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UniProtKB - P05085 (ARGR2_YEAST)

Entry version 172 (29 Sep 2021)
Sequence version 3 (01 Feb 1996)
Previous versions | rss
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Protein

Arginine metabolism regulation protein II

Gene

ARG81

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

With ARG80, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi21 – 48Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processArginine metabolism, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine metabolism regulation protein II
Alternative name(s):
Arginine-requiring protein 81
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARG81
Synonyms:ARGR2
Ordered Locus Names:YML099C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000004565, ARG81

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YML099C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149371 – 880Arginine metabolism regulation protein IIAdd BLAST880

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P05085

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05085

PRoteomics IDEntifications database

More...PRIDEi		P05085

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05085

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARG80 and MCM1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35044, 85 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1152, ARGR-MCM1 transcription regulation complex

Database of interacting proteins

More...DIPi		DIP-1346N

Protein interaction database and analysis system

More...IntActi		P05085, 14 interactors

Molecular INTeraction database

More...MINTi		P05085

STRING: functional protein association networks

More...STRINGi		4932.YML099C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05085, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05085

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQBG, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009030_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05085

Identification of Orthologs from Complete Genome Data

More...OMAi		AKTFTGC

Family and domain databases

Conserved Domains Database

More...CDDi		cd00067, GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021858, Fun_TF
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11951, Fungal_trans_2, 1 hit
PF00172, Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00066, GAL4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57701, SSF57701, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P05085-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGISSKNGPK KMGRAKTFTG CWTCRGRKVK CDLRHPHCQR CEKSNLPCGG 
        60         70         80         90        100
YDIKLRWSKP MQFDPYGVPI PQNSPATTTN LSGSVDEPQY QRRNIDFVRY 
       110        120        130        140        150
DEEYVYHEDM DDELTMLHTP PIEKISDNKT WIIKKFGVFK GTDKIDKQYA 
       160        170        180        190        200
PRKKRNRKRV AKSLESSASI SLSSLPSSST ISFPIRHIED KLRNKGHVKT 
       210        220        230        240        250
GILSANDGVP PTPNLLDYDW NNLNITGYEW ISSELRDDAL LSAVTLQGHH 
       260        270        280        290        300
LGHTQPQEIS LEENSNVVSG EEHVNAKEHG CAFEADNQGS STLPNKAASA 
       310        320        330        340        350
NDKLYQQNLK LLFQKNSSNS EEPDPQALID DVFVNIEPRS LPASDLNKIT 
       360        370        380        390        400
LAPPNEESRM PKSMLELTSY SSDLPPELVD IIPKTDLTVH GLARFLLNHY 
       410        420        430        440        450
FNNVADKMTV VVLEKNPWKT LYFPRALMAL GDLAGLGQSS NSRNALLNAL 
       460        470        480        490        500
LAVSCFHLQS KYPRNYKLQK YFLGLGIELR NQASNFLRLC LNTKSSIPEK 
       510        520        530        540        550
YKDVLTAILS MNSIDVVWGT MADCQDHLAL CEDFVESRMK LRPNISEKTK 
       560        570        580        590        600
TLHRIFSFLK LIQDSTALDK VRAKEIVILP SEEDDNYKPL DTSNATTSSS 
       610        620        630        640        650
EPRVDVVQEG LFREALNEND GKIHIEFVKE PITNVSADST PSSTTPPIFT 
       660        670        680        690        700
NIATESYYNK SDISKLVSKT DENIIGTDSL YGLPNSLILL FSDCVRIVRH 
       710        720        730        740        750
NEYYNLTYLP VPRKFNELSL NFEKRLLKWK SEWNFHQENS EGKSFINSTA 
       760        770        780        790        800
EALYHHTMSF YFSLIIYYFT MARSLNCQFL QNYVAKVLDH LNAMEELVDQ 
       810        820        830        840        850
KKVKIVPLIW QGFMAGCACT DENRQQEFRR WAAKLAESGV GSYWGARQVM 
       860        870        880
LEVWRRRKED EPGDNWYSVY KDWEMNLMLS
Length:880
Mass (Da):100,282
Last modified:February 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA033AB2B373F415
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4S → F in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti129Missing in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti283F → V in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti345D → V in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti366E → Q in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti549T → A in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti597T → S in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti665K → N in CAA27577 (PubMed:3709534).Curated1
Sequence conflicti869V → I in CAA27577 (PubMed:3709534).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X03940 Genomic DNA Translation: CAA27577.1
Z46660 Genomic DNA Translation: CAA86638.1
BK006946 Genomic DNA Translation: DAA09800.1

Protein sequence database of the Protein Information Resource

More...PIRi		S49627

NCBI Reference Sequences

More...RefSeqi		NP_013610.1, NM_001182459.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YML099C_mRNA; YML099C; YML099C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		854874

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YML099C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03940 Genomic DNA Translation: CAA27577.1
Z46660 Genomic DNA Translation: CAA86638.1
BK006946 Genomic DNA Translation: DAA09800.1
PIRiS49627
RefSeqiNP_013610.1, NM_001182459.1

3D structure databases

SMRiP05085
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35044, 85 interactors
ComplexPortaliCPX-1152, ARGR-MCM1 transcription regulation complex
DIPiDIP-1346N
IntActiP05085, 14 interactors
MINTiP05085
STRINGi4932.YML099C

PTM databases

iPTMnetiP05085

Proteomic databases

MaxQBiP05085
PaxDbiP05085
PRIDEiP05085

Genome annotation databases

EnsemblFungiiYML099C_mRNA; YML099C; YML099C
GeneIDi854874
KEGGisce:YML099C

Organism-specific databases

SGDiS000004565, ARG81
VEuPathDBiFungiDB:YML099C

Phylogenomic databases

eggNOGiENOG502QQBG, Eukaryota
HOGENOMiCLU_009030_1_0_1
InParanoidiP05085
OMAiAKTFTGC

Miscellaneous databases

Protein Ontology

More...PROi		PR:P05085
RNActiP05085, protein

Family and domain databases

CDDicd00067, GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR021858, Fun_TF
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF11951, Fungal_trans_2, 1 hit
PF00172, Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066, GAL4, 1 hit
SUPFAMiSSF57701, SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARGR2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05085
Secondary accession number(s): D6W0I6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: September 29, 2021
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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