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Protein

Fructose-bisphosphate aldolase B

Gene

ALDOB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.6 µM for fructose 1,6-bisphosphate1 Publication
  2. KM=2.3 mM for fructose 1-phosphate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

    This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase
    3. ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, liver type (PFKL), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKM)
    4. Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase (ALDOC)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56Substrate1
    Binding sitei147Substrate1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei188Proton acceptorBy similarity1
    Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATPase binding Source: BHF-UCL
    • cytoskeletal protein binding Source: BHF-UCL
    • fructose-1-phosphate aldolase activity Source: MGI
    • fructose binding Source: BHF-UCL
    • fructose-bisphosphate aldolase activity Source: BHF-UCL
    • identical protein binding Source: BHF-UCL

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processGlycolysis
    LigandSchiff base

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS06234-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    4.1.2.13 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-5657560 Hereditary fructose intolerance
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis
    R-HSA-70350 Fructose catabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P05062

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P05062

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00109;UER00183

    Protein family/group databases

    MoonDB Database of extreme multifunctional and moonlighting proteins

    More...
    MoonDBi
    P05062 Curated

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase B (EC:4.1.2.13)
    Alternative name(s):
    Liver-type aldolase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ALDOB
    Synonyms:ALDB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000136872.17

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:417 ALDOB

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612724 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P05062

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Hereditary fructose intolerance (HFI)11 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAutosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life.
    See also OMIM:229600
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07534846R → W in HFI; reduced enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs41281039EnsemblClinVar.1
    Natural variantiVAR_02082274I → T in HFI; affects proper folding. 1 PublicationCorresponds to variant dbSNP:rs781023784EnsemblClinVar.1
    Natural variantiVAR_020823120 – 121Missing in HFI. 1 Publication2
    Natural variantiVAR_000551135C → R in HFI; America; partial activity. 1 Publication1
    Natural variantiVAR_000553150A → P in HFI; frequent mutation. 6 PublicationsCorresponds to variant dbSNP:rs1800546EnsemblClinVar.1
    Natural variantiVAR_000554175A → D in HFI; frequent mutation. 6 PublicationsCorresponds to variant dbSNP:rs76917243EnsemblClinVar.1
    Natural variantiVAR_058211178C → R in HFI. 1 Publication1
    Natural variantiVAR_020824185P → R in HFI. 1 Publication1
    Natural variantiVAR_020826222V → F in HFI; affects proper folding. 1 Publication1
    Natural variantiVAR_020827229L → P in HFI; affects proper folding. 1 Publication1
    Natural variantiVAR_000555257L → P in HFI; Italy. 3 PublicationsCorresponds to variant dbSNP:rs764701775Ensembl.1
    Natural variantiVAR_058212284L → P in HFI. 1 Publication1
    Natural variantiVAR_020828304R → Q in HFI; 100-fold decrease in catalytic efficiency for substrates FBP and F1P. 1 PublicationCorresponds to variant dbSNP:rs145078268EnsemblClinVar.1
    Natural variantiVAR_000556304R → W in HFI; Turkey; 4800-fold decrease in catalytic efficiency for FBP and inactive with F1P. 2 PublicationsCorresponds to variant dbSNP:rs555935217Ensembl.1
    Natural variantiVAR_000557335N → K in HFI; frequent mutation. 5 PublicationsCorresponds to variant dbSNP:rs78340951EnsemblClinVar.1
    Natural variantiVAR_000558338A → V in HFI; Turkey and South Europe. 2 PublicationsCorresponds to variant dbSNP:rs77718928EnsemblClinVar.1
    Natural variantiVAR_075349343Y → H in HFI; almost no effect on enzymatic activity at 30 degrees Celsius, but reduced activity at higher temperatures. 1 PublicationCorresponds to variant dbSNP:rs369586696EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    229

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    ALDOB

    MalaCards human disease database

    More...
    MalaCardsi
    ALDOB
    MIMi229600 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000136872

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    469 Hereditary fructose intolerance

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24710

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB02515 3-Phosphoglycerol

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ALDOB

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    113611

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002169402 – 364Fructose-bisphosphate aldolase BAdd BLAST363

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
    Modified residuei13N6-succinyllysineBy similarity1
    Modified residuei36PhosphoserineCombined sources1
    Modified residuei39PhosphothreonineCombined sources1
    Modified residuei89PhosphoserineCombined sources1
    Modified residuei119PhosphothreonineCombined sources1
    Modified residuei121N6-succinyllysineBy similarity1
    Modified residuei132PhosphoserineCombined sources1
    Modified residuei272PhosphoserineCombined sources1
    Modified residuei276PhosphoserineCombined sources1
    Modified residuei299PhosphoserineBy similarity1
    Modified residuei301PhosphoserineBy similarity1
    Modified residuei309PhosphoserineCombined sources1
    Modified residuei317N6-succinyllysineBy similarity1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P05062

