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UniProtKB - P05085 (ARGR2_YEAST)
Protein
Arginine metabolism regulation protein II
Gene
ARG81
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
With ARG80, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 21 – 48 | Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST | 28 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- transcription coregulator activity Source: SGD
- zinc ion binding Source: InterPro
GO - Biological processi
- arginine metabolic process Source: UniProtKB-KW
- regulation of arginine metabolic process Source: SGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Arginine metabolism, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Arginine metabolism regulation protein IIAlternative name(s): Arginine-requiring protein 81 |
Gene namesi | Name:ARG81 Synonyms:ARGR2 Ordered Locus Names:YML099C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004565, ARG81 |
VEuPathDBi | FungiDB:YML099C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114937 | 1 – 880 | Arginine metabolism regulation protein IIAdd BLAST | 880 |
Proteomic databases
MaxQBi | P05085 |
PaxDbi | P05085 |
PRIDEi | P05085 |
PTM databases
iPTMneti | P05085 |
Interactioni
Subunit structurei
Interacts with ARG80 and MCM1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 35044, 85 interactors |
ComplexPortali | CPX-1152, ARGR-MCM1 transcription regulation complex |
DIPi | DIP-1346N |
IntActi | P05085, 14 interactors |
MINTi | P05085 |
STRINGi | 4932.YML099C |
Miscellaneous databases
RNActi | P05085, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QQBG, Eukaryota |
HOGENOMi | CLU_009030_1_0_1 |
InParanoidi | P05085 |
OMAi | AKTFTGC |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR021858, Fun_TF IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF11951, Fungal_trans_2, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P05085-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGISSKNGPK KMGRAKTFTG CWTCRGRKVK CDLRHPHCQR CEKSNLPCGG
60 70 80 90 100
YDIKLRWSKP MQFDPYGVPI PQNSPATTTN LSGSVDEPQY QRRNIDFVRY
110 120 130 140 150
DEEYVYHEDM DDELTMLHTP PIEKISDNKT WIIKKFGVFK GTDKIDKQYA
160 170 180 190 200
PRKKRNRKRV AKSLESSASI SLSSLPSSST ISFPIRHIED KLRNKGHVKT
210 220 230 240 250
GILSANDGVP PTPNLLDYDW NNLNITGYEW ISSELRDDAL LSAVTLQGHH
260 270 280 290 300
LGHTQPQEIS LEENSNVVSG EEHVNAKEHG CAFEADNQGS STLPNKAASA
310 320 330 340 350
NDKLYQQNLK LLFQKNSSNS EEPDPQALID DVFVNIEPRS LPASDLNKIT
360 370 380 390 400
LAPPNEESRM PKSMLELTSY SSDLPPELVD IIPKTDLTVH GLARFLLNHY
410 420 430 440 450
FNNVADKMTV VVLEKNPWKT LYFPRALMAL GDLAGLGQSS NSRNALLNAL
460 470 480 490 500
LAVSCFHLQS KYPRNYKLQK YFLGLGIELR NQASNFLRLC LNTKSSIPEK
510 520 530 540 550
YKDVLTAILS MNSIDVVWGT MADCQDHLAL CEDFVESRMK LRPNISEKTK
560 570 580 590 600
TLHRIFSFLK LIQDSTALDK VRAKEIVILP SEEDDNYKPL DTSNATTSSS
610 620 630 640 650
EPRVDVVQEG LFREALNEND GKIHIEFVKE PITNVSADST PSSTTPPIFT
660 670 680 690 700
NIATESYYNK SDISKLVSKT DENIIGTDSL YGLPNSLILL FSDCVRIVRH
710 720 730 740 750
NEYYNLTYLP VPRKFNELSL NFEKRLLKWK SEWNFHQENS EGKSFINSTA
760 770 780 790 800
EALYHHTMSF YFSLIIYYFT MARSLNCQFL QNYVAKVLDH LNAMEELVDQ
810 820 830 840 850
KKVKIVPLIW QGFMAGCACT DENRQQEFRR WAAKLAESGV GSYWGARQVM
860 870 880
LEVWRRRKED EPGDNWYSVY KDWEMNLMLS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | S → F in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 129 | Missing in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 283 | F → V in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 345 | D → V in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 366 | E → Q in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 549 | T → A in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 597 | T → S in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 665 | K → N in CAA27577 (PubMed:3709534).Curated | 1 | |
Sequence conflicti | 869 | V → I in CAA27577 (PubMed:3709534).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03940 Genomic DNA Translation: CAA27577.1 Z46660 Genomic DNA Translation: CAA86638.1 BK006946 Genomic DNA Translation: DAA09800.1 |
PIRi | S49627 |
RefSeqi | NP_013610.1, NM_001182459.1 |
Genome annotation databases
EnsemblFungii | YML099C_mRNA; YML099C; YML099C |
GeneIDi | 854874 |
KEGGi | sce:YML099C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03940 Genomic DNA Translation: CAA27577.1 Z46660 Genomic DNA Translation: CAA86638.1 BK006946 Genomic DNA Translation: DAA09800.1 |
PIRi | S49627 |
RefSeqi | NP_013610.1, NM_001182459.1 |
3D structure databases
SMRi | P05085 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35044, 85 interactors |
ComplexPortali | CPX-1152, ARGR-MCM1 transcription regulation complex |
DIPi | DIP-1346N |
IntActi | P05085, 14 interactors |
MINTi | P05085 |
STRINGi | 4932.YML099C |
PTM databases
iPTMneti | P05085 |
Proteomic databases
MaxQBi | P05085 |
PaxDbi | P05085 |
PRIDEi | P05085 |
Genome annotation databases
EnsemblFungii | YML099C_mRNA; YML099C; YML099C |
GeneIDi | 854874 |
KEGGi | sce:YML099C |
Organism-specific databases
SGDi | S000004565, ARG81 |
VEuPathDBi | FungiDB:YML099C |
Phylogenomic databases
eggNOGi | ENOG502QQBG, Eukaryota |
HOGENOMi | CLU_009030_1_0_1 |
InParanoidi | P05085 |
OMAi | AKTFTGC |
Miscellaneous databases
PROi | PR:P05085 |
RNActi | P05085, protein |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR021858, Fun_TF IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF11951, Fungal_trans_2, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARGR2_YEAST | |
Accessioni | P05085Primary (citable) accession number: P05085 Secondary accession number(s): D6W0I6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | February 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 172 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names