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Protein

Interleukin-4

Gene

IL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB
  • interleukin-4 receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Growth factor
Biological processB-cell activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P05112

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05112

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell stimulatory factor 1
Short name:
BSF-1
Binetrakin
Lymphocyte stimulatory factor 1
Pitrakinra
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000113520.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6014 IL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147780 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05112

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ischemic stroke (ISCHSTR)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
See also OMIM:601367

Organism-specific databases

DisGeNET

More...
DisGeNETi
3565
MIMi601367 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113520

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA197

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712894

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Add BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001553225 – 153Interleukin-4Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 1511 Publication
Disulfide bondi48 ↔ 891 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi62N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi70 ↔ 123

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05112

PeptideAtlas

More...
PeptideAtlasi
P05112

PRoteomics IDEntifications database

More...
PRIDEi
P05112

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51797
51798 [P05112-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05112

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05112

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113520 Expressed in 78 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05112 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05112 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA072995

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109779, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P05112

Database of interacting proteins

More...
DIPi
DIP-3222N

Protein interaction database and analysis system

More...
IntActi
P05112, 3 interactors

Molecular INTeraction database

More...
MINTi
P05112

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000231449

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BBNNMR-A25-153[»]
1BCNNMR-A25-153[»]
1CYLNMR-A25-153[»]
1HIJX-ray3.00A25-153[»]
1HIKX-ray2.60A25-153[»]
1HZIX-ray2.05A25-153[»]
1IARX-ray2.30A25-153[»]
1ILLmodel-425-153[»]
1ITEmodel-A25-153[»]
1ITINMR-A25-153[»]
1ITLNMR-A25-153[»]
1ITMNMR-A25-153[»]
1RCBX-ray2.25A25-153[»]
2B8UX-ray1.80A25-153[»]
2B8XX-ray1.70A25-153[»]
2B8YX-ray1.80A25-153[»]
2B8ZX-ray2.50A25-153[»]
2B90X-ray2.10A25-153[»]
2B91X-ray2.00A25-153[»]
2CYKNMR-A25-153[»]
2D48X-ray1.65A25-153[»]
2INTX-ray2.35A25-153[»]
3BPLX-ray2.93A25-153[»]
3BPNX-ray3.02A25-153[»]
3QB7X-ray3.24A/B25-153[»]
4YDYX-ray2.00I/J25-153[»]
5FHXX-ray2.55A30-153[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P05112

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05112

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05112

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3886 Eukaryota
ENOG410XQ0R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000254781

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000290

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05112

KEGG Orthology (KO)

More...
KOi
K05430

Identification of Orthologs from Complete Genome Data

More...
OMAi
LACTSNF

Database of Orthologous Groups

More...
OrthoDBi
1495672at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05112

TreeFam database of animal gene trees

More...
TreeFami
TF336383

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002354 IL-4
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00727 IL4, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001941 Interleukin_4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00431 INTERLEUKIN4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00190 IL4_13, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P05112-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE
60 70 80 90 100
LTVTDIFAAS KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH
110 120 130 140 150
KQLIRFLKRL DRNLWGLAGL NSCPVKEANQ STLENFLERL KTIMREKYSK

CSS
Length:153
Mass (Da):17,492
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8725BF64B34D45F7
GO
Isoform 2 (identifier: P05112-2) [UniParc]FASTAAdd to basket
Also known as: Short, IL-4delta2

The sequence of this isoform differs from the canonical sequence as follows:
     46-61: Missing.

Show »
Length:137
Mass (Da):15,797
Checksum:i3B621F60D0F0D261
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3LVN1U3LVN1_HUMAN
Interleukin 4 variant 2
IL4
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02039227C → R. Corresponds to variant dbSNP:rs4986964Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00267246 – 61Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13982 mRNA Translation: AAA59149.1
M23442 Genomic DNA Translation: AAA59150.1
X81851 mRNA Translation: CAA57444.1
AF395008 Genomic DNA Translation: AAK71324.1
BC066277 mRNA Translation: AAH66277.1
BC067514 mRNA Translation: AAH67514.1
BC070123 mRNA Translation: AAH70123.1
X06750 Genomic DNA Translation: CAA29925.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4158.1 [P05112-1]
CCDS4159.1 [P05112-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A30546 A25946

NCBI Reference Sequences

More...
RefSeqi
NP_000580.1, NM_000589.3 [P05112-1]
NP_758858.1, NM_172348.2 [P05112-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.73917

