Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P05177 (CP1A2_HUMAN)

Entry version 201 (05 Jun 2019)
Sequence version 4 (12 Sep 2018)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4 µM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole1 Publication
  2. KM=21 µM for 2-amino-3-methylimidazo[4,5-f]quinoline1 Publication
  3. KM=26 µM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline1 Publication
  4. KM=27 µM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline1 Publication
  5. KM=71 µM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine1 Publication
  6. KM=25 µM for phenacetin1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei226SubstrateCurated1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi458Iron (heme axial ligand)1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMonooxygenase, Oxidoreductase
    Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
    LigandHeme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS06728-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		1.14.14.1 2681
    1.14.99.38 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-156581 Methylation
    R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
    R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    R-HSA-5423646 Aflatoxin activation and detoxification
    R-HSA-9018681 Biosynthesis of protectins
    R-HSA-9027307 Biosynthesis of maresin-like SPMs

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P05177

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000001202

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.11 Publication)
    Alternative name(s):
    CYPIA2
    Cholesterol 25-hydroxylase1 Publication
    Cytochrome P(3)450
    Cytochrome P450 4
    Cytochrome P450-P3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CYP1A2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:2596 CYP1A2

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		108330 gene
    124060 gene+phenotype

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P05177

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		1544

    MalaCards human disease database

    More...    MalaCardsi    		CYP1A2
    MIMi124060 gene+phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000140505

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		284121 Toxicity or absent response to clozapine

