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UniProtKB - P05177 (CP1A2_HUMAN)

Entry version 212 (02 Dec 2020)
Sequence version 4 (12 Sep 2018)
Previous versions | rss
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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).1 Publication8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=19 µM for 17beta-estradiol (2-hydroxylation)1 Publication
  2. KM=9 µM for all-trans retinol1 Publication
  3. KM=4 µM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole1 Publication
  4. KM=21 µM for 2-amino-3-methylimidazo[4,5-f]quinoline1 Publication
  5. KM=26 µM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline1 Publication
  6. KM=27 µM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline1 Publication
  7. KM=71 µM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine1 Publication
  8. KM=25 µM for phenacetin1 Publication
  1. Vmax=9.2 nmol/min/nmol enzyme toward 17beta-estradiol (2-hydroxylation)1 Publication
  2. Vmax=491 pmol/min/nmol enzyme toward all-trans retinol1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

Pathwayi: arachidonate metabolism

This protein is involved in the pathway arachidonate metabolism, which is part of Lipid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway arachidonate metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei226SubstrateCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi458Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS06728-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.14.14.1, 2681
1.14.99.38, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05177

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156581, Methylation
R-HSA-211957, Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-5423646, Aflatoxin activation and detoxification
R-HSA-9018681, Biosynthesis of protectins
R-HSA-9027307, Biosynthesis of maresin-like SPMs

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P05177

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00296
UPA00383
UPA00912

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001202

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 1A21 Publication (EC:1.14.14.13 Publications)
Alternative name(s):
CYPIA2
Cholesterol 25-hydroxylase1 Publication
Cytochrome P(3)450
Cytochrome P450 4
Cytochrome P450-P3
Hydroperoxy icosatetraenoate dehydratase1 Publication (EC:4.2.1.1521 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP1A21 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000140505.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:2596, CYP1A2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		108330, gene
124060, gene+phenotype

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05177

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1544
MIMi124060, gene+phenotype

Open Targets

More...OpenTargetsi		ENSG00000140505

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		284121, Toxicity or absent response to clozapine

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27093

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05177, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3356

