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UniProtKB - P05160 (F13B_HUMAN)

Entry version 193 (10 Feb 2021)
Sequence version 3 (17 Apr 2007)
Previous versions | rss
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Protein

Coagulation factor XIII B chain

Gene

F13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05160

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140875, Common Pathway of Fibrin Clot Formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor XIII B chain
Alternative name(s):
Fibrin-stabilizing factor B subunit
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F13B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3534, F13B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		134580, gene+phenotype

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05160

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143278.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Factor XIII subunit B deficiency (FA13BD)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07456325C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl.1
Natural variantiVAR_074564101I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl.1
Natural variantiVAR_074565136L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl.1
Natural variantiVAR_074566237V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl.1
Natural variantiVAR_074567336C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl.1
Natural variantiVAR_074568421V → E in FA13BD; impaired interaction with F13A1. 2 Publications1
Natural variantiVAR_074569448P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications1
Natural variantiVAR_007475450C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		2165

MalaCards human disease database

More...MalaCardsi		F13B
MIMi134580, gene+phenotype
613235, phenotype

Open Targets

More...OpenTargetsi		ENSG00000143278

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		331, Congenital factor XIII deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27944

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05160, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3351193

Drug and drug target database

More...DrugBanki		DB09310, Catridecacog
DB11571, Human thrombin
DB11300, Thrombin
DB01593, Zinc
DB14487, Zinc acetate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		F13B

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559473

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002122221 – 661Coagulation factor XIII B chainAdd BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 76PROSITE-ProRule annotation
Disulfide bondi59 ↔ 87PROSITE-ProRule annotation
Disulfide bondi91 ↔ 135PROSITE-ProRule annotation
Disulfide bondi118 ↔ 146PROSITE-ProRule annotation
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi162N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi180 ↔ 208PROSITE-ProRule annotation
Disulfide bondi213 ↔ 255PROSITE-ProRule annotation
Disulfide bondi241 ↔ 267PROSITE-ProRule annotation
Disulfide bondi274 ↔ 316PROSITE-ProRule annotation
Disulfide bondi302 ↔ 327PROSITE-ProRule annotation
Disulfide bondi336 ↔ 378PROSITE-ProRule annotation
Disulfide bondi364 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 439PROSITE-ProRule annotation
Disulfide bondi425 ↔ 450PROSITE-ProRule annotation
Disulfide bondi454 ↔ 505PROSITE-ProRule annotation
Disulfide bondi486 ↔ 515PROSITE-ProRule annotation
Disulfide bondi524 ↔ 567PROSITE-ProRule annotation
Glycosylationi545N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi553 ↔ 578PROSITE-ProRule annotation
Disulfide bondi582 ↔ 636PROSITE-ProRule annotation
Disulfide bondi616 ↔ 646PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05160

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05160

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05160

PeptideAtlas

More...PeptideAtlasi		P05160

PRoteomics IDEntifications database

More...PRIDEi		P05160

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51808

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1122, 8 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05160, 3 sites, 6 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05160

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143278, Expressed in liver and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P05160, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05160, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143278, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108463, 2 interactors

Protein interaction database and analysis system

More...IntActi		P05160, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05160, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05160

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 88Sushi 1PROSITE-ProRule annotationAdd BLAST65
Domaini89 – 148Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini151 – 210Sushi 3PROSITE-ProRule annotationAdd BLAST60
Domaini211 – 269Sushi 4PROSITE-ProRule annotationAdd BLAST59
Domaini272 – 329Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini334 – 391Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini394 – 452Sushi 7PROSITE-ProRule annotationAdd BLAST59
Domaini453 – 516Sushi 8PROSITE-ProRule annotationAdd BLAST64
Domaini522 – 580Sushi 9PROSITE-ProRule annotationAdd BLAST59
Domaini581 – 647Sushi 10PROSITE-ProRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi617 – 619Cell attachment site3

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RDCS, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154967

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020107_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05160

Identification of Orthologs from Complete Genome Data

More...OMAi		IFHGEYI

Database of Orthologous Groups

More...OrthoDBi		296899at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05160

