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Entry version 189 (07 Oct 2020)
Sequence version 3 (01 Oct 1994)
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Protein

Galectin-2

Gene

LGALS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein binds beta-galactoside. Its physiological function is not yet known.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P05162

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P05162

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galectin-2
Short name:
Gal-2
Alternative name(s):
Beta-galactoside-binding lectin L-14-II
HL14
Lactose-binding lectin 2
S-Lac lectin 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LGALS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100079.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6562, LGALS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
150571, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05162

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3957

MalaCards human disease database

More...
MalaCardsi
LGALS2

Open Targets

More...
OpenTargetsi
ENSG00000100079

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164741896

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P05162, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5977

Drug and drug target database

More...
DrugBanki
DB02379, Beta-D-Glucose

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LGALS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
585388

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769241 – 132Galectin-2Add BLAST132

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P05162

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P05162

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P05162

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05162

PeptideAtlas

More...
PeptideAtlasi
P05162

PRoteomics IDEntifications database

More...
PRIDEi
P05162

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51810

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05162

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05162

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100079, Expressed in body of pancreas and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05162, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05162, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100079, Group enriched (blood, gallbladder, intestine, kidney, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110148, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-95, Galectin-2 complex

Protein interaction database and analysis system

More...
IntActi
P05162, 3 interactors

Molecular INTeraction database

More...
MINTi
P05162

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000215886

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P05162

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P05162, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P05162

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05162

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 131GalectinPROSITE-ProRule annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni65 – 71Beta-galactoside bindingSequence analysis7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3587, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037794_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05162

KEGG Orthology (KO)

More...
KOi
K10090

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCNSRDG

Database of Orthologous Groups

More...
OrthoDBi
1429018at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05162

TreeFam database of animal gene trees

More...
TreeFami
TF315551

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00070, GLECT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001079, Galectin_CRD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00337, Gal-bind_lectin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00908, Gal-bind_lectin, 1 hit
SM00276, GLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51304, GALECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGELEVKNM DMKPGSTLKI TGSIADGTDG FVINLGQGTD KLNLHFNPRF
60 70 80 90 100
SESTIVCNSL DGSNWGQEQR EDHLCFSPGS EVKFTVTFES DKFKVKLPDG
110 120 130
HELTFPNRLG HSHLSYLSVR GGFNMSSFKL KE
Length:132
Mass (Da):14,644
Last modified:October 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE30B8768630A2ACB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYC9B0QYC9_HUMAN
Galectin-2
LGALS2
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049767119V → I1 PublicationCorresponds to variant dbSNP:rs2235339Ensembl.1
Natural variantiVAR_036570132E → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1434020843Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M87860 M87859 Genomic DNA Translation: AAA59512.1
M87842 mRNA Translation: AAA59513.1
CR456512 mRNA Translation: CAG30398.1
CR541972 mRNA Translation: CAG46770.1
CR542000 mRNA Translation: CAG46797.1
AL022315 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60167.1
BC059782 mRNA Translation: AAH59782.1
M14079 mRNA Translation: AAA36171.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13950.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38140

NCBI Reference Sequences

More...
RefSeqi
NP_006489.1, NM_006498.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215886; ENSP00000215886; ENSG00000100079

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3957

UCSC genome browser

More...
UCSCi
uc003ata.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87860 M87859 Genomic DNA Translation: AAA59512.1
M87842 mRNA Translation: AAA59513.1
CR456512 mRNA Translation: CAG30398.1
CR541972 mRNA Translation: CAG46770.1
CR542000 mRNA Translation: CAG46797.1
AL022315 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60167.1
BC059782 mRNA Translation: AAH59782.1
M14079 mRNA Translation: AAA36171.1
CCDSiCCDS13950.1
PIRiA38140
RefSeqiNP_006489.1, NM_006498.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLCX-ray2.90A/B4-132[»]
5DG1X-ray3.20A/B/C/D/H/I1-132[»]
5DG2X-ray1.61A/B1-132[»]
5EWSX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-131[»]
SMRiP05162
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110148, 9 interactors
ComplexPortaliCPX-95, Galectin-2 complex
IntActiP05162, 3 interactors
MINTiP05162
STRINGi9606.ENSP00000215886

Chemistry databases

BindingDBiP05162
ChEMBLiCHEMBL5977
DrugBankiDB02379, Beta-D-Glucose

Protein family/group databases

UniLectiniP05162

PTM databases

iPTMnetiP05162
PhosphoSitePlusiP05162

Polymorphism and mutation databases

BioMutaiLGALS2
DMDMi585388

Proteomic databases

jPOSTiP05162
MassIVEiP05162
MaxQBiP05162
PaxDbiP05162
PeptideAtlasiP05162
PRIDEiP05162
ProteomicsDBi51810

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
286, 284 antibodies

The DNASU plasmid repository

More...
DNASUi
3957

Genome annotation databases

EnsembliENST00000215886; ENSP00000215886; ENSG00000100079
GeneIDi3957
KEGGihsa:3957
UCSCiuc003ata.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3957
DisGeNETi3957
EuPathDBiHostDB:ENSG00000100079.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LGALS2
HGNCiHGNC:6562, LGALS2
HPAiENSG00000100079, Group enriched (blood, gallbladder, intestine, kidney, pancreas)
MalaCardsiLGALS2
MIMi150571, gene
neXtProtiNX_P05162
OpenTargetsiENSG00000100079
PharmGKBiPA164741896

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3587, Eukaryota
GeneTreeiENSGT00940000155025
HOGENOMiCLU_037794_5_0_1
InParanoidiP05162
KOiK10090
OMAiVCNSRDG
OrthoDBi1429018at2759
PhylomeDBiP05162
TreeFamiTF315551

Enzyme and pathway databases

PathwayCommonsiP05162

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3957, 5 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LGALS2, human
EvolutionaryTraceiP05162

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LGALS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3957
PharosiP05162, Tbio

Protein Ontology

More...
PROi
PR:P05162
RNActiP05162, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100079, Expressed in body of pancreas and 155 other tissues
ExpressionAtlasiP05162, baseline and differential
GenevisibleiP05162, HS

Family and domain databases

CDDicd00070, GLECT, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001079, Galectin_CRD
PfamiView protein in Pfam
PF00337, Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908, Gal-bind_lectin, 1 hit
SM00276, GLECT, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304, GALECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05162
Secondary accession number(s): Q6FGY4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1994
Last modified: October 7, 2020
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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