UniProtKB - P05160 (F13B_HUMAN)
Protein
Coagulation factor XIII B chain
Gene
F13B
Organism
Homo sapiens (Human)
Status
Functioni
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.2 Publications
GO - Biological processi
- blood coagulation Source: Reactome
- negative regulation of cellular protein catabolic process Source: Ensembl
Keywordsi
Biological process | Blood coagulation, Hemostasis |
Enzyme and pathway databases
PathwayCommonsi | P05160 |
Reactomei | R-HSA-140875, Common Pathway of Fibrin Clot Formation |
Names & Taxonomyi
Protein namesi | Recommended name: Coagulation factor XIII B chainAlternative name(s): Fibrin-stabilizing factor B subunit Protein-glutamine gamma-glutamyltransferase B chain Transglutaminase B chain |
Gene namesi | Name:F13B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3534, F13B |
MIMi | 134580, gene+phenotype |
neXtProti | NX_P05160 |
VEuPathDBi | HostDB:ENSG00000143278.3 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Factor XIII subunit B deficiency (FA13BD)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074563 | 25 | C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl. | 1 | |
Natural variantiVAR_074564 | 101 | I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl. | 1 | |
Natural variantiVAR_074565 | 136 | L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl. | 1 | |
Natural variantiVAR_074566 | 237 | V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl. | 1 | |
Natural variantiVAR_074567 | 336 | C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl. | 1 | |
Natural variantiVAR_074568 | 421 | V → E in FA13BD; impaired interaction with F13A1. 2 Publications | 1 | |
Natural variantiVAR_074569 | 448 | P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications | 1 | |
Natural variantiVAR_007475 | 450 | C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 2165 |
MalaCardsi | F13B |
MIMi | 134580, gene+phenotype 613235, phenotype |
OpenTargetsi | ENSG00000143278 |
Orphaneti | 331, Congenital factor XIII deficiency |
PharmGKBi | PA27944 |
Miscellaneous databases
Pharosi | P05160, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3351193 |
DrugBanki | DB09310, Catridecacog DB11571, Human thrombin DB11300, Thrombin DB01593, Zinc DB14487, Zinc acetate |
Genetic variation databases
BioMutai | F13B |
DMDMi | 145559473 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000021222 | 21 – 661 | Coagulation factor XIII B chainAdd BLAST | 641 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 76 | PROSITE-ProRule annotation | ||
Disulfide bondi | 59 ↔ 87 | PROSITE-ProRule annotation | ||
Disulfide bondi | 91 ↔ 135 | PROSITE-ProRule annotation | ||
Disulfide bondi | 118 ↔ 146 | PROSITE-ProRule annotation | ||
Disulfide bondi | 153 ↔ 197 | PROSITE-ProRule annotation | ||
Glycosylationi | 162 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 180 ↔ 208 | PROSITE-ProRule annotation | ||
Disulfide bondi | 213 ↔ 255 | PROSITE-ProRule annotation | ||
Disulfide bondi | 241 ↔ 267 | PROSITE-ProRule annotation | ||
Disulfide bondi | 274 ↔ 316 | PROSITE-ProRule annotation | ||
Disulfide bondi | 302 ↔ 327 | PROSITE-ProRule annotation | ||
Disulfide bondi | 336 ↔ 378 | PROSITE-ProRule annotation | ||
Disulfide bondi | 364 ↔ 389 | PROSITE-ProRule annotation | ||
Disulfide bondi | 396 ↔ 439 | PROSITE-ProRule annotation | ||
Disulfide bondi | 425 ↔ 450 | PROSITE-ProRule annotation | ||
Disulfide bondi | 454 ↔ 505 | PROSITE-ProRule annotation | ||
Disulfide bondi | 486 ↔ 515 | PROSITE-ProRule annotation | ||
Disulfide bondi | 524 ↔ 567 | PROSITE-ProRule annotation | ||
Glycosylationi | 545 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 553 ↔ 578 | PROSITE-ProRule annotation | ||
Disulfide bondi | 582 ↔ 636 | PROSITE-ProRule annotation | ||
Disulfide bondi | 616 ↔ 646 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P05160 |
MassIVEi | P05160 |
PaxDbi | P05160 |
PeptideAtlasi | P05160 |
PRIDEi | P05160 |
ProteomicsDBi | 51808 |
PTM databases
GlyConnecti | 1122, 8 N-Linked glycans (2 sites) |
GlyGeni | P05160, 3 sites, 6 N-linked glycans (2 sites), 1 O-linked glycan (1 site) |
iPTMneti | P05160 |
PhosphoSitePlusi | P05160 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143278, Expressed in liver and 36 other tissues |
