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Protein

Interleukin-5

Gene

IL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP05113
SIGNORiP05113

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
B-cell differentiation factor I
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
Gene namesi
Name:IL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113525.9
HGNCiHGNC:6016 IL5
MIMi147850 gene
neXtProtiNX_P05113

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3567
OpenTargetsiENSG00000113525
PharmGKBiPA29833

Chemistry databases

ChEMBLiCHEMBL1169600
DrugBankiDB06612 Mepolizumab
DB01411 Pranlukast

Polymorphism and mutation databases

BioMutaiIL5
DMDMi124341

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001556020 – 134Interleukin-5Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22O-linked (GalNAc...) threonine1 Publication1
Glycosylationi47N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi63Interchain (with C-105)1 Publication
Disulfide bondi105Interchain (with C-63)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei90Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05113
PeptideAtlasiP05113
PRIDEiP05113
ProteomicsDBi51799

PTM databases

iPTMnetiP05113
PhosphoSitePlusiP05113

Expressioni

Gene expression databases

BgeeiENSG00000113525 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_IL5
ExpressionAtlasiP05113 baseline and differential
GenevisibleiP05113 HS

Organism-specific databases

HPAiCAB010304

Interactioni

Subunit structurei

Homodimer; disulfide-linked.4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109781, 2 interactors
DIPiDIP-28N
IntActiP05113, 2 interactors
STRINGi9606.ENSP00000231454

Chemistry databases

BindingDBiP05113

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05113
SMRiP05113
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05113

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJN Eukaryota
ENOG41117ER LUCA
GeneTreeiENSGT00390000016991
HOGENOMiHOG000074049
HOVERGENiHBG003865
InParanoidiP05113
KOiK05428
OMAiGVINTEW
OrthoDBiEOG091G0XPD
PhylomeDBiP05113
TreeFamiTF338422

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000186 IL-5
PANTHERiPTHR45421 PTHR45421, 1 hit
PfamiView protein in Pfam
PF02025 IL5, 1 hit
PRINTSiPR00432 INTERLEUKIN5
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721 Interleukin_5, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMLLHLSLL ALGAAYVYAI PTEIPTSALV KETLALLSTH RTLLIANETL
60 70 80 90 100
RIPVPVHKNH QLCTEEIFQG IGTLESQTVQ GGTVERLFKN LSLIKKYIDG
110 120 130
QKKKCGEERR RVNQFLDYLQ EFLGVMNTEW IIES
Length:134
Mass (Da):15,238
Last modified:August 13, 1987 - v1
Checksum:iDC984467179556A3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQP9C9JQP9_HUMAN
Interleukin-5
IL5
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88F → L in CAA31210 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04688 mRNA Translation: CAA28390.1
J03478 Genomic DNA Translation: AAA74469.1
J02971 Genomic DNA Translation: AAA98620.1
X12705 mRNA Translation: CAA31210.1
X12706 Genomic DNA Translation: CAA31211.1
AF353265 Genomic DNA Translation: AAK19759.1
BC066282 mRNA Translation: AAH66282.1
CCDSiCCDS4156.1
PIRiA28477
RefSeqiNP_000870.1, NM_000879.2
XP_011541675.1, XM_011543373.2
XP_011541676.1, XM_011543374.2
UniGeneiHs.2247

Genome annotation databases

EnsembliENST00000231454; ENSP00000231454; ENSG00000113525
GeneIDi3567
KEGGihsa:3567
UCSCiuc003kxe.1 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-5 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04688 mRNA Translation: CAA28390.1
J03478 Genomic DNA Translation: AAA74469.1
J02971 Genomic DNA Translation: AAA98620.1
X12705 mRNA Translation: CAA31210.1
X12706 Genomic DNA Translation: CAA31211.1
AF353265 Genomic DNA Translation: AAK19759.1
BC066282 mRNA Translation: AAH66282.1
CCDSiCCDS4156.1
PIRiA28477
RefSeqiNP_000870.1, NM_000879.2
XP_011541675.1, XM_011543373.2
XP_011541676.1, XM_011543374.2
UniGeneiHs.2247

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HULX-ray2.40A/B24-131[»]
3QT2X-ray2.55C/D/E/F19-134[»]
3VA2X-ray2.70A/B23-134[»]
ProteinModelPortaliP05113
SMRiP05113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109781, 2 interactors
DIPiDIP-28N
IntActiP05113, 2 interactors
STRINGi9606.ENSP00000231454

Chemistry databases

BindingDBiP05113
ChEMBLiCHEMBL1169600
DrugBankiDB06612 Mepolizumab
DB01411 Pranlukast

PTM databases

iPTMnetiP05113
PhosphoSitePlusiP05113

Polymorphism and mutation databases

BioMutaiIL5
DMDMi124341

Proteomic databases

PaxDbiP05113
PeptideAtlasiP05113
PRIDEiP05113
ProteomicsDBi51799

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231454; ENSP00000231454; ENSG00000113525
GeneIDi3567
KEGGihsa:3567
UCSCiuc003kxe.1 human

Organism-specific databases

CTDi3567
DisGeNETi3567
EuPathDBiHostDB:ENSG00000113525.9
GeneCardsiIL5
HGNCiHGNC:6016 IL5
HPAiCAB010304
MIMi147850 gene
neXtProtiNX_P05113
OpenTargetsiENSG00000113525
PharmGKBiPA29833
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYJN Eukaryota
ENOG41117ER LUCA
GeneTreeiENSGT00390000016991
HOGENOMiHOG000074049
HOVERGENiHBG003865
InParanoidiP05113
KOiK05428
OMAiGVINTEW
OrthoDBiEOG091G0XPD
PhylomeDBiP05113
TreeFamiTF338422

Enzyme and pathway databases

ReactomeiR-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP05113
SIGNORiP05113

Miscellaneous databases

ChiTaRSiIL5 human
EvolutionaryTraceiP05113
GeneWikiiInterleukin_5
GenomeRNAii3567
PROiPR:P05113
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113525 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_IL5
ExpressionAtlasiP05113 baseline and differential
GenevisibleiP05113 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000186 IL-5
PANTHERiPTHR45421 PTHR45421, 1 hit
PfamiView protein in Pfam
PF02025 IL5, 1 hit
PRINTSiPR00432 INTERLEUKIN5
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721 Interleukin_5, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL5_HUMAN
AccessioniPrimary (citable) accession number: P05113
Secondary accession number(s): Q13840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 12, 2018
This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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