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Protein

Integrin beta-2

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi138Calcium; via carbonyl oxygen1
Metal bindingi141Calcium1
Metal bindingi142Calcium1
Metal bindingi347Calcium1

GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • cell adhesion molecule binding Source: UniProtKB
  • complement component C3b binding Source: ARUK-UCL
  • heat shock protein binding Source: CAFA
  • ICAM-3 receptor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein-containing complex binding Source: Ensembl
  • protein heterodimerization activity Source: ARUK-UCL
  • protein kinase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Phagocytosis
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP05107
SIGNORiP05107

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-2
Alternative name(s):
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
Complement receptor C3 subunit beta
CD_antigen: CD18
Gene namesi
Name:ITGB2
Synonyms:CD18, MFI7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160255.16
HGNCiHGNC:6155 ITGB2
MIMi600065 gene
neXtProtiNX_P05107

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 700ExtracellularSequence analysisAdd BLAST678
Transmembranei701 – 723HelicalSequence analysisAdd BLAST23
Topological domaini724 – 769CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Leukocyte adhesion deficiency 1 (LAD1)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionLAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
See also OMIM:116920
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003984128D → N in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_065661128D → Y in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_013402138S → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852617EnsemblClinVar.1
Natural variantiVAR_003985149L → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852611EnsemblClinVar.1
Natural variantiVAR_003986169G → R in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852612EnsemblClinVar.1
Natural variantiVAR_003987178P → L in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852614EnsemblClinVar.1
Natural variantiVAR_003988196K → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852610EnsemblClinVar.1
Natural variantiVAR_065662239A → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363873EnsemblClinVar.1
Natural variantiVAR_013403273G → R in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852618EnsemblClinVar.1
Natural variantiVAR_003989284G → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852616EnsemblClinVar.1
Natural variantiVAR_065663300D → V in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363874EnsemblClinVar.1
Natural variantiVAR_003990351N → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852613EnsemblClinVar.1
Natural variantiVAR_003991586R → W in LAD1. 1 PublicationCorresponds to variant dbSNP:rs5030672EnsemblClinVar.1
Natural variantiVAR_003992593R → C in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852609EnsemblClinVar.1
Natural variantiVAR_065664716G → A in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363872EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi758T → A: Abolishes phosphorylation. Reduces COS cell adhesion to ICAM1. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3689
MalaCardsiITGB2
MIMi116920 phenotype
Orphaneti99842 Leukocyte adhesion deficiency type I
PharmGKBiPA29955

Chemistry databases

ChEMBLiCHEMBL3631
DrugBankiDB00641 Simvastatin
GuidetoPHARMACOLOGYi2456

Polymorphism and mutation databases

BioMutaiITGB2
DMDMi124056465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001634123 – 769Integrin beta-2Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi25 ↔ 431 Publication
Disulfide bondi33 ↔ 4471 Publication
Disulfide bondi36 ↔ 621 Publication
Disulfide bondi46 ↔ 731 Publication
Glycosylationi50N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi116N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi191 ↔ 1981 Publication
Glycosylationi212N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi246 ↔ 2861 Publication
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi386 ↔ 4001 Publication
Disulfide bondi420 ↔ 4451 Publication
Disulfide bondi449 ↔ 4671 Publication
Disulfide bondi459 ↔ 4701 Publication
Disulfide bondi472 ↔ 4811 Publication
Disulfide bondi483 ↔ 5141 Publication
Disulfide bondi497 ↔ 5121 Publication
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi506 ↔ 5171 Publication
Disulfide bondi519 ↔ 5341 Publication
Disulfide bondi536 ↔ 5591 Publication
Disulfide bondi541 ↔ 5571 Publication
Disulfide bondi549 ↔ 5621 Publication
Disulfide bondi564 ↔ 5731 Publication
Disulfide bondi575 ↔ 5981 Publication
Disulfide bondi582 ↔ 5961 Publication
Disulfide bondi590 ↔ 6011 Publication
Disulfide bondi603 ↔ 6121 Publication
Disulfide bondi615 ↔ 6181 Publication
Disulfide bondi622 ↔ 6621 Publication
Disulfide bondi628 ↔ 6471 Publication
Disulfide bondi631 ↔ 6431 Publication
Glycosylationi642N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi670 ↔ 6951 Publication
Modified residuei745Phosphoserine; by PKC1 Publication1
Modified residuei756Phosphoserine1 Publication1
Modified residuei758Phosphothreonine; by PKC; in vitro2 Publications1
Modified residuei759PhosphothreonineSequence analysis1
Modified residuei760Phosphothreonine; by PKC/PRKCA; in vitro1 Publication1