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA27093

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3356

    Drug and drug target database

    More...    DrugBanki    		DB07453 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE
    DB05812 Abiraterone
    DB01418 Acenocoumarol
    DB00316 Acetaminophen
    DB00787 Aciclovir
    DB06594 Agomelatine
    DB00518 Albendazole
    DB00523 Alitretinoin
    DB00918 Almotriptan
    DB00969 Alosetron
    DB00357 Aminoglutethimide
    DB01424 Aminophenazone
    DB01223 Aminophylline
    DB01118 Amiodarone
    DB00321 Amitriptyline
    DB00381 Amlodipine
    DB00261 Anagrelide
    DB01217 Anastrozole
    DB01435 Antipyrine
    DB06605 Apixaban
    DB00714 Apomorphine
    DB00673 Aprepitant
    DB06413 Armodafinil
    DB06216 Asenapine
    DB01072 Atazanavir
    DB00572 Atropine
    DB06626 Axitinib
    DB00972 Azelastine
    DB00207 Azithromycin
    DB06769 Bendamustine
    DB06770 Benzyl alcohol
    DB06732 beta-Naphthoflavone
    DB00195 Betaxolol
    DB00188 Bortezomib
    DB01558 Bromazepam
    DB01200 Bromocriptine
    DB00297 Bupivacaine
    DB00921 Buprenorphine
    DB01156 Bupropion
    DB00201 Caffeine
    DB06774 Capsaicin
    DB00564 Carbamazepine
    DB00389 Carbimazole
    DB00262 Carmustine
    DB01136 Carvedilol
    DB00477 Chlorpromazine
    DB00356 Chlorzoxazone
    DB01166 Cilostazol
    DB00501 Cimetidine
    DB01012 Cinacalcet
    DB00568 Cinnarizine
    DB00537 Ciprofloxacin
    DB00604 Cisapride
    DB00215 Citalopram
    DB01211 Clarithromycin
    DB01407 Clenbuterol
    DB04920 Clevidipine
    DB01013 Clobetasol propionate
    DB00882 Clomifene
    DB01242 Clomipramine
    DB00575 Clonidine
    DB00758 Clopidogrel
    DB00257 Clotrimazole
    DB00363 Clozapine
    DB00286 Conjugated Equine Estrogens
    DB05219 Crisaborole
    DB00924 Cyclobenzaprine
    DB00851 Dacarbazine
    DB04816 Dantron
    DB06292 Dapagliflozin
    DB01254 Dasatinib
    DB00694 Daunorubicin
    DB00705 Delavirdine
    DB01151 Desipramine
    DB00967 Desloratadine
    DB01191 Dexfenfluramine
    DB00633 Dexmedetomidine
    DB00829 Diazepam
    DB00586 Diclofenac
    DB00917 Dinoprostone
    DB01075 Diphenhydramine
    DB00822 Disulfiram
    DB01184 Domperidone
    DB00988 Dopamine
    DB01142 Doxepin
    DB00476 Duloxetine
    DB00974 Edetic Acid
    DB00625 Efavirenz
    DB06210 Eltrombopag
    DB00467 Enoxacin
    DB00494 Entacapone
    DB00668 Epinephrine
    DB00696 Ergotamine
    DB00530 Erlotinib
    DB00199 Erythromycin
    DB00783 Estradiol
    DB00655 Estrone
    DB04574 Estrone sulfate
    DB00898 Ethanol
    DB00773 Etoposide
    DB01628 Etoricoxib
    DB00196 Fluconazole
    DB04841 Flunarizine
    DB01544 Flunitrazepam
    DB00544 Fluorouracil
    DB00472 Fluoxetine
    DB00623 Fluphenazine
    DB00499 Flutamide
    DB01095 Fluvastatin
    DB00176 Fluvoxamine
    DB00998 Frovatriptan
    DB01241 Gemfibrozil
    DB01645 Genistein
    DB08909 Glycerol Phenylbutyrate
    DB00365 Grepafloxacin
    DB00400 Griseofulvin
    DB05708 GTS-21
    DB00629 Guanabenz
    DB00502 Haloperidol
    DB01094 Hesperetin
    DB01355 Hexobarbital
    DB11737 Icotinib
    DB04946 Iloperidone
    DB00619 Imatinib
    DB00458 Imipramine
    DB00724 Imiquimod
    DB01306 Insulin Aspart
    DB09456 Insulin Beef
    DB01307 Insulin Detemir
    DB00047 Insulin Glargine
    DB01309 Insulin Glulisine
    DB00030 Insulin Human
    DB00046 Insulin Lispro
    DB00071 Insulin Pork
    DB00033 Interferon gamma-1b
    DB01029 Irbesartan
