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Protein

Plasminogen activator inhibitor 2

Gene

SERPINB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei380 – 381Reactive bond2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processPlasminogen activation

Enzyme and pathway databases

ReactomeiR-HSA-75205 Dissolution of Fibrin Clot
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP05120

Protein family/group databases

MEROPSiI04.007

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2
Short name:
PAI-2
Alternative name(s):
Monocyte Arg-serpin
Placental plasminogen activator inhibitor
Serpin B2
Urokinase inhibitor
Gene namesi
Name:SERPINB2
Synonyms:PAI2, PLANH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000197632.8
HGNCiHGNC:8584 SERPINB2
MIMi173390 gene
neXtProtiNX_P05120

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5055
OpenTargetsiENSG00000197632
PharmGKBiPA35500

Chemistry databases

DrugBankiDB00031 Tenecteplase
DB00013 Urokinase

Polymorphism and mutation databases

BioMutaiSERPINB2
DMDMi1352712

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232961 – 415Plasminogen activator inhibitor 2Add BLAST415
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 405
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP05120
MaxQBiP05120
PaxDbiP05120
PeptideAtlasiP05120
PRIDEiP05120
ProteomicsDBi51801

PTM databases

iPTMnetiP05120
PhosphoSitePlusiP05120
SwissPalmiP05120

Expressioni

Gene expression databases

BgeeiENSG00000197632 Expressed in 118 organ(s), highest expression level in amniotic fluid
CleanExiHS_SERPINB2
ExpressionAtlasiP05120 baseline and differential
GenevisibleiP05120 HS

Organism-specific databases

HPAiHPA015480

Interactioni

Subunit structurei

Interacts with PSMB1.1 Publication

Protein-protein interaction databases

BioGridi111092, 56 interactors
IntActiP05120, 1 interactor
STRINGi9606.ENSP00000299502

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05120
SMRiP05120
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05120

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP05120
KOiK19821
OMAiFIMHKIT
OrthoDBiEOG091G0ION
PhylomeDBiP05120
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR015556 PAI-2
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF61 PTHR11461:SF61, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P05120-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST
60 70 80 90 100
EDQMAKVLQF NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA
110 120 130 140 150
DKIHSSFRSL SSAINASTGN YLLESVNKLF GEKSASFREE YIRLCQKYYS
160 170 180 190 200
SEPQAVDFLE CAEEARKKIN SWVKTQTKGK IPNLLPEGSV DGDTRMVLVN
210 220 230 240 250
AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK LNIGYIEDLK
260 270 280 290 300
AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM
310 320 330 340 350
AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF
360 370 380 390 400
LSEVFHQAMV DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH
410
KITNCILFFG RFSSP
Length:415
Mass (Da):46,596
Last modified:February 1, 1996 - v2
Checksum:i10DFAB5A4B1246FF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERB5E7ERB5_HUMAN
Plasminogen activator inhibitor 2
SERPINB2
132Annotation score:
E9PDK7E9PDK7_HUMAN
Plasminogen activator inhibitor 2
SERPINB2
113Annotation score:
E7EPJ9E7EPJ9_HUMAN
Plasminogen activator inhibitor 2
SERPINB2
161Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170N → Y in AAH12609 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011743120N → D1 PublicationCorresponds to variant dbSNP:rs6098Ensembl.1
Natural variantiVAR_014173229R → H1 PublicationCorresponds to variant dbSNP:rs6100Ensembl.1
Natural variantiVAR_051946374G → A. Corresponds to variant dbSNP:rs34066931Ensembl.1
Natural variantiVAR_011744404N → K1 PublicationCorresponds to variant dbSNP:rs6103Ensembl.1
Natural variantiVAR_011745413S → C1 PublicationCorresponds to variant dbSNP:rs6104Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02685 mRNA Translation: AAA36413.1
M18082 mRNA Translation: AAA60006.1
Y00630 mRNA Translation: CAA68666.1
J03603 mRNA Translation: AAA60004.1
M24657
, M24651, M24652, M24653, M24654, M24655, M24656 Genomic DNA Translation: AAA60348.1
M31551
, M31547, M31548, M31549, M31550 Genomic DNA Translation: AAA36797.1
BC012609 mRNA Translation: AAH12609.1
CCDSiCCDS11989.1
PIRiA32853
RefSeqiNP_001137290.1, NM_001143818.1
NP_002566.1, NM_002575.2
UniGeneiHs.594481

Genome annotation databases

EnsembliENST00000299502; ENSP00000299502; ENSG00000197632
ENST00000457692; ENSP00000401645; ENSG00000197632
GeneIDi5055
KEGGihsa:5055
UCSCiuc002ljo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02685 mRNA Translation: AAA36413.1
M18082 mRNA Translation: AAA60006.1
Y00630 mRNA Translation: CAA68666.1
J03603 mRNA Translation: AAA60004.1
M24657
, M24651, M24652, M24653, M24654, M24655, M24656 Genomic DNA Translation: AAA60348.1
M31551
, M31547, M31548, M31549, M31550 Genomic DNA Translation: AAA36797.1
BC012609 mRNA Translation: AAH12609.1
CCDSiCCDS11989.1
PIRiA32853
RefSeqiNP_001137290.1, NM_001143818.1
NP_002566.1, NM_002575.2
UniGeneiHs.594481

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY7X-ray2.00A1-415[»]
1JRRX-ray1.60A1-415[»]
P367-380[»]
2ARQX-ray1.85A1-415[»]
P367-380[»]
2ARRX-ray1.55A1-415[»]
P367-380[»]
ProteinModelPortaliP05120
SMRiP05120
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111092, 56 interactors
IntActiP05120, 1 interactor
STRINGi9606.ENSP00000299502

Chemistry databases

DrugBankiDB00031 Tenecteplase
DB00013 Urokinase

Protein family/group databases

MEROPSiI04.007

PTM databases

iPTMnetiP05120
PhosphoSitePlusiP05120
SwissPalmiP05120

Polymorphism and mutation databases

BioMutaiSERPINB2
DMDMi1352712

Proteomic databases

EPDiP05120
MaxQBiP05120
PaxDbiP05120
PeptideAtlasiP05120
PRIDEiP05120
ProteomicsDBi51801

Protocols and materials databases

DNASUi5055
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299502; ENSP00000299502; ENSG00000197632
ENST00000457692; ENSP00000401645; ENSG00000197632
GeneIDi5055
KEGGihsa:5055
UCSCiuc002ljo.4 human

Organism-specific databases

CTDi5055
DisGeNETi5055
EuPathDBiHostDB:ENSG00000197632.8
GeneCardsiSERPINB2
H-InvDBiHIX0212740
HGNCiHGNC:8584 SERPINB2
HPAiHPA015480
MIMi173390 gene
neXtProtiNX_P05120
OpenTargetsiENSG00000197632
PharmGKBiPA35500
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP05120
KOiK19821
OMAiFIMHKIT
OrthoDBiEOG091G0ION
PhylomeDBiP05120
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-HSA-75205 Dissolution of Fibrin Clot
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP05120

Miscellaneous databases

ChiTaRSiSERPINB2 human
EvolutionaryTraceiP05120
GeneWikiiPlasminogen_activator_inhibitor-2
GenomeRNAii5055
PROiPR:P05120
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197632 Expressed in 118 organ(s), highest expression level in amniotic fluid
CleanExiHS_SERPINB2
ExpressionAtlasiP05120 baseline and differential
GenevisibleiP05120 HS

Family and domain databases

InterProiView protein in InterPro
IPR015556 PAI-2
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF61 PTHR11461:SF61, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAI2_HUMAN
AccessioniPrimary (citable) accession number: P05120
Secondary accession number(s): Q96E96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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