Post-translational modificationi

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP05107
MaxQBiP05107
PaxDbiP05107
PeptideAtlasiP05107
PRIDEiP05107
ProteomicsDBi51793

PTM databases

GlyConnecti1415
iPTMnetiP05107
PhosphoSitePlusiP05107

Miscellaneous databases

PMAP-CutDBiP05107

Expressioni

Tissue specificityi

Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).3 Publications

Gene expression databases

BgeeiENSG00000160255 Expressed in 187 organ(s), highest expression level in blood
CleanExiHS_ITGB2
ExpressionAtlasiP05107 baseline and differential
GenevisibleiP05107 HS

Organism-specific databases

HPAiHPA008877
HPA016894

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit (PubMed:20033057). ITGB2 associates with either ITGAL, ITGAM, ITGAX or ITGAD. Found in a complex with CD177 and ITGAM/CD11b (PubMed:21193407, PubMed:28807980). Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9 (PubMed:10766246, PubMed:14722085). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450). Interacts with THBD (PubMed:27055590).By similarity7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109895, 36 interactors
ComplexPortaliCPX-1825 Integrin alphaL-beta2 complex
CPX-1826 Integrin alphaM-beta2 complex
CPX-1827 Integrin alphaX-beta2 complex
CPX-1828 Integrin alphaD-beta2 complex
CORUMiP05107
DIPiDIP-478N
ELMiP05107
IntActiP05107, 27 interactors
MINTiP05107
STRINGi9606.ENSP00000303242

Chemistry databases

BindingDBiP05107

Structurei

Secondary structure

1769
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05107
SMRiP05107
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05107

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 363VWFAAdd BLAST240
Repeati449 – 496IAdd BLAST48
Repeati497 – 540IIAdd BLAST44
Repeati541 – 581IIIAdd BLAST41
Repeati582 – 617IVAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni449 – 617Cysteine-rich tandem repeatsAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi397 – 399Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP05107
KOiK06464
OrthoDBiEOG091G029W
PhylomeDBiP05107
TreeFamiTF105392

Family and domain databases

Gene3Di1.20.5.630, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR014836 Integrin_bsu_cyt_dom
IPR037076 Integrin_bsu_cyt_dom_sf
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS00243 INTEGRIN_BETA, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

P05107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN
60 70 80 90 100
FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP
110 120 130 140 150
QKVTLYLRPG QAAAFNVTFR RAKGYPIDLY YLMDLSYSML DDLRNVKKLG
160 170 180 190 200
GDLLRALNEI TESGRIGFGS FVDKTVLPFV NTHPDKLRNP CPNKEKECQP
210 220 230 240 250
PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM MQVAACPEEI
260 270 280 290 300
GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD
310 320 330 340 350
YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS
360 370 380 390 400
NVVQLIKNAY NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC
410 420 430 440 450
DGVQINVPIT FQVKVTATEC IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR
460 470 480 490 500
DQSRDRSLCH GKGFLECGIC RCDTGYIGKN CECQTQGRSS QELEGSCRKD
510 520 530 540 550
NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN CERYNGQVCG
560 570 580 590 600
GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV
610 620 630 640 650
CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL
660 670 680 690 700
QLSNNPVKGR TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN
710 720 730 740 750
IAAIVGGTVA GIVLIGILLL VIWKALIHLS DLREYRRFEK EKLKSQWNND
760
NPLFKSATTT VMNPKFAES
Length:769
Mass (Da):84,782
Last modified:January 23, 2007 - v2
Checksum:iEB9F3C3DF338B4E1
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DSM0D3DSM0_HUMAN
Integrin beta
ITGB2 hCG_401305
712Annotation score:
E5RK25E5RK25_HUMAN
Integrin beta
ITGB2
160Annotation score:
E7EVZ9E7EVZ9_HUMAN
Integrin beta
ITGB2
166Annotation score:
J3KNI6J3KNI6_HUMAN
Integrin beta
ITGB2
322Annotation score:
E5RIG7E5RIG7_HUMAN
Integrin beta-2
ITGB2
120Annotation score:
A8MVG7A8MVG7_HUMAN
Integrin beta-2
ITGB2
108Annotation score:
E5RFI0E5RFI0_HUMAN
Integrin beta-2
ITGB2
70Annotation score:
E5RIE4E5RIE4_HUMAN
Integrin beta-2
ITGB2
93Annotation score:
E5RHT0E5RHT0_HUMAN
Integrin beta-2
ITGB2
49Annotation score:
E5RK54E5RK54_HUMAN
Integrin beta-2
ITGB2
49Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAD96225 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199Q → P in CAA68266 (PubMed:2954816).Curated1
Sequence conflicti279L → P in BAD96225 (Ref. 4) Curated1
Sequence conflicti526G → C in BAG53190 (PubMed:14702039).Curated1
Sequence conflicti630E → K in BAG53190 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003984128D → N in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_065661128D → Y in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_013402138S → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852617EnsemblClinVar.1
Natural variantiVAR_003985149L → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852611EnsemblClinVar.1
Natural variantiVAR_003986169G → R in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852612EnsemblClinVar.1
Natural variantiVAR_003987178P → L in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852614EnsemblClinVar.1
Natural variantiVAR_003988196K → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852610EnsemblClinVar.1
Natural variantiVAR_065662239A → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363873EnsemblClinVar.1
Natural variantiVAR_013403273G → R in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852618EnsemblClinVar.1
Natural variantiVAR_003989284G → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852616EnsemblClinVar.1
Natural variantiVAR_065663300D → V in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363874EnsemblClinVar.1
Natural variantiVAR_003990351N → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852613EnsemblClinVar.1
Natural variantiVAR_030035354Q → H8 PublicationsCorresponds to variant dbSNP:rs235330Ensembl.1
Natural variantiVAR_003991586R → W in LAD1. 1 PublicationCorresponds to variant dbSNP:rs5030672EnsemblClinVar.1
Natural variantiVAR_003992593R → C in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852609EnsemblClinVar.1
Natural variantiVAR_065664716G → A in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363872EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15395 mRNA Translation: AAA59490.1
X64072
, X64073, X64074, X64075, X64076, X64077, X64078, X64079, X64080, X64081, X64082, X64083, X63924, X63925, X63926 Genomic DNA Translation: CAA45427.1
AK095992 mRNA Translation: BAG53190.1
AK222505 mRNA Translation: BAD96225.1 Different initiation.
AL163300 Genomic DNA Translation: CAB90553.1
CH471079 Genomic DNA Translation: EAX09381.1
CH471079 Genomic DNA Translation: EAX09382.1
CH471079 Genomic DNA Translation: EAX09385.1
BC005861 mRNA Translation: AAH05861.1
Y00057 mRNA Translation: CAA68266.1
S81234 mRNA Translation: AAB21404.1
CCDSiCCDS13716.1
PIRiA25967 IJHULM
RefSeqiNP_000202.3, NM_000211.4
NP_001120963.2, NM_001127491.2
NP_001290167.1, NM_001303238.1
UniGeneiHs.375957

Genome annotation databases

EnsembliENST00000302347; ENSP00000303242; ENSG00000160255
ENST00000355153; ENSP00000347279; ENSG00000160255
ENST00000397850; ENSP00000380948; ENSG00000160255
ENST00000397852; ENSP00000380950; ENSG00000160255
ENST00000397857; ENSP00000380955; ENSG00000160255
GeneIDi3689
KEGGihsa:3689
UCSCiuc002zgd.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

ITGB2base

ITGB2 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15395 mRNA Translation: AAA59490.1
X64072
, X64073, X64074, X64075, X64076, X64077, X64078, X64079, X64080, X64081, X64082, X64083, X63924, X63925, X63926 Genomic DNA Translation: CAA45427.1
AK095992 mRNA Translation: BAG53190.1
AK222505 mRNA Translation: BAD96225.1 Different initiation.
AL163300 Genomic DNA Translation: CAB90553.1
CH471079 Genomic DNA Translation: EAX09381.1
CH471079 Genomic DNA Translation: EAX09382.1
CH471079 Genomic DNA Translation: EAX09385.1
BC005861 mRNA Translation: AAH05861.1
Y00057 mRNA Translation: CAA68266.1
S81234 mRNA Translation: AAB21404.1
CCDSiCCDS13716.1
PIRiA25967 IJHULM
RefSeqiNP_000202.3, NM_000211.4
NP_001120963.2, NM_001127491.2
NP_001290167.1, NM_001303238.1
UniGeneiHs.375957

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JX3model-A126-364[»]
1L3YNMR-A535-574[»]
1YUKX-ray1.80A23-125[»]
B365-482[»]
2JF1X-ray2.20T735-769[»]
2P26X-ray1.75A23-535[»]
2P28X-ray2.20A23-122[»]
B362-574[»]
2V7DX-ray2.50P/Q/R/S755-764[»]
3K6SX-ray3.50B/D/F/H23-699[»]
3K71X-ray3.95B/D/F/H23-699[»]
3K72X-ray3.70B/D23-699[»]
4NEHX-ray2.75B23-695[»]
4NENX-ray2.90B23-696[»]
5E6RX-ray2.90B23-482[»]
5E6SX-ray2.15B/D/F23-482[»]
5E6UX-ray2.50B23-482[»]
5E6VX-ray1.80A24-482[»]
5E6WX-ray2.20A23-118[»]
A362-574[»]
5E6XX-ray1.75A23-535[»]
5ES4X-ray3.30B/D/F/H23-696[»]
5XR1NMR-A752-763[»]
ProteinModelPortaliP05107
SMRiP05107
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109895, 36 interactors
ComplexPortaliCPX-1825 Integrin alphaL-beta2 complex
CPX-1826 Integrin alphaM-beta2 complex
CPX-1827 Integrin alphaX-beta2 complex
CPX-1828 Integrin alphaD-beta2 complex
CORUMiP05107
DIPiDIP-478N
ELMiP05107
IntActiP05107, 27 interactors
MINTiP05107
STRINGi9606.ENSP00000303242

Chemistry databases

BindingDBiP05107
ChEMBLiCHEMBL3631
DrugBankiDB00641 Simvastatin
GuidetoPHARMACOLOGYi2456

PTM databases

GlyConnecti1415
iPTMnetiP05107
PhosphoSitePlusiP05107

Polymorphism and mutation databases

BioMutaiITGB2
DMDMi124056465

Proteomic databases

EPDiP05107
MaxQBiP05107
PaxDbiP05107
PeptideAtlasiP05107
PRIDEiP05107
ProteomicsDBi51793

Protocols and materials databases

DNASUi3689
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302347; ENSP00000303242; ENSG00000160255
ENST00000355153; ENSP00000347279; ENSG00000160255
ENST00000397850; ENSP00000380948; ENSG00000160255
ENST00000397852; ENSP00000380950; ENSG00000160255
ENST00000397857; ENSP00000380955; ENSG00000160255
GeneIDi3689
KEGGihsa:3689
UCSCiuc002zgd.4 human

Organism-specific databases

CTDi3689
DisGeNETi3689
EuPathDBiHostDB:ENSG00000160255.16
GeneCardsiITGB2
HGNCiHGNC:6155 ITGB2
HPAiHPA008877
HPA016894
MalaCardsiITGB2
MIMi116920 phenotype
600065 gene
neXtProtiNX_P05107
Orphaneti99842 Leukocyte adhesion deficiency type I
PharmGKBiPA29955
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP05107
KOiK06464
OrthoDBiEOG091G029W
PhylomeDBiP05107
TreeFamiTF105392

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP05107
SIGNORiP05107

Miscellaneous databases

ChiTaRSiITGB2 human
EvolutionaryTraceiP05107
GeneWikiiCD18
GenomeRNAii3689
PMAP-CutDBiP05107
PROiPR:P05107
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160255 Expressed in 187 organ(s), highest expression level in blood
CleanExiHS_ITGB2
ExpressionAtlasiP05107 baseline and differential
GenevisibleiP05107 HS

Family and domain databases

Gene3Di1.20.5.630, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR014836 Integrin_bsu_cyt_dom
IPR037076 Integrin_bsu_cyt_dom_sf
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS00243 INTEGRIN_BETA, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiITB2_HUMAN
AccessioniPrimary (citable) accession number: P05107
Secondary accession number(s): B3KTS8
, D3DSM1, Q16418, Q53HS5, Q9UD72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 234 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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