Drug and drug target database

More...DrugBanki		DB08496, (R)-warfarin
DB01667, 8-azaguanine
DB14132, 8-chlorotheophylline
DB04356, 9-Deazaguanine
DB02489, 9-Methylguanine
DB12001, Abemaciclib
DB05812, Abiraterone
DB13573, Acefylline
DB01418, Acenocoumarol
DB00316, Acetaminophen
DB06594, Agomelatine
DB00518, Albendazole
DB05396, Albinterferon Alfa-2B
DB00969, Alosetron
DB07453, alpha-Naphthoflavone
DB01424, Aminophenazone
DB01223, Aminophylline
DB01118, Amiodarone
DB00321, Amitriptyline
DB00261, Anagrelide
DB01217, Anastrozole
DB01435, Antipyrine
DB06605, Apixaban
DB05676, Apremilast
DB06413, Armodafinil
DB06216, Asenapine
DB01072, Atazanavir
DB06442, Avasimibe
DB06626, Axitinib
DB00993, Azathioprine
DB00972, Azelastine
DB13203, Bamifylline
DB05015, Belinostat
DB06769, Bendamustine
DB06770, Benzyl alcohol
DB06771, Besifloxacin
DB06732, beta-Naphthoflavone
DB00195, Betaxolol
DB04889, Bicifadine
DB11967, Binimetinib
DB13975, Black cohosh
DB00188, Bortezomib
DB01558, Bromazepam
DB14018, Bromotheophylline
DB13812, Bufylline
DB00201, Caffeine
DB09061, Cannabidiol
DB11791, Capmatinib
DB06774, Capsaicin
DB00564, Carbamazepine
DB01136, Carvedilol
DB12814, Cepeginterferon alfa-2B
DB00477, Chlorpromazine
DB00356, Chlorzoxazone
DB01166, Cilostazol
DB00501, Cimetidine
DB01012, Cinacalcet
DB00568, Cinnarizine
DB00827, Cinoxacin
DB00537, Ciprofloxacin
DB00215, Citalopram
DB14025, Clinafloxacin
DB01242, Clomipramine
DB00575, Clonidine
DB00758, Clopidogrel
DB00363, Clozapine
DB00286, Conjugated estrogens
DB11672, Curcumin
DB14635, Curcumin sulfate
DB00924, Cyclobenzaprine
DB00851, Dacarbazine
DB06292, Dapagliflozin
DB01254, Dasatinib
DB01609, Deferasirox
DB01151, Desipramine
DB12161, Deutetrabenazine
DB01191, Dexfenfluramine
DB00633, Dexmedetomidine
DB11994, Diacerein
DB00586, Diclofenac
DB11511, Difloxacin
DB12945, Dihydralazine
DB00280, Disopyramide
DB01184, Domperidone
DB09167, Dosulepin
DB05928, Dovitinib
DB01142, Doxepin
DB09273, Doxofylline
DB00476, Duloxetine
DB00625, Efavirenz
DB15444, Elexacaftor
DB06210, Eltrombopag
DB13874, Enasidenib
DB00467, Enoxacin
DB11404, Enrofloxacin
DB00530, Erlotinib
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB04574, Estrone sulfate
DB13592, Etamiphylline
DB00898, Ethanol
DB00977, Ethinylestradiol
DB00773, Etoposide
DB01628, Etoricoxib
DB00927, Famotidine
DB01482, Fenethylline
DB01195, Flecainide
DB08972, Flumequine
DB04841, Flunarizine
DB00544, Fluorouracil
DB00472, Fluoxetine
DB00499, Flutamide
DB00176, Fluvoxamine
DB01320, Fosphenytoin
DB00998, Frovatriptan
DB14029, Furafylline
DB06160, Garenoxacin
DB01044, Gatifloxacin
DB01241, Gemfibrozil
DB01155, Gemifloxacin
DB01645, Genistein
DB00365, Grepafloxacin
DB00400, Griseofulvin
DB05708, GTS-21
DB00629, Guanabenz
DB00502, Haloperidol
DB01094, Hesperetin
DB14999, Human interferon beta
DB04076, Hypoxanthine
DB11737, Icotinib
DB00619, Imatinib
DB00458, Imipramine
DB01306, Insulin aspart
DB09456, Insulin beef
DB09564, Insulin degludec
DB01307, Insulin detemir
DB00047, Insulin glargine
DB01309, Insulin glulisine
DB00030, Insulin human
DB00046, Insulin lispro
DB11567, Insulin peglispro
DB00071, Insulin pork
DB11568, Insulin tregopil
DB05258, Interferon alfa
DB00034, Interferon alfa-2a, Recombinant
DB00105, Interferon alfa-2b
DB15131, Interferon alfa-2c
DB00011, Interferon alfa-n1
DB00018, Interferon alfa-n3
DB00069, Interferon alfacon-1
DB00060, Interferon beta-1a
DB00068, Interferon beta-1b
DB00033, Interferon gamma-1b
DB00951, Isoniazid
DB11757, Istradefylline
DB09570, Ixazomib
DB01026, Ketoconazole
