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UniProtKB - P05141 (ADT2_HUMAN)

Entry version 234 (25 May 2022)
Sequence version 7 (11 Jan 2011)
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Protein

ADP/ATP translocase 2

Gene

SLC25A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).

Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).

In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity).

Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity).

Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity).

Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity).

Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity).

Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789).

It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity).

Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).

As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Chromosome partition, Host-virus interaction, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05141

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-180897, Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P05141

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.29.1.1, the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP/ATP translocase 2Curated
Alternative name(s):
ADP,ATP carrier protein 21 Publication
ADP,ATP carrier protein, fibroblast isoform1 Publication
Adenine nucleotide translocator 21 Publication
Short name:
ANT 2
Solute carrier family 25 member 5Curated
Cleaved into the following chain:
ADP/ATP translocase 2, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A5Imported
Synonyms:AAC2By similarity, ANT21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10991, SLC25A5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05141

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000005022

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7Mitochondrial intermembraneCurated7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Topological domaini38 – 74Mitochondrial matrixCuratedAdd BLAST37
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Topological domaini100 – 109Mitochondrial intermembraneCurated10
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Topological domaini131 – 178Mitochondrial matrixCuratedAdd BLAST48
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Topological domaini200 – 210Mitochondrial intermembraneCuratedAdd BLAST11
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Topological domaini232 – 273Mitochondrial matrixCuratedAdd BLAST42
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18
Topological domaini292 – 298Mitochondrial intermembraneCurated7

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		292

Open Targets

More...OpenTargetsi		ENSG00000005022

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35867

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05141, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3709670

Drug and drug target database

More...DrugBanki		DB00720, Clodronic acid
DB01077, Etidronic acid

DrugCentral

More...DrugCentrali		P05141

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC25A5

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373597

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232201 – 298ADP/ATP translocase 2Add BLAST298
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000905792 – 298ADP/ATP translocase 2, N-terminally processedAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in ADP/ATP translocase 2, N-terminally processedCombined sources2 Publications1
Modified residuei7PhosphoserineBy similarity1
Modified residuei23N6-malonyllysine1 Publication1
Modified residuei43N6-succinyllysineBy similarity1
Modified residuei52N6,N6,N6-trimethyllysine; alternateCombined sources1 Publication1
Modified residuei52N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei52N6-methyllysine; alternate1 Publication1
Modified residuei92N6-malonyllysine1 Publication1
Modified residuei96N6-malonyllysine1 Publication1
Modified residuei105N6-acetyllysine; alternateCombined sources1
Modified residuei105N6-succinyllysine; alternateBy similarity1
Modified residuei147N6-acetyllysine; alternateBy similarity1
Modified residuei147N6-malonyllysine; alternate1 Publication1
Modified residuei147N6-methyllysine; alternateCombined sources1
Modified residuei147N6-succinyllysine; alternateBy similarity1
Modified residuei163N6-acetyllysineCombined sources1
Modified residuei166N6-acetyllysineBy similarity1
Modified residuei268N6-acetyllysine; alternateBy similarity1
Modified residuei268N6-succinyllysine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Trimethylated by ANTKMT at Lys-52.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05141

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05141

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05141

MaxQB - The MaxQuant DataBase

More...MaxQBi		P05141

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05141

PeptideAtlas

More...PeptideAtlasi		P05141

PRoteomics IDEntifications database

More...PRIDEi		P05141

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51804

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P05141

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05141, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05141

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P05141

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05141

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P05141

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in erythrocytes (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000005022, Expressed in cortex of kidney and 248 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05141, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000005022, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (By similarity).

Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5/ANT2 (PubMed:20797633).

Interacts with AK4 (PubMed:19130895).

Interacts with ARHGAP11B, thereby inhibiting the mitochondrial permeability transition pore (mPTP) (PubMed:31883789).

Interacts with TIMM44; leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).

By similarity3 Publications

(Microbial infection) Interacts with HIV-1 Vpr.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106789, 314 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P05141

Database of interacting proteins

More...DIPi		DIP-33873N

Protein interaction database and analysis system

More...IntActi		P05141, 184 interactors

Molecular INTeraction database

More...MINTi		P05141

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360671

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05141, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P05141

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05141

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi235 – 240Nucleotide carrier signature motifBy similarity6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0749, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154400

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015166_12_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05141

Identification of Orthologs from Complete Genome Data

More...OMAi		GYGKWLA

Database of Orthologous Groups

More...OrthoDBi		870903at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05141

TreeFam database of animal gene trees

More...TreeFami		TF300743

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002113, ADT_euk_type
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR45635, PTHR45635, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00153, Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00927, ADPTRNSLCASE
PR00926, MITOCARRIER