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000231449; ENSP00000231449; ENSG00000113520 [P05112-1]
ENST00000350025; ENSP00000325190; ENSG00000113520 [P05112-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3565

UCSC genome browser

More...
UCSCi
uc003kxk.3 human [P05112-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13982 mRNA Translation: AAA59149.1
M23442 Genomic DNA Translation: AAA59150.1
X81851 mRNA Translation: CAA57444.1
AF395008 Genomic DNA Translation: AAK71324.1
BC066277 mRNA Translation: AAH66277.1
BC067514 mRNA Translation: AAH67514.1
BC070123 mRNA Translation: AAH70123.1
X06750 Genomic DNA Translation: CAA29925.1
CCDSiCCDS4158.1 [P05112-1]
CCDS4159.1 [P05112-2]
PIRiA30546 A25946
RefSeqiNP_000580.1, NM_000589.3 [P05112-1]
NP_758858.1, NM_172348.2 [P05112-2]
UniGeneiHs.73917

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BBNNMR-A25-153[»]
1BCNNMR-A25-153[»]
1CYLNMR-A25-153[»]
1HIJX-ray3.00A25-153[»]
1HIKX-ray2.60A25-153[»]
1HZIX-ray2.05A25-153[»]
1IARX-ray2.30A25-153[»]
1ILLmodel-425-153[»]
1ITEmodel-A25-153[»]
1ITINMR-A25-153[»]
1ITLNMR-A25-153[»]
1ITMNMR-A25-153[»]
1RCBX-ray2.25A25-153[»]
2B8UX-ray1.80A25-153[»]
2B8XX-ray1.70A25-153[»]
2B8YX-ray1.80A25-153[»]
2B8ZX-ray2.50A25-153[»]
2B90X-ray2.10A25-153[»]
2B91X-ray2.00A25-153[»]
2CYKNMR-A25-153[»]
2D48X-ray1.65A25-153[»]
2INTX-ray2.35A25-153[»]
3BPLX-ray2.93A25-153[»]
3BPNX-ray3.02A25-153[»]
3QB7X-ray3.24A/B25-153[»]
4YDYX-ray2.00I/J25-153[»]
5FHXX-ray2.55A30-153[»]
ProteinModelPortaliP05112
SMRiP05112
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109779, 3 interactors
CORUMiP05112
DIPiDIP-3222N
IntActiP05112, 3 interactors
MINTiP05112
STRINGi9606.ENSP00000231449

Chemistry databases

ChEMBLiCHEMBL3712894

PTM databases

iPTMnetiP05112
PhosphoSitePlusiP05112

Polymorphism and mutation databases

BioMutaiIL4
DMDMi124337

Proteomic databases

PaxDbiP05112
PeptideAtlasiP05112
PRIDEiP05112
ProteomicsDBi51797
51798 [P05112-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3565
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231449; ENSP00000231449; ENSG00000113520 [P05112-1]
ENST00000350025; ENSP00000325190; ENSG00000113520 [P05112-2]
GeneIDi3565
KEGGihsa:3565
UCSCiuc003kxk.3 human [P05112-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3565
DisGeNETi3565
EuPathDBiHostDB:ENSG00000113520.10

GeneCards: human genes, protein and diseases

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GeneCardsi
IL4

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0164435
HGNCiHGNC:6014 IL4
HPAiHPA072995
MIMi147780 gene
601367 phenotype
neXtProtiNX_P05112
OpenTargetsiENSG00000113520
PharmGKBiPA197

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3886 Eukaryota
ENOG410XQ0R LUCA
GeneTreeiENSGT00390000013108
HOGENOMiHOG000254781
HOVERGENiHBG000290
InParanoidiP05112
KOiK05430
OMAiLACTSNF
OrthoDBi1495672at2759
PhylomeDBiP05112
TreeFamiTF336383

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling
SignaLinkiP05112
SIGNORiP05112

Miscellaneous databases

EvolutionaryTraceiP05112

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3565

Protein Ontology

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PROi
PR:P05112

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113520 Expressed in 78 organ(s), highest expression level in oocyte
CleanExiHS_IL4
ExpressionAtlasiP05112 baseline and differential
GenevisibleiP05112 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002354 IL-4
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PfamiView protein in Pfam
PF00727 IL4, 1 hit
PIRSFiPIRSF001941 Interleukin_4, 1 hit
PRINTSiPR00431 INTERLEUKIN4
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05112
Secondary accession number(s): Q14630, Q6NZ77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: January 16, 2019
This is version 216 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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