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Entry version 217 (13 Feb 2019)
Sequence version 1 (13 Aug 1987)
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Protein

Myeloperoxidase

Gene

MPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei260Heme (covalent; via 3 links)1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei261Proton acceptor1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi262Calcium1
Metal bindingi334Calcium1
Metal bindingi336Calcium; via carbonyl oxygen1
Metal bindingi338Calcium1
Metal bindingi340Calcium1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei405Transition state stabilizer1
Binding sitei408Heme (covalent; via 3 links)1
Binding sitei409Heme (covalent; via 3 links)1
Metal bindingi502Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: ProtInc
  • heme binding Source: InterPro
  • heparin binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • peroxidase activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00140-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.11.2.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-8941413 Events associated with phagocytolytic activity of PMN cells

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05164

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
3315 HsMPO

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myeloperoxidase (EC:1.11.2.21 Publication)
Short name:
MPO
Cleaved into the following 5 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000005381.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7218 MPO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606989 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05164

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myeloperoxidase deficiency (MPOD)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.
See also OMIM:254600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015377173Y → C in MPOD; affects proteolytic processing and secretion. 1 PublicationCorresponds to variant dbSNP:rs78950939EnsemblClinVar.1
Natural variantiVAR_015378251M → T in MPOD. 1 PublicationCorresponds to variant dbSNP:rs56378716EnsemblClinVar.1
Natural variantiVAR_015379569R → W in MPOD; suppress post-translational processing. 3 PublicationsCorresponds to variant dbSNP:rs119468010EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4353

MalaCards human disease database

More...
MalaCardsi
MPO
MIMi254600 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000005381

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2587 Myeloperoxidase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA243

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2439

Drug and drug target database

More...
DrugBanki
DB00233 Aminosalicylic Acid
DB00006 Bivalirudin
DB02300 Calcipotriol
DB06774 Capsaicin
DB00958 Carboplatin
DB00833 Cefaclor
DB00535 Cefdinir
DB00515 Cisplatin
DB00847 Cysteamine
DB00250 Dapsone
DB05161 Elafin
DB01225 Enoxaparin
DB04827 Ethyl carbamate
DB00062 Human Serum Albumin
DB00583 L-Carnitine
DB01065 Melatonin
DB00244 Mesalazine
DB00461 Nabumetone
DB04821 Nomifensine
DB00104 Octreotide
DB00526 Oxaliplatin
DB00550 Propylthiouracil
DB00208 Ticlopidine
DB06823 Tiopronin
DB00500 Tolmetin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2789

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MPO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
129825

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 482 PublicationsAdd BLAST48
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002365149 – 74589 kDa myeloperoxidaseAdd BLAST697
ChainiPRO_0000023653155 – 74584 kDa myeloperoxidaseAdd BLAST591
ChainiPRO_0000023654165 – 745MyeloperoxidaseAdd BLAST581
ChainiPRO_0000023655165 – 278Myeloperoxidase light chainAdd BLAST114
ChainiPRO_0000023656279 – 745Myeloperoxidase heavy chainAdd BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi139N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 180
Disulfide bondi281 ↔ 291
Disulfide bondi285 ↔ 309
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei316Cysteine sulfenic acid (-SOH)1 Publication1
Disulfide bondi319Interchain
Glycosylationi323N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi355N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi387 ↔ 398
Glycosylationi391N-linked (GlcNAc...) asparagine2 Publications1
GlycosylationiCAR_000220483N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi606 ↔ 663
Disulfide bondi704 ↔ 730
Glycosylationi729N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Oxidation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P05164

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P05164

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05164

PeptideAtlas

More...
PeptideAtlasi
P05164

PRoteomics IDEntifications database

More...
PRIDEi
P05164

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51811
51812 [P05164-2]
51813 [P05164-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
428

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05164

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05164

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P05164

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P05164

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P05164

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005381 Expressed in 99 organ(s), highest expression level in bone marrow cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05164 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P05164 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000059
HPA021147
HPA061464

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110493, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P05164

Protein interaction database and analysis system

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IntActi
P05164, 5 interactors