ExpressionAtlasi | P05160, baseline and differential |
Genevisiblei | P05160, HS |
Organism-specific databases
HPAi | ENSG00000143278, Tissue enriched (liver) |
Interactioni
Subunit structurei
Tetramer of two A chains (F13A1) and two B (F13B) chains.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 108463, 2 interactors |
IntActi | P05160, 11 interactors |
STRINGi | 9606.ENSP00000356382 |
Miscellaneous databases
RNActi | P05160, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 88 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 89 – 148 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 151 – 210 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 211 – 269 | Sushi 4PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 272 – 329 | Sushi 5PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 334 – 391 | Sushi 6PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 394 – 452 | Sushi 7PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 453 – 516 | Sushi 8PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 522 – 580 | Sushi 9PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 581 – 647 | Sushi 10PROSITE-ProRule annotationAdd BLAST | 67 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 617 – 619 | Cell attachment site | 3 |
Keywords - Domaini
Repeat, Signal, SushiPhylogenomic databases
eggNOGi | ENOG502RDCS, Eukaryota |
GeneTreei | ENSGT00940000154967 |
HOGENOMi | CLU_020107_6_0_1 |
InParanoidi | P05160 |
OMAi | IFHGEYI |
OrthoDBi | 296899at2759 |
PhylomeDBi | P05160 |
TreeFami | TF326157 |
Family and domain databases
CDDi | cd00033, CCP, 7 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 8 hits |
SMARTi | View protein in SMART SM00032, CCP, 8 hits |
SUPFAMi | SSF57535, SSF57535, 10 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 7 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P05160-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS
60 70 80 90 100
IDKKLSFFCL AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY
110 120 130 140 150
ISDVKLLYKI QENMRYGCAS GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH
160 170 180 190 200
ETCLAPELYN GNYSTTQKTF KVKDKVQYEC ATGYYTAGGK KTEEVECLTY
210 220 230 240 250
GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF CHENYYLSGS
260 270 280 290 300
DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI
310 320 330 340 350
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH
360 370 380 390 400
SKIYYNGDKV TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP
410 420 430 440 450
VVMNGAVADG ILASYATGSS VEYRCNEYYL LRGSKISRCE QGKWSSPPVC
460 470 480 490 500
LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD LIDFVCKQGY DLSPLTPLSE
510 520 530 540 550
LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV DTYENGSSVE
560 570 580 590 600
YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF
610 620 630 640 650
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ
660
STLSYQEPLR T
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IS66 | A0A3B3IS66_HUMAN | Coagulation factor XIII B chain | F13B | 246 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074563 | 25 | C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl. | 1 | |
Natural variantiVAR_013930 | 49 | M → V1 PublicationCorresponds to variant dbSNP:rs6002Ensembl. | 1 | |
Natural variantiVAR_074564 | 101 | I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl. | 1 | |
Natural variantiVAR_013931 | 115 | R → H4 PublicationsCorresponds to variant dbSNP:rs6003EnsemblClinVar. | 1 | |
Natural variantiVAR_074565 | 136 | L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl. | 1 | |
Natural variantiVAR_074566 | 237 | V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl. | 1 | |
Natural variantiVAR_074567 | 336 | C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl. | 1 | |
Natural variantiVAR_020612 | 342 | I → T1 PublicationCorresponds to variant dbSNP:rs17514281EnsemblClinVar. | 1 | |
Natural variantiVAR_013932 | 350 | H → R2 PublicationsCorresponds to variant dbSNP:rs5999EnsemblClinVar. | 1 | |
Natural variantiVAR_013933 | 388 | E → V1 PublicationCorresponds to variant dbSNP:rs5991EnsemblClinVar. | 1 | |
Natural variantiVAR_074568 | 421 | V → E in FA13BD; impaired interaction with F13A1. 2 Publications | 1 | |
Natural variantiVAR_074569 | 448 | P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications | 1 | |
Natural variantiVAR_007475 | 450 | C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar. | 1 | |
Natural variantiVAR_020613 | 529 | L → P1 PublicationCorresponds to variant dbSNP:rs17549671EnsemblClinVar. | 1 | |
Natural variantiVAR_013934 | 543 | Y → S1 PublicationCorresponds to variant dbSNP:rs6001Ensembl. | 1 | |
Natural variantiVAR_013935 | 569 | D → E3 PublicationsCorresponds to variant dbSNP:rs6000EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64554 Genomic DNA Translation: AAA51821.1 M14057 mRNA Translation: AAA88042.1 AK290560 mRNA Translation: BAF83249.1 AY692223 Genomic DNA Translation: AAT85802.1 AL353809 Genomic DNA No translation available. X51823 mRNA Translation: CAA36123.1 |
CCDSi | CCDS1388.1 |
PIRi | A36397, KFHU13 |
RefSeqi | NP_001985.2, NM_001994.2 |
Genome annotation databases
Ensembli | ENST00000367412; ENSP00000356382; ENSG00000143278 |
GeneIDi | 2165 |
KEGGi | hsa:2165 |
UCSCi | uc001gtt.1, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Factor XIII entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64554 Genomic DNA Translation: AAA51821.1 M14057 mRNA Translation: AAA88042.1 AK290560 mRNA Translation: BAF83249.1 AY692223 Genomic DNA Translation: AAT85802.1 AL353809 Genomic DNA No translation available. X51823 mRNA Translation: CAA36123.1 |
CCDSi | CCDS1388.1 |
PIRi | A36397, KFHU13 |
RefSeqi | NP_001985.2, NM_001994.2 |
3D structure databases
SMRi | P05160 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108463, 2 interactors |
IntActi | P05160, 11 interactors |
STRINGi | 9606.ENSP00000356382 |
Chemistry databases
ChEMBLi | CHEMBL3351193 |
DrugBanki | DB09310, Catridecacog DB11571, Human thrombin DB11300, Thrombin DB01593, Zinc DB14487, Zinc acetate |
PTM databases
GlyConnecti | 1122, 8 N-Linked glycans (2 sites) |
GlyGeni | P05160, 3 sites, 6 N-linked glycans (2 sites), 1 O-linked glycan (1 site) |
iPTMneti | P05160 |
PhosphoSitePlusi | P05160 |
Genetic variation databases
BioMutai | F13B |
DMDMi | 145559473 |
Proteomic databases
EPDi | P05160 |
MassIVEi | P05160 |
PaxDbi | P05160 |
PeptideAtlasi | P05160 |
PRIDEi | P05160 |
ProteomicsDBi | 51808 |
Protocols and materials databases
Antibodypediai | 868, 224 antibodies |
DNASUi | 2165 |
Genome annotation databases
Ensembli | ENST00000367412; ENSP00000356382; ENSG00000143278 |
GeneIDi | 2165 |
KEGGi | hsa:2165 |
UCSCi | uc001gtt.1, human |
Organism-specific databases
CTDi | 2165 |
DisGeNETi | 2165 |
GeneCardsi | F13B |
HGNCi | HGNC:3534, F13B |
HPAi | ENSG00000143278, Tissue enriched (liver) |
MalaCardsi | F13B |
MIMi | 134580, gene+phenotype 613235, phenotype |
neXtProti | NX_P05160 |
OpenTargetsi | ENSG00000143278 |
Orphaneti | 331, Congenital factor XIII deficiency |
PharmGKBi | PA27944 |
VEuPathDBi | HostDB:ENSG00000143278.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RDCS, Eukaryota |
GeneTreei | ENSGT00940000154967 |
HOGENOMi | CLU_020107_6_0_1 |
InParanoidi | P05160 |
OMAi | IFHGEYI |
OrthoDBi | 296899at2759 |
PhylomeDBi | P05160 |
TreeFami | TF326157 |
Enzyme and pathway databases
PathwayCommonsi | P05160 |
Reactomei | R-HSA-140875, Common Pathway of Fibrin Clot Formation |
Miscellaneous databases
BioGRID-ORCSi | 2165, 2 hits in 864 CRISPR screens |
GeneWikii | F13B |
GenomeRNAii | 2165 |
Pharosi | P05160, Tbio |
PROi | PR:P05160 |
RNActi | P05160, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143278, Expressed in liver and 36 other tissues |
ExpressionAtlasi | P05160, baseline and differential |
Genevisiblei | P05160, HS |
Family and domain databases
CDDi | cd00033, CCP, 7 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 8 hits |
SMARTi | View protein in SMART SM00032, CCP, 8 hits |
SUPFAMi | SSF57535, SSF57535, 10 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F13B_HUMAN | |
Accessioni | P05160Primary (citable) accession number: P05160 Secondary accession number(s): A8K3E5, Q5VYL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | April 17, 2007 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants