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Protein

Complement factor I

Gene

CFI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.

Catalytic activityi

Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei380Charge relay systemBy similarity1
Active sitei429Charge relay systemBy similarity1
Active sitei525Charge relay systemBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi239 – 2531Add BLAST15
Calcium bindingi276 – 2902Add BLAST15

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processComplement pathway, Immunity, Innate immunity
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.21.45 2681
ReactomeiR-HSA-977606 Regulation of Complement cascade
SIGNORiP05156

Protein family/group databases

MEROPSiS01.199

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor I (EC:3.4.21.45)
Alternative name(s):
C3B/C4B inactivator
Cleaved into the following 2 chains:
Gene namesi
Name:CFI
Synonyms:IF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000205403.12
HGNCiHGNC:5394 CFI
MIMi217030 gene
neXtProtiNX_P05156

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hemolytic uremic syndrome atypical 3 (AHUS3)4 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype.
Disease descriptionAn atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
See also OMIM:612923
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06366564P → L in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs773187287Ensembl.1
Natural variantiVAR_063667183H → R in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs75612300Ensembl.1
Natural variantiVAR_063668287G → R in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs182078921EnsemblClinVar.1
Natural variantiVAR_063669317R → W in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs121964917EnsemblClinVar.1
Natural variantiVAR_030343340I → T in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs769419740Ensembl.1
Natural variantiVAR_063670416I → L in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs61733901EnsemblClinVar.1
Natural variantiVAR_063671519D → N in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs121964918EnsemblClinVar.1
Natural variantiVAR_063672522K → T in AHUS3. 1 Publication1
Natural variantiVAR_030344524D → V in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs121964914EnsemblClinVar.1
Complement factor I deficiency (CFI deficiency)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive condition associated with a propensity to pyogenic infections.
See also OMIM:610984
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034907243G → D in CFI deficiency. 1 PublicationCorresponds to variant dbSNP:rs121964916EnsemblClinVar.1
Natural variantiVAR_026757418H → L in CFI deficiency. 1 PublicationCorresponds to variant dbSNP:rs121964912EnsemblClinVar.1
Macular degeneration, age-related, 13 (ARMD13)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
See also OMIM:615439

Keywords - Diseasei

Age-related macular degeneration, Disease mutation, Hemolytic uremic syndrome

Organism-specific databases

DisGeNETi3426
GeneReviewsiCFI
MalaCardsiCFI
MIMi610984 phenotype
612923 phenotype
615439 phenotype
OpenTargetsiENSG00000205403
Orphaneti93580 Atypical hemolytic-uremic syndrome with I factor anomaly
244275 De novo thrombotic microangiopathy after kidney transplantation
75376 Familial drusen
244242 HELLP syndrome
200418 Immunodeficiency with factor I anomaly
279 NON RARE IN EUROPE: Age-related macular degeneration
PharmGKBiPA29641

Polymorphism and mutation databases

BioMutaiCFI
DMDMi317373341

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000002756819 – 583Complement factor IAdd BLAST565
ChainiPRO_000002756919 – 335Complement factor I heavy chainAdd BLAST317
ChainiPRO_0000027570340 – 583Complement factor I light chainAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 2551 Publication
Disulfide bondi43 ↔ 541 Publication
Disulfide bondi48 ↔ 591 Publication
Disulfide bondi61 ↔ 931 Publication
Disulfide bondi67 ↔ 861 Publication
Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi75 ↔ 1061 Publication
Glycosylationi103N-linked (GlcNAc...) (complex) asparagine4 Publications1
Disulfide bondi141 ↔ 1811 Publication
Disulfide bondi154 ↔ 2141 Publication
Glycosylationi177N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi186 ↔ 1961 Publication
Disulfide bondi229 ↔ 2471 Publication
Disulfide bondi259 ↔ 2711 Publication
Disulfide bondi266 ↔ 2841 Publication
Disulfide bondi278 ↔ 2931 Publication
Disulfide bondi327 ↔ 453Interchain (between heavy and light chains)PROSITE-ProRule annotation1 Publication
Disulfide bondi365 ↔ 3811 Publication
Disulfide bondi373 ↔ 4441 Publication
Glycosylationi464N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi467 ↔ 5311 Publication
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi495 ↔ 5101 Publication
Disulfide bondi521 ↔ 5501 Publication
Glycosylationi536N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP05156
MaxQBiP05156
PaxDbiP05156
PeptideAtlasiP05156
PRIDEiP05156
ProteomicsDBi51807