    DB00951 Isoniazid
    DB09570 Ixazomib
    DB01026 Ketoconazole
    DB00448 Lansoprazole
    DB01097 Leflunomide
    DB01002 Levobupivacaine
    DB01137 Levofloxacin
    DB00281 Lidocaine
    DB00978 Lomefloxacin
    DB01601 Lopinavir
    DB04871 Lorcaserin
    DB00678 Losartan
    DB01283 Lumiracoxib
    DB00772 Malathion
    DB00934 Maprotiline
    DB00737 Meclizine
    DB01065 Melatonin
    DB00170 Menadione
    DB00532 Mephenytoin
    DB01357 Mestranol
    DB00333 Methadone
    DB00763 Methimazole
    DB01403 Methotrimeprazine
    DB00553 Methoxsalen
    DB01028 Methoxyflurane
    DB00379 Mexiletine
    DB06148 Mianserin
    DB01388 Mibefradil
    DB01110 Miconazole
    DB00834 Mifepristone
    DB00370 Mirtazapine
    DB01171 Moclobemide
    DB00745 Modafinil
    DB00461 Nabumetone
    DB00607 Nafcillin
    DB00788 Naproxen
    DB01149 Nefazodone
    DB00220 Nelfinavir
    DB00238 Nevirapine
    DB06803 Niclosamide
    DB00184 Nicotine
    DB01115 Nifedipine
    DB06712 Nilvadipine
    DB00401 Nisoldipine
    DB00435 Nitric Oxide
    DB00325 Nitroprusside
    DB00368 Norepinephrine
    DB01059 Norfloxacin
    DB00540 Nortriptyline
    DB05990 Obeticholic acid
    DB01165 Ofloxacin
    DB00334 Olanzapine
    DB00338 Omeprazole
    DB00904 Ondansetron
    DB01173 Orphenadrine
    DB09330 Osimertinib
    DB00526 Oxaliplatin
    DB01303 Oxtriphylline
    DB06412 Oxymetholone
    DB00377 Palonosetron
    DB00213 Pantoprazole
    DB00715 Paroxetine
    DB06589 Pazopanib
    DB00487 Pefloxacin
    DB00008 Peginterferon alfa-2a
    DB00022 Peginterferon alfa-2b
    DB00738 Pentamidine
    DB00806 Pentoxifylline
    DB00850 Perphenazine
    DB03783 Phenacetin
    DB01174 Phenobarbital
    DB00191 Phentermine
    DB00388 Phenylephrine
    DB00397 Phenylpropanolamine
    DB01100 Pimozide
    DB01621 Pipotiazine
    DB08910 Pomalidomide
    DB01058 Praziquantel
    DB01087 Primaquine
    DB00794 Primidone
    DB00396 Progesterone
    DB01131 Proguanil
    DB00420 Promazine
    DB01182 Propafenone
    DB00818 Propofol
    DB00571 Propranolol
    DB00339 Pyrazinamide
    DB00908 Quinidine
    DB00468 Quinine
    DB01129 Rabeprazole
    DB00980 Ramelteon
    DB00863 Ranitidine
    DB01367 Rasagiline
    DB02709 Resveratrol
    DB00615 Rifabutin
    DB01045 Rifampicin
    DB08864 Rilpivirine
    DB00740 Riluzole
    DB00503 Ritonavir
    DB00953 Rizatriptan
    DB00533 Rofecoxib
    DB00268 Ropinirole
    DB00296 Ropivacaine
    DB00412 Rosiglitazone
    DB05271 Rotigotine
    DB00778 Roxithromycin
    DB12332 Rucaparib
    DB00418 Secobarbital
    DB01037 Selegiline
    DB01104 Sertraline
    DB06290 Simeprevir
    DB06819 Sodium phenylbutyrate
    DB00398 Sorafenib
    DB00428 Streptozocin
    DB06820 Sulconazole
    DB00605 Sulindac
    DB00382 Tacrine
    DB00675 Tamoxifen
    DB01079 Tegaserod
    DB00976 Telithromycin
    DB01405 Temafloxacin
    DB00300 Tenofovir
    DB00857 Terbinafine
    DB01041 Thalidomide
    DB01412 Theobromine
    DB00277 Theophylline
    DB00730 Thiabendazole
    DB00679 Thioridazine
    DB01623 Thiothixene
    DB00208 Ticlopidine
    DB01007 Tioconazole
    DB00697 Tizanidine
    DB01056 Tocainide
    DB00539 Toremifene
    DB00752 Tranylcypromine
    DB00384 Triamterene
    DB00831 Trifluoperazine
    DB08867 Ulipristal
    DB00577 Valaciclovir
    DB00313 Valproic Acid
    DB08881 Vemurafenib
    DB00661 Verapamil
    DB00682 Warfarin
    DB00549 Zafirlukast
    DB00744 Zileuton
    DB00246 Ziprasidone
    DB00315 Zolmitriptan
    DB00425 Zolpidem