Molecular INTeraction database

More...
MINTi
P05164

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000225275

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P05164

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1745
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CXPX-ray1.80A/B167-270[»]
C/D279-744[»]
1D2VX-ray1.75A/B167-270[»]
C/D279-744[»]
1D5LX-ray1.90A/B167-270[»]
C/D279-744[»]
1D7WX-ray1.90A/B167-270[»]
C/D279-744[»]
1DNUX-ray1.85A/B167-270[»]
C/D279-744[»]
1DNWX-ray1.90A/B167-270[»]
C/D279-744[»]
1MHLX-ray2.25A/B165-272[»]
C/D279-744[»]
1MYPX-ray3.00A/B165-272[»]
C/D279-744[»]
3F9PX-ray2.93A/B165-278[»]
C/D279-745[»]
3ZS0X-ray2.30A/B165-272[»]
C/D279-745[»]
3ZS1X-ray2.60A/B165-278[»]
C/D279-745[»]
4C1MX-ray2.00A/B165-272[»]
C/D279-745[»]
4DL1X-ray2.00A/B/E/F/I/J/M/N167-270[»]
C/D/G/H/K/L/O/P279-744[»]
4EJXX-ray4.69B165-278[»]
D279-745[»]
5FIWX-ray1.70A/B167-271[»]
C/D279-744[»]
5MFAX-ray1.20A49-745[»]
5UZUX-ray2.40A167-744[»]
6AZPX-ray2.29A167-743[»]
6BMTX-ray2.40A1-745[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P05164

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05164

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05164

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2408 Eukaryota
ENOG410XPZ3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161343

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016084

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000071

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05164

KEGG Orthology (KO)

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KOi
K10789

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSSGCAY

Database of Orthologous Groups

More...
OrthoDBi
276568at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P05164

TreeFam database of animal gene trees

More...
TreeFami
TF314316

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019791 Haem_peroxidase_animal
IPR010255 Haem_peroxidase_sf
IPR037120 Haem_peroxidase_sf_animal
IPR029609 MPO

The PANTHER Classification System

More...
PANTHERi
PTHR11475:SF108 PTHR11475:SF108, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098 An_peroxidase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457 ANPEROXIDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48113 SSF48113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50292 PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform H17 (identifier: P05164-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVPFFSSLR CMVDLGPCWA GGLTAEMKLL LALAGLLAIL ATPQPSEGAA
60 70 80 90 100
PAVLGEVDTS LVLSSMEEAK QLVDKAYKER RESIKQRLRS GSASPMELLS
110 120 130 140 150
YFKQPVAATR TAVRAADYLH VALDLLERKL RSLWRRPFNV TDVLTPAQLN
160 170 180 190 200
VLSKSSGCAY QDVGVTCPEQ DKYRTITGMC NNRRSPTLGA SNRAFVRWLP
210 220 230 240 250
AEYEDGFSLP YGWTPGVKRN GFPVALARAV SNEIVRFPTD QLTPDQERSL
260 270 280 290 300
MFMQWGQLLD HDLDFTPEPA ARASFVTGVN CETSCVQQPP CFPLKIPPND
310 320 330 340 350
PRIKNQADCI PFFRSCPACP GSNITIRNQI NALTSFVDAS MVYGSEEPLA
360 370 380 390 400
RNLRNMSNQL GLLAVNQRFQ DNGRALLPFD NLHDDPCLLT NRSARIPCFL
410 420 430 440 450
AGDTRSSEMP ELTSMHTLLL REHNRLATEL KSLNPRWDGE RLYQEARKIV
460 470 480 490 500
GAMVQIITYR DYLPLVLGPT AMRKYLPTYR SYNDSVDPRI ANVFTNAFRY
510 520 530 540 550
GHTLIQPFMF RLDNRYQPME PNPRVPLSRV FFASWRVVLE GGIDPILRGL
560 570 580 590 600
MATPAKLNRQ NQIAVDEIRE RLFEQVMRIG LDLPALNMQR SRDHGLPGYN
610 620 630 640 650
AWRRFCGLPQ PETVGQLGTV LRNLKLARKL MEQYGTPNNI DIWMGGVSEP
660 670 680 690 700
LKRKGRVGPL LACIIGTQFR KLRDGDRFWW ENEGVFSMQQ RQALAQISLP
710 720 730 740
RIICDNTGIT TVSKNNIFMS NSYPRDFVNC STLPALNLAS WREAS
Length:745
Mass (Da):83,869
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i348B1CE0A11038B4
GO
Isoform H14 (identifier: P05164-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:650
Mass (Da):73,854
Checksum:i7A29F89DFE6B4916
GO
Isoform H7 (identifier: P05164-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     182-182: N → NRCGWLGVAAGTGLREASRTPQASRCQRPVLPC