DB01097, Leflunomide
DB09078, Lenvatinib
DB01002, Levobupivacaine
DB01137, Levofloxacin
DB00281, Lidocaine
DB12406, Lisofylline
DB09198, Lobeglitazone
DB04948, Lofexidine
DB00978, Lomefloxacin
DB01601, Lopinavir
DB00455, Loratadine
DB04871, Lorcaserin
DB06077, Lumateperone
DB01283, Lumiracoxib
DB00772, Malathion
DB00934, Maprotiline
DB14009, Medical Cannabis
DB01065, Melatonin
DB00170, Menadione
DB00454, Meperidine
DB00532, Mephenytoin
DB00333, Methadone
DB00763, Methimazole
DB00553, Methoxsalen
DB01028, Methoxyflurane
DB09241, Methylene blue
DB01233, Metoclopramide
DB00379, Mexiletine
DB06148, Mianserin
DB01388, Mibefradil
DB06595, Midostaurin
DB00370, Mirtazapine
DB00745, Modafinil
DB00218, Moxifloxacin
DB06510, Muraglitazar
DB14011, Nabiximols
DB00461, Nabumetone
DB00607, Nafcillin
DB00779, Nalidixic acid
DB00788, Naproxen
DB06600, Nemonoxacin
DB00238, Nevirapine
DB06803, Niclosamide
DB00184, Nicotine
DB01115, Nifedipine
DB00435, Nitric Oxide
DB05115, NN344
DB00717, Norethisterone
DB01059, Norfloxacin
DB00540, Nortriptyline
DB05990, Obeticholic acid
DB01165, Ofloxacin
DB00334, Olanzapine
DB00338, Omeprazole
DB00904, Ondansetron
DB11443, Orbifloxacin
DB01173, Orphenadrine
DB11837, Osilodrostat
DB09330, Osimertinib
DB13627, Oxolinic acid
DB01303, Oxtriphylline
DB00377, Palonosetron
DB00715, Paroxetine
DB06589, Pazopanib
DB11774, Pazufloxacin
DB00487, Pefloxacin
DB00008, Peginterferon alfa-2a
DB00022, Peginterferon alfa-2b
DB09122, Peginterferon beta-1a
DB13634, Pentifylline
DB00806, Pentoxifylline
DB11198, Peppermint oil
DB08883, Perampanel
DB00850, Perphenazine
DB03783, Phenacetin
DB01174, Phenobarbital
DB00388, Phenylephrine
DB00252, Phenytoin
DB11450, Pimobendan
DB01100, Pimozide
DB13823, Pipemidic acid
DB04951, Pirfenidone
DB11642, Pitolisant
DB08910, Pomalidomide
DB01058, Praziquantel
DB01087, Primaquine
DB00794, Primidone
DB00420, Promazine
DB09288, Propacetamol
DB01182, Propafenone
DB06479, Propentofylline
DB00818, Propofol
DB00571, Propranolol
DB13449, Proxyphylline
DB11892, Prulifloxacin
DB00908, Quinidine
DB00468, Quinine
DB01129, Rabeprazole
DB00980, Ramelteon
DB09290, Ramosetron
DB00863, Ranitidine
DB01367, Rasagiline
DB02709, Resveratrol
DB13174, Rhein
DB01045, Rifampicin
DB11753, Rifamycin
DB00740, Riluzole
DB00503, Ritonavir
DB00533, Rofecoxib
DB15119, Ropeginterferon alfa-2b
DB00268, Ropinirole
DB00296, Ropivacaine
DB00412, Rosiglitazone
DB00817, Rosoxacin
DB12332, Rucaparib
DB13772, Rufloxacin
DB06654, Safinamide
DB11491, Sarafloxacin
DB00418, Secobarbital
DB01037, Selegiline
DB11689, Selumetinib
DB06290, Simeprevir
DB13261, Sitafloxacin
DB00398, Sorafenib
DB01208, Sparfloxacin
DB09118, Stiripentol
DB00428, Streptozocin
DB06820, Sulconazole
DB00382, Tacrine
DB00675, Tamoxifen
DB09071, Tasimelteon
DB05488, Technetium Tc-99m ciprofloxacin
DB09256, Tegafur
DB01079, Tegaserod
DB01405, Temafloxacin
DB00857, Terbinafine
DB08880, Teriflunomide
DB01412, Theobromine
DB00277, Theophylline
DB00730, Thiabendazole
DB01623, Thiothixene
DB00208, Ticlopidine
DB00697, Tizanidine
DB01056, Tocainide
DB06264, Tolperisone
DB00752, Tranylcypromine
DB00384, Triamterene
DB12245, Triclabendazole
DB00831, Trifluoperazine
DB00440, Trimethoprim
DB00685, Trovafloxacin
DB08867, Ulipristal
DB13609, Umifenovir
DB06235, Vadimezan
DB00313, Valproic acid
DB08881, Vemurafenib
DB00661, Verapamil
DB09185, Viloxazine
DB12026, Voxilaprevir
DB00682, Warfarin
DB02134, Xanthine
DB00549, Zafirlukast
DB00744, Zileuton
DB00315, Zolmitriptan
DB00425, Zolpidem
DB09225, Zotepine
DB09120, Zucapsaicin

