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Protein

Galectin-2

Gene

LGALS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds beta-galactoside. Its physiological function is not yet known.

GO - Molecular functioni

Keywordsi

LigandLectin

Protein family/group databases

UniLectiniP05162

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-2
Short name:
Gal-2
Alternative name(s):
Beta-galactoside-binding lectin L-14-II
HL14
Lactose-binding lectin 2
S-Lac lectin 2
Gene namesi
Name:LGALS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100079.6
HGNCiHGNC:6562 LGALS2
MIMi150571 gene
neXtProtiNX_P05162

Pathology & Biotechi

Organism-specific databases

DisGeNETi3957
MalaCardsiLGALS2
OpenTargetsiENSG00000100079
PharmGKBiPA164741896

Chemistry databases

ChEMBLiCHEMBL5977
DrugBankiDB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMutaiLGALS2
DMDMi585388

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769241 – 132Galectin-2Add BLAST132

Proteomic databases

MaxQBiP05162
PaxDbiP05162
PeptideAtlasiP05162
PRIDEiP05162
ProteomicsDBi51810

PTM databases

iPTMnetiP05162
PhosphoSitePlusiP05162

Expressioni

Gene expression databases

BgeeiENSG00000100079 Expressed in 135 organ(s), highest expression level in body of pancreas
CleanExiHS_LGALS2
ExpressionAtlasiP05162 baseline and differential
GenevisibleiP05162 HS

Organism-specific databases

HPAiCAB025198
HPA003536

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

Protein-protein interaction databases

BioGridi110148, 8 interactors
ComplexPortaliCPX-95 Galectin-2 complex
IntActiP05162, 3 interactors
MINTiP05162
STRINGi9606.ENSP00000215886

Chemistry databases

BindingDBiP05162

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05162
SMRiP05162
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05162

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 131GalectinPROSITE-ProRule annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 71Beta-galactoside bindingSequence analysis7

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP05162
KOiK10090
OMAiVCNSRDG
OrthoDBiEOG091G0S7H
PhylomeDBiP05162
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGELEVKNM DMKPGSTLKI TGSIADGTDG FVINLGQGTD KLNLHFNPRF
60 70 80 90 100
SESTIVCNSL DGSNWGQEQR EDHLCFSPGS EVKFTVTFES DKFKVKLPDG
110 120 130
HELTFPNRLG HSHLSYLSVR GGFNMSSFKL KE
Length:132
Mass (Da):14,644
Last modified:October 1, 1994 - v3
Checksum:iE30B8768630A2ACB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYC9B0QYC9_HUMAN
Galectin-2
LGALS2
29Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049767119V → I1 PublicationCorresponds to variant dbSNP:rs2235339Ensembl.1
Natural variantiVAR_036570132E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87860
, M87857, M87858, M87859 Genomic DNA Translation: AAA59512.1
M87842 mRNA Translation: AAA59513.1
CR456512 mRNA Translation: CAG30398.1
CR541972 mRNA Translation: CAG46770.1
CR542000 mRNA Translation: CAG46797.1
AL022315 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60167.1
BC059782 mRNA Translation: AAH59782.1
M14079 mRNA Translation: AAA36171.1
CCDSiCCDS13950.1
PIRiA38140
RefSeqiNP_006489.1, NM_006498.2
UniGeneiHs.531776

Genome annotation databases

EnsembliENST00000215886; ENSP00000215886; ENSG00000100079
GeneIDi3957
KEGGihsa:3957
UCSCiuc003ata.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87860
, M87857, M87858, M87859 Genomic DNA Translation: AAA59512.1
M87842 mRNA Translation: AAA59513.1
CR456512 mRNA Translation: CAG30398.1
CR541972 mRNA Translation: CAG46770.1
CR542000 mRNA Translation: CAG46797.1
AL022315 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60167.1
BC059782 mRNA Translation: AAH59782.1
M14079 mRNA Translation: AAA36171.1
CCDSiCCDS13950.1
PIRiA38140
RefSeqiNP_006489.1, NM_006498.2
UniGeneiHs.531776

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLCX-ray2.90A/B4-132[»]
5DG1X-ray3.20A/B/C/D/H/I1-132[»]
5DG2X-ray1.61A/B1-132[»]
5EWSX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-131[»]
ProteinModelPortaliP05162
SMRiP05162
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110148, 8 interactors
ComplexPortaliCPX-95 Galectin-2 complex
IntActiP05162, 3 interactors
MINTiP05162
STRINGi9606.ENSP00000215886

Chemistry databases

BindingDBiP05162
ChEMBLiCHEMBL5977
DrugBankiDB02379 Beta-D-Glucose

Protein family/group databases

UniLectiniP05162

PTM databases

iPTMnetiP05162
PhosphoSitePlusiP05162

Polymorphism and mutation databases

BioMutaiLGALS2
DMDMi585388

Proteomic databases

MaxQBiP05162
PaxDbiP05162
PeptideAtlasiP05162
PRIDEiP05162
ProteomicsDBi51810

Protocols and materials databases

DNASUi3957
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215886; ENSP00000215886; ENSG00000100079
GeneIDi3957
KEGGihsa:3957
UCSCiuc003ata.4 human

Organism-specific databases

CTDi3957
DisGeNETi3957
EuPathDBiHostDB:ENSG00000100079.6
GeneCardsiLGALS2
HGNCiHGNC:6562 LGALS2
HPAiCAB025198
HPA003536
MalaCardsiLGALS2
MIMi150571 gene
neXtProtiNX_P05162
OpenTargetsiENSG00000100079
PharmGKBiPA164741896
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP05162
KOiK10090
OMAiVCNSRDG
OrthoDBiEOG091G0S7H
PhylomeDBiP05162
TreeFamiTF315551

Miscellaneous databases

ChiTaRSiLGALS2 human
EvolutionaryTraceiP05162
GeneWikiiLGALS2
GenomeRNAii3957
PROiPR:P05162
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100079 Expressed in 135 organ(s), highest expression level in body of pancreas
CleanExiHS_LGALS2
ExpressionAtlasiP05162 baseline and differential
GenevisibleiP05162 HS

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEG2_HUMAN
AccessioniPrimary (citable) accession number: P05162
Secondary accession number(s): Q6FGY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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