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		1319

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		CYP1A2

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		117144

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516512 – 516Cytochrome P450 1A2Add BLAST515

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69O-linked (GlcNAc) serineBy similarity1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P05177

    PeptideAtlas

    More...    PeptideAtlasi    		P05177

    PRoteomics IDEntifications database

    More...    PRIDEi    		P05177

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		51818
    51819

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P05177

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P05177

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Liver.

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000140505 Expressed in 164 organ(s), highest expression level in liver

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P05177 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		CAB016531

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		107924, 7 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P05177, 2 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000342007

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P05177

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1516
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P05177

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P05177

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0156 Eukaryota
    COG2124 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00950000183037

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000036991

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P05177

    KEGG Orthology (KO)

    More...    KOi    		K07409

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		VIGAMCF

    Database of Orthologous Groups

    More...    OrthoDBi    		920162at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P05177

    TreeFam database of animal gene trees

    More...    TreeFami    		TF105095

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.630.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR001128 Cyt_P450
    IPR017972 Cyt_P450_CS
    IPR002401 Cyt_P450_E_grp-I
    IPR008066 Cyt_P450_E_grp-I_CYP1
    IPR036396 Cyt_P450_sf

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00067 p450, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00463 EP450I
    PR01683 EP450ICYP1A
    PR00385 P450

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48264 SSF48264, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00086 CYTOCHROME_P450, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P05177-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL 
            60         70         80         90        100
    LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR 
           110        120        130        140        150
    QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA 
           160        170        180        190        200
    SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI 
           210        220        230        240        250
    GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL 
           260        270        280        290        300
    QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN 
           310        320        330        340        350
    LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV 
           360        370        380        390        400
    IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY 
           410        420        430        440        450
    IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML 
           460        470        480        490        500
    FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK 
           510 
    HARCEHVQAR LRFSIN
    Length:516
    Mass (Da):58,407
    Last modified:September 12, 2018 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8557AB02860C4806
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79R → S in AAA35738 (PubMed:3462722).Curated1
    Sequence conflicti81G → D in AAH67427 (PubMed:15489334).Curated1
    Sequence conflicti170K → M in AAF13599 (Ref. 5) Curated1
    Sequence conflicti311V → L in AAA52154 (PubMed:3462722).Curated1
    Sequence conflicti380S → P in AAH67429 (PubMed:15489334).Curated1
    Sequence conflicti450 – 451LF → MLV in AAA52154 (PubMed:3462722).Curated2
    Sequence conflicti492T → I in AAF13599 (Ref. 5) Curated1
    Sequence conflicti511Missing in CAA77335 (PubMed:3755823).Curated1
    Sequence conflicti511Missing in AAA52146 (PubMed:2575218).Curated1
    Sequence conflicti511Missing in AAA52163 (PubMed:2575218).Curated1
    Sequence conflicti512R → P in AAA35738 (PubMed:3462722).Curated1

    <p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02319618S → C2 PublicationsCorresponds to variant dbSNP:rs17861152Ensembl.1
    Natural variantiVAR_00834921F → L in allele CYP1A2*2. 1 PublicationCorresponds to variant dbSNP:rs56160784Ensembl.1
    Natural variantiVAR_02518242P → R in allele CYP1A2*15. 1 PublicationCorresponds to variant dbSNP:rs72547511Ensembl.1
    Natural variantiVAR_02518373G → R1 PublicationCorresponds to variant dbSNP:rs45565238Ensembl.1
    Natural variantiVAR_02084883T → M in allele CYP1A2*9. 1 PublicationCorresponds to variant dbSNP:rs138652540Ensembl.1
    Natural variantiVAR_025184104D → N1 PublicationCorresponds to variant dbSNP:rs34067076Ensembl.1
    Natural variantiVAR_025185111L → F1 PublicationCorresponds to variant dbSNP:rs45442197Ensembl.1
    Natural variantiVAR_020849168E → Q in allele CYP1A2*10. 1 PublicationCorresponds to variant dbSNP:rs72547512Ensembl.1
    Natural variantiVAR_020850186F → L in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value. 1 PublicationCorresponds to variant dbSNP:rs72547513Ensembl.1
    Natural variantiVAR_025186205F → V1 PublicationCorresponds to variant dbSNP:rs45540640Ensembl.1
    Natural variantiVAR_020851212S → C in allele CYP1A2*12. 1 PublicationCorresponds to variant dbSNP:rs758748797Ensembl.1
    Natural variantiVAR_025187281R → W1 PublicationCorresponds to variant dbSNP:rs45468096Ensembl.1
    Natural variantiVAR_024709298S → R1 PublicationCorresponds to variant dbSNP:rs17861157Ensembl.1
    Natural variantiVAR_020852299G → S in allele CYP1A2*13. 1 PublicationCorresponds to variant dbSNP:rs35796837Ensembl.1
    Natural variantiVAR_024710314I → V2 PublicationsCorresponds to variant dbSNP:rs28399418Ensembl.1
    Natural variantiVAR_020793348D → N in allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity. 2 PublicationsCorresponds to variant dbSNP:rs56276455Ensembl.1
    Natural variantiVAR_025188377R → Q in allele CYP1A2*16. 1 PublicationCorresponds to variant dbSNP:rs72547515Ensembl.1
    Natural variantiVAR_020794386I → F in allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin. 2 PublicationsCorresponds to variant dbSNP:rs72547516Ensembl.1
    Natural variantiVAR_020795406C → Y in allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation. 2 PublicationsCorresponds to variant dbSNP:rs55889066Ensembl.1
    Natural variantiVAR_020796431R → W in allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure. 3 PublicationsCorresponds to variant dbSNP:rs28399424Ensembl.1
    Natural variantiVAR_020853438T → I in allele CYP1A2*14. 2 PublicationsCorresponds to variant dbSNP:rs45486893Ensembl.1
    Natural variantiVAR_025189456R → H in allele CYP1A2*8. 1 PublicationCorresponds to variant dbSNP:rs72547517Ensembl.1
    Natural variantiVAR_055563457R → W. Corresponds to variant dbSNP:rs34151816Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		Z00036 mRNA Translation: CAA77335.1
    M55053 mRNA Translation: AAA52146.1
    M12078 mRNA Translation: AAA52154.1
    L00389
    , L00384, L00385, L00386, L00388, L00387 Genomic DNA Translation: AAA35738.1
    M31667
    , M31664, M31665, M31666 Genomic DNA Translation: AAA52163.1
    AF182274 mRNA Translation: AAF13599.1
    AF253322 Genomic DNA Translation: AAK25728.1
    DQ022432 Genomic DNA Translation: AAY26399.1
    BC067424 mRNA Translation: AAH67424.1
    BC067425 mRNA Translation: AAH67425.1
    BC067426 mRNA Translation: AAH67426.1
    BC067427 mRNA Translation: AAH67427.1
    BC067428 mRNA Translation: AAH67428.1
    BC067429 mRNA Translation: AAH67429.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS32293.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		S16718 O4HU4