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P05062

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P05062

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P05062

    PeptideAtlas

    More...
    PeptideAtlasi
    P05062

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P05062

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    51773

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P05062

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P05062

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000136872 Expressed in 171 organ(s), highest expression level in jejunal mucosa

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_ALDOB

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P05062 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P05062 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB020827
    HPA002198

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    106730, 16 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P05062, 28 interactors

    Molecular INTeraction database

    More...
    MINTi
    P05062

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000363988

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1364
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1QO5X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-364[»]
    1XDLX-ray3.00A/B/C/D/W/X/Y/Z2-364[»]
    1XDMX-ray3.00A/B/C/D/W/X/Y/Z2-364[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P05062

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P05062

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P05062

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1557 Eukaryota
    COG3588 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000010235

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000220876

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG002386

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P05062

    KEGG Orthology (KO)

    More...
    KOi
    K01623

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PLCKPWA

    Database of Orthologous Groups

    More...
    OrthoDBi
    799973at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P05062

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314203

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00274 Glycolytic, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    P05062-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAHRFPALTQ EQKKELSEIA QSIVANGKGI LAADESVGTM GNRLQRIKVE
    60 70 80 90 100
    NTEENRRQFR EILFSVDSSI NQSIGGVILF HETLYQKDSQ GKLFRNILKE
    110 120 130 140 150
    KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA
    160 170 180 190 200
    VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VIPDGDHDLE
    210 220 230 240 250
    HCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA
    260 270 280 290 300
    MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINLC PLPKPWKLSF
    310 320 330 340 350
    SYGRALQASA LAAWGGKAAN KEATQEAFMK RAMANCQAAK GQYVHTGSSG
    360
    AASTQSLFTA CYTY
    Length:364
    Mass (Da):39,473
    Last modified:January 23, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCE314E7AC5586CA
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A087WXX2A0A087WXX2_HUMAN
    Fructose-bisphosphate aldolase
    ALDOB
    316Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3IS80A0A3B3IS80_HUMAN
    Fructose-bisphosphate aldolase
    ALDOB
    342Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ITZ0A0A3B3ITZ0_HUMAN
    Fructose-bisphosphate aldolase B
    ALDOB
    75Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54E → D in AAA51691 (PubMed:3016456).Curated1
    Sequence conflicti250A → D in CAA25072 (PubMed:6689266).Curated1
    Sequence conflicti278E → D in BAA00125 (PubMed:2830249).Curated1
    Sequence conflicti309S → V no nucleotide entry (PubMed:6585824).Curated1
    Sequence conflicti348S → C in BAA00125 (PubMed:2830249).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_07534846R → W in HFI; reduced enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs41281039EnsemblClinVar.1
    Natural variantiVAR_02082274I → T in HFI; affects proper folding. 1 PublicationCorresponds to variant dbSNP:rs781023784EnsemblClinVar.1
    Natural variantiVAR_020823120 – 121Missing in HFI. 1 Publication2
    Natural variantiVAR_038429134R → S. Corresponds to variant dbSNP:rs10123355Ensembl.1
    Natural variantiVAR_000551135C → R in HFI; America; partial activity. 1 Publication1
    Natural variantiVAR_000552148W → R in one subject with fructose intolerance; rare variant; America. 1 PublicationCorresponds to variant dbSNP:rs118204430EnsemblClinVar.1
    Natural variantiVAR_000553150A → P in HFI; frequent mutation. 6 PublicationsCorresponds to variant dbSNP:rs1800546EnsemblClinVar.1
    Natural variantiVAR_000554175A → D in HFI; frequent mutation. 6 PublicationsCorresponds to variant dbSNP:rs76917243EnsemblClinVar.1
    Natural variantiVAR_058211178C → R in HFI. 1 Publication1
    Natural variantiVAR_020824185P → R in HFI. 1 Publication1
    Natural variantiVAR_020825207E → Q. Corresponds to variant dbSNP:rs3739721EnsemblClinVar.1
    Natural variantiVAR_020826222V → F in HFI; affects proper folding. 1 Publication1
    Natural variantiVAR_020827229L → P in HFI; affects proper folding. 1 Publication1
    Natural variantiVAR_000555257L → P in HFI; Italy. 3 PublicationsCorresponds to variant dbSNP:rs764701775Ensembl.1
    Natural variantiVAR_038430268I → N. Corresponds to variant dbSNP:rs10989495Ensembl.1
    Natural variantiVAR_058212284L → P in HFI. 1 Publication1
    Natural variantiVAR_020828304R → Q in HFI; 100-fold decrease in catalytic efficiency for substrates FBP and F1P. 1 PublicationCorresponds to variant dbSNP:rs145078268EnsemblClinVar.1
    Natural variantiVAR_000556304R → W in HFI; Turkey; 4800-fold decrease in catalytic efficiency for FBP and inactive with F1P. 2 PublicationsCorresponds to variant dbSNP:rs555935217Ensembl.1
    Natural variantiVAR_000557335N → K in HFI; frequent mutation. 5 PublicationsCorresponds to variant dbSNP:rs78340951EnsemblClinVar.1
    Natural variantiVAR_000558338A → V in HFI; Turkey and South Europe. 2 PublicationsCorresponds to variant dbSNP:rs77718928EnsemblClinVar.1
    Natural variantiVAR_075349343Y → H in HFI; almost no effect on enzymatic activity at 30 degrees Celsius, but reduced activity at higher temperatures. 1 PublicationCorresponds to variant dbSNP:rs369586696EnsemblClinVar.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X02747 mRNA Translation: CAA26526.1
    D00183 Genomic DNA Translation: BAA00125.1
    M15656, M15657 Genomic DNA Translation: AAA51691.1
    AL353621 Genomic DNA No translation available.
    CH471105 Genomic DNA Translation: EAW58951.1
    X00270 mRNA Translation: CAA25072.1
    X01098 mRNA Translation: CAA25572.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6756.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A41505 ADHUB