2D gel databases

SWISS-2DPAGEiP05156

PTM databases

GlyConnecti742
iPTMnetiP05156
PhosphoSitePlusiP05156
UniCarbKBiP05156

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSG00000205403 Expressed in 177 organ(s), highest expression level in visceral pleura
CleanExiHS_CFI
ExpressionAtlasiP05156 baseline and differential
GenevisibleiP05156 HS

Organism-specific databases

HPAiCAB016777
HPA001143
HPA024061

Interactioni

Subunit structurei

Heterodimer of a light and heavy chains; disulfide-linked. The fully processed and mature protein circulates as a zymogen, and is allosterically activated by substrate-induced remodeling of the active site.1 Publication

Protein-protein interaction databases

BioGridi109652, 4 interactors
IntActiP05156, 1 interactor
STRINGi9606.ENSP00000378130

Structurei

Secondary structure

1583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05156
SMRiP05156
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05156

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 108Kazal-likePROSITE-ProRule annotationAdd BLAST54
Domaini114 – 212SRCRPROSITE-ProRule annotationAdd BLAST99
Domaini213 – 257LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST45
Domaini258 – 294LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini340 – 574Peptidase S1PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00930000151042
HOGENOMiHOG000060288
HOVERGENiHBG005311
InParanoidiP05156
KOiK01333
PhylomeDBiP05156
TreeFamiTF330647

Family and domain databases

CDDicd00112 LDLa, 2 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR003884 FacI_MAC
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 2 hits
PF00530 SRCR, 1 hit
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00057 FIMAC, 1 hit
SM00192 LDLa, 2 hits
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 2 hits
PS50287 SRCR_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P05156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP
60 70 80 90 100
WQRCIEGTCV CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF
110 120 130 140 150
LNNGTCTAEG KFSVSLKHGN TDSEGIVEVK LVDQDKTMFI CKSSWSMREA
160 170 180 190 200
NVACLDLGFQ QGADTQRRFK LSDLSINSTE CLHVHCRGLE TSLAECTFTK
210 220 230 240 250
RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA CDGINDCGDQ
260 270 280 290 300
SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAGFASVT
310 320 330 340 350
QEETEILTAD MDAERRRIKS LLPKLSCGVK NRMHIRRKRI VGGKRAQLGD
360 370 380 390 400
LPWQVAIKDA SGITCGGIYI GGCWILTAAH CLRASKTHRY QIWTTVVDWI
410 420 430 440 450
HPDLKRIVIE YVDRIIFHEN YNAGTYQNDI ALIEMKKDGN KKDCELPRSI
460 470 480 490 500
PACVPWSPYL FQPNDTCIVS GWGREKDNER VFSLQWGEVK LISNCSKFYG
510 520 530 540 550
NRFYEKEMEC AGTYDGSIDA CKGDSGGPLV CMDANNVTYV WGVVSWGENC
560 570 580
GKPEFPGVYT KVANYFDWIS YHVGRPFISQ YNV
Length:583
Mass (Da):65,750
Last modified:January 11, 2011 - v2
Checksum:iF06070EFE6B572A1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ETH0E7ETH0_HUMAN
Complement factor I
CFI
591Annotation score:
G3XAM2G3XAM2_HUMAN
Complement factor I
CFI hCG_21044
576Annotation score:
A0A087X0I2A0A087X0I2_HUMAN
Complement factor I
CFI
378Annotation score:
D6R9Z8D6R9Z8_HUMAN
Complement factor I
CFI
161Annotation score:

Sequence cautioni

The sequence CAA68416 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti558V → F in AAA52455 (PubMed:2956252).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06366564P → L in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs773187287Ensembl.1
Natural variantiVAR_063666119G → R in AHUS3 and ARMD13; the mutant is both expressed and secreted at lower levels than wild-type protein; mediates C3 degradation to a lesser extent than that of controls. 2 PublicationsCorresponds to variant dbSNP:rs141853578EnsemblClinVar.1
Natural variantiVAR_063667183H → R in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs75612300Ensembl.1
Natural variantiVAR_070843188G → A1 Publication1
Natural variantiVAR_034907243G → D in CFI deficiency. 1 PublicationCorresponds to variant dbSNP:rs121964916EnsemblClinVar.1
Natural variantiVAR_063668287G → R in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs182078921EnsemblClinVar.1
Natural variantiVAR_034908300T → ACombined sources2 PublicationsCorresponds to variant dbSNP:rs11098044Ensembl.1
Natural variantiVAR_063669317R → W in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs121964917EnsemblClinVar.1
Natural variantiVAR_030343340I → T in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs769419740Ensembl.1
Natural variantiVAR_063670416I → L in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs61733901EnsemblClinVar.1
Natural variantiVAR_026757418H → L in CFI deficiency. 1 PublicationCorresponds to variant dbSNP:rs121964912EnsemblClinVar.1
Natural variantiVAR_063671519D → N in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs121964918EnsemblClinVar.1
Natural variantiVAR_063672522K → T in AHUS3. 1 Publication1
Natural variantiVAR_030344524D → V in AHUS3. 1 PublicationCorresponds to variant dbSNP:rs121964914EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00318 mRNA Translation: CAA68416.1 Different initiation.
J02770 mRNA Translation: AAA52455.1
AC126283 Genomic DNA No translation available.
AF005095 Genomic DNA Translation: AAC08733.2
CCDSiCCDS34049.1
PIRiA29154
RefSeqiNP_000195.2, NM_000204.4
NP_001317964.1, NM_001331035.1
UniGeneiHs.312485

Genome annotation databases

EnsembliENST00000394634; ENSP00000378130; ENSG00000205403
GeneIDi3426
KEGGihsa:3426
UCSCiuc003hzr.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

CFIbase

CFI mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00318 mRNA Translation: CAA68416.1 Different initiation.
J02770 mRNA Translation: AAA52455.1
AC126283 Genomic DNA No translation available.
AF005095 Genomic DNA Translation: AAC08733.2
CCDSiCCDS34049.1
PIRiA29154
RefSeqiNP_000195.2, NM_000204.4
NP_001317964.1, NM_001331035.1
UniGeneiHs.312485

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XRCX-ray2.69A/B/C/D19-583[»]
5O32X-ray2.69D/H19-339[»]
I/J340-583[»]
ProteinModelPortaliP05156
SMRiP05156
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109652, 4 interactors
IntActiP05156, 1 interactor
STRINGi9606.ENSP00000378130

Protein family/group databases

MEROPSiS01.199

PTM databases

GlyConnecti742
iPTMnetiP05156
PhosphoSitePlusiP05156
UniCarbKBiP05156

Polymorphism and mutation databases

BioMutaiCFI
DMDMi317373341

2D gel databases

SWISS-2DPAGEiP05156

Proteomic databases

EPDiP05156
MaxQBiP05156
PaxDbiP05156
PeptideAtlasiP05156
PRIDEiP05156
ProteomicsDBi51807

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394634; ENSP00000378130; ENSG00000205403
GeneIDi3426
KEGGihsa:3426
UCSCiuc003hzr.5 human

Organism-specific databases

CTDi3426
DisGeNETi3426
EuPathDBiHostDB:ENSG00000205403.12
GeneCardsiCFI
GeneReviewsiCFI
HGNCiHGNC:5394 CFI
HPAiCAB016777
HPA001143
HPA024061
MalaCardsiCFI
MIMi217030 gene
610984 phenotype
612923 phenotype
615439 phenotype
neXtProtiNX_P05156
OpenTargetsiENSG00000205403
Orphaneti93580 Atypical hemolytic-uremic syndrome with I factor anomaly
244275 De novo thrombotic microangiopathy after kidney transplantation
75376 Familial drusen
244242 HELLP syndrome
200418 Immunodeficiency with factor I anomaly
279 NON RARE IN EUROPE: Age-related macular degeneration
PharmGKBiPA29641
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00930000151042
HOGENOMiHOG000060288
HOVERGENiHBG005311
InParanoidiP05156
KOiK01333
PhylomeDBiP05156
TreeFamiTF330647

Enzyme and pathway databases

BRENDAi3.4.21.45 2681
ReactomeiR-HSA-977606 Regulation of Complement cascade
SIGNORiP05156

Miscellaneous databases

EvolutionaryTraceiP05156
GeneWikiiComplement_factor_I
GenomeRNAii3426
PROiPR:P05156
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205403 Expressed in 177 organ(s), highest expression level in visceral pleura
CleanExiHS_CFI
ExpressionAtlasiP05156 baseline and differential
GenevisibleiP05156 HS

Family and domain databases

CDDicd00112 LDLa, 2 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR003884 FacI_MAC
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 2 hits
PF00530 SRCR, 1 hit
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00057 FIMAC, 1 hit
SM00192 LDLa, 2 hits
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 2 hits
PS50287 SRCR_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFAI_HUMAN
AccessioniPrimary (citable) accession number: P05156
Secondary accession number(s): O60442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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