    NCBI Reference Sequences

    More...    RefSeqi    		NP_000752.2, NM_000761.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000343932; ENSP00000342007; ENSG00000140505

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		1544

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:1544

    UCSC genome browser

    More...    UCSCi    		uc002ayr.2 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP1A2 alleles

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		Z00036 mRNA Translation: CAA77335.1
    M55053 mRNA Translation: AAA52146.1
    M12078 mRNA Translation: AAA52154.1
    L00389
    , L00384, L00385, L00386, L00388, L00387 Genomic DNA Translation: AAA35738.1
    M31667
    , M31664, M31665, M31666 Genomic DNA Translation: AAA52163.1
    AF182274 mRNA Translation: AAF13599.1
    AF253322 Genomic DNA Translation: AAK25728.1
    DQ022432 Genomic DNA Translation: AAY26399.1
    BC067424 mRNA Translation: AAH67424.1
    BC067425 mRNA Translation: AAH67425.1
    BC067426 mRNA Translation: AAH67426.1
    BC067427 mRNA Translation: AAH67427.1
    BC067428 mRNA Translation: AAH67428.1
    BC067429 mRNA Translation: AAH67429.1
    CCDSiCCDS32293.1
    PIRiS16718 O4HU4
    RefSeqiNP_000752.2, NM_000761.4

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2HI4X-ray1.95A27-516[»]
    SMRiP05177
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi107924, 7 interactors
    IntActiP05177, 2 interactors
    STRINGi9606.ENSP00000342007