Show »
Length:777
Mass (Da):87,248
Checksum:iF15BC771A9C6F6A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSF7J3QSF7_HUMAN
Myeloperoxidase
MPO
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36L → V in CAA28565 (PubMed:3031585).Curated1
Sequence conflicti36L → V in CAA33438 (PubMed:2552418).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02399553V → F1 PublicationCorresponds to variant dbSNP:rs7208693Ensembl.1
Natural variantiVAR_015377173Y → C in MPOD; affects proteolytic processing and secretion. 1 PublicationCorresponds to variant dbSNP:rs78950939EnsemblClinVar.1
Natural variantiVAR_015378251M → T in MPOD. 1 PublicationCorresponds to variant dbSNP:rs56378716EnsemblClinVar.1
Natural variantiVAR_036517447R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs762688992Ensembl.1
Natural variantiVAR_015379569R → W in MPOD; suppress post-translational processing. 3 PublicationsCorresponds to variant dbSNP:rs119468010EnsemblClinVar.1
Natural variantiVAR_023996604R → C1 PublicationCorresponds to variant dbSNP:rs35670089Ensembl.1
Natural variantiVAR_023997683E → Q1 PublicationCorresponds to variant dbSNP:rs35702888Ensembl.1
Natural variantiVAR_012066717I → V1 PublicationCorresponds to variant dbSNP:rs2759Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0072061 – 95Missing in isoform H14. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_007207182N → NRCGWLGVAAGTGLREASRT PQASRCQRPVLPC in isoform H7. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02694 mRNA Translation: AAA59896.1
M17176
, M17170, M17171, M17172, M17173, M17174, M17175 Genomic DNA Translation: AAA60346.1
X04876 mRNA Translation: CAA28565.1
M19507 mRNA Translation: AAA59863.1
M19508 Genomic DNA Translation: AAA59864.1
M19508 Genomic DNA Translation: AAA59865.1
X15377 Genomic DNA Translation: CAA33438.1
S56200 mRNA Translation: AAB25582.1
DQ088846 Genomic DNA Translation: AAY68218.1
CH471109 Genomic DNA Translation: EAW94470.1
BC130476 mRNA Translation: AAI30477.1
D14466 Genomic DNA Translation: BAA03362.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11604.1 [P05164-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A29467 OPHUM
B28894
D28894

NCBI Reference Sequences

More...
RefSeqi
NP_000241.1, NM_000250.1 [P05164-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.458272

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000225275; ENSP00000225275; ENSG00000005381 [P05164-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4353

UCSC genome browser

More...
UCSCi
uc002ivu.1 human [P05164-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

MPObase

MPO mutation db

NIEHS-SNPs
Wikipedia

Myeloperoxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02694 mRNA Translation: AAA59896.1
M17176
, M17170, M17171, M17172, M17173, M17174, M17175 Genomic DNA Translation: AAA60346.1
X04876 mRNA Translation: CAA28565.1
M19507 mRNA Translation: AAA59863.1
M19508 Genomic DNA Translation: AAA59864.1
M19508 Genomic DNA Translation: AAA59865.1
X15377 Genomic DNA Translation: CAA33438.1
S56200 mRNA Translation: AAB25582.1
DQ088846 Genomic DNA Translation: AAY68218.1
CH471109 Genomic DNA Translation: EAW94470.1
BC130476 mRNA Translation: AAI30477.1
D14466 Genomic DNA Translation: BAA03362.1
CCDSiCCDS11604.1 [P05164-1]
PIRiA29467 OPHUM
B28894
D28894
RefSeqiNP_000241.1, NM_000250.1 [P05164-1]
UniGeneiHs.458272

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CXPX-ray1.80A/B167-270[»]
C/D279-744[»]
1D2VX-ray1.75A/B167-270[»]
C/D279-744[»]
1D5LX-ray1.90A/B167-270[»]
C/D279-744[»]
1D7WX-ray1.90A/B167-270[»]
C/D279-744[»]
1DNUX-ray1.85A/B167-270[»]
C/D279-744[»]
1DNWX-ray1.90A/B167-270[»]
C/D279-744[»]
1MHLX-ray2.25A/B165-272[»]
C/D279-744[»]
1MYPX-ray3.00A/B165-272[»]
C/D279-744[»]
3F9PX-ray2.93A/B165-278[»]
C/D279-745[»]
3ZS0X-ray2.30A/B165-272[»]
C/D279-745[»]
3ZS1X-ray2.60A/B165-278[»]
C/D279-745[»]
4C1MX-ray2.00A/B165-272[»]
C/D279-745[»]
4DL1X-ray2.00A/B/E/F/I/J/M/N167-270[»]
C/D/G/H/K/L/O/P279-744[»]
4EJXX-ray4.69B165-278[»]
D279-745[»]
5FIWX-ray1.70A/B167-271[»]
C/D279-744[»]
5MFAX-ray1.20A49-745[»]
5UZUX-ray2.40A167-744[»]
6AZPX-ray2.29A167-743[»]
6BMTX-ray2.40A1-745[»]
ProteinModelPortaliP05164
SMRiP05164
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110493, 6 interactors
CORUMiP05164
IntActiP05164, 5 interactors
MINTiP05164
STRINGi9606.ENSP00000225275

Chemistry databases

BindingDBiP05164
ChEMBLiCHEMBL2439
DrugBankiDB00233 Aminosalicylic Acid
DB00006 Bivalirudin
DB02300 Calcipotriol
DB06774 Capsaicin
DB00958 Carboplatin
DB00833 Cefaclor
DB00535 Cefdinir
DB00515 Cisplatin
DB00847 Cysteamine
DB00250 Dapsone
DB05161 Elafin
DB01225 Enoxaparin
DB04827 Ethyl carbamate
DB00062 Human Serum Albumin
DB00583 L-Carnitine
DB01065 Melatonin
DB00244 Mesalazine
DB00461 Nabumetone
DB04821 Nomifensine
DB00104 Octreotide
DB00526 Oxaliplatin
DB00550 Propylthiouracil
DB00208 Ticlopidine
DB06823 Tiopronin
DB00500 Tolmetin
GuidetoPHARMACOLOGYi2789

Protein family/group databases

PeroxiBasei3315 HsMPO

PTM databases

GlyConnecti428
iPTMnetiP05164
PhosphoSitePlusiP05164
SwissPalmiP05164
UniCarbKBiP05164

Polymorphism and mutation databases

BioMutaiMPO
DMDMi129825

Proteomic databases

EPDiP05164
jPOSTiP05164
PaxDbiP05164
PeptideAtlasiP05164
PRIDEiP05164
ProteomicsDBi51811
51812 [P05164-2]
51813 [P05164-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4353
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225275; ENSP00000225275; ENSG00000005381 [P05164-1]
GeneIDi4353
KEGGihsa:4353
UCSCiuc002ivu.1 human [P05164-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4353
DisGeNETi4353
EuPathDBiHostDB:ENSG00000005381.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MPO

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0039242
HGNCiHGNC:7218 MPO
HPAiCAB000059
HPA021147
HPA061464
MalaCardsiMPO
MIMi254600 phenotype
606989 gene
neXtProtiNX_P05164
OpenTargetsiENSG00000005381
Orphaneti2587 Myeloperoxidase deficiency
PharmGKBiPA243

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00940000161343
HOGENOMiHOG000016084
HOVERGENiHBG000071
InParanoidiP05164
KOiK10789
OMAiKSSGCAY
OrthoDBi276568at2759
PhylomeDBiP05164
TreeFamiTF314316

Enzyme and pathway databases

BioCyciMetaCyc:HS00140-MONOMER
BRENDAi1.11.2.2 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8941413 Events associated with phagocytolytic activity of PMN cells
SIGNORiP05164

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MPO human
EvolutionaryTraceiP05164

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Myeloperoxidase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4353
PMAP-CutDBiP05164

Protein Ontology

More...
PROi
PR:P05164

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000005381 Expressed in 99 organ(s), highest expression level in bone marrow cell
ExpressionAtlasiP05164 baseline and differential
GenevisibleiP05164 HS

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR019791 Haem_peroxidase_animal
IPR010255 Haem_peroxidase_sf
IPR037120 Haem_peroxidase_sf_animal
IPR029609 MPO
PANTHERiPTHR11475:SF108 PTHR11475:SF108, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50292 PEROXIDASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPERM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05164
Secondary accession number(s): A1L4B8
, Q14862, Q4PJH5, Q9UCL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 13, 2019
This is version 217 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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