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UniProtKB - P05060 (SCG1_HUMAN)
Protein
Secretogranin-1
Gene
CHGB
Organism
Homo sapiens (Human)
Status
Functioni
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
GO - Molecular functioni
- hormone activity Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | P05060 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | P05060 |
Names & Taxonomyi
Protein namesi | Recommended name: Secretogranin-1Alternative name(s): Chromogranin-B Short name: CgB Secretogranin I Short name: SgI Cleaved into the following 3 chains: |
Gene namesi | Name:CHGB Synonyms:SCG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1930, CHGB |
MIMi | 118920, gene |
neXtProti | NX_P05060 |
VEuPathDBi | HostDB:ENSG00000089199 |
Subcellular locationi
Extracellular region or secreted
Note: Neuroendocrine and endocrine secretory granules.
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- secretory granule Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1114 |
OpenTargetsi | ENSG00000089199 |
PharmGKBi | PA26462 |
Miscellaneous databases
Pharosi | P05060, Tbio |
Genetic variation databases
BioMutai | CHGB |
DMDMi | 311033509 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 2 PublicationsAdd BLAST | 20 | |
ChainiPRO_0000005438 | 21 – 677 | Secretogranin-1Add BLAST | 657 | |
PeptideiPRO_0000005439 | 440 – 513 | GAWK peptideAdd BLAST | 74 | |
PeptideiPRO_0000432730 | 575 – 585 | PE-11By similarityAdd BLAST | 11 | |
PeptideiPRO_0000005440 | 617 – 673 | CCB peptideAdd BLAST | 57 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 57 | |||
Modified residuei | 79 | PhosphothreonineCurated | 1 | |
Modified residuei | 93 | PhosphoserineBy similarity | 1 | |
Modified residuei | 99 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 100 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 130 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 149 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 183 | PhosphoserineBy similarity | 1 | |
Modified residuei | 225 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 259 | PhosphoserineCombined sources | 1 | |
Modified residuei | 263 | PhosphoserineCombined sources | 1 | |
Modified residuei | 293 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 294 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 311 | PhosphoserineCombined sources | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 341 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 367 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 377 | Phosphoserine; by FAM20CCombined sources1 Publication | 1 | |
Modified residuei | 380 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 401 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 405 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 474 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 533 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 534 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 566 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 617 | PhosphoserineCombined sources | 1 | |
Modified residuei | 624 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 626 | PhosphoserineBy similarity | 1 | |
Modified residuei | 631 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).By similarity
O-glycosylated.1 Publication
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, SulfationProteomic databases
EPDi | P05060 |
jPOSTi | P05060 |
MassIVEi | P05060 |
PaxDbi | P05060 |
PeptideAtlasi | P05060 |
PRIDEi | P05060 |
ProteomicsDBi | 51772 |
PTM databases
GlyConnecti | 1727, 1 N-Linked glycan (1 site) |
GlyGeni | P05060, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | P05060 |
PhosphoSitePlusi | P05060 |
Expressioni
Tissue specificityi
Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.1 Publication
Gene expression databases
Bgeei | ENSG00000089199, Expressed in pituitary gland and 183 other tissues |
