Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 230 (12 Aug 2020)
Sequence version 4 (05 Oct 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Propionyl-CoA carboxylase alpha chain, mitochondrial

Gene

PCCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:8434582, PubMed:6765947). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:8434582, PubMed:6765947, PubMed:10101253). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.08 mM for ATP1 Publication
  2. KM=3.0 mM for hydrogencarbonate1 Publication

    pH dependencei

    Optimum pH is 7.2-8.8 for the propionyl-CoA carboxylase activity measured for the holoenzyme.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: propanoyl-CoA degradation

    This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.2 Publications
    Proteins known to be involved in the 3 steps of the subpathway in this organism are:
    1. Propanoyl-CoA:carbon dioxide ligase subunit alpha (PCCA), Propanoyl-CoA:carbon dioxide ligase subunit alpha (PCCA), Propanoyl-CoA:carbon dioxide ligase subunit alpha, Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA), Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB), Propanoyl-CoA:carbon dioxide ligase subunit alpha (PCCA)
    2. no protein annotated in this organism
    3. no protein annotated in this organism
    This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei177ATPBy similarity1
    Binding sitei261ATPBy similarity1
    Binding sitei296ATPBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi336Magnesium or manganese 1PROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei349By similarity1
    Metal bindingi349Magnesium or manganese 1PROSITE-ProRule annotation1
    Metal bindingi349Magnesium or manganese 2PROSITE-ProRule annotation1
    Metal bindingi351Magnesium or manganese 2PROSITE-ProRule annotation1
    Binding sitei409Biotin; via carbonyl oxygenBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi209 – 270ATPPROSITE-ProRule annotationAdd BLAST62

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • biotin binding Source: ProtInc
    • CoA carboxylase activity Source: GO_Central
    • enzyme binding Source: UniProtKB
    • metal ion binding Source: UniProtKB-KW
    • propionyl-CoA carboxylase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLigase
    Biological processLipid degradation, Lipid metabolism
    LigandATP-binding, Biotin, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:ENSG00000175198-MONOMER

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P05165

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-196780, Biotin transport and metabolism
    R-HSA-3371599, Defective HLCS causes multiple carboxylase deficiency
    R-HSA-71032, Propionyl-CoA catabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P05165

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00945;UER00908

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Propionyl-CoA carboxylase alpha chain, mitochondrial1 Publication (EC:6.4.1.32 Publications)
    Short name:
    PCCase subunit alpha
    Alternative name(s):
    Propanoyl-CoA:carbon dioxide ligase subunit alpha
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PCCAImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000175198.14

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:8653, PCCA

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    232000, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P05165

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Propionic acidemia type I (PA-1)4 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionLife-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00908775A → P in PA-1. 1 PublicationCorresponds to variant dbSNP:rs794727479EnsemblClinVar.1
    Natural variantiVAR_00908877R → W in PA-1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs141371306EnsemblClinVar.1
    Natural variantiVAR_009089138A → T in PA-1; loss of function. 1 PublicationCorresponds to variant dbSNP:rs202247814EnsemblClinVar.1
    Natural variantiVAR_009090164I → T in PA-1; loss of function. 1 PublicationCorresponds to variant dbSNP:rs202247815EnsemblClinVar.1
    Natural variantiVAR_023843197G → E in PA-1. 1 Publication1
    Natural variantiVAR_009091229M → K in PA-1. 1 PublicationCorresponds to variant dbSNP:rs375628794EnsemblClinVar.1
    Natural variantiVAR_009092297Q → R in PA-1. 1 Publication1
    Natural variantiVAR_009093368D → G in PA-1. 1 Publication1
    Natural variantiVAR_009094373M → K in PA-1; unstable protein; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121964958EnsemblClinVar.1
    Natural variantiVAR_009095379G → V in PA-1. 1 PublicationCorresponds to variant dbSNP:rs794727087EnsemblClinVar.1
    Natural variantiVAR_023844398C → R in PA-1. 1 Publication1
    Natural variantiVAR_009096399R → Q in PA-1. 1 PublicationCorresponds to variant dbSNP:rs1301904623Ensembl.1
    Natural variantiVAR_009097423P → L in PA-1. 1 PublicationCorresponds to variant dbSNP:rs1443858896EnsemblClinVar.1
    Natural variantiVAR_023845532Missing in PA-1. 1 Publication1
    Natural variantiVAR_009099559W → L in PA-1. 1 PublicationCorresponds to variant dbSNP:rs118169528EnsemblClinVar.1
    Natural variantiVAR_009100631G → R in PA-1; loss of function. 1 PublicationCorresponds to variant dbSNP:rs796052018EnsemblClinVar.1
    Natural variantiVAR_009101668G → R in PA-1; loss of biotinylation. 1 PublicationCorresponds to variant dbSNP:rs771438170EnsemblClinVar.1
    Natural variantiVAR_009102712Missing in PA-1; loss of biotinylation. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5095