TreeFam database of animal gene trees

More...TreeFami		TF326157

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00084, Sushi, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57535, SSF57535, 10 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50923, SUSHI, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS 
        60         70         80         90        100
IDKKLSFFCL AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY 
       110        120        130        140        150
ISDVKLLYKI QENMRYGCAS GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH 
       160        170        180        190        200
ETCLAPELYN GNYSTTQKTF KVKDKVQYEC ATGYYTAGGK KTEEVECLTY 
       210        220        230        240        250
GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF CHENYYLSGS 
       260        270        280        290        300
DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI 
       310        320        330        340        350
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH 
       360        370        380        390        400
SKIYYNGDKV TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP 
       410        420        430        440        450
VVMNGAVADG ILASYATGSS VEYRCNEYYL LRGSKISRCE QGKWSSPPVC 
       460        470        480        490        500
LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD LIDFVCKQGY DLSPLTPLSE 
       510        520        530        540        550
LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV DTYENGSSVE 
       560        570        580        590        600
YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF 
       610        620        630        640        650
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ 
       660 
STLSYQEPLR T
Length:661
Mass (Da):75,511
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57A2FD2A0E35B812
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IS66A0A3B3IS66_HUMAN
Coagulation factor XIII B chain
F13B
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07456325C → R in FA13BD; may disrupt a disulfide bond; impaired subcellular location leading to accumulation in the endoplasmic reticulum; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs1232302447Ensembl.1
Natural variantiVAR_01393049M → V1 PublicationCorresponds to variant dbSNP:rs6002Ensembl.1
Natural variantiVAR_074564101I → N in FA13BD; impaired interaction with F13A1. 2 PublicationsCorresponds to variant dbSNP:rs753009140Ensembl.1
Natural variantiVAR_013931115R → H4 PublicationsCorresponds to variant dbSNP:rs6003EnsemblClinVar.1
Natural variantiVAR_074565136L → F in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs757094432Ensembl.1
Natural variantiVAR_074566237V → I in FA13BD; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs145637157Ensembl.1
Natural variantiVAR_074567336C → F in FA13BD; may disrupt a disulfide bond; impaired interaction with F13A1; impaired structure. 2 PublicationsCorresponds to variant dbSNP:rs778826479Ensembl.1
Natural variantiVAR_020612342I → T1 PublicationCorresponds to variant dbSNP:rs17514281EnsemblClinVar.1
Natural variantiVAR_013932350H → R2 PublicationsCorresponds to variant dbSNP:rs5999EnsemblClinVar.1
Natural variantiVAR_013933388E → V1 PublicationCorresponds to variant dbSNP:rs5991EnsemblClinVar.1
Natural variantiVAR_074568421V → E in FA13BD; impaired interaction with F13A1. 2 Publications1
Natural variantiVAR_074569448P → S in FA13BD; impaired interaction with F13A1; impaired structure. 2 Publications1
Natural variantiVAR_007475450C → F in FA13BD. 1 PublicationCorresponds to variant dbSNP:rs121913075EnsemblClinVar.1
Natural variantiVAR_020613529L → P1 PublicationCorresponds to variant dbSNP:rs17549671EnsemblClinVar.1
Natural variantiVAR_013934543Y → S1 PublicationCorresponds to variant dbSNP:rs6001Ensembl.1
Natural variantiVAR_013935569D → E3 PublicationsCorresponds to variant dbSNP:rs6000EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M64554 Genomic DNA Translation: AAA51821.1
M14057 mRNA Translation: AAA88042.1
AK290560 mRNA Translation: BAF83249.1
AY692223 Genomic DNA Translation: AAT85802.1
AL353809 Genomic DNA No translation available.
X51823 mRNA Translation: CAA36123.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1388.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36397, KFHU13

NCBI Reference Sequences

More...RefSeqi		NP_001985.2, NM_001994.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367412; ENSP00000356382; ENSG00000143278

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2165

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2165

UCSC genome browser

More...UCSCi		uc001gtt.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64554 Genomic DNA Translation: AAA51821.1
M14057 mRNA Translation: AAA88042.1
AK290560 mRNA Translation: BAF83249.1
AY692223 Genomic DNA Translation: AAT85802.1
AL353809 Genomic DNA No translation available.
X51823 mRNA Translation: CAA36123.1
CCDSiCCDS1388.1
PIRiA36397, KFHU13
RefSeqiNP_001985.2, NM_001994.2

3D structure databases

SMRiP05160
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108463, 2 interactors
IntActiP05160, 11 interactors
STRINGi9606.ENSP00000356382

Chemistry databases

ChEMBLiCHEMBL3351193
DrugBankiDB09310, Catridecacog
DB11571, Human thrombin
DB11300, Thrombin
DB01593, Zinc
DB14487, Zinc acetate

PTM databases

GlyConnecti1122, 8 N-Linked glycans (2 sites)
GlyGeniP05160, 3 sites, 6 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
iPTMnetiP05160
PhosphoSitePlusiP05160

Genetic variation databases

BioMutaiF13B
DMDMi145559473

Proteomic databases

EPDiP05160
MassIVEiP05160
PaxDbiP05160
PeptideAtlasiP05160
PRIDEiP05160
ProteomicsDBi51808

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		868, 224 antibodies

The DNASU plasmid repository

More...DNASUi		2165

Genome annotation databases

EnsembliENST00000367412; ENSP00000356382; ENSG00000143278
GeneIDi2165
KEGGihsa:2165
UCSCiuc001gtt.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2165
DisGeNETi2165

GeneCards: human genes, protein and diseases

More...GeneCardsi		F13B
HGNCiHGNC:3534, F13B
HPAiENSG00000143278, Tissue enriched (liver)
MalaCardsiF13B
MIMi134580, gene+phenotype
613235, phenotype
neXtProtiNX_P05160
OpenTargetsiENSG00000143278
Orphaneti331, Congenital factor XIII deficiency
PharmGKBiPA27944
VEuPathDBiHostDB:ENSG00000143278.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RDCS, Eukaryota
GeneTreeiENSGT00940000154967
HOGENOMiCLU_020107_6_0_1
InParanoidiP05160
OMAiIFHGEYI
OrthoDBi296899at2759
PhylomeDBiP05160
TreeFamiTF326157

Enzyme and pathway databases

PathwayCommonsiP05160
ReactomeiR-HSA-140875, Common Pathway of Fibrin Clot Formation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2165, 2 hits in 864 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		F13B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2165
PharosiP05160, Tbio

Protein Ontology

More...PROi		PR:P05160
RNActiP05160, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143278, Expressed in liver and 36 other tissues
ExpressionAtlasiP05160, baseline and differential
GenevisibleiP05160, HS

Family and domain databases

CDDicd00033, CCP, 7 hits
InterProiView protein in InterPro
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084, Sushi, 8 hits
SMARTiView protein in SMART
SM00032, CCP, 8 hits
SUPFAMiSSF57535, SSF57535, 10 hits
PROSITEiView protein in PROSITE
PS50923, SUSHI, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF13B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05160
Secondary accession number(s): A8K3E5, Q5VYL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 17, 2007
Last modified: February 10, 2021
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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