ExpressionAtlasi | P05060, baseline and differential |
Genevisiblei | P05060, HS |
Organism-specific databases
HPAi | ENSG00000089199, Group enriched (adrenal gland, pituitary gland) |
Interactioni
Binary interactionsi
P05060
With | #Exp. | IntAct |
---|---|---|
FAM20C [Q8IXL6] | 2 | EBI-712619,EBI-7147442 |
LRRK2 [Q5S007] | 3 | EBI-712619,EBI-5323863 |
SMAD2 [Q15796] | 2 | EBI-712619,EBI-1040141 |
GO - Molecular functioni
- hormone activity Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 107539, 35 interactors |
IntActi | P05060, 38 interactors |
MINTi | P05060 |
STRINGi | 9606.ENSP00000368244 |
Miscellaneous databases
RNActi | P05060, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 64 – 463 | DisorderedSequence analysisAdd BLAST | 400 | |
Regioni | 116 – 120 | O-glycosylated at one site | 5 | |
Regioni | 475 – 512 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 622 – 653 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 64 – 98 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 114 – 138 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 149 – 163 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 172 – 192 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 204 – 261 | Basic and acidic residuesSequence analysisAdd BLAST | 58 | |
Compositional biasi | 319 – 344 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 356 – 463 | Basic and acidic residuesSequence analysisAdd BLAST | 108 | |
Compositional biasi | 489 – 512 | Basic and acidic residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the chromogranin/secretogranin protein family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QRBF, Eukaryota |
GeneTreei | ENSGT00940000154206 |
HOGENOMi | CLU_026095_0_0_1 |
InParanoidi | P05060 |
OMAi | WGYEKRS |
OrthoDBi | 670416at2759 |
PhylomeDBi | P05060 |
TreeFami | TF336596 |
Family and domain databases
InterProi | View protein in InterPro IPR001819, Chromogranin_AB IPR018054, Chromogranin_CS IPR001990, Granin |
PANTHERi | PTHR10583, PTHR10583, 1 hit |
Pfami | View protein in Pfam PF01271, Granin, 1 hit |
PRINTSi | PR00659, CHROMOGRANIN |
PROSITEi | View protein in PROSITE PS00422, GRANINS_1, 1 hit PS00423, GRANINS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P05060-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA
60 70 80 90 100
PPITPECRQV LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS
110 120 130 140 150
RGEAGAPGEE DIQGPTKADT EKWAEGGGHS RERADEPQWS LYPSDSQVSE
160 170 180 190 200
EVKTRHSEKS QREDEEEEEG ENYQKGERGE DSSEEKHLEE PGETQNAFLN
210 220 230 240 250
ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG EETGSQENHP
260 270 280 290 300
QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP
310 320 330 340 350
SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG
360 370 380 390 400
VQAPEDLEWE RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG
410 420 430 440 450
YGEESEEERG LEPGKGRHHR GRGGEPRAYF MSDTREEKRF LGEGHHRVQE
460 470 480 490 500
NQMDKARRHP QGAWKELDRN YLNYGEEGAP GKWQQQGDLQ DTKENREEAR
510 520 530 540 550
FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD NMNDNFLEGE
560 570 580 590 600
EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ
610 620 630 640 650
YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE
660 670
DEKKELENLA AMDLELQKIA EKFSQRG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MT66 | A0A0A0MT66_HUMAN | Secretogranin-1 | CHGB | 289 | Annotation score: |
Sequence cautioni
The sequence BAD92949 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | D → E in BAF82075 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043578 | 93 | S → T2 PublicationsCorresponds to variant dbSNP:rs6085324Ensembl. | 1 | |
Natural variantiVAR_024414 | 117 | K → N. Corresponds to variant dbSNP:rs236150Ensembl. | 1 | |
Natural variantiVAR_028235 | 145 | D → N. Corresponds to variant dbSNP:rs6133278Ensembl. | 1 | |