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    PCCA

    MalaCards human disease database

    More...
    MalaCardsi
    PCCA
    MIMi606054, phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000175198

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    35, Propionic acidemia

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA32992

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P05165, Tbio

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB00121, Biotin

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PCCA

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    308153661

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 52Mitochondrion1 PublicationAdd BLAST52
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000283753 – 728Propionyl-CoA carboxylase alpha chain, mitochondrialAdd BLAST676

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei65N6-acetyllysine; alternateBy similarity1
    Modified residuei65N6-succinyllysine; alternateBy similarity1
    Modified residuei119N6-succinyllysineBy similarity1
    Modified residuei150N6-acetyllysine; alternateBy similarity1
    Modified residuei150N6-succinyllysine; alternateBy similarity1
    Modified residuei200N6-acetyllysine; alternateBy similarity1
    Modified residuei200N6-succinyllysine; alternateBy similarity1
    Modified residuei252PhosphoserineBy similarity1
    Modified residuei262N6-succinyllysineBy similarity1
    Modified residuei328N6-acetyllysine; alternateBy similarity1
    Modified residuei328N6-succinyllysine; alternateBy similarity1
    Modified residuei385N6-succinyllysineBy similarity1
    Modified residuei407N6-succinyllysineBy similarity1
    Modified residuei496N6-acetyllysineBy similarity1
    Modified residuei502N6-succinyllysineBy similarity1
    Modified residuei513N6-succinyllysineBy similarity1
    Modified residuei648N6-succinyllysineBy similarity1
    Modified residuei694N6-biotinyllysine; by HLCSPROSITE-ProRule annotation1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Acetylated.By similarity
    The biotin cofactor is covalently attached to the C-terminal biotinyl-binding domain and is required for the catalytic activity (PubMed:10329019). Biotinylation is catalyzed by HLCS (PubMed:7753853, PubMed:20443544).3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P05165

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P05165

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P05165

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P05165

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P05165

    PeptideAtlas

    More...
    PeptideAtlasi
    P05165

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P05165

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    11147
    51814 [P05165-1]
    51815 [P05165-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P05165

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P05165

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P05165

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000175198, Expressed in adult mammalian kidney and 238 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P05165, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P05165, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000175198, Tissue enhanced (epididymis)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits (PubMed:6765947, PubMed:20725044).

    Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705).

    Interacts with SIRT3 and SIRT5 (PubMed:23438705).

    Curated3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    111128, 42 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    P05165

    Database of interacting proteins

    More...
    DIPi
    DIP-57493N

    Protein interaction database and analysis system

    More...
    IntActi
    P05165, 24 interactors

    Molecular INTeraction database

    More...
    MINTi
    P05165

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000365462

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P05165, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1728
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P05165

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P05165

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 509Biotin carboxylationPROSITE-ProRule annotationAdd BLAST448
    Domaini181 – 378ATP-graspPROSITE-ProRule annotationAdd BLAST198
    Domaini653 – 728Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST76

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the transient carboxylation of the biotin covalently attached to the C-terminal biotinyl-binding/biotin carboxyl carrier (BCC) domain.1 Publication

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0238, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156083

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_000395_3_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P05165

