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Protein

Integrin beta-2

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi138Calcium; via carbonyl oxygen1
Metal bindingi141Calcium1
Metal bindingi142Calcium1
Metal bindingi347Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • cell adhesion molecule binding Source: UniProtKB
  • complement component C3b binding Source: ARUK-UCL
  • heat shock protein binding Source: CAFA
  • ICAM-3 receptor activity Source: UniProtKB
  • integrin binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: ARUK-UCL
  • protein kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Phagocytosis
LigandMetal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P05107

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05107

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin beta-2
Alternative name(s):
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
Complement receptor C3 subunit beta
CD_antigen: CD18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGB2
Synonyms:CD18, MFI7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000160255.16

Human Gene Nomenclature Database

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HGNCi
HGNC:6155 ITGB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600065 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05107

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 700ExtracellularSequence analysisAdd BLAST678
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei701 – 723HelicalSequence analysisAdd BLAST23
Topological domaini724 – 769CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukocyte adhesion deficiency 1 (LAD1)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionLAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
See also OMIM:116920
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_003984128D → N in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_065661128D → Y in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_013402138S → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852617EnsemblClinVar.1
Natural variantiVAR_003985149L → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852611EnsemblClinVar.1
Natural variantiVAR_003986169G → R in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852612EnsemblClinVar.1
Natural variantiVAR_003987178P → L in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852614EnsemblClinVar.1
Natural variantiVAR_003988196K → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852610EnsemblClinVar.1
Natural variantiVAR_065662239A → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363873EnsemblClinVar.1
Natural variantiVAR_013403273G → R in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852618EnsemblClinVar.1
Natural variantiVAR_003989284G → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852616EnsemblClinVar.1
Natural variantiVAR_065663300D → V in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363874EnsemblClinVar.1
Natural variantiVAR_003990351N → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852613EnsemblClinVar.1
Natural variantiVAR_003991586R → W in LAD1. 1 PublicationCorresponds to variant dbSNP:rs5030672EnsemblClinVar.1
Natural variantiVAR_003992593R → C in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852609EnsemblClinVar.1
Natural variantiVAR_065664716G → A in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363872EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi758T → A: Abolishes phosphorylation. Reduces COS cell adhesion to ICAM1. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3689

MalaCards human disease database

More...
MalaCardsi
ITGB2
MIMi116920 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99842 Leukocyte adhesion deficiency type I

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29955

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3631

Drug and drug target database

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DrugBanki
DB00641 Simvastatin

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2456

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ITGB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124056465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Add BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001634123 – 769Integrin beta-2Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 431 Publication
Disulfide bondi33 ↔ 4471 Publication
Disulfide bondi36 ↔ 621 Publication
Disulfide bondi46 ↔ 731 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi116N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi191 ↔ 1981 Publication
Glycosylationi212N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi246 ↔ 2861 Publication
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi386 ↔ 4001 Publication
Disulfide bondi420 ↔ 4451 Publication
Disulfide bondi449 ↔ 4671 Publication
Disulfide bondi459 ↔ 4701 Publication
Disulfide bondi472 ↔ 4811 Publication
Disulfide bondi483 ↔ 5141 Publication
Disulfide bondi497 ↔ 5121 Publication
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi506 ↔ 5171 Publication
Disulfide bondi519 ↔ 5341 Publication
Disulfide bondi536 ↔ 5591 Publication
Disulfide bondi541 ↔ 5571 Publication
Disulfide bondi549 ↔ 5621 Publication
Disulfide bondi564 ↔ 5731 Publication
Disulfide bondi575 ↔ 5981 Publication
Disulfide bondi582 ↔ 5961 Publication
Disulfide bondi590 ↔ 6011 Publication
Disulfide bondi603 ↔ 6121 Publication
Disulfide bondi615 ↔ 6181 Publication
Disulfide bondi622 ↔ 6621 Publication
Disulfide bondi628 ↔ 6471 Publication
Disulfide bondi631 ↔ 6431 Publication
Glycosylationi642N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi670 ↔ 6951 Publication
Modified residuei745Phosphoserine; by PKC1 Publication1
Modified residuei756Phosphoserine1 Publication1
Modified residuei758Phosphothreonine; by PKC; in vitro2 Publications1
Modified residuei759PhosphothreonineSequence analysis1
Modified residuei760Phosphothreonine; by PKC/PRKCA; in vitro1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P05107

MaxQB - The MaxQuant DataBase

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MaxQBi
P05107

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P05107

PeptideAtlas

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PeptideAtlasi
P05107

PRoteomics IDEntifications database

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PRIDEi
P05107

ProteomicsDB human proteome resource

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ProteomicsDBi
51793

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1415

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05107

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05107

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P05107

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160255 Expressed in 187 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_ITGB2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05107 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05107 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008877
HPA016894

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit (PubMed:20033057). ITGB2 associates with either ITGAL, ITGAM, ITGAX or ITGAD. Found in a complex with CD177 and ITGAM/CD11b (PubMed:21193407, PubMed:28807980). Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9 (PubMed:10766246, PubMed:14722085). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450). Interacts with THBD (PubMed:27055590).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109895, 36 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1825 Integrin alphaL-beta2 complex
CPX-1826 Integrin alphaM-beta2 complex
CPX-1827 Integrin alphaX-beta2 complex
CPX-1828 Integrin alphaD-beta2 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P05107

Database of interacting proteins

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DIPi
DIP-478N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P05107

Protein interaction database and analysis system

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IntActi
P05107, 27 interactors

Molecular INTeraction database

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MINTi
P05107

STRING: functional protein association networks

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STRINGi
9606.ENSP00000303242

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P05107

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1769
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P05107

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05107

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05107

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini124 – 363VWFAAdd BLAST240
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati449 – 496IAdd BLAST48
Repeati497 – 540IIAdd BLAST44
Repeati541 – 581IIIAdd BLAST41
Repeati582 – 617IVAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni449 – 617Cysteine-rich tandem repeatsAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi397 – 399Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1226 Eukaryota
ENOG410XP60 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252936

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006190

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05107

KEGG Orthology (KO)

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KOi
K06464

Database of Orthologous Groups

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OrthoDBi
EOG091G029W

Database for complete collections of gene phylogenies

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PhylomeDBi
P05107

TreeFam database of animal gene trees

More...
TreeFami
TF105392

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.630, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR014836 Integrin_bsu_cyt_dom
IPR037076 Integrin_bsu_cyt_dom_sf
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002512 Integrin_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01186 INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS00243 INTEGRIN_BETA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

P05107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN
60 70 80 90 100
FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP
110 120 130 140 150
QKVTLYLRPG QAAAFNVTFR RAKGYPIDLY YLMDLSYSML DDLRNVKKLG
160 170 180 190 200
GDLLRALNEI TESGRIGFGS FVDKTVLPFV NTHPDKLRNP CPNKEKECQP
210 220 230 240 250
PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM MQVAACPEEI
260 270 280 290 300
GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD
310 320 330 340 350
YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS
360 370 380 390 400
NVVQLIKNAY NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC
410 420 430 440 450
DGVQINVPIT FQVKVTATEC IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR
460 470 480 490 500
DQSRDRSLCH GKGFLECGIC RCDTGYIGKN CECQTQGRSS QELEGSCRKD
510 520 530 540 550
NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN CERYNGQVCG
560 570 580 590 600
GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV
610 620 630 640 650
CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL
660 670 680 690 700
QLSNNPVKGR TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN
710 720 730 740 750
IAAIVGGTVA GIVLIGILLL VIWKALIHLS DLREYRRFEK EKLKSQWNND
760
NPLFKSATTT VMNPKFAES
Length:769
Mass (Da):84,782
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB9F3C3DF338B4E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DSM0D3DSM0_HUMAN
Integrin beta
ITGB2 hCG_401305
712Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVZ9E7EVZ9_HUMAN
Integrin beta
ITGB2
166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK25E5RK25_HUMAN
Integrin beta
ITGB2
160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNI6J3KNI6_HUMAN
Integrin beta
ITGB2
322Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIG7E5RIG7_HUMAN
Integrin beta-2
ITGB2
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFI0E5RFI0_HUMAN
Integrin beta-2
ITGB2
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MVG7A8MVG7_HUMAN
Integrin beta-2
ITGB2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIE4E5RIE4_HUMAN
Integrin beta-2
ITGB2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHT0E5RHT0_HUMAN
Integrin beta-2
ITGB2
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK54E5RK54_HUMAN
Integrin beta-2
ITGB2
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD96225 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199Q → P in CAA68266 (PubMed:2954816).Curated1
Sequence conflicti279L → P in BAD96225 (Ref. 4) Curated1
Sequence conflicti526G → C in BAG53190 (PubMed:14702039).Curated1
Sequence conflicti630E → K in BAG53190 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003984128D → N in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_065661128D → Y in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852615EnsemblClinVar.1
Natural variantiVAR_013402138S → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852617EnsemblClinVar.1
Natural variantiVAR_003985149L → P in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852611EnsemblClinVar.1
Natural variantiVAR_003986169G → R in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852612EnsemblClinVar.1
Natural variantiVAR_003987178P → L in LAD1. 2 PublicationsCorresponds to variant dbSNP:rs137852614EnsemblClinVar.1
Natural variantiVAR_003988196K → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852610EnsemblClinVar.1
Natural variantiVAR_065662239A → T in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363873EnsemblClinVar.1
Natural variantiVAR_013403273G → R in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852618EnsemblClinVar.1
Natural variantiVAR_003989284G → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852616EnsemblClinVar.1
Natural variantiVAR_065663300D → V in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363874EnsemblClinVar.1
Natural variantiVAR_003990351N → S in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852613EnsemblClinVar.1
Natural variantiVAR_030035354Q → H8 PublicationsCorresponds to variant dbSNP:rs235330Ensembl.1
Natural variantiVAR_003991586R → W in LAD1. 1 PublicationCorresponds to variant dbSNP:rs5030672EnsemblClinVar.1
Natural variantiVAR_003992593R → C in LAD1. 1 PublicationCorresponds to variant dbSNP:rs137852609EnsemblClinVar.1
Natural variantiVAR_065664716G → A in LAD1. 1 PublicationCorresponds to variant dbSNP:rs179363872EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15395 mRNA Translation: AAA59490.1
X64072
, X64073, X64074, X64075, X64076, X64077, X64078, X64079, X64080, X64081, X64082, X64083, X63924, X63925, X63926 Genomic DNA Translation: CAA45427.1
AK095992 mRNA Translation: BAG53190.1
AK222505 mRNA Translation: BAD96225.1 Different initiation.
AL163300 Genomic DNA Translation: CAB90553.1
CH471079 Genomic DNA Translation: EAX09381.1
CH471079 Genomic DNA Translation: EAX09382.1
CH471079 Genomic DNA Translation: EAX09385.1
BC005861 mRNA Translation: AAH05861.1
Y00057 mRNA Translation: CAA68266.1
S81234 mRNA Translation: AAB21404.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13716.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A25967 IJHULM

NCBI Reference Sequences

More...
RefSeqi
NP_000202.3, NM_000211.4
NP_001120963.2, NM_001127491.2
NP_001290167.1, NM_001303238.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.375957

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302347; ENSP00000303242; ENSG00000160255
ENST00000355153; ENSP00000347279; ENSG00000160255
ENST00000397850; ENSP00000380948; ENSG00000160255
ENST00000397852; ENSP00000380950; ENSG00000160255
ENST00000397857; ENSP00000380955; ENSG00000160255

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3689

UCSC genome browser

More...
UCSCi
uc002zgd.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ITGB2base

ITGB2 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15395 mRNA Translation: AAA59490.1
X64072
, X64073, X64074, X64075, X64076, X64077, X64078, X64079, X64080, X64081, X64082, X64083, X63924, X63925, X63926 Genomic DNA Translation: CAA45427.1
AK095992 mRNA Translation: BAG53190.1
AK222505 mRNA Translation: BAD96225.1 Different initiation.
AL163300 Genomic DNA Translation: CAB90553.1
CH471079 Genomic DNA Translation: EAX09381.1
CH471079 Genomic DNA Translation: EAX09382.1
CH471079 Genomic DNA Translation: EAX09385.1
BC005861 mRNA Translation: AAH05861.1
Y00057 mRNA Translation: CAA68266.1
S81234 mRNA Translation: AAB21404.1
CCDSiCCDS13716.1
PIRiA25967 IJHULM
RefSeqiNP_000202.3, NM_000211.4
NP_001120963.2, NM_001127491.2
NP_001290167.1, NM_001303238.1
UniGeneiHs.375957

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JX3model-A126-364[»]
1L3YNMR-A535-574[»]
1YUKX-ray1.80A23-125[»]
B365-482[»]
2JF1X-ray2.20T735-769[»]
2P26X-ray1.75A23-535[»]
2P28X-ray2.20A23-122[»]
B362-574[»]
2V7DX-ray2.50P/Q/R/S755-764[»]
3K6SX-ray3.50B/D/F/H23-699[»]
3K71X-ray3.95B/D/F/H23-699[»]
3K72X-ray3.70B/D23-699[»]
4NEHX-ray2.75B23-695[»]
4NENX-ray2.90B23-696[»]
5E6RX-ray2.90B23-482[»]
5E6SX-ray2.15B/D/F23-482[»]
5E6UX-ray2.50B23-482[»]
5E6VX-ray1.80A24-482[»]
5E6WX-ray2.20A23-118[»]
A362-574[»]
5E6XX-ray1.75A23-535[»]
5ES4X-ray3.30B/D/F/H23-696[»]
5XR1NMR-A752-763[»]
5ZAZNMR-A689-739[»]
ProteinModelPortaliP05107
SMRiP05107
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109895, 36 interactors
ComplexPortaliCPX-1825 Integrin alphaL-beta2 complex
CPX-1826 Integrin alphaM-beta2 complex
CPX-1827 Integrin alphaX-beta2 complex
CPX-1828 Integrin alphaD-beta2 complex
CORUMiP05107
DIPiDIP-478N
ELMiP05107
IntActiP05107, 27 interactors
MINTiP05107
STRINGi9606.ENSP00000303242

Chemistry databases

BindingDBiP05107
ChEMBLiCHEMBL3631
DrugBankiDB00641 Simvastatin
GuidetoPHARMACOLOGYi2456

PTM databases

GlyConnecti1415
iPTMnetiP05107
PhosphoSitePlusiP05107

Polymorphism and mutation databases

BioMutaiITGB2
DMDMi124056465

Proteomic databases

EPDiP05107
MaxQBiP05107
PaxDbiP05107
PeptideAtlasiP05107
PRIDEiP05107
ProteomicsDBi51793

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3689
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302347; ENSP00000303242; ENSG00000160255
ENST00000355153; ENSP00000347279; ENSG00000160255
ENST00000397850; ENSP00000380948; ENSG00000160255
ENST00000397852; ENSP00000380950; ENSG00000160255
ENST00000397857; ENSP00000380955; ENSG00000160255
GeneIDi3689
KEGGihsa:3689
UCSCiuc002zgd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3689
DisGeNETi3689
EuPathDBiHostDB:ENSG00000160255.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ITGB2
HGNCiHGNC:6155 ITGB2
HPAiHPA008877
HPA016894
MalaCardsiITGB2
MIMi116920 phenotype
600065 gene
neXtProtiNX_P05107
Orphaneti99842 Leukocyte adhesion deficiency type I
PharmGKBiPA29955

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP05107
KOiK06464
OrthoDBiEOG091G029W
PhylomeDBiP05107
TreeFamiTF105392

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP05107
SIGNORiP05107

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITGB2 human
EvolutionaryTraceiP05107

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3689
PMAP-CutDBiP05107

Protein Ontology

More...
PROi
PR:P05107

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160255 Expressed in 187 organ(s), highest expression level in blood
CleanExiHS_ITGB2
ExpressionAtlasiP05107 baseline and differential
GenevisibleiP05107 HS

Family and domain databases

Gene3Di1.20.5.630, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR014836 Integrin_bsu_cyt_dom
IPR037076 Integrin_bsu_cyt_dom_sf
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS00243 INTEGRIN_BETA, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05107
Secondary accession number(s): B3KTS8
, D3DSM1, Q16418, Q53HS5, Q9UD72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 236 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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