ	NX_P05177
OpenTargetsⁱ	ENSG00000140505
Orphanetⁱ	284121 Toxicity or absent response to clozapine
PharmGKBⁱ	PA27093
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00940000153539
HOGENOMⁱ	HOG000036991
HOVERGENⁱ	HBG106944
InParanoidⁱ	P05177
OMAⁱ	VIGAMCF
OrthoDBⁱ	920162at2759
PhylomeDBⁱ	P05177
TreeFamⁱ	TF105095

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06728-MONOMER
BRENDAⁱ	1.14.14.1 2681 1.14.99.38 2681
Reactomeⁱ	R-HSA-156581 Methylation R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-5423646 Aflatoxin activation and detoxification R-HSA-9018681 Biosynthesis of protectins R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKⁱ	P05177

Miscellaneous databases

EvolutionaryTraceⁱ	P05177
GeneWikiⁱ	CYP1A2
GenomeRNAiⁱ	1544
Protein Ontology More...PROⁱ	PR:P05177
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140505 Expressed in 164 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP1A2
Genevisibleⁱ	P05177 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP1A2_HUMAN
Accessionⁱ	P05177Primary (citable) accession number: P05177 Secondary accession number(s): Q16754 , Q6NWU3, Q6NWU5, Q9BXX7, Q9UK49
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	September 12, 2018
	Last modified:	January 16, 2019
	This is version 197 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P05177 (CP1A2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cytochrome P450 1A2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Catalytic activityⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