    KEGG Orthology (KO)

    More...
    KOi
    K01965

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FVEICSH

    Database of Orthologous Groups

    More...
    OrthoDBi
    254436at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P05165

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF354220

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011761, ATP-grasp
    IPR005481, BC-like_N
    IPR001882, Biotin_BS
    IPR011764, Biotin_carboxylation_dom
    IPR005482, Biotin_COase_C
    IPR000089, Biotin_lipoyl
    IPR005479, CbamoylP_synth_lsu-like_ATP-bd
    IPR041265, PCC_BT
    IPR016185, PreATP-grasp_dom_sf
    IPR011054, Rudment_hybrid_motif
    IPR011053, Single_hybrid_motif

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02785, Biotin_carb_C, 1 hit
    PF00289, Biotin_carb_N, 1 hit
    PF00364, Biotin_lipoyl, 1 hit
    PF02786, CPSase_L_D2, 1 hit
    PF18140, PCC_BT, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00878, Biotin_carb_C, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51230, SSF51230, 1 hit
    SSF51246, SSF51246, 1 hit
    SSF52440, SSF52440, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50975, ATP_GRASP, 1 hit
    PS50979, BC, 1 hit
    PS00188, BIOTIN, 1 hit
    PS50968, BIOTINYL_LIPOYL, 1 hit
    PS00866, CPSASE_1, 1 hit
    PS00867, CPSASE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P05165-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAGFWVGTAP LVAAGRRGRW PPQQLMLSAA LRTLKHVLYY SRQCLMVSRN
    60 70 80 90 100
    LGSVGYDPNE KTFDKILVAN RGEIACRVIR TCKKMGIKTV AIHSDVDASS
    110 120 130 140 150
    VHVKMADEAV CVGPAPTSKS YLNMDAIMEA IKKTRAQAVH PGYGFLSENK
    160 170 180 190 200
    EFARCLAAED VVFIGPDTHA IQAMGDKIES KLLAKKAEVN TIPGFDGVVK
    210 220 230 240 250
    DAEEAVRIAR EIGYPVMIKA SAGGGGKGMR IAWDDEETRD GFRLSSQEAA
    260 270 280 290 300
    SSFGDDRLLI EKFIDNPRHI EIQVLGDKHG NALWLNEREC SIQRRNQKVV
    310 320 330 340 350
    EEAPSIFLDA ETRRAMGEQA VALARAVKYS SAGTVEFLVD SKKNFYFLEM
    360 370 380 390 400
    NTRLQVEHPV TECITGLDLV QEMIRVAKGY PLRHKQADIR INGWAVECRV
    410 420 430 440 450
    YAEDPYKSFG LPSIGRLSQY QEPLHLPGVR VDSGIQPGSD ISIYYDPMIS
    460 470 480 490 500
    KLITYGSDRT EALKRMADAL DNYVIRGVTH NIALLREVII NSRFVKGDIS
    510 520 530 540 550
    TKFLSDVYPD GFKGHMLTKS EKNQLLAIAS SLFVAFQLRA QHFQENSRMP
    560 570 580 590 600
    VIKPDIANWE LSVKLHDKVH TVVASNNGSV FSVEVDGSKL NVTSTWNLAS
    610 620 630 640 650
    PLLSVSVDGT QRTVQCLSRE AGGNMSIQFL GTVYKVNILT RLAAELNKFM
    660 670 680 690 700
    LEKVTEDTSS VLRSPMPGVV VAVSVKPGDA VAEGQEICVI EAMKMQNSMT
    710 720
    AGKTGTVKSV HCQAGDTVGE GDLLVELE
    Length:728
    Mass (Da):80,059
    Last modified:October 5, 2010 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i065F64186A0B8CCC
    GO
    Isoform 2 (identifier: P05165-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-61: Missing.

    Show »
    Length:702
    Mass (Da):77,048
    Checksum:iB75C63581796ED53
    GO
    Isoform 3 (identifier: P05165-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         634-680: Missing.

    Show »
    Length:681
    Mass (Da):75,002
    Checksum:iCF5795BE08D8BD5B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1B0GU58A0A1B0GU58_HUMAN
    Propanoyl-CoA:carbon dioxide ligase...
    PCCA
    615Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1B0GWI4A0A1B0GWI4_HUMAN
    Propanoyl-CoA:carbon dioxide ligase...
    PCCA
    461Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y4B9H0Y4B9_HUMAN
    Propanoyl-CoA:carbon dioxide ligase...
    PCCA
    134Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1B0GUX9A0A1B0GUX9_HUMAN
    Propionyl-CoA carboxylase alpha cha...
    PCCA
    398Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1B0GWA1A0A1B0GWA1_HUMAN
    Propionyl-CoA carboxylase alpha cha...
    PCCA
    326Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y5U0H0Y5U0_HUMAN
    Propionyl-CoA carboxylase alpha cha...
    PCCA
    139Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q5JVH2Q5JVH2_HUMAN
    Propionyl-CoA carboxylase alpha cha...
    PCCA
    111Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q5JTW6Q5JTW6_HUMAN
    Propionyl-CoA carboxylase alpha cha...
    PCCA
    149Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y798H0Y798_HUMAN
    Propionyl-CoA carboxylase alpha cha...
    PCCA
    84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1B0GTR1A0A1B0GTR1_HUMAN
    Propionyl-CoA carboxylase alpha cha...
    PCCA
    245Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There is more potential isoformShow all

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA60035 differs from that shown. Reason: Frameshift.Curated
    The sequence AAH00140 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence AAK61392 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence CAA32763 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61K → E in BAG60571 (PubMed:14702039).Curated1
    Sequence conflicti93H → Y in BAG59350 (Ref. 4) Curated1
    Sequence conflicti373M → R in AAA60035 (PubMed:3460076).Curated1
    Sequence conflicti378 – 379KG → RS in AAA60035 (PubMed:3460076).Curated2
    Sequence conflicti558N → H in AAA60035 (PubMed:3460076).Curated1
    Sequence conflicti610T → A in BAG59350 (Ref. 4) Curated1
    Sequence conflicti679D → A in AAA36424 (PubMed:3555348).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_00908775A → P in PA-1. 1 PublicationCorresponds to variant dbSNP:rs794727479EnsemblClinVar.1
    Natural variantiVAR_00908877R → W in PA-1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs141371306EnsemblClinVar.1
    Natural variantiVAR_009089138A → T in PA-1; loss of function. 1 PublicationCorresponds to variant dbSNP:rs202247814EnsemblClinVar.1
    Natural variantiVAR_009090164I → T in PA-1; loss of function. 1 PublicationCorresponds to variant dbSNP:rs202247815EnsemblClinVar.1
    Natural variantiVAR_023843197G → E in PA-1. 1 Publication1
    Natural variantiVAR_009091229M → K in PA-1. 1 PublicationCorresponds to variant dbSNP:rs375628794EnsemblClinVar.1
    Natural variantiVAR_009092297Q → R in PA-1. 1 Publication1
    Natural variantiVAR_009093368D → G in PA-1. 1 Publication1
    Natural variantiVAR_009094373M → K in PA-1; unstable protein; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121964958EnsemblClinVar.1
    Natural variantiVAR_009095379G → V in PA-1. 1 PublicationCorresponds to variant dbSNP:rs794727087EnsemblClinVar.1
    Natural variantiVAR_023844398C → R in PA-1. 1 Publication1
    Natural variantiVAR_009096399R → Q in PA-1. 1 PublicationCorresponds to variant dbSNP:rs1301904623Ensembl.1
    Natural variantiVAR_009097423P → L in PA-1. 1 PublicationCorresponds to variant dbSNP:rs1443858896EnsemblClinVar.1
    Natural variantiVAR_009098475I → V. Corresponds to variant dbSNP:rs35719359EnsemblClinVar.1
    Natural variantiVAR_023845532Missing in PA-1. 1 Publication1
    Natural variantiVAR_023846551V → F1 PublicationCorresponds to variant dbSNP:rs61749895EnsemblClinVar.1
    Natural variantiVAR_009099559W → L in PA-1. 1 PublicationCorresponds to variant dbSNP:rs118169528EnsemblClinVar.1
    Natural variantiVAR_009100631G → R in PA-1; loss of function. 1 PublicationCorresponds to variant dbSNP:rs796052018EnsemblClinVar.1
    Natural variantiVAR_009101668G → R in PA-1; loss of biotinylation. 1 PublicationCorresponds to variant dbSNP:rs771438170EnsemblClinVar.1
    Natural variantiVAR_009102712Missing in PA-1; loss of biotinylation. 1 Publication1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03985736 – 61Missing in isoform 2. 1 PublicationAdd BLAST26
    Alternative sequenceiVSP_044458634 – 680Missing in isoform 3. 1 PublicationAdd BLAST47

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF385926 mRNA Translation: AAL66189.1
    AY035808 AY035807 Genomic DNA Translation: AAK61392.1 Different initiation.
    AK296771 mRNA Translation: BAG59350.1
    AK298318 mRNA Translation: BAG60571.1
    AL355338 Genomic DNA No translation available.
    AL356575 Genomic DNA No translation available.
    AL136526 Genomic DNA No translation available.
    AL353697 Genomic DNA No translation available.
    CH471085 Genomic DNA Translation: EAX09034.1
    BC000140 mRNA Translation: AAH00140.1 Different initiation.
    X14608 mRNA Translation: CAA32763.1 Frameshift.
    S55656 mRNA Translation: AAB25345.1
    M13572 mRNA Translation: AAA60035.1 Frameshift.
    M26121 mRNA Translation: AAA36424.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS45065.1 [P05165-2]
    CCDS53878.1 [P05165-3]
    CCDS9496.2 [P05165-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S04613, A27883

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000273.2, NM_000282.3 [P05165-1]
    NP_001121164.1, NM_001127692.2 [P05165-2]
    NP_001171475.1, NM_001178004.1 [P05165-3]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000376279; ENSP00000365456; ENSG00000175198 [P05165-3]
    ENST00000376285; ENSP00000365462; ENSG00000175198 [P05165-1]
    ENST00000376286; ENSP00000365463; ENSG00000175198 [P05165-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5095

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5095

    UCSC genome browser

    More...
    UCSCi
    uc001voo.4, human [P05165-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF385926 mRNA Translation: AAL66189.1
    AY035808 AY035807 Genomic DNA Translation: AAK61392.1 Different initiation.
    AK296771 mRNA Translation: BAG59350.1
    AK298318 mRNA Translation: BAG60571.1
    AL355338 Genomic DNA No translation available.
    AL356575 Genomic DNA No translation available.
    AL136526 Genomic DNA No translation available.
    AL353697 Genomic DNA No translation available.
    CH471085 Genomic DNA Translation: EAX09034.1
    BC000140 mRNA Translation: AAH00140.1 Different initiation.
    X14608 mRNA Translation: CAA32763.1 Frameshift.
    S55656 mRNA Translation: AAB25345.1
    M13572 mRNA Translation: AAA60035.1 Frameshift.
    M26121 mRNA Translation: AAA36424.1
    CCDSiCCDS45065.1 [P05165-2]
    CCDS53878.1 [P05165-3]
    CCDS9496.2 [P05165-1]
    PIRiS04613, A27883
    RefSeqiNP_000273.2, NM_000282.3 [P05165-1]
    NP_001121164.1, NM_001127692.2 [P05165-2]
    NP_001171475.1, NM_001178004.1 [P05165-3]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2CQYNMR-A176-270[»]
    2JKUX-ray1.50A658-728[»]
    SMRiP05165
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi111128, 42 interactors
    CORUMiP05165
    DIPiDIP-57493N
    IntActiP05165, 24 interactors
    MINTiP05165
    STRINGi9606.ENSP00000365462

    Chemistry databases

    DrugBankiDB00121, Biotin

    PTM databases

    iPTMnetiP05165
    PhosphoSitePlusiP05165
    SwissPalmiP05165

    Polymorphism and mutation databases

    BioMutaiPCCA
    DMDMi308153661

    Proteomic databases

    EPDiP05165
    jPOSTiP05165
    MassIVEiP05165
    MaxQBiP05165
    PaxDbiP05165
    PeptideAtlasiP05165
    PRIDEiP05165
    ProteomicsDBi11147
    51814 [P05165-1]
    51815 [P05165-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    25211, 185 antibodies

    Genome annotation databases

    EnsembliENST00000376279; ENSP00000365456; ENSG00000175198 [P05165-3]
    ENST00000376285; ENSP00000365462; ENSG00000175198 [P05165-1]
    ENST00000376286; ENSP00000365463; ENSG00000175198 [P05165-2]
    GeneIDi5095
    KEGGihsa:5095
    UCSCiuc001voo.4, human [P05165-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5095
    DisGeNETi5095
    EuPathDBiHostDB:ENSG00000175198.14

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PCCA
    GeneReviewsiPCCA
    HGNCiHGNC:8653, PCCA
    HPAiENSG00000175198, Tissue enhanced (epididymis)
    MalaCardsiPCCA
    MIMi232000, gene
    606054, phenotype
    neXtProtiNX_P05165
    OpenTargetsiENSG00000175198
    Orphaneti35, Propionic acidemia
    PharmGKBiPA32992

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0238, Eukaryota
    GeneTreeiENSGT00940000156083
    HOGENOMiCLU_000395_3_3_1
    InParanoidiP05165
    KOiK01965
    OMAiFVEICSH
    OrthoDBi254436at2759
    PhylomeDBiP05165
    TreeFamiTF354220

    Enzyme and pathway databases

    UniPathwayiUPA00945;UER00908
    BioCyciMetaCyc:ENSG00000175198-MONOMER
    PathwayCommonsiP05165
    ReactomeiR-HSA-196780, Biotin transport and metabolism
    R-HSA-3371599, Defective HLCS causes multiple carboxylase deficiency
    R-HSA-71032, Propionyl-CoA catabolism
    SABIO-RKiP05165

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    5095, 5 hits in 868 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PCCA, human
    EvolutionaryTraceiP05165

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5095
    PharosiP05165, Tbio

    Protein Ontology

    More...
    PROi
    PR:P05165
    RNActiP05165, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000175198, Expressed in adult mammalian kidney and 238 other tissues
    ExpressionAtlasiP05165, baseline and differential
    GenevisibleiP05165, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR011761, ATP-grasp
    IPR005481, BC-like_N
    IPR001882, Biotin_BS
    IPR011764, Biotin_carboxylation_dom
    IPR005482, Biotin_COase_C
    IPR000089, Biotin_lipoyl
    IPR005479, CbamoylP_synth_lsu-like_ATP-bd
    IPR041265, PCC_BT
    IPR016185, PreATP-grasp_dom_sf
    IPR011054, Rudment_hybrid_motif
    IPR011053, Single_hybrid_motif
    PfamiView protein in Pfam
    PF02785, Biotin_carb_C, 1 hit
    PF00289, Biotin_carb_N, 1 hit
    PF00364, Biotin_lipoyl, 1 hit
    PF02786, CPSase_L_D2, 1 hit
    PF18140, PCC_BT, 1 hit
    SMARTiView protein in SMART
    SM00878, Biotin_carb_C, 1 hit
    SUPFAMiSSF51230, SSF51230, 1 hit
    SSF51246, SSF51246, 1 hit
    SSF52440, SSF52440, 1 hit
    PROSITEiView protein in PROSITE
    PS50975, ATP_GRASP, 1 hit
    PS50979, BC, 1 hit
    PS00188, BIOTIN, 1 hit
    PS50968, BIOTINYL_LIPOYL, 1 hit
    PS00866, CPSASE_1, 1 hit
    PS00867, CPSASE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCCA_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05165
    Secondary accession number(s): B4DKY8
    , B4DPF9, C9JPQ8, Q15979, Q8WXQ7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: October 5, 2010
    Last modified: August 12, 2020
    This is version 230 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again