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Protein

Coagulation factor XIII B chain

Gene

F13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.2 Publications

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII B chain
Alternative name(s):
Fibrin-stabilizing factor B subunit
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
Gene namesi
Name:F13B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143278.3
HGNCiHGNC:3534 F13B
MIMi134580 gene+phenotype
neXtProtiNX_P05160

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Factor XIII subunit B deficiency (FA13BD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
See also OMIM:613235
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07456325C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl.1
Natural variantiVAR_074564101I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl.1
Natural variantiVAR_074565136L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl.1
Natural variantiVAR_074566237V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl.1
Natural variantiVAR_074567336C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl.1
Natural variantiVAR_074568421V → E in FA13BD; impaired interaction with F13A1. 2 Publications1
Natural variantiVAR_074569448P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications1
Natural variantiVAR_007475450C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi2165
MalaCardsiF13B
MIMi134580 gene+phenotype
613235 phenotype
OpenTargetsiENSG00000143278
Orphaneti331 Congenital factor XIII deficiency
PharmGKBiPA27944

Chemistry databases

ChEMBLiCHEMBL3351193

Polymorphism and mutation databases

BioMutaiF13B
DMDMi145559473

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000002122221 – 661Coagulation factor XIII B chainAdd BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 76PROSITE-ProRule annotation
Disulfide bondi59 ↔ 87PROSITE-ProRule annotation
Disulfide bondi91 ↔ 135PROSITE-ProRule annotation
Disulfide bondi118 ↔ 146PROSITE-ProRule annotation
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi180 ↔ 208PROSITE-ProRule annotation
Disulfide bondi213 ↔ 255PROSITE-ProRule annotation
Disulfide bondi241 ↔ 267PROSITE-ProRule annotation
Disulfide bondi274 ↔ 316PROSITE-ProRule annotation
Disulfide bondi302 ↔ 327PROSITE-ProRule annotation
Disulfide bondi336 ↔ 378PROSITE-ProRule annotation
Disulfide bondi364 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 439PROSITE-ProRule annotation
Disulfide bondi425 ↔ 450PROSITE-ProRule annotation
Disulfide bondi454 ↔ 505PROSITE-ProRule annotation
Disulfide bondi486 ↔ 515PROSITE-ProRule annotation
Disulfide bondi524 ↔ 567PROSITE-ProRule annotation
Glycosylationi545N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi553 ↔ 578PROSITE-ProRule annotation
Disulfide bondi582 ↔ 636PROSITE-ProRule annotation
Disulfide bondi616 ↔ 646PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP05160
PaxDbiP05160
PeptideAtlasiP05160
PRIDEiP05160
ProteomicsDBi51808

PTM databases

GlyConnecti1122
iPTMnetiP05160
PhosphoSitePlusiP05160

Expressioni

Gene expression databases

BgeeiENSG00000143278 Expressed in 22 organ(s), highest expression level in right lobe of liver
CleanExiHS_F13B
GenevisibleiP05160 HS

Organism-specific databases

HPAiHPA003827
HPA052139

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.2 Publications

Protein-protein interaction databases

BioGridi108463, 2 interactors
STRINGi9606.ENSP00000356382

Structurei

3D structure databases

ProteinModelPortaliP05160
SMRiP05160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 88Sushi 1PROSITE-ProRule annotationAdd BLAST65
Domaini89 – 148Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini151 – 210Sushi 3PROSITE-ProRule annotationAdd BLAST60
Domaini211 – 269Sushi 4PROSITE-ProRule annotationAdd BLAST59
Domaini272 – 329Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini334 – 391Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini394 – 452Sushi 7PROSITE-ProRule annotationAdd BLAST59
Domaini453 – 516Sushi 8PROSITE-ProRule annotationAdd BLAST64
Domaini522 – 580Sushi 9PROSITE-ProRule annotationAdd BLAST59
Domaini581 – 647Sushi 10PROSITE-ProRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi617 – 619Cell attachment site3

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IE82 Eukaryota
ENOG410YE48 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000049250
HOVERGENiHBG005626
InParanoidiP05160
KOiK03906
OMAiCYNFGWY
OrthoDBiEOG091G03MW
PhylomeDBiP05160
TreeFamiTF326157

Family and domain databases

CDDicd00033 CCP, 7 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 8 hits
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SUPFAMiSSF57535 SSF57535, 10 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS
60 70 80 90 100
IDKKLSFFCL AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY
110 120 130 140 150
ISDVKLLYKI QENMRYGCAS GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH
160 170 180 190 200
ETCLAPELYN GNYSTTQKTF KVKDKVQYEC ATGYYTAGGK KTEEVECLTY
210 220 230 240 250
GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF CHENYYLSGS
260 270 280 290 300
DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI
310 320 330 340 350
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH
360 370 380 390 400
SKIYYNGDKV TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP
410 420 430 440 450
VVMNGAVADG ILASYATGSS VEYRCNEYYL LRGSKISRCE QGKWSSPPVC
460 470 480 490 500
LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD LIDFVCKQGY DLSPLTPLSE
510 520 530 540 550
LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV DTYENGSSVE
560 570 580 590 600
YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF
610 620 630 640 650
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ
660
STLSYQEPLR T
Length:661
Mass (Da):75,511
Last modified:April 17, 2007 - v3
Checksum:i57A2FD2A0E35B812
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07456325C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl.1
Natural variantiVAR_01393049M → V1 PublicationCorresponds to variant dbSNP:rs6002Ensembl.1
Natural variantiVAR_074564101I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl.1
Natural variantiVAR_013931115R → H4 PublicationsCorresponds to variant dbSNP:rs6003EnsemblClinVar.1
Natural variantiVAR_074565136L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl.1
Natural variantiVAR_074566237V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl.1
Natural variantiVAR_074567336C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl.1
Natural variantiVAR_020612342I → T1 PublicationCorresponds to variant dbSNP:rs17514281EnsemblClinVar.1
Natural variantiVAR_013932350H → R2 PublicationsCorresponds to variant dbSNP:rs5999Ensembl.1
Natural variantiVAR_013933388E → V1 PublicationCorresponds to variant dbSNP:rs5991EnsemblClinVar.1
Natural variantiVAR_074568421V → E in FA13BD; impaired interaction with F13A1. 2 Publications1
Natural variantiVAR_074569448P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications1
Natural variantiVAR_007475450C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar.1
Natural variantiVAR_020613529L → P1 PublicationCorresponds to variant dbSNP:rs17549671Ensembl.1
Natural variantiVAR_013934543Y → S1 PublicationCorresponds to variant dbSNP:rs6001Ensembl.1
Natural variantiVAR_013935569D → E3 PublicationsCorresponds to variant dbSNP:rs6000EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64554 Genomic DNA Translation: AAA51821.1
M14057 mRNA Translation: AAA88042.1
AK290560 mRNA Translation: BAF83249.1
AY692223 Genomic DNA Translation: AAT85802.1
AL353809 Genomic DNA No translation available.
X51823 mRNA Translation: CAA36123.1
CCDSiCCDS1388.1
PIRiA36397 KFHU13
RefSeqiNP_001985.2, NM_001994.2
UniGeneiHs.435782

Genome annotation databases

EnsembliENST00000367412; ENSP00000356382; ENSG00000143278
GeneIDi2165
KEGGihsa:2165
UCSCiuc001gtt.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64554 Genomic DNA Translation: AAA51821.1
M14057 mRNA Translation: AAA88042.1
AK290560 mRNA Translation: BAF83249.1
AY692223 Genomic DNA Translation: AAT85802.1
AL353809 Genomic DNA No translation available.
X51823 mRNA Translation: CAA36123.1
CCDSiCCDS1388.1
PIRiA36397 KFHU13
RefSeqiNP_001985.2, NM_001994.2
UniGeneiHs.435782

3D structure databases

ProteinModelPortaliP05160
SMRiP05160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108463, 2 interactors
STRINGi9606.ENSP00000356382

Chemistry databases

ChEMBLiCHEMBL3351193

PTM databases

GlyConnecti1122
iPTMnetiP05160
PhosphoSitePlusiP05160

Polymorphism and mutation databases

BioMutaiF13B
DMDMi145559473

Proteomic databases

EPDiP05160
PaxDbiP05160
PeptideAtlasiP05160
PRIDEiP05160
ProteomicsDBi51808

Protocols and materials databases

DNASUi2165
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367412; ENSP00000356382; ENSG00000143278
GeneIDi2165
KEGGihsa:2165
UCSCiuc001gtt.1 human

Organism-specific databases

CTDi2165
DisGeNETi2165
EuPathDBiHostDB:ENSG00000143278.3
GeneCardsiF13B
H-InvDBiHIX0028859
HGNCiHGNC:3534 F13B
HPAiHPA003827
HPA052139
MalaCardsiF13B
MIMi134580 gene+phenotype
613235 phenotype
neXtProtiNX_P05160
OpenTargetsiENSG00000143278
Orphaneti331 Congenital factor XIII deficiency
PharmGKBiPA27944
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE82 Eukaryota
ENOG410YE48 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000049250
HOVERGENiHBG005626
InParanoidiP05160
KOiK03906
OMAiCYNFGWY
OrthoDBiEOG091G03MW
PhylomeDBiP05160
TreeFamiTF326157

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation

Miscellaneous databases

GeneWikiiF13B
GenomeRNAii2165
PROiPR:P05160
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143278 Expressed in 22 organ(s), highest expression level in right lobe of liver
CleanExiHS_F13B
GenevisibleiP05160 HS

Family and domain databases

CDDicd00033 CCP, 7 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 8 hits
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SUPFAMiSSF57535 SSF57535, 10 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF13B_HUMAN
AccessioniPrimary (citable) accession number: P05160
Secondary accession number(s): A8K3E5, Q5VYL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 17, 2007
Last modified: October 10, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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