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Protein

Interleukin-5

Gene

IL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-912526 Interleukin receptor SHC signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P05113

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05113

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
B-cell differentiation factor I
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113525.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6016 IL5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147850 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05113

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3567

Open Targets

More...
OpenTargetsi
ENSG00000113525

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29833

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1169600

Drug and drug target database

More...
DrugBanki
DB06612 Mepolizumab
DB01411 Pranlukast

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124341

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001556020 – 134Interleukin-5Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi22O-linked (GalNAc...) threonine1 Publication1
Glycosylationi47N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi63Interchain (with C-105)1 Publication
Disulfide bondi105Interchain (with C-63)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei90Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05113

PeptideAtlas

More...
PeptideAtlasi
P05113

PRoteomics IDEntifications database

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PRIDEi
P05113

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51799

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05113

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05113

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113525 Expressed in 80 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05113 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05113 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010304

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109781, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-28N

Protein interaction database and analysis system

More...
IntActi
P05113, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000231454

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P05113

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HULX-ray2.40A/B24-131[»]
3QT2X-ray2.55C/D/E/F19-134[»]
3VA2X-ray2.70A/B23-134[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P05113

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05113

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05113

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYJN Eukaryota
ENOG41117ER LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016991

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074049

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003865

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05113

KEGG Orthology (KO)

More...
KOi
K05428

Identification of Orthologs from Complete Genome Data

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OMAi
GVINTEW

Database of Orthologous Groups

More...
OrthoDBi
1469027at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P05113

TreeFam database of animal gene trees

More...
TreeFami
TF338422

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000186 IL-5

The PANTHER Classification System

More...
PANTHERi
PTHR45421 PTHR45421, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02025 IL5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00432 INTERLEUKIN5

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD006721 Interleukin_5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMLLHLSLL ALGAAYVYAI PTEIPTSALV KETLALLSTH RTLLIANETL
60 70 80 90 100
RIPVPVHKNH QLCTEEIFQG IGTLESQTVQ GGTVERLFKN LSLIKKYIDG
110 120 130
QKKKCGEERR RVNQFLDYLQ EFLGVMNTEW IIES
Length:134
Mass (Da):15,238
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC984467179556A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQP9C9JQP9_HUMAN
Interleukin-5
IL5
51Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti88F → L in CAA31210 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04688 mRNA Translation: CAA28390.1
J03478 Genomic DNA Translation: AAA74469.1
J02971 Genomic DNA Translation: AAA98620.1
X12705 mRNA Translation: CAA31210.1
X12706 Genomic DNA Translation: CAA31211.1
AF353265 Genomic DNA Translation: AAK19759.1
BC066282 mRNA Translation: AAH66282.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4156.1

Protein sequence database of the Protein Information Resource

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PIRi
A28477

NCBI Reference Sequences

More...
RefSeqi
NP_000870.1, NM_000879.2
XP_011541675.1, XM_011543373.2
XP_011541676.1, XM_011543374.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2247

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000231454; ENSP00000231454; ENSG00000113525

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3567

UCSC genome browser

More...
UCSCi
uc003kxe.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-5 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04688 mRNA Translation: CAA28390.1
J03478 Genomic DNA Translation: AAA74469.1
J02971 Genomic DNA Translation: AAA98620.1
X12705 mRNA Translation: CAA31210.1
X12706 Genomic DNA Translation: CAA31211.1
AF353265 Genomic DNA Translation: AAK19759.1
BC066282 mRNA Translation: AAH66282.1
CCDSiCCDS4156.1
PIRiA28477
RefSeqiNP_000870.1, NM_000879.2
XP_011541675.1, XM_011543373.2
XP_011541676.1, XM_011543374.2
UniGeneiHs.2247

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HULX-ray2.40A/B24-131[»]
3QT2X-ray2.55C/D/E/F19-134[»]
3VA2X-ray2.70A/B23-134[»]
ProteinModelPortaliP05113
SMRiP05113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109781, 2 interactors
DIPiDIP-28N
IntActiP05113, 2 interactors
STRINGi9606.ENSP00000231454

Chemistry databases

BindingDBiP05113
ChEMBLiCHEMBL1169600
DrugBankiDB06612 Mepolizumab
DB01411 Pranlukast

PTM databases

iPTMnetiP05113
PhosphoSitePlusiP05113

Polymorphism and mutation databases

BioMutaiIL5
DMDMi124341

Proteomic databases

PaxDbiP05113
PeptideAtlasiP05113
PRIDEiP05113
ProteomicsDBi51799

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231454; ENSP00000231454; ENSG00000113525
GeneIDi3567
KEGGihsa:3567
UCSCiuc003kxe.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3567
DisGeNETi3567
EuPathDBiHostDB:ENSG00000113525.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL5
HGNCiHGNC:6016 IL5
HPAiCAB010304
MIMi147850 gene
neXtProtiNX_P05113
OpenTargetsiENSG00000113525
PharmGKBiPA29833

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYJN Eukaryota
ENOG41117ER LUCA
GeneTreeiENSGT00390000016991
HOGENOMiHOG000074049
HOVERGENiHBG003865
InParanoidiP05113
KOiK05428
OMAiGVINTEW
OrthoDBi1469027at2759
PhylomeDBiP05113
TreeFamiTF338422

Enzyme and pathway databases

ReactomeiR-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP05113
SIGNORiP05113

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL5 human
EvolutionaryTraceiP05113

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3567

Protein Ontology

More...
PROi
PR:P05113

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113525 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_IL5
ExpressionAtlasiP05113 baseline and differential
GenevisibleiP05113 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000186 IL-5
PANTHERiPTHR45421 PTHR45421, 1 hit
PfamiView protein in Pfam
PF02025 IL5, 1 hit
PRINTSiPR00432 INTERLEUKIN5
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721 Interleukin_5, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05113
Secondary accession number(s): Q13840
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: January 16, 2019
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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