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Protein

Natriuretic peptides A

Gene

Nppa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive

Enzyme and pathway databases

ReactomeiR-MMU-5578768 Physiological factors

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following 5 chains:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Alternative name(s):
Atriopeptin I
Alternative name(s):
Atriopeptin II
Gene namesi
Name:Nppa
Synonyms:Pnd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97367 Nppa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display increased arterial blood pressure which is dietary salt intake independent. During pregnancy, increased blood pressure is observed, leading to late gestational proteinuria and smaller litters. Impaired trophoblast invasion and smaller spiral arteries are also observed in E12.5 embryos. In E18.5 embryos, mice display fewer trophoblasts and smaller arteries in the decidua and myometrium than those in wild-type mice.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi122R → A: Abolishes maturation and cleavage by CORIN. 1 Publication1
Mutagenesisi125R → A: Does not affect maturation and cleavage by CORIN. 1 Publication1
Mutagenesisi126R → A: Does not affect maturation and cleavage by CORIN. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
PropeptideiPRO_000000149525 – 122CuratedAdd BLAST98
PeptideiPRO_0000391784123 – 150Atrial natriuretic factor1 PublicationAdd BLAST28
PeptideiPRO_0000001496126 – 150Auriculin-BBy similarityAdd BLAST25
PeptideiPRO_0000001497126 – 149Auriculin-ABy similarityAdd BLAST24
PeptideiPRO_0000001498127 – 149Atriopeptin-1By similarityAdd BLAST23
PeptideiPRO_0000001499127 – 147Atriopeptin-2By similarityAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi129 ↔ 145By similarity

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.2 Publications
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei122 – 123Cleavage; by CORIN1 Publication2
Sitei129 – 130Cleavage; by MMEBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP05125
PeptideAtlasiP05125
PRIDEiP05125

PTM databases

iPTMnetiP05125
PhosphoSitePlusiP05125

Expressioni

Gene expression databases

BgeeiENSMUSG00000041616 Expressed in 83 organ(s), highest expression level in cardiac atrium
CleanExiMM_NPPA
GenevisibleiP05125 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP05125, 4 interactors
MINTiP05125
STRINGi10090.ENSMUSP00000099520

Structurei

3D structure databases

ProteinModelPortaliP05125
SMRiP05125
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F Eukaryota
ENOG410ZUY6 LUCA
GeneTreeiENSGT00510000048659
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiP05125
KOiK12334
OMAiCNSFRYR
OrthoDBiEOG091G0SV3
TreeFamiTF106304

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002407 Natriuretic_peptide_atrial
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00711 ANATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05125-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSFSITLGF FLVLAFWLPG HIGANPVYSA VSNTDLMDFK NLLDHLEEKM
60 70 80 90 100
PVEDEVMPPQ ALSEQTEEAG AALSSLPEVP PWTGEVNPPL RDGSALGRSP
110 120 130 140 150
WDPSDRSALL KSKLRALLAG PRSLRRSSCF GGRIDRIGAQ SGLGCNSFRY

RR
Length:152
Mass (Da):16,572
Last modified:October 3, 2012 - v2
Checksum:i1693D134B5FCA23D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96 – 97LG → SR in AAA37235 (PubMed:6542248).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02781 Genomic DNA Translation: AAA37235.1
AK147180 mRNA Translation: BAE27742.1
AL714013 Genomic DNA Translation: CAM14483.1
CU210867 Genomic DNA Translation: CAQ52160.1
CH466594 Genomic DNA Translation: EDL14792.1
BC089615 mRNA Translation: AAH89615.1
CCDSiCCDS18927.1
PIRiA29370 AWMS
RefSeqiNP_032751.1, NM_008725.3
UniGeneiMm.482123

Genome annotation databases

EnsembliENSMUST00000103230; ENSMUSP00000099520; ENSMUSG00000041616
GeneIDi230899
KEGGimmu:230899
UCSCiuc008vtq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiANF_MOUSE
AccessioniPrimary (citable) accession number: P05125
Secondary accession number(s): Q5FW59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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