    Chemistry databases

    BindingDBiP05177
    ChEMBLiCHEMBL3356
    DrugBankiDB07453 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE
    DB05812 Abiraterone
    DB01418 Acenocoumarol
    DB00316 Acetaminophen
    DB00787 Aciclovir
    DB06594 Agomelatine
    DB00518 Albendazole
    DB00523 Alitretinoin
    DB00918 Almotriptan
    DB00969 Alosetron
    DB00357 Aminoglutethimide
    DB01424 Aminophenazone
    DB01223 Aminophylline
    DB01118 Amiodarone
    DB00321 Amitriptyline
    DB00381 Amlodipine
    DB00261 Anagrelide
    DB01217 Anastrozole
    DB01435 Antipyrine
    DB06605 Apixaban
    DB00714 Apomorphine
    DB00673 Aprepitant
    DB06413 Armodafinil
    DB06216 Asenapine
    DB01072 Atazanavir
    DB00572 Atropine
    DB06626 Axitinib
    DB00972 Azelastine
    DB00207 Azithromycin
    DB06769 Bendamustine
    DB06770 Benzyl alcohol
    DB06732 beta-Naphthoflavone
    DB00195 Betaxolol
    DB00188 Bortezomib
    DB01558 Bromazepam
    DB01200 Bromocriptine
    DB00297 Bupivacaine
    DB00921 Buprenorphine
    DB01156 Bupropion
    DB00201 Caffeine
    DB06774 Capsaicin
    DB00564 Carbamazepine
    DB00389 Carbimazole
    DB00262 Carmustine
    DB01136 Carvedilol
    DB00477 Chlorpromazine
    DB00356 Chlorzoxazone
    DB01166 Cilostazol
    DB00501 Cimetidine
    DB01012 Cinacalcet
    DB00568 Cinnarizine
    DB00537 Ciprofloxacin
    DB00604 Cisapride
    DB00215 Citalopram
    DB01211 Clarithromycin
    DB01407 Clenbuterol
    DB04920 Clevidipine
    DB01013 Clobetasol propionate
    DB00882 Clomifene
    DB01242 Clomipramine
    DB00575 Clonidine
    DB00758 Clopidogrel
    DB00257 Clotrimazole
    DB00363 Clozapine
    DB00286 Conjugated Equine Estrogens
    DB05219 Crisaborole
    DB00924 Cyclobenzaprine
    DB00851 Dacarbazine
    DB04816 Dantron
    DB06292 Dapagliflozin
    DB01254 Dasatinib
    DB00694 Daunorubicin
    DB00705 Delavirdine
    DB01151 Desipramine
    DB00967 Desloratadine
    DB01191 Dexfenfluramine
    DB00633 Dexmedetomidine
    DB00829 Diazepam
    DB00586 Diclofenac
    DB00917 Dinoprostone
    DB01075 Diphenhydramine
    DB00822 Disulfiram
    DB01184 Domperidone
    DB00988 Dopamine
    DB01142 Doxepin
    DB00476 Duloxetine
    DB00974 Edetic Acid
    DB00625 Efavirenz
    DB06210 Eltrombopag
    DB00467 Enoxacin
    DB00494 Entacapone
    DB00668 Epinephrine
    DB00696 Ergotamine
    DB00530 Erlotinib
    DB00199 Erythromycin
    DB00783 Estradiol
    DB00655 Estrone
    DB04574 Estrone sulfate
    DB00898 Ethanol
    DB00773 Etoposide
    DB01628 Etoricoxib
    DB00196 Fluconazole
    DB04841 Flunarizine
    DB01544 Flunitrazepam
    DB00544 Fluorouracil
    DB00472 Fluoxetine
    DB00623 Fluphenazine
    DB00499 Flutamide
    DB01095 Fluvastatin
    DB00176 Fluvoxamine
    DB00998 Frovatriptan
    DB01241 Gemfibrozil
    DB01645 Genistein
    DB08909 Glycerol Phenylbutyrate
    DB00365 Grepafloxacin
    DB00400 Griseofulvin
    DB05708 GTS-21
    DB00629 Guanabenz
    DB00502 Haloperidol
    DB01094 Hesperetin
    DB01355 Hexobarbital
    DB11737 Icotinib
    DB04946 Iloperidone
    DB00619 Imatinib
    DB00458 Imipramine
    DB00724 Imiquimod
    DB01306 Insulin Aspart
    DB09456 Insulin Beef
    DB01307 Insulin Detemir
    DB00047 Insulin Glargine
    DB01309 Insulin Glulisine
    DB00030 Insulin Human
    DB00046 Insulin Lispro
    DB00071 Insulin Pork
    DB00033 Interferon gamma-1b
    DB01029 Irbesartan
    DB00951 Isoniazid
    DB09570 Ixazomib
    DB01026 Ketoconazole
    DB00448 Lansoprazole