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000026.2, NM_000035.3

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.530274

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000374855; ENSP00000363988; ENSG00000136872
    ENST00000647789; ENSP00000497767; ENSG00000136872
    ENST00000648064; ENSP00000497990; ENSG00000136872
    ENST00000648758; ENSP00000497731; ENSG00000136872

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    229

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:229

    UCSC genome browser

    More...
    UCSCi
    uc004bbk.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X02747 mRNA Translation: CAA26526.1
    D00183 Genomic DNA Translation: BAA00125.1
    M15656, M15657 Genomic DNA Translation: AAA51691.1
    AL353621 Genomic DNA No translation available.
    CH471105 Genomic DNA Translation: EAW58951.1
    X00270 mRNA Translation: CAA25072.1
    X01098 mRNA Translation: CAA25572.1
    CCDSiCCDS6756.1
    PIRiA41505 ADHUB
    RefSeqiNP_000026.2, NM_000035.3
    UniGeneiHs.530274

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1QO5X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-364[»]
    1XDLX-ray3.00A/B/C/D/W/X/Y/Z2-364[»]
    1XDMX-ray3.00A/B/C/D/W/X/Y/Z2-364[»]
    ProteinModelPortaliP05062
    SMRiP05062
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi106730, 16 interactors
    IntActiP05062, 28 interactors
    MINTiP05062
    STRINGi9606.ENSP00000363988

    Chemistry databases

    DrugBankiDB02515 3-Phosphoglycerol

    Protein family/group databases

    MoonDBiP05062 Curated

    PTM databases

    iPTMnetiP05062
    PhosphoSitePlusiP05062

    Polymorphism and mutation databases

    BioMutaiALDOB
    DMDMi113611

    Proteomic databases

    EPDiP05062
    jPOSTiP05062
    MaxQBiP05062
    PaxDbiP05062
    PeptideAtlasiP05062
    PRIDEiP05062
    ProteomicsDBi51773

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000374855; ENSP00000363988; ENSG00000136872
    ENST00000647789; ENSP00000497767; ENSG00000136872
    ENST00000648064; ENSP00000497990; ENSG00000136872
    ENST00000648758; ENSP00000497731; ENSG00000136872
    GeneIDi229
    KEGGihsa:229
    UCSCiuc004bbk.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    229
    DisGeNETi229
    EuPathDBiHostDB:ENSG00000136872.17

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ALDOB
    GeneReviewsiALDOB

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0125611
    HGNCiHGNC:417 ALDOB
    HPAiCAB020827
    HPA002198
    MalaCardsiALDOB
    MIMi229600 phenotype
    612724 gene
    neXtProtiNX_P05062
    OpenTargetsiENSG00000136872
    Orphaneti469 Hereditary fructose intolerance
    PharmGKBiPA24710

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1557 Eukaryota
    COG3588 LUCA
    GeneTreeiENSGT00390000010235
    HOGENOMiHOG000220876
    HOVERGENiHBG002386
    InParanoidiP05062
    KOiK01623
    OMAiPLCKPWA
    OrthoDBi799973at2759
    PhylomeDBiP05062
    TreeFamiTF314203

    Enzyme and pathway databases

    UniPathwayi
    UPA00109;UER00183

    BioCyciMetaCyc:HS06234-MONOMER
    BRENDAi4.1.2.13 2681
    ReactomeiR-HSA-5657560 Hereditary fructose intolerance
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis
    R-HSA-70350 Fructose catabolism
    SABIO-RKiP05062
    SIGNORiP05062

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ALDOB human
    EvolutionaryTraceiP05062

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Aldolase_B

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    229

    Protein Ontology

    More...
    PROi
    PR:P05062

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000136872 Expressed in 171 organ(s), highest expression level in jejunal mucosa
    CleanExiHS_ALDOB
    ExpressionAtlasiP05062 baseline and differential
    GenevisibleiP05062 HS

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I
    PfamiView protein in Pfam
    PF00274 Glycolytic, 1 hit
    PROSITEiView protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALDOB_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05062
    Secondary accession number(s): Q13741, Q13742, Q5T7D6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: January 16, 2019
    This is version 206 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
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