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103506, SSF103506, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50920, SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P05141-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ 
        60         70         80         90        100
YKGIIDCVVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL 
       110        120        130        140        150
GGVDKRTQFW LYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKAGA 
       160        170        180        190        200
EREFRGLGDC LVKIYKSDGI KGLYQGFNVS VQGIIIYRAA YFGIYDTAKG 
       210        220        230        240        250
MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM QSGRKGTDIM 
       260        270        280        290 
YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT
Length:298
Mass (Da):32,852
Last modified:January 11, 2011 - v7
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC53D083E7217AFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6V → L in AAA35579 (PubMed:3031073).Curated1
Sequence conflicti43K → M in BAG37698 (PubMed:14702039).Curated1
Sequence conflicti66G → E in AAA35579 (PubMed:3031073).Curated1
Sequence conflicti162V → G in AAA36749 (PubMed:2829183).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030039111L → R4 PublicationsCorresponds to variant dbSNP:rs371749Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M57424 Genomic DNA Translation: AAA51737.1
J02683 mRNA Translation: AAA35579.1
L78810 Genomic DNA Translation: AAB39266.1
AK315292 mRNA Translation: BAG37698.1
AC004000 Genomic DNA Translation: AAB96347.1
BC056160 mRNA Translation: AAH56160.1
J03591 mRNA Translation: AAA36749.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14578.1

Protein sequence database of the Protein Information Resource

More...PIRi		A29132

NCBI Reference Sequences

More...RefSeqi		NP_001143.2, NM_001152.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317881.9; ENSP00000360671.4; ENSG00000005022.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		292

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:292

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000317881.9; ENSP00000360671.4; NM_001152.5; NP_001143.2

UCSC genome browser

More...UCSCi		uc004erh.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57424 Genomic DNA Translation: AAA51737.1
J02683 mRNA Translation: AAA35579.1
L78810 Genomic DNA Translation: AAB39266.1
AK315292 mRNA Translation: BAG37698.1
AC004000 Genomic DNA Translation: AAB96347.1
BC056160 mRNA Translation: AAH56160.1
J03591 mRNA Translation: AAA36749.1
CCDSiCCDS14578.1
PIRiA29132
RefSeqiNP_001143.2, NM_001152.4

3D structure databases

AlphaFoldDBiP05141
SMRiP05141
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106789, 314 interactors
CORUMiP05141
DIPiDIP-33873N
IntActiP05141, 184 interactors
MINTiP05141
STRINGi9606.ENSP00000360671

Chemistry databases

ChEMBLiCHEMBL3709670
DrugBankiDB00720, Clodronic acid
DB01077, Etidronic acid
DrugCentraliP05141

Protein family/group databases

TCDBi2.A.29.1.1, the mitochondrial carrier (mc) family

PTM databases

GlyGeniP05141, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP05141
MetOSiteiP05141
PhosphoSitePlusiP05141
SwissPalmiP05141

Genetic variation databases

BioMutaiSLC25A5
DMDMi317373597

Proteomic databases

EPDiP05141
jPOSTiP05141
MassIVEiP05141
MaxQBiP05141
PaxDbiP05141
PeptideAtlasiP05141
PRIDEiP05141
ProteomicsDBi51804
TopDownProteomicsiP05141

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29785, 106 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		292

Genome annotation databases

EnsembliENST00000317881.9; ENSP00000360671.4; ENSG00000005022.6
GeneIDi292
KEGGihsa:292
MANE-SelectiENST00000317881.9; ENSP00000360671.4; NM_001152.5; NP_001143.2
UCSCiuc004erh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		292
DisGeNETi292

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC25A5
HGNCiHGNC:10991, SLC25A5
HPAiENSG00000005022, Low tissue specificity
MIMi300150, gene
neXtProtiNX_P05141
OpenTargetsiENSG00000005022
PharmGKBiPA35867
VEuPathDBiHostDB:ENSG00000005022

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0749, Eukaryota
GeneTreeiENSGT00940000154400
HOGENOMiCLU_015166_12_0_1
InParanoidiP05141
OMAiGYGKWLA
OrthoDBi870903at2759
PhylomeDBiP05141
TreeFamiTF300743

Enzyme and pathway databases

PathwayCommonsiP05141
ReactomeiR-HSA-180897, Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
SignaLinkiP05141

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		292, 180 hits in 704 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC25A5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		292
PharosiP05141, Tchem

Protein Ontology

More...PROi		PR:P05141
RNActiP05141, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000005022, Expressed in cortex of kidney and 248 other tissues
GenevisibleiP05141, HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113, ADT_euk_type
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf
PANTHERiPTHR45635, PTHR45635, 1 hit
PfamiView protein in Pfam
PF00153, Mito_carr, 3 hits
PRINTSiPR00927, ADPTRNSLCASE
PR00926, MITOCARRIER
SUPFAMiSSF103506, SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920, SOLCAR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05141
Secondary accession number(s): B2RCV1, O43350
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 11, 2011
Last modified: May 25, 2022
This is version 234 of the entry and version 7 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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