    DB01097 Leflunomide
    DB01002 Levobupivacaine
    DB01137 Levofloxacin
    DB00281 Lidocaine
    DB00978 Lomefloxacin
    DB01601 Lopinavir
    DB04871 Lorcaserin
    DB00678 Losartan
    DB01283 Lumiracoxib
    DB00772 Malathion
    DB00934 Maprotiline
    DB00737 Meclizine
    DB01065 Melatonin
    DB00170 Menadione
    DB00532 Mephenytoin
    DB01357 Mestranol
    DB00333 Methadone
    DB00763 Methimazole
    DB01403 Methotrimeprazine
    DB00553 Methoxsalen
    DB01028 Methoxyflurane
    DB00379 Mexiletine
    DB06148 Mianserin
    DB01388 Mibefradil
    DB01110 Miconazole
    DB00834 Mifepristone
    DB00370 Mirtazapine
    DB01171 Moclobemide
    DB00745 Modafinil
    DB00461 Nabumetone
    DB00607 Nafcillin
    DB00788 Naproxen
    DB01149 Nefazodone
    DB00220 Nelfinavir
    DB00238 Nevirapine
    DB06803 Niclosamide
    DB00184 Nicotine
    DB01115 Nifedipine
    DB06712 Nilvadipine
    DB00401 Nisoldipine
    DB00435 Nitric Oxide
    DB00325 Nitroprusside
    DB00368 Norepinephrine
    DB01059 Norfloxacin
    DB00540 Nortriptyline
    DB05990 Obeticholic acid
    DB01165 Ofloxacin
    DB00334 Olanzapine
    DB00338 Omeprazole
    DB00904 Ondansetron
    DB01173 Orphenadrine
    DB09330 Osimertinib
    DB00526 Oxaliplatin
    DB01303 Oxtriphylline
    DB06412 Oxymetholone
    DB00377 Palonosetron
    DB00213 Pantoprazole
    DB00715 Paroxetine
    DB06589 Pazopanib
    DB00487 Pefloxacin
    DB00008 Peginterferon alfa-2a
    DB00022 Peginterferon alfa-2b
    DB00738 Pentamidine
    DB00806 Pentoxifylline
    DB00850 Perphenazine
    DB03783 Phenacetin
    DB01174 Phenobarbital
    DB00191 Phentermine
    DB00388 Phenylephrine
    DB00397 Phenylpropanolamine
    DB01100 Pimozide
    DB01621 Pipotiazine
    DB08910 Pomalidomide
    DB01058 Praziquantel
    DB01087 Primaquine
    DB00794 Primidone
    DB00396 Progesterone
    DB01131 Proguanil
    DB00420 Promazine
    DB01182 Propafenone
    DB00818 Propofol
    DB00571 Propranolol
    DB00339 Pyrazinamide
    DB00908 Quinidine
    DB00468 Quinine
    DB01129 Rabeprazole
    DB00980 Ramelteon
    DB00863 Ranitidine
    DB01367 Rasagiline
    DB02709 Resveratrol
    DB00615 Rifabutin
    DB01045 Rifampicin
    DB08864 Rilpivirine
    DB00740 Riluzole
    DB00503 Ritonavir
    DB00953 Rizatriptan
    DB00533 Rofecoxib
    DB00268 Ropinirole
    DB00296 Ropivacaine
    DB00412 Rosiglitazone
    DB05271 Rotigotine
    DB00778 Roxithromycin
    DB12332 Rucaparib
    DB00418 Secobarbital
    DB01037 Selegiline
    DB01104 Sertraline
    DB06290 Simeprevir
    DB06819 Sodium phenylbutyrate
    DB00398 Sorafenib
    DB00428 Streptozocin
    DB06820 Sulconazole
    DB00605 Sulindac
    DB00382 Tacrine
    DB00675 Tamoxifen
    DB01079 Tegaserod
    DB00976 Telithromycin
    DB01405 Temafloxacin
    DB00300 Tenofovir
    DB00857 Terbinafine
    DB01041 Thalidomide
    DB01412 Theobromine
    DB00277 Theophylline
    DB00730 Thiabendazole
    DB00679 Thioridazine
    DB01623 Thiothixene
    DB00208 Ticlopidine
    DB01007 Tioconazole
    DB00697 Tizanidine
    DB01056 Tocainide
    DB00539 Toremifene
    DB00752 Tranylcypromine
    DB00384 Triamterene
    DB00831 Trifluoperazine
    DB08867 Ulipristal
    DB00577 Valaciclovir
    DB00313 Valproic Acid
    DB08881 Vemurafenib
    DB00661 Verapamil
    DB00682 Warfarin
    DB00549 Zafirlukast
    DB00744 Zileuton
    DB00246 Ziprasidone
    DB00315 Zolmitriptan
    DB00425 Zolpidem
    GuidetoPHARMACOLOGYi1319
    SwissLipidsiSLP:000001202

