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Protein

Coagulation factor XIII B chain

Gene

F13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140875 Common Pathway of Fibrin Clot Formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor XIII B chain
Alternative name(s):
Fibrin-stabilizing factor B subunit
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F13B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143278.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3534 F13B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
134580 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05160

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Factor XIII subunit B deficiency (FA13BD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
See also OMIM:613235
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07456325C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl.1
Natural variantiVAR_074564101I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl.1
Natural variantiVAR_074565136L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl.1
Natural variantiVAR_074566237V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl.1
Natural variantiVAR_074567336C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl.1
Natural variantiVAR_074568421V → E in FA13BD; impaired interaction with F13A1. 2 Publications1
Natural variantiVAR_074569448P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications1
Natural variantiVAR_007475450C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2165

MalaCards human disease database

More...
MalaCardsi
F13B
MIMi134580 gene+phenotype
613235 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000143278

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
331 Congenital factor XIII deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27944

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3351193

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
F13B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559473

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002122221 – 661Coagulation factor XIII B chainAdd BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 76PROSITE-ProRule annotation
Disulfide bondi59 ↔ 87PROSITE-ProRule annotation
Disulfide bondi91 ↔ 135PROSITE-ProRule annotation
Disulfide bondi118 ↔ 146PROSITE-ProRule annotation
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi162N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi180 ↔ 208PROSITE-ProRule annotation
Disulfide bondi213 ↔ 255PROSITE-ProRule annotation
Disulfide bondi241 ↔ 267PROSITE-ProRule annotation
Disulfide bondi274 ↔ 316PROSITE-ProRule annotation
Disulfide bondi302 ↔ 327PROSITE-ProRule annotation
Disulfide bondi336 ↔ 378PROSITE-ProRule annotation
Disulfide bondi364 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 439PROSITE-ProRule annotation
Disulfide bondi425 ↔ 450PROSITE-ProRule annotation
Disulfide bondi454 ↔ 505PROSITE-ProRule annotation
Disulfide bondi486 ↔ 515PROSITE-ProRule annotation
Disulfide bondi524 ↔ 567PROSITE-ProRule annotation
Glycosylationi545N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi553 ↔ 578PROSITE-ProRule annotation
Disulfide bondi582 ↔ 636PROSITE-ProRule annotation
Disulfide bondi616 ↔ 646PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P05160

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P05160

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05160

PeptideAtlas

More...
PeptideAtlasi
P05160

PRoteomics IDEntifications database

More...
PRIDEi
P05160

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51808

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1122

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05160

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143278 Expressed in 22 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_F13B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05160 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003827
HPA052139

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108463, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356382

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P05160

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P05160

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 88Sushi 1PROSITE-ProRule annotationAdd BLAST65
Domaini89 – 148Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini151 – 210Sushi 3PROSITE-ProRule annotationAdd BLAST60
Domaini211 – 269Sushi 4PROSITE-ProRule annotationAdd BLAST59
Domaini272 – 329Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini334 – 391Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini394 – 452Sushi 7PROSITE-ProRule annotationAdd BLAST59
Domaini453 – 516Sushi 8PROSITE-ProRule annotationAdd BLAST64
Domaini522 – 580Sushi 9PROSITE-ProRule annotationAdd BLAST59
Domaini581 – 647Sushi 10PROSITE-ProRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi617 – 619Cell attachment site3

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE82 Eukaryota
ENOG410YE48 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154967

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049250

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005626

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05160

KEGG Orthology (KO)

More...
KOi
K03906

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYNFGWY

Database of Orthologous Groups

More...
OrthoDBi
296899at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05160