DrugCentral

More...DrugCentrali		P05177

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1319

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CYP1A2

Domain mapping of disease mutations (DMDM)

More...DMDMi		117144

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516512 – 516Cytochrome P450 1A2Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05177

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05177

PeptideAtlas

More...PeptideAtlasi		P05177

PRoteomics IDEntifications database

More...PRIDEi		P05177

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05177, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05177

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05177

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140505, Expressed in liver and 165 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05177, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140505, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107924, 8 interactors

Protein interaction database and analysis system

More...IntActi		P05177, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000342007

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P05177

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05177, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1516
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05177

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P05177

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0156, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001570_22_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05177

Identification of Orthologs from Complete Genome Data

More...OMAi		AKWEVFL

Database of Orthologous Groups

More...OrthoDBi		702827at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05177

TreeFam database of animal gene trees

More...TreeFami		TF105095

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008066, Cyt_P450_E_grp-I_CYP1
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00463, EP450I
PR01683, EP450ICYP1A
PR00385, P450

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P05177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL 
        60         70         80         90        100
LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR 
       110        120        130        140        150
QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA 
       160        170        180        190        200
SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI 
       210        220        230        240        250
GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL 
       260        270        280        290        300
QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN 
       310        320        330        340        350
LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV 
       360        370        380        390        400
IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY 
       410        420        430        440        450
IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML 
       460        470        480        490        500
FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK 
       510 
HARCEHVQAR LRFSIN
Length:516
Mass (Da):58,407
Last modified:September 12, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8557AB02860C4806
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79R → S in AAA35738 (PubMed:3462722).Curated1
Sequence conflicti81G → D in AAH67427 (PubMed:15489334).Curated1
Sequence conflicti170K → M in AAF13599 (Ref. 5) Curated1
Sequence conflicti311V → L in AAA52154 (PubMed:3462722).Curated1
Sequence conflicti380S → P in AAH67429 (PubMed:15489334).Curated1
Sequence conflicti450 – 451LF → MLV in AAA52154 (PubMed:3462722).Curated2
Sequence conflicti492T → I in AAF13599 (Ref. 5) Curated1
Sequence conflicti511Missing in CAA77335 (PubMed:3755823).Curated1
Sequence conflicti511Missing in AAA52146 (PubMed:2575218).Curated1
Sequence conflicti511Missing in AAA52163 (PubMed:2575218).Curated1
Sequence conflicti512R → P in AAA35738 (PubMed:3462722).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02319618S → C2 PublicationsCorresponds to variant dbSNP:rs17861152Ensembl.1
Natural variantiVAR_00834921F → L in allele CYP1A2*2. 1 PublicationCorresponds to variant dbSNP:rs56160784Ensembl.1
Natural variantiVAR_02518242P → R in allele CYP1A2*15. 1 PublicationCorresponds to variant dbSNP:rs72547511Ensembl.1
Natural variantiVAR_02518373G → R1 PublicationCorresponds to variant dbSNP:rs45565238Ensembl.1
Natural variantiVAR_02084883T → M in allele CYP1A2*9. 1 PublicationCorresponds to variant dbSNP:rs138652540Ensembl.1
Natural variantiVAR_025184104D → N1 PublicationCorresponds to variant dbSNP:rs34067076Ensembl.1
Natural variantiVAR_025185111L → F1 PublicationCorresponds to variant dbSNP:rs45442197Ensembl.1
Natural variantiVAR_020849168E → Q in allele CYP1A2*10. 1 PublicationCorresponds to variant dbSNP:rs72547512Ensembl.1
Natural variantiVAR_020850186F → L in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value. 1 PublicationCorresponds to variant dbSNP:rs72547513Ensembl.1
Natural variantiVAR_025186205F → V1 PublicationCorresponds to variant dbSNP:rs45540640Ensembl.1
Natural variantiVAR_020851212S → C in allele CYP1A2*12. 1 PublicationCorresponds to variant dbSNP:rs758748797Ensembl.1
Natural variantiVAR_025187281R → W1 PublicationCorresponds to variant dbSNP:rs45468096EnsemblClinVar.1
Natural variantiVAR_024709298S → R1 PublicationCorresponds to variant dbSNP:rs17861157Ensembl.1
Natural variantiVAR_020852299G → S in allele CYP1A2*13. 1 PublicationCorresponds to variant dbSNP:rs35796837Ensembl.1
Natural variantiVAR_024710314I → V2 PublicationsCorresponds to variant dbSNP:rs28399418Ensembl.1
Natural variantiVAR_020793348D → N in allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity. 2 PublicationsCorresponds to variant dbSNP:rs56276455Ensembl.1
Natural variantiVAR_025188377R → Q in allele CYP1A2*16. 1 PublicationCorresponds to variant dbSNP:rs72547515Ensembl.1
Natural variantiVAR_020794386I → F in allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin. 2 PublicationsCorresponds to variant dbSNP:rs72547516Ensembl.1
Natural variantiVAR_020795406C → Y in allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation. 2 PublicationsCorresponds to variant dbSNP:rs55889066Ensembl.1
Natural variantiVAR_020796431R → W in allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure. 3 PublicationsCorresponds to variant dbSNP:rs28399424Ensembl.1
Natural variantiVAR_020853438T → I in allele CYP1A2*14. 2 PublicationsCorresponds to variant dbSNP:rs45486893Ensembl.1
Natural variantiVAR_025189456R → H in allele CYP1A2*8. 1 PublicationCorresponds to variant dbSNP:rs72547517Ensembl.1
Natural variantiVAR_055563457R → W. Corresponds to variant dbSNP:rs34151816Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z00036 mRNA Translation: CAA77335.1
M55053 mRNA Translation: AAA52146.1
M12078 mRNA Translation: AAA52154.1
L00389 L00387 Genomic DNA Translation: AAA35738.1
M31667 M31666 Genomic DNA Translation: AAA52163.1
AF182274 mRNA Translation: AAF13599.1
AF253322 Genomic DNA Translation: AAK25728.1
DQ022432 Genomic DNA Translation: AAY26399.1
BC067424 mRNA Translation: AAH67424.1
BC067425 mRNA Translation: AAH67425.1
BC067426 mRNA Translation: AAH67426.1
BC067427 mRNA Translation: AAH67427.1
BC067428 mRNA Translation: AAH67428.1
BC067429 mRNA Translation: AAH67429.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32293.1

