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Entry version 224 (08 May 2019)
Sequence version 1 (13 Aug 1987)
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Protein

Plasminogen activator inhibitor 1

Gene

SERPINE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).By similarity11 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei369 – 370Reactive bond2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-3000178 ECM proteoglycans
R-HSA-75205 Dissolution of Fibrin Clot

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05121

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I04.020

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasminogen activator inhibitor 1
Short name:
PAI
Short name:
PAI-1
Alternative name(s):
Endothelial plasminogen activator inhibitor
Serpin E1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERPINE1
Synonyms:PAI1, PLANH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8583 SERPINE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173360 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05121

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Plasminogen activator inhibitor-1 deficiency (PAI-1D)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. A rare PAI-1D mutation resulting in a frameshift and protein truncation has been found in an Old Order Amish community. Homozygous mutation carriers suffer from episodes of major hemorrhage, while heterozygous carriers do not manifest abnormal bleeding (PubMed:9207454). Heterozygosity for the mutation is associated with longer leukocyte telomere length, lower fasting insulin levels, lower prevalence of diabetes mellitus, and a longer life span (PubMed:29152572).2 Publications
Disease descriptionA hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.
See also OMIM:613329

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi197Q → C: Increased half-life of the active form when associated with C-355. 1 Publication1
Mutagenesisi355G → C: Increased half-life of the active form when associated with C-197. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5054

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SERPINE1

MalaCards human disease database

More...
MalaCardsi
SERPINE1
MIMi613329 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000106366

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
465 Congenital plasminogen activator inhibitor type 1 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA261

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3475

Drug and drug target database

More...
DrugBanki
DB00009 Alteplase
DB00029 Anistreplase
DB00055 Drotrecogin alfa
DB05254 Plasmin
DB00015 Reteplase
DB00031 Tenecteplase
DB00197 Troglitazone
DB00013 Urokinase

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERPINE1

Domain mapping of disease mutations (DMDM)

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DMDMi
129576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Add BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003249924 – 402Plasminogen activator inhibitor 1Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi232N-linked (GlcNAc...) asparagine1
Glycosylationi288N-linked (GlcNAc...) asparagine1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P05121

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P05121

MaxQB - The MaxQuant DataBase

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MaxQBi
P05121

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05121

PeptideAtlas

More...
PeptideAtlasi
P05121

PRoteomics IDEntifications database

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PRIDEi
P05121

ProteomicsDB human proteome resource

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ProteomicsDBi
51802

2D gel databases

USC-OGP 2-DE database

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OGPi
P05121

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P05121

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
639

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P05121

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P05121

UniCarbKB; an annotated and curated database of glycan structures

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UniCarbKBi
P05121

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P05121

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106366 Expressed in 173 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P05121 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P05121 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068501
HPA050039

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with TMPRSS7 (PubMed:15853774). Interacts with VTN (PubMed:7522053). Binds LRP1B; binding is followed by internalization and degradation (PubMed:11384978). Interacts with PPP1CB (PubMed:28296156).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111091, 18 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-475 Vitronectin-PAI-1 complex
CPX-483 uPA-PAI-1 complex
CPX-494 tPA-PAI-1 complex

Protein interaction database and analysis system

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IntActi
P05121, 18 interactors

Molecular INTeraction database

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MINTi
P05121

STRING: functional protein association networks

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STRINGi
9606.ENSP00000223095

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P05121

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1402
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7CX-ray1.95A24-402[»]
1B3KX-ray2.99A/B/C/D24-402[»]
1C5GX-ray2.60A1-402[»]
1DB2X-ray2.70A/B26-402[»]
1DVMX-ray2.40A/B/C/D24-402[»]
1DVNX-ray2.10A24-402[»]
1LJ5X-ray1.80A24-402[»]
1OC0X-ray2.28A24-402[»]
3CVMX-ray2.02A/B21-402[»]
3EOXX-ray2.61A24-402[»]
3PB1X-ray2.30I24-402[»]
3Q02X-ray2.30A/B24-402[»]
3Q03X-ray2.64A/B24-402[»]
3R4LX-ray2.70A24-402[»]
3UT3X-ray2.42A/B/C/D28-402[»]
4AQHX-ray2.40A/B/C24-402[»]
4G8OX-ray2.71A/B/C/D28-402[»]
4G8RX-ray2.19A/B28-402[»]
4IC0X-ray2.32A/B/C/D24-402[»]
5BRRX-ray3.16I24-402[»]
6I8SX-ray2.90A/B/C/D24-402[»]
9PAIX-ray2.70A24-369[»]
B370-402[»]

Database of protein disorder

More...
DisProti
DP00320

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05121

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05121

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2392 Eukaryota
COG4826 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160621

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000238519

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05121

KEGG Orthology (KO)

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KOi
K03982

Identification of Orthologs from Complete Genome Data

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OMAi
YFNGQWK

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P05121

TreeFam database of animal gene trees

More...
TreeFami
TF352620

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf

The PANTHER Classification System

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PANTHERi
PTHR11461 PTHR11461, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00079 Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00093 SERPIN, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56574 SSF56574, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00284 SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P05121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQMSPALTCL VLGLALVFGE GSAVHHPPSY VAHLASDFGV RVFQQVAQAS
60 70 80 90 100
KDRNVVFSPY GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH
110 120 130 140 150
LYKELMGPWN KDEISTTDAI FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS
160 170 180 190 200
EVERARFIIN DWVKTHTKGM ISNLLGKGAV DQLTRLVLVN ALYFNGQWKT
210 220 230 240 250
PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD GHYYDILELP
260 270 280 290 300
YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK
310 320 330 340 350
FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE
360 370 380 390 400
VNESGTVASS STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM

EP
Length:402
Mass (Da):45,060
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2E181ED28DD6082
GO
Isoform 2 (identifier: P05121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-45: Missing.

Note: No experimental confirmation available.
Show »
Length:387
Mass (Da):43,404
Checksum:i9BFE4D37D0F81361
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53R → A in CAA31208 (Ref. 7) Curated1
Sequence conflicti55V → L in AAA60009 (PubMed:2820474).Curated1
Sequence conflicti75G → V in CAA31208 (Ref. 7) Curated1
Sequence conflicti138R → K in CAA31208 (Ref. 7) Curated1
Sequence conflicti226A → V in BAH12656 (PubMed:14702039).Curated1
Sequence conflicti280 – 282QLI → HVM in CAA31208 (Ref. 7) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00709915A → T3 PublicationsCorresponds to variant dbSNP:rs6092EnsemblClinVar.1
Natural variantiVAR_01175017V → I2 PublicationsCorresponds to variant dbSNP:rs6090EnsemblClinVar.1
Natural variantiVAR_01308625H → P1 PublicationCorresponds to variant dbSNP:rs2227647Ensembl.1
Natural variantiVAR_013087209R → H1 PublicationCorresponds to variant dbSNP:rs2227669Ensembl.1
Natural variantiVAR_013088255T → N1 PublicationCorresponds to variant dbSNP:rs2227685Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04549331 – 45Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04429 mRNA Translation: CAA28025.1
M14083 mRNA Translation: AAA60008.1
X04729 mRNA Translation: CAA28438.1
X04731 mRNA Translation: CAA28442.1
M16006 mRNA Translation: AAA60003.1
M22321
, M22314, M22315, M22316, M22317, M22318, M22319, M22320 Genomic DNA Translation: AAA60009.1
X13323 Genomic DNA No translation available.
X13338 Genomic DNA Translation: CAA31722.1
X13339 Genomic DNA Translation: CAB51639.1
X13340 Genomic DNA Translation: CAB51737.1
X13341 Genomic DNA Translation: CAB51606.1
X13342 Genomic DNA Translation: CAB51607.1
X13343 Genomic DNA Translation: CAB51738.1
X13344 Genomic DNA Translation: CAB51739.1
X13345 Genomic DNA Translation: CAA31729.1
J03764 Genomic DNA Translation: AAA60007.1
X12701 mRNA Translation: CAA31208.1
AF386492 Genomic DNA Translation: AAK60338.1
AK297728 mRNA Translation: BAH12656.1
AC004876 Genomic DNA Translation: AAD45828.1
BC010860 mRNA Translation: AAH10860.1
X04744 mRNA Translation: CAA28444.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5711.1 [P05121-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A28107 ITHUP1

NCBI Reference Sequences

More...
RefSeqi
NP_000593.1, NM_000602.4 [P05121-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000223095; ENSP00000223095; ENSG00000106366 [P05121-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5054

UCSC genome browser

More...
UCSCi
uc003uxt.4 human [P05121-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Plasminogen activator inhibitor-1 entry

SeattleSNPs
Protein Spotlight

Giving in to time - Issue 203 of May 2018

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04429 mRNA Translation: CAA28025.1
M14083 mRNA Translation: AAA60008.1
X04729 mRNA Translation: CAA28438.1
X04731 mRNA Translation: CAA28442.1
M16006 mRNA Translation: AAA60003.1
M22321
, M22314, M22315, M22316, M22317, M22318, M22319, M22320 Genomic DNA Translation: AAA60009.1
X13323 Genomic DNA No translation available.
X13338 Genomic DNA Translation: CAA31722.1
X13339 Genomic DNA Translation: CAB51639.1
X13340 Genomic DNA Translation: CAB51737.1
X13341 Genomic DNA Translation: CAB51606.1
X13342 Genomic DNA Translation: CAB51607.1
X13343 Genomic DNA Translation: CAB51738.1
X13344 Genomic DNA Translation: CAB51739.1
X13345 Genomic DNA Translation: CAA31729.1
J03764 Genomic DNA Translation: AAA60007.1
X12701 mRNA Translation: CAA31208.1
AF386492 Genomic DNA Translation: AAK60338.1
AK297728 mRNA Translation: BAH12656.1
AC004876 Genomic DNA Translation: AAD45828.1
BC010860 mRNA Translation: AAH10860.1
X04744 mRNA Translation: CAA28444.1
CCDSiCCDS5711.1 [P05121-1]
PIRiA28107 ITHUP1
RefSeqiNP_000593.1, NM_000602.4 [P05121-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7CX-ray1.95A24-402[»]
1B3KX-ray2.99A/B/C/D24-402[»]
1C5GX-ray2.60A1-402[»]
1DB2X-ray2.70A/B26-402[»]
1DVMX-ray2.40A/B/C/D24-402[»]
1DVNX-ray2.10A24-402[»]
1LJ5X-ray1.80A24-402[»]
1OC0X-ray2.28A24-402[»]
3CVMX-ray2.02A/B21-402[»]
3EOXX-ray2.61A24-402[»]
3PB1X-ray2.30I24-402[»]
3Q02X-ray2.30A/B24-402[»]
3Q03X-ray2.64A/B24-402[»]
3R4LX-ray2.70A24-402[»]
3UT3X-ray2.42A/B/C/D28-402[»]
4AQHX-ray2.40A/B/C24-402[»]
4G8OX-ray2.71A/B/C/D28-402[»]
4G8RX-ray2.19A/B28-402[»]
4IC0X-ray2.32A/B/C/D24-402[»]
5BRRX-ray3.16I24-402[»]
6I8SX-ray2.90A/B/C/D24-402[»]
9PAIX-ray2.70A24-369[»]
B370-402[»]
DisProtiDP00320
SMRiP05121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111091, 18 interactors
ComplexPortaliCPX-475 Vitronectin-PAI-1 complex
CPX-483 uPA-PAI-1 complex
CPX-494 tPA-PAI-1 complex
IntActiP05121, 18 interactors
MINTiP05121
STRINGi9606.ENSP00000223095

Chemistry databases

BindingDBiP05121
ChEMBLiCHEMBL3475
DrugBankiDB00009 Alteplase
DB00029 Anistreplase
DB00055 Drotrecogin alfa
DB05254 Plasmin
DB00015 Reteplase
DB00031 Tenecteplase
DB00197 Troglitazone
DB00013 Urokinase

Protein family/group databases

MEROPSiI04.020

PTM databases

GlyConnecti639
iPTMnetiP05121
PhosphoSitePlusiP05121
UniCarbKBiP05121

Polymorphism and mutation databases

BioMutaiSERPINE1
DMDMi129576

2D gel databases

OGPiP05121
SWISS-2DPAGEiP05121

Proteomic databases

EPDiP05121
jPOSTiP05121
MaxQBiP05121
PaxDbiP05121
PeptideAtlasiP05121
PRIDEiP05121
ProteomicsDBi51802

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5054
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223095; ENSP00000223095; ENSG00000106366 [P05121-1]
GeneIDi5054
KEGGihsa:5054
UCSCiuc003uxt.4 human [P05121-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5054
DisGeNETi5054

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SERPINE1
GeneReviewsiSERPINE1
HGNCiHGNC:8583 SERPINE1
HPAiCAB068501
HPA050039
MalaCardsiSERPINE1
MIMi173360 gene
613329 phenotype
neXtProtiNX_P05121
OpenTargetsiENSG00000106366
Orphaneti465 Congenital plasminogen activator inhibitor type 1 deficiency
PharmGKBiPA261

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00940000160621
HOGENOMiHOG000238519
InParanoidiP05121
KOiK03982
OMAiYFNGQWK
OrthoDBi1318335at2759
PhylomeDBiP05121
TreeFamiTF352620

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-3000178 ECM proteoglycans
R-HSA-75205 Dissolution of Fibrin Clot
SIGNORiP05121

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SERPINE1 human
EvolutionaryTraceiP05121

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Plasminogen_activator_inhibitor-1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5054
PMAP-CutDBiP05121

Protein Ontology

More...
PROi
PR:P05121

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106366 Expressed in 173 organ(s), highest expression level in left coronary artery
ExpressionAtlasiP05121 baseline and differential
GenevisibleiP05121 HS

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05121
Secondary accession number(s): B7Z4S0, F8WD53
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 8, 2019
This is version 224 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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