TreeFam database of animal gene trees

More...
TreeFami
TF326157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS
60 70 80 90 100
IDKKLSFFCL AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY
110 120 130 140 150
ISDVKLLYKI QENMRYGCAS GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH
160 170 180 190 200
ETCLAPELYN GNYSTTQKTF KVKDKVQYEC ATGYYTAGGK KTEEVECLTY
210 220 230 240 250
GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF CHENYYLSGS
260 270 280 290 300
DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI
310 320 330 340 350
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH
360 370 380 390 400
SKIYYNGDKV TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP
410 420 430 440 450
VVMNGAVADG ILASYATGSS VEYRCNEYYL LRGSKISRCE QGKWSSPPVC
460 470 480 490 500
LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD LIDFVCKQGY DLSPLTPLSE
510 520 530 540 550
LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV DTYENGSSVE
560 570 580 590 600
YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF
610 620 630 640 650
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ
660
STLSYQEPLR T
Length:661
Mass (Da):75,511
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57A2FD2A0E35B812
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IS66A0A3B3IS66_HUMAN
Coagulation factor XIII B chain
F13B
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07456325C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl.1
Natural variantiVAR_01393049M → V1 PublicationCorresponds to variant dbSNP:rs6002Ensembl.1
Natural variantiVAR_074564101I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl.1
Natural variantiVAR_013931115R → H4 PublicationsCorresponds to variant dbSNP:rs6003EnsemblClinVar.1
Natural variantiVAR_074565136L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl.1
Natural variantiVAR_074566237V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl.1
Natural variantiVAR_074567336C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl.1
Natural variantiVAR_020612342I → T1 PublicationCorresponds to variant dbSNP:rs17514281EnsemblClinVar.1
Natural variantiVAR_013932350H → R2 PublicationsCorresponds to variant dbSNP:rs5999Ensembl.1
Natural variantiVAR_013933388E → V1 PublicationCorresponds to variant dbSNP:rs5991EnsemblClinVar.1
Natural variantiVAR_074568421V → E in FA13BD; impaired interaction with F13A1. 2 Publications1
Natural variantiVAR_074569448P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications1
Natural variantiVAR_007475450C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar.1
Natural variantiVAR_020613529L → P1 PublicationCorresponds to variant dbSNP:rs17549671Ensembl.1
Natural variantiVAR_013934543Y → S1 PublicationCorresponds to variant dbSNP:rs6001Ensembl.1
Natural variantiVAR_013935569D → E3 PublicationsCorresponds to variant dbSNP:rs6000EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M64554 Genomic DNA Translation: AAA51821.1
M14057 mRNA Translation: AAA88042.1
AK290560 mRNA Translation: BAF83249.1
AY692223 Genomic DNA Translation: AAT85802.1
AL353809 Genomic DNA No translation available.
X51823 mRNA Translation: CAA36123.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1388.1

Protein sequence database of the Protein Information Resource

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PIRi
A36397 KFHU13

NCBI Reference Sequences

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RefSeqi
NP_001985.2, NM_001994.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.435782

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367412; ENSP00000356382; ENSG00000143278

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2165

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2165

UCSC genome browser

More...
UCSCi
uc001gtt.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64554 Genomic DNA Translation: AAA51821.1
M14057 mRNA Translation: AAA88042.1
AK290560 mRNA Translation: BAF83249.1
AY692223 Genomic DNA Translation: AAT85802.1
AL353809 Genomic DNA No translation available.
X51823 mRNA Translation: CAA36123.1
CCDSiCCDS1388.1
PIRiA36397 KFHU13
RefSeqiNP_001985.2, NM_001994.2
UniGeneiHs.435782

3D structure databases

ProteinModelPortaliP05160
SMRiP05160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108463, 2 interactors
STRINGi9606.ENSP00000356382

Chemistry databases

ChEMBLiCHEMBL3351193

PTM databases

GlyConnecti1122
iPTMnetiP05160
PhosphoSitePlusiP05160

Polymorphism and mutation databases

BioMutaiF13B
DMDMi145559473

Proteomic databases

EPDiP05160
jPOSTiP05160
PaxDbiP05160
PeptideAtlasiP05160
PRIDEiP05160
ProteomicsDBi51808

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2165
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367412; ENSP00000356382; ENSG00000143278
GeneIDi2165
KEGGihsa:2165
UCSCiuc001gtt.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2165
DisGeNETi2165
EuPathDBiHostDB:ENSG00000143278.3

GeneCards: human genes, protein and diseases

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GeneCardsi
F13B

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0028859
HGNCiHGNC:3534 F13B
HPAiHPA003827
HPA052139
MalaCardsiF13B
MIMi134580 gene+phenotype
613235 phenotype
neXtProtiNX_P05160
OpenTargetsiENSG00000143278
Orphaneti331 Congenital factor XIII deficiency
PharmGKBiPA27944

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE82 Eukaryota
ENOG410YE48 LUCA
GeneTreeiENSGT00940000154967
HOGENOMiHOG000049250
HOVERGENiHBG005626
InParanoidiP05160
KOiK03906
OMAiCYNFGWY
OrthoDBi296899at2759
PhylomeDBiP05160
TreeFamiTF326157

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
F13B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2165

Protein Ontology

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PROi
PR:P05160

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143278 Expressed in 22 organ(s), highest expression level in right lobe of liver
CleanExiHS_F13B
GenevisibleiP05160 HS

Family and domain databases

CDDicd00033 CCP, 7 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 8 hits
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SUPFAMiSSF57535 SSF57535, 10 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF13B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05160
Secondary accession number(s): A8K3E5, Q5VYL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 17, 2007
Last modified: January 16, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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