Protein sequence database of the Protein Information Resource

More...PIRi		S16718, O4HU4

NCBI Reference Sequences

More...RefSeqi		NP_000752.2, NM_000761.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343932; ENSP00000342007; ENSG00000140505

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1544

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1544

UCSC genome browser

More...UCSCi		uc002ayr.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP1A2 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z00036 mRNA Translation: CAA77335.1
M55053 mRNA Translation: AAA52146.1
M12078 mRNA Translation: AAA52154.1
L00389 L00387 Genomic DNA Translation: AAA35738.1
M31667 M31666 Genomic DNA Translation: AAA52163.1
AF182274 mRNA Translation: AAF13599.1
AF253322 Genomic DNA Translation: AAK25728.1
DQ022432 Genomic DNA Translation: AAY26399.1
BC067424 mRNA Translation: AAH67424.1
BC067425 mRNA Translation: AAH67425.1
BC067426 mRNA Translation: AAH67426.1
BC067427 mRNA Translation: AAH67427.1
BC067428 mRNA Translation: AAH67428.1
BC067429 mRNA Translation: AAH67429.1
CCDSiCCDS32293.1
PIRiS16718, O4HU4
RefSeqiNP_000752.2, NM_000761.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HI4X-ray1.95A27-516[»]
SMRiP05177
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107924, 8 interactors
IntActiP05177, 6 interactors
STRINGi9606.ENSP00000342007

