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Protein

Inhibin alpha chain

Gene

INHA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • hormone activity Source: UniProtKB
  • inhibin binding Source: Ensembl
  • protein heterodimerization activity Source: Ensembl
  • signaling receptor binding Source: HGNC
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-HSA-209822 Glycoprotein hormones
SIGNORiP05111

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chain
Gene namesi
Name:INHA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000123999.4
HGNCiHGNC:6065 INHA
MIMi147380 gene
neXtProtiNX_P05111

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56 – 57RR → AA: Loss of cleavage; when associated with 60-AA-61. 1 Publication2
Mutagenesisi60 – 61RR → AA: Loss of cleavage; when associated with 55-AA-56. 1 Publication2
Mutagenesisi231 – 232RR → EA: Loss of cleavage. 1 Publication2
Mutagenesisi268N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi302N → Q: Loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi3623
OpenTargetsiENSG00000123999
PharmGKBiPA29876

Polymorphism and mutation databases

BioMutaiINHA
DMDMi124274

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000003368519 – 61Add BLAST43
PropeptideiPRO_000003368662 – 232Inhibin alpha N-terminal regionAdd BLAST171
ChainiPRO_0000033687233 – 366Inhibin alpha chainAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 328By similarity
Glycosylationi268N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi291 ↔ 363By similarity
Disulfide bondi295 ↔ 365By similarity
Glycosylationi302N-linked (GlcNAc...) asparagine; partial1 Publication1
Disulfide bondi327InterchainBy similarity

Post-translational modificationi

Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei61 – 62Cleavage2
Sitei232 – 233Cleavage2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05111
PeptideAtlasiP05111
PRIDEiP05111
ProteomicsDBi51796

PTM databases

iPTMnetiP05111
PhosphoSitePlusiP05111

Expressioni

Tissue specificityi

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.1 Publication

Gene expression databases

BgeeiENSG00000123999 Expressed in 99 organ(s), highest expression level in right adrenal gland
CleanExiHS_INHA
GenevisibleiP05111 HS

Organism-specific databases

HPAiCAB000047
HPA019141

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109835, 6 interactors
DIPiDIP-5826N
ELMiP05111
IntActiP05111, 1 interactor
STRINGi9606.ENSP00000243786

Structurei

3D structure databases

ProteinModelPortaliP05111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000005935
HOGENOMiHOG000013165
HOVERGENiHBG052131
InParanoidiP05111
KOiK05500
OMAiFIFHYCH
OrthoDBiEOG091G0CTF
PhylomeDBiP05111
TreeFamiTF331531

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG
60 70 80 90 100
GDPGVRRLPR RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR
110 120 130 140 150
GLAQEAEEGL FRYMFRPSQH TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP
160 170 180 190 200
LLGLLALSPG GPVAVPMSLG HAPPHWAVLH LATSALSLLT HPVLVLLLRC
210 220 230 240 250
PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP WSPSALRLLQ
260 270 280 290 300
RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP
310 320 330 340 350
PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF
360
KYETVPNLLT QHCACI
Length:366
Mass (Da):39,670
Last modified:August 13, 1987 - v1
Checksum:i0E03D2AB12BF8E57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17H → V (PubMed:3754442).Curated1
Sequence conflicti19C → S (PubMed:3754442).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07263960R → L Found in a patient with early-onset epithelial ovarian tumor; unknown pathological significance; alters the ratio of secreted activins and ihibins. 1 Publication1
Natural variantiVAR_034016227G → R. Corresponds to variant dbSNP:rs12720061Ensembl.1
Natural variantiVAR_015110257A → T Polymorphism; may play a role in premature ovarian failure. 1 PublicationCorresponds to variant dbSNP:rs12720062EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13981 mRNA Translation: AAA59166.1
X04445, X04446 Genomic DNA Translation: CAA28040.1
BT006954 mRNA Translation: AAP35600.1
AK292340 mRNA Translation: BAF85029.1
CH471063 Genomic DNA Translation: EAW70774.1
BC006391 mRNA Translation: AAH06391.1
M13144 mRNA Translation: AAA59167.1
CCDSiCCDS2444.1
PIRiA23556 A24248
RefSeqiNP_002182.1, NM_002191.3
UniGeneiHs.407506

Genome annotation databases

EnsembliENST00000243786; ENSP00000243786; ENSG00000123999
GeneIDi3623
KEGGihsa:3623
UCSCiuc002vmk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Inhibin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13981 mRNA Translation: AAA59166.1
X04445, X04446 Genomic DNA Translation: CAA28040.1
BT006954 mRNA Translation: AAP35600.1
AK292340 mRNA Translation: BAF85029.1
CH471063 Genomic DNA Translation: EAW70774.1
BC006391 mRNA Translation: AAH06391.1
M13144 mRNA Translation: AAA59167.1
CCDSiCCDS2444.1
PIRiA23556 A24248
RefSeqiNP_002182.1, NM_002191.3
UniGeneiHs.407506

3D structure databases

ProteinModelPortaliP05111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109835, 6 interactors
DIPiDIP-5826N
ELMiP05111
IntActiP05111, 1 interactor
STRINGi9606.ENSP00000243786

PTM databases

iPTMnetiP05111
PhosphoSitePlusiP05111

Polymorphism and mutation databases

BioMutaiINHA
DMDMi124274

Proteomic databases

PaxDbiP05111
PeptideAtlasiP05111
PRIDEiP05111
ProteomicsDBi51796

Protocols and materials databases

DNASUi3623
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243786; ENSP00000243786; ENSG00000123999
GeneIDi3623
KEGGihsa:3623
UCSCiuc002vmk.3 human

Organism-specific databases

CTDi3623
DisGeNETi3623
EuPathDBiHostDB:ENSG00000123999.4
GeneCardsiINHA
HGNCiHGNC:6065 INHA
HPAiCAB000047
HPA019141
MIMi147380 gene
neXtProtiNX_P05111
OpenTargetsiENSG00000123999
PharmGKBiPA29876
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000005935
HOGENOMiHOG000013165
HOVERGENiHBG052131
InParanoidiP05111
KOiK05500
OMAiFIFHYCH
OrthoDBiEOG091G0CTF
PhylomeDBiP05111
TreeFamiTF331531

Enzyme and pathway databases

ReactomeiR-HSA-209822 Glycoprotein hormones
SIGNORiP05111

Miscellaneous databases

GeneWikiiINHA
GenomeRNAii3623
PROiPR:P05111
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123999 Expressed in 99 organ(s), highest expression level in right adrenal gland
CleanExiHS_INHA
GenevisibleiP05111 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINHA_HUMAN
AccessioniPrimary (citable) accession number: P05111
Secondary accession number(s): A8K8H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 12, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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