Natural variantiVAR_020287 | 178 | R → Q2 PublicationsCorresponds to variant dbSNP:rs910122Ensembl. | 1 | |
Natural variantiVAR_028236 | 200 | N → H. Corresponds to variant dbSNP:rs881118Ensembl. | 1 | |
Natural variantiVAR_028237 | 232 | R → Q. Corresponds to variant dbSNP:rs6139873Ensembl. | 1 | |
Natural variantiVAR_024415 | 243 | T → A6 PublicationsCorresponds to variant dbSNP:rs236151Ensembl. | 1 | |
Natural variantiVAR_024416 | 353 | A → G2 PublicationsCorresponds to variant dbSNP:rs236152Ensembl. | 1 | |
Natural variantiVAR_028238 | 413 | P → L. Corresponds to variant dbSNP:rs742710Ensembl. | 1 | |
Natural variantiVAR_022012 | 417 | R → H2 PublicationsCorresponds to variant dbSNP:rs742711Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00064 mRNA Translation: CAA68271.1 AK289386 mRNA Translation: BAF82075.1 CR456726 mRNA Translation: CAG33007.1 AB209712 mRNA Translation: BAD92949.1 Different initiation. AL035461 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10410.1 BC000375 mRNA Translation: AAH00375.1 |
CCDSi | CCDS13092.1 |
PIRi | A29264, CNHUB |
RefSeqi | NP_001810.2, NM_001819.2 |
Genome annotation databases
Ensembli | ENST00000378961; ENSP00000368244; ENSG00000089199 |
GeneIDi | 1114 |
KEGGi | hsa:1114 |
MANE-Selecti | ENST00000378961.9; ENSP00000368244.4; NM_001819.3; NP_001810.2 |
UCSCi | uc002wmg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00064 mRNA Translation: CAA68271.1 AK289386 mRNA Translation: BAF82075.1 CR456726 mRNA Translation: CAG33007.1 AB209712 mRNA Translation: BAD92949.1 Different initiation. AL035461 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10410.1 BC000375 mRNA Translation: AAH00375.1 |
CCDSi | CCDS13092.1 |
PIRi | A29264, CNHUB |
RefSeqi | NP_001810.2, NM_001819.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107539, 35 interactors |
IntActi | P05060, 38 interactors |
MINTi | P05060 |
STRINGi | 9606.ENSP00000368244 |
PTM databases
GlyConnecti | 1727, 1 N-Linked glycan (1 site) |
GlyGeni | P05060, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | P05060 |
PhosphoSitePlusi | P05060 |
Genetic variation databases
BioMutai | CHGB |
DMDMi | 311033509 |
Proteomic databases
EPDi | P05060 |
jPOSTi | P05060 |
MassIVEi | P05060 |
PaxDbi | P05060 |
PeptideAtlasi | P05060 |
PRIDEi | P05060 |
ProteomicsDBi | 51772 |
Protocols and materials databases
Antibodypediai | 2170, 241 antibodies from 32 providers |
DNASUi | 1114 |
Genome annotation databases
Ensembli | ENST00000378961; ENSP00000368244; ENSG00000089199 |
GeneIDi | 1114 |
KEGGi | hsa:1114 |
MANE-Selecti | ENST00000378961.9; ENSP00000368244.4; NM_001819.3; NP_001810.2 |
UCSCi | uc002wmg.4, human |
Organism-specific databases
CTDi | 1114 |
DisGeNETi | 1114 |
GeneCardsi | CHGB |
HGNCi | HGNC:1930, CHGB |
HPAi | ENSG00000089199, Group enriched (adrenal gland, pituitary gland) |
MIMi | 118920, gene |
neXtProti | NX_P05060 |
OpenTargetsi | ENSG00000089199 |
PharmGKBi | PA26462 |
VEuPathDBi | HostDB:ENSG00000089199 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRBF, Eukaryota |
GeneTreei | ENSGT00940000154206 |
HOGENOMi | CLU_026095_0_0_1 |
InParanoidi | P05060 |
OMAi | WGYEKRS |
OrthoDBi | 670416at2759 |
PhylomeDBi | P05060 |
TreeFami | TF336596 |
Enzyme and pathway databases
PathwayCommonsi | P05060 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | P05060 |
Miscellaneous databases
BioGRID-ORCSi | 1114, 9 hits in 1040 CRISPR screens |
ChiTaRSi | CHGB, human |
GeneWikii | Secretoneurin |
GenomeRNAii | 1114 |
Pharosi | P05060, Tbio |
PROi | PR:P05060 |
RNActi | P05060, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000089199, Expressed in pituitary gland and 183 other tissues |
ExpressionAtlasi | P05060, baseline and differential |
Genevisiblei | P05060, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001819, Chromogranin_AB IPR018054, Chromogranin_CS IPR001990, Granin |
PANTHERi | PTHR10583, PTHR10583, 1 hit |
Pfami | View protