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Protein

Fructose-bisphosphate aldolase C

Gene

Aldoc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1)
  3. ATP-dependent 6-phosphofructokinase, muscle type (Pfkm), ATP-dependent 6-phosphofructokinase, liver type (Pfkl), ATP-dependent 6-phosphofructokinase, platelet type (Pfkp), ATP-dependent 6-phosphofructokinase (Pfkm), ATP-dependent 6-phosphofructokinase (Pfkp)
  4. Fructose-bisphosphate aldolase C (Aldoc), Fructose-bisphosphate aldolase B (Aldob), Fructose-bisphosphate aldolase A (Aldoa), Fructose-bisphosphate aldolase (Aldob), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoart2), Fructose-bisphosphate aldolase (Aldob), Fructose-bisphosphate aldolase (Aldoart1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56Substrate1
Binding sitei147Substrate1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
Sitei363Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis
SABIO-RKiP05063
UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C (EC:4.1.2.13)
Alternative name(s):
Aldolase 3
Brain-type aldolase
Scrapie-responsive protein 2
Zebrin II
Gene namesi
Name:Aldoc
Synonyms:Aldo3, Scrg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:101863 Aldoc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002169492 – 363Fructose-bisphosphate aldolase CAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphotyrosineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei111N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05063
MaxQBiP05063
PaxDbiP05063
PeptideAtlasiP05063
PRIDEiP05063

2D gel databases

REPRODUCTION-2DPAGEiIPI00119458
UCD-2DPAGEiP05063

PTM databases

iPTMnetiP05063
PhosphoSitePlusiP05063
SwissPalmiP05063

Expressioni

Tissue specificityi

Expressed exclusively in Purkinje cells in bands running from anterior to posterior across most of the cerebellum. Expressed at higher levels in the brains of BSE-infected animals.2 Publications

Developmental stagei

Expression begins in the first week of postnatal life.1 Publication

Gene expression databases

BgeeiENSMUSG00000017390 Expressed in 268 organ(s), highest expression level in cerebellum
CleanExiMM_ALDOC
GenevisibleiP05063 MM

Interactioni

Subunit structurei

Homotetramer. Interacts with ATP6V1E1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198068, 3 interactors
IntActiP05063, 6 interactors
MINTiP05063
STRINGi10090.ENSMUSP00000017534

Structurei

3D structure databases

ProteinModelPortaliP05063
SMRiP05063
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiP05063
KOiK01623
OMAiMTHQYPA
OrthoDBiEOG091G0A9T
PhylomeDBiP05063
TreeFamiTF314203

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05063-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHSYPALSA EQKKELSDIA LRIVTPGKGI LAADESVGSM AKRLSQIGVE
60 70 80 90 100
NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD
110 120 130 140 150
KGILVGIKVD KGVVPLAGTD GETTTQGLDG LLERCAQYKK DGADFAKWRC
160 170 180 190 200
VLKISDRTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
210 220 230 240 250
RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYSPEEIA
260 270 280 290 300
MATVTALRRT VPPAVPGVTF LSGGQSEEEA SLNLNAINRC PLPRPWALTF
310 320 330 340 350
SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEMNGLAAQ GRYEGSGDGG
360
AAAQSLYIAN HAY
Length:363
Mass (Da):39,395
Last modified:January 23, 2007 - v4
Checksum:i085C58AF163581C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25T → A in AAH04802 (PubMed:15489334).Curated1
Sequence conflicti25T → A in AAH08184 (PubMed:15489334).Curated1
Sequence conflicti46Q → E in BAC30300 (PubMed:16141072).Curated1
Sequence conflicti62V → A in CAA27422 (PubMed:3009179).Curated1
Sequence conflicti113V → L in CAA27422 (PubMed:3009179).Curated1
Sequence conflicti201R → H in AAH04802 (PubMed:15489334).Curated1
Sequence conflicti201R → H in AAH08184 (PubMed:15489334).Curated1
Sequence conflicti280A → V in AAB32064 (PubMed:7925012).Curated1
Sequence conflicti358I → V in AAH04802 (PubMed:15489334).Curated1
Sequence conflicti358I → V in AAH08184 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72537 mRNA Translation: AAB32064.1
AK005077 mRNA Translation: BAB23801.1
AK039267 mRNA Translation: BAC30300.1
BC004802 mRNA Translation: AAH04802.1
BC008184 mRNA Translation: AAH08184.1
X03796 mRNA Translation: CAA27422.1
AJ132391 mRNA Translation: CAB77178.1
CCDSiCCDS25099.1
PIRiA25388 ADMSC
I53145
RefSeqiNP_001290352.1, NM_001303423.1
NP_033787.2, NM_009657.4
UniGeneiMm.7729

Genome annotation databases

EnsembliENSMUST00000017534; ENSMUSP00000017534; ENSMUSG00000017390
ENSMUST00000102478; ENSMUSP00000099536; ENSMUSG00000017390
GeneIDi11676
KEGGimmu:11676
UCSCiuc007kiw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72537 mRNA Translation: AAB32064.1
AK005077 mRNA Translation: BAB23801.1
AK039267 mRNA Translation: BAC30300.1
BC004802 mRNA Translation: AAH04802.1
BC008184 mRNA Translation: AAH08184.1
X03796 mRNA Translation: CAA27422.1
AJ132391 mRNA Translation: CAB77178.1
CCDSiCCDS25099.1
PIRiA25388 ADMSC
I53145
RefSeqiNP_001290352.1, NM_001303423.1
NP_033787.2, NM_009657.4
UniGeneiMm.7729

3D structure databases

ProteinModelPortaliP05063
SMRiP05063
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198068, 3 interactors
IntActiP05063, 6 interactors
MINTiP05063
STRINGi10090.ENSMUSP00000017534

PTM databases

iPTMnetiP05063
PhosphoSitePlusiP05063
SwissPalmiP05063

2D gel databases

REPRODUCTION-2DPAGEiIPI00119458
UCD-2DPAGEiP05063

Proteomic databases

EPDiP05063
MaxQBiP05063
PaxDbiP05063
PeptideAtlasiP05063
PRIDEiP05063

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017534; ENSMUSP00000017534; ENSMUSG00000017390
ENSMUST00000102478; ENSMUSP00000099536; ENSMUSG00000017390
GeneIDi11676
KEGGimmu:11676
UCSCiuc007kiw.2 mouse

Organism-specific databases

CTDi230
MGIiMGI:101863 Aldoc

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiP05063
KOiK01623
OMAiMTHQYPA
OrthoDBiEOG091G0A9T
PhylomeDBiP05063
TreeFamiTF314203

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis
SABIO-RKiP05063

Miscellaneous databases

ChiTaRSiAldoc mouse
PROiPR:P05063
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017390 Expressed in 268 organ(s), highest expression level in cerebellum
CleanExiMM_ALDOC
GenevisibleiP05063 MM

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALDOC_MOUSE
AccessioniPrimary (citable) accession number: P05063
Secondary accession number(s): Q64011
, Q8CA91, Q99K96, Q9DBA4, Q9JK32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 177 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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