    PTM databases

    iPTMnetiP05177
    PhosphoSitePlusiP05177

    Polymorphism and mutation databases

    BioMutaiCYP1A2
    DMDMi117144

    Proteomic databases

    PaxDbiP05177
    PeptideAtlasiP05177
    PRIDEiP05177
    ProteomicsDBi51818
    51819

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000343932; ENSP00000342007; ENSG00000140505
    GeneIDi1544
    KEGGihsa:1544
    UCSCiuc002ayr.2 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		1544
    DisGeNETi1544

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		CYP1A2
    HGNCiHGNC:2596 CYP1A2
    HPAiCAB016531
    MalaCardsiCYP1A2
    MIMi108330 gene
    124060 gene+phenotype
    neXtProtiNX_P05177
    OpenTargetsiENSG00000140505
    Orphaneti284121 Toxicity or absent response to clozapine
    PharmGKBiPA27093

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0156 Eukaryota
    COG2124 LUCA
    GeneTreeiENSGT00950000183037
    HOGENOMiHOG000036991
    InParanoidiP05177
    KOiK07409
    OMAiVIGAMCF
    OrthoDBi920162at2759
    PhylomeDBiP05177
    TreeFamiTF105095

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06728-MONOMER
    BRENDAi1.14.14.1 2681
    1.14.99.38 2681
    ReactomeiR-HSA-156581 Methylation
    R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
    R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    R-HSA-5423646 Aflatoxin activation and detoxification
    R-HSA-9018681 Biosynthesis of protectins
    R-HSA-9027307 Biosynthesis of maresin-like SPMs
    SABIO-RKiP05177

    Miscellaneous databases

    EvolutionaryTraceiP05177

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		CYP1A2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		1544

    Protein Ontology

    More...    PROi    		PR:P05177

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000140505 Expressed in 164 organ(s), highest expression level in liver
    GenevisibleiP05177 HS

    Family and domain databases

    Gene3Di1.10.630.10, 1 hit
    InterProiView protein in InterPro
    IPR001128 Cyt_P450
    IPR017972 Cyt_P450_CS
    IPR002401 Cyt_P450_E_grp-I
    IPR008066 Cyt_P450_E_grp-I_CYP1
    IPR036396 Cyt_P450_sf
    PfamiView protein in Pfam
    PF00067 p450, 1 hit
    PRINTSiPR00463 EP450I
    PR01683 EP450ICYP1A
    PR00385 P450
    SUPFAMiSSF48264 SSF48264, 1 hit
    PROSITEiView protein in PROSITE
    PS00086 CYTOCHROME_P450, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP1A2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05177
    Secondary accession number(s): Q16754
    , Q6NWU3, Q6NWU5, Q9BXX7, Q9UK49
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: September 12, 2018
    Last modified: June 5, 2019
    This is version 201 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again