Chemistry databases

BindingDBiP05177
ChEMBLiCHEMBL3356
DrugBankiDB08496, (R)-warfarin
DB01667, 8-azaguanine
DB14132, 8-chlorotheophylline
DB04356, 9-Deazaguanine
DB02489, 9-Methylguanine
DB12001, Abemaciclib
DB05812, Abiraterone
DB13573, Acefylline
DB01418, Acenocoumarol
DB00316, Acetaminophen
DB06594, Agomelatine
DB00518, Albendazole
DB05396, Albinterferon Alfa-2B
DB00969, Alosetron
DB07453, alpha-Naphthoflavone
DB01424, Aminophenazone
DB01223, Aminophylline
DB01118, Amiodarone
DB00321, Amitriptyline
DB00261, Anagrelide
DB01217, Anastrozole
DB01435, Antipyrine
DB06605, Apixaban
DB05676, Apremilast
DB06413, Armodafinil
DB06216, Asenapine
DB01072, Atazanavir
DB06442, Avasimibe
DB06626, Axitinib
DB00993, Azathioprine
DB00972, Azelastine
DB13203, Bamifylline
DB05015, Belinostat
DB06769, Bendamustine
DB06770, Benzyl alcohol
DB06771, Besifloxacin
DB06732, beta-Naphthoflavone
DB00195, Betaxolol
DB04889, Bicifadine
DB11967, Binimetinib
DB13975, Black cohosh
DB00188, Bortezomib
DB01558, Bromazepam
DB14018, Bromotheophylline
DB13812, Bufylline
DB00201, Caffeine
DB09061, Cannabidiol
DB11791, Capmatinib
DB06774, Capsaicin
DB00564, Carbamazepine
DB01136, Carvedilol
DB12814, Cepeginterferon alfa-2B
DB00477, Chlorpromazine
DB00356, Chlorzoxazone
DB01166, Cilostazol
DB00501, Cimetidine
DB01012, Cinacalcet
DB00568, Cinnarizine
DB00827, Cinoxacin
DB00537, Ciprofloxacin
DB00215, Citalopram
DB14025, Clinafloxacin
DB01242, Clomipramine
DB00575, Clonidine
DB00758, Clopidogrel
DB00363, Clozapine
DB00286, Conjugated estrogens
DB11672, Curcumin
DB14635, Curcumin sulfate
DB00924, Cyclobenzaprine
DB00851, Dacarbazine
DB06292, Dapagliflozin
DB01254, Dasatinib
DB01609, Deferasirox
DB01151, Desipramine
DB12161, Deutetrabenazine
DB01191, Dexfenfluramine
DB00633, Dexmedetomidine
DB11994, Diacerein
DB00586, Diclofenac
DB11511, Difloxacin
DB12945, Dihydralazine
DB00280, Disopyramide
DB01184, Domperidone
DB09167, Dosulepin
DB05928, Dovitinib
DB01142, Doxepin
DB09273, Doxofylline
DB00476, Duloxetine
DB00625, Efavirenz
DB15444, Elexacaftor
DB06210, Eltrombopag
DB13874, Enasidenib
DB00467, Enoxacin
DB11404, Enrofloxacin
DB00530, Erlotinib
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB04574, Estrone sulfate
DB13592, Etamiphylline
DB00898, Ethanol
DB00977, Ethinylestradiol
DB00773, Etoposide
DB01628, Etoricoxib
DB00927, Famotidine
DB01482, Fenethylline
DB01195, Flecainide
DB08972, Flumequine
DB04841, Flunarizine
DB00544, Fluorouracil
DB00472, Fluoxetine
DB00499, Flutamide
DB00176, Fluvoxamine
DB01320, Fosphenytoin
DB00998, Frovatriptan
DB14029, Furafylline
DB06160, Garenoxacin
DB01044, Gatifloxacin
DB01241, Gemfibrozil
DB01155, Gemifloxacin
DB01645, Genistein
DB00365, Grepafloxacin
DB00400, Griseofulvin
DB05708, GTS-21
DB00629, Guanabenz
DB00502, Haloperidol
DB01094, Hesperetin
DB14999, Human interferon beta
DB04076, Hypoxanthine
DB11737, Icotinib
DB00619, Imatinib
DB00458, Imipramine
DB01306, Insulin aspart
DB09456, Insulin beef
DB09564, Insulin degludec
DB01307, Insulin detemir
DB00047, Insulin glargine
DB01309, Insulin glulisine
DB00030, Insulin human
DB00046, Insulin lispro
DB11567, Insulin peglispro
DB00071, Insulin pork
DB11568, Insulin tregopil
DB05258, Interferon alfa
DB00034, Interferon alfa-2a, Recombinant
DB00105, Interferon alfa-2b
DB15131, Interferon alfa-2c
DB00011, Interferon alfa-n1
DB00018, Interferon alfa-n3
DB00069, Interferon alfacon-1
DB00060, Interferon beta-1a
DB00068, Interferon beta-1b
DB00033, Interferon gamma-1b
DB00951, Isoniazid
DB11757, Istradefylline
DB09570, Ixazomib
DB01026, Ketoconazole
DB01097, Leflunomide
DB09078, Lenvatinib
DB01002, Levobupivacaine
DB01137, Levofloxacin
DB00281, Lidocaine
DB12406, Lisofylline
DB09198, Lobeglitazone
DB04948, Lofexidine
DB00978, Lomefloxacin
DB01601, Lopinavir
DB00455, Loratadine
DB04871, Lorcaserin
DB06077, Lumateperone
DB01283, Lumiracoxib
DB00772, Malathion
DB00934, Maprotiline
DB14009, Medical Cannabis
DB01065, Melatonin
DB00170, Menadione
DB00454, Meperidine
DB00532, Mephenytoin
DB00333, Methadone
DB00763, Methimazole
DB00553, Methoxsalen
DB01028, Methoxyflurane
DB09241, Methylene blue
DB01233, Metoclopramide
DB00379, Mexiletine
DB06148, Mianserin
DB01388, Mibefradil
DB06595, Midostaurin
DB00370, Mirtazapine
DB00745, Modafinil
DB00218, Moxifloxacin
DB06510, Muraglitazar
DB14011, Nabiximols
DB00461, Nabumetone
DB00607, Nafcillin
DB00779, Nalidixic acid
DB00788, Naproxen
DB06600, Nemonoxacin
DB00238, Nevirapine
DB06803, Niclosamide
DB00184, Nicotine
DB01115, Nifedipine
DB00435, Nitric Oxide
DB05115, NN344
DB00717, Norethisterone
DB01059, Norfloxacin
DB00540, Nortriptyline
DB05990, Obeticholic acid
DB01165, Ofloxacin
DB00334, Olanzapine
DB00338, Omeprazole
DB00904, Ondansetron
DB11443, Orbifloxacin
DB01173, Orphenadrine
DB11837, Osilodrostat
DB09330, Osimertinib
DB13627, Oxolinic acid
DB01303, Oxtriphylline
DB00377, Palonosetron
DB00715, Paroxetine
DB06589, Pazopanib
DB11774, Pazufloxacin
DB00487, Pefloxacin
DB00008, Peginterferon alfa-2a
DB00022, Peginterferon alfa-2b
DB09122, Peginterferon beta-1a
DB13634, Pentifylline
DB00806, Pentoxifylline
DB11198, Peppermint oil
DB08883, Perampanel
DB00850, Perphenazine
DB03783, Phenacetin
DB01174, Phenobarbital
DB00388, Phenylephrine
DB00252, Phenytoin
DB11450, Pimobendan
DB01100, Pimozide
DB13823, Pipemidic acid
DB04951, Pirfenidone
DB11642, Pitolisant
DB08910, Pomalidomide
DB01058, Praziquantel
DB01087, Primaquine
DB00794, Primidone
DB00420, Promazine
DB09288, Propacetamol
DB01182, Propafenone
DB06479, Propentofylline
DB00818, Propofol
DB00571, Propranolol
DB13449, Proxyphylline
DB11892, Prulifloxacin
DB00908, Quinidine
DB00468, Quinine
DB01129, Rabeprazole
DB00980, Ramelteon
DB09290, Ramosetron
DB00863, Ranitidine
DB01367, Rasagiline
DB02709, Resveratrol
DB13174, Rhein
DB01045, Rifampicin
DB11753, Rifamycin
DB00740, Riluzole
DB00503, Ritonavir
DB00533, Rofecoxib
DB15119, Ropeginterferon alfa-2b
DB00268, Ropinirole
DB00296, Ropivacaine
DB00412, Rosiglitazone
DB00817, Rosoxacin
DB12332, Rucaparib
DB13772, Rufloxacin
DB06654, Safinamide
DB11491, Sarafloxacin
DB00418, Secobarbital
DB01037, Selegiline
DB11689, Selumetinib
DB06290, Simeprevir
DB13261, Sitafloxacin
DB00398, Sorafenib
DB01208, Sparfloxacin
DB09118, Stiripentol
DB00428, Streptozocin
DB06820, Sulconazole
DB00382, Tacrine
DB00675, Tamoxifen
DB09071, Tasimelteon
DB05488, Technetium Tc-99m ciprofloxacin
DB09256, Tegafur
DB01079, Tegaserod
DB01405, Temafloxacin
DB00857, Terbinafine
DB08880, Teriflunomide
DB01412, Theobromine
DB00277, Theophylline
DB00730, Thiabendazole
DB01623, Thiothixene
DB00208, Ticlopidine
DB00697, Tizanidine
DB01056, Tocainide
DB06264, Tolperisone
DB00752, Tranylcypromine
DB00384, Triamterene
DB12245, Triclabendazole
DB00831, Trifluoperazine
DB00440, Trimethoprim
DB00685, Trovafloxacin
DB08867, Ulipristal
DB13609, Umifenovir
DB06235, Vadimezan
DB00313, Valproic acid
DB08881, Vemurafenib
DB00661, Verapamil
DB09185, Viloxazine
DB12026, Voxilaprevir
DB00682, Warfarin
DB02134, Xanthine
DB00549, Zafirlukast
DB00744, Zileuton
DB00315, Zolmitriptan
DB00425, Zolpidem
DB09225, Zotepine
DB09120, Zucapsaicin
DrugCentraliP05177
GuidetoPHARMACOLOGYi1319
SwissLipidsiSLP:000001202

PTM databases

GlyGeniP05177, 1 site
iPTMnetiP05177
PhosphoSitePlusiP05177

Polymorphism and mutation databases

BioMutaiCYP1A2
DMDMi117144

Proteomic databases

MassIVEiP05177
PaxDbiP05177
PeptideAtlasiP05177
PRIDEiP05177

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4221, 718 antibodies

Genome annotation databases

EnsembliENST00000343932; ENSP00000342007; ENSG00000140505
GeneIDi1544
KEGGihsa:1544
UCSCiuc002ayr.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1544
DisGeNETi1544
EuPathDBiHostDB:ENSG00000140505.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		CYP1A2
HGNCiHGNC:2596, CYP1A2
HPAiENSG00000140505, Tissue enriched (liver)
MIMi108330, gene
124060, gene+phenotype
neXtProtiNX_P05177
OpenTargetsiENSG00000140505
Orphaneti284121, Toxicity or absent response to clozapine
PharmGKBiPA27093

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0156, Eukaryota
GeneTreeiENSGT00950000183037
HOGENOMiCLU_001570_22_0_1
InParanoidiP05177
OMAiAKWEVFL
OrthoDBi702827at2759
PhylomeDBiP05177
TreeFamiTF105095

Enzyme and pathway databases

UniPathwayiUPA00296
UPA00383
UPA00912
BioCyciMetaCyc:HS06728-MONOMER
BRENDAi1.14.14.1, 2681
1.14.99.38, 2681
PathwayCommonsiP05177
ReactomeiR-HSA-156581, Methylation
R-HSA-211957, Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-5423646, Aflatoxin activation and detoxification
R-HSA-9018681, Biosynthesis of protectins
R-HSA-9027307, Biosynthesis of maresin-like SPMs
SABIO-RKiP05177

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1544, 5 hits in 843 CRISPR screens
EvolutionaryTraceiP05177

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CYP1A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1544
PharosiP05177, Tchem

Protein Ontology

More...PROi		PR:P05177
RNActiP05177, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140505, Expressed in liver and 165 other tissues
GenevisibleiP05177, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008066, Cyt_P450_E_grp-I_CYP1
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR01683, EP450ICYP1A
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP1A2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05177
Secondary accession number(s): Q16754
, Q6NWU3, Q6NWU5, Q9BXX7, Q9UK49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: September 12, 2018
Last modified: December 2, 2020
This is version 212 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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