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Protein

Apolipoprotein D

Gene

APOD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

Miscellaneous

APOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace amounts in VLDL and LDL.

GO - Molecular functioni

  • cholesterol binding Source: UniProtKB
  • lipid transporter activity Source: UniProtKB

GO - Biological processi

  • aging Source: UniProtKB
  • angiogenesis Source: UniProtKB
  • brain development Source: UniProtKB
  • glucose metabolic process Source: UniProtKB
  • lipid metabolic process Source: UniProtKB
  • negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
  • negative regulation of focal adhesion assembly Source: UniProtKB
  • negative regulation of lipoprotein lipid oxidation Source: UniProtKB
  • negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
  • negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
  • negative regulation of protein import into nucleus Source: UniProtKB
  • negative regulation of smooth muscle cell-matrix adhesion Source: UniProtKB
  • negative regulation of smooth muscle cell proliferation Source: UniProtKB
  • negative regulation of T cell migration Source: UniProtKB
  • peripheral nervous system axon regeneration Source: UniProtKB
  • response to axon injury Source: UniProtKB
  • response to drug Source: UniProtKB
  • response to reactive oxygen species Source: UniProtKB
  • tissue regeneration Source: UniProtKB

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-804914 Transport of fatty acids

Chemistry databases

SwissLipidsiSLP:000001524

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein D
Short name:
Apo-D
Short name:
ApoD
Gene namesi
Name:APOD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000189058.8
HGNCiHGNC:612 APOD
MIMi107740 gene
neXtProtiNX_P05090

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi347
OpenTargetsiENSG00000189058
PharmGKBiPA24900

Polymorphism and mutation databases

BioMutaiAPOD
DMDMi114034

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001787221 – 189Apolipoprotein DAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acid2 Publications1
Disulfide bondi28 ↔ 1341 Publication
Disulfide bondi61 ↔ 1851 Publication
Glycosylationi65N-linked (GlcNAc...) (complex) asparagine4 Publications1
Glycosylationi98N-linked (GlcNAc...) (complex) asparagine8 Publications1
Disulfide bondi136Interchain (with C-29 in APOA2)1 Publication

Post-translational modificationi

N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor).8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP05090
PaxDbiP05090
PeptideAtlasiP05090
PRIDEiP05090
ProteomicsDBi51787

2D gel databases

SWISS-2DPAGEiP05090

PTM databases

GlyConnecti677
iPTMnetiP05090
PhosphoSitePlusiP05090
UniCarbKBiP05090

Expressioni

Tissue specificityi

Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.

Gene expression databases

BgeeiENSG00000189058
CleanExiHS_APOD
ExpressionAtlasiP05090 baseline and differential
GenevisibleiP05090 HS

Organism-specific databases

HPAiHPA040520

Interactioni

Subunit structurei

Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi106844, 58 interactors
IntActiP05090, 50 interactors
MINTiP05090
STRINGi9606.ENSP00000345179

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 27Combined sources4
Helixi39 – 41Combined sources3
Beta strandi44 – 51Combined sources8
Beta strandi60 – 68Combined sources9
Beta strandi74 – 81Combined sources8
Beta strandi87 – 97Combined sources11
Beta strandi104 – 108Combined sources5
Beta strandi116 – 123Combined sources8
Beta strandi125 – 138Combined sources14
Beta strandi141 – 153Combined sources13
Helixi157 – 169Combined sources13
Beta strandi183 – 185Combined sources3

3D structure databases

ProteinModelPortaliP05090
SMRiP05090
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05090

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4824 Eukaryota
COG3040 LUCA
GeneTreeiENSGT00510000046981
HOGENOMiHOG000061525
HOVERGENiHBG018734
InParanoidiP05090
KOiK03098
PhylomeDBiP05090
TreeFamiTF324836

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR026222 ApoD_vertbrte
IPR002969 ApolipopD
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PfamiView protein in Pfam
PF08212 Lipocalin_2, 1 hit
PIRSFiPIRSF036893 Lipocalin_ApoD, 1 hit
PRINTSiPR02058 APODVERTBRTE
PR01219 APOLIPOPROTD
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMLLLLLSA LAGLFGAAEG QAFHLGKCPN PPVQENFDVN KYLGRWYEIE
60 70 80 90 100
KIPTTFENGR CIQANYSLME NGKIKVLNQE LRADGTVNQI EGEATPVNLT
110 120 130 140 150
EPAKLEVKFS WFMPSAPYWI LATDYENYAL VYSCTCIIQL FHVDFAWILA
160 170 180
RNPNLPPETV DSLKNILTSN NIDVKKMTVT DQVNCPKLS
Length:189
Mass (Da):21,276
Last modified:August 13, 1987 - v1
Checksum:i0EAA6DE03D5E71A8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01193115F → S1 PublicationCorresponds to variant dbSNP:rs5952Ensembl.1
Natural variantiVAR_011932115S → L1 PublicationCorresponds to variant dbSNP:rs5954Ensembl.1
Natural variantiVAR_011933178T → K1 PublicationCorresponds to variant dbSNP:rs5955Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02611 mRNA Translation: AAB59517.1
M16696 Genomic DNA Translation: AAA51764.1
BT019860 mRNA Translation: AAV38663.1
BT019861 mRNA Translation: AAV38664.1
CR456838 mRNA Translation: CAG33119.1
CR541773 mRNA Translation: CAG46572.1
AK312090 mRNA Translation: BAG35026.1
CH471052 Genomic DNA Translation: EAW78023.1
CH471052 Genomic DNA Translation: EAW78024.1
BC007402 mRNA Translation: AAH07402.1
S80440 mRNA Translation: AAB35919.1
CCDSiCCDS33925.1
PIRiA26958 LPHUD
RefSeqiNP_001638.1, NM_001647.3
UniGeneiHs.522555

Genome annotation databases

EnsembliENST00000343267; ENSP00000345179; ENSG00000189058
GeneIDi347
KEGGihsa:347
UCSCiuc003fur.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPOD_HUMAN
AccessioniPrimary (citable) accession number: P05090
Secondary accession number(s): B2R579, D3DNW6, Q6IBG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 18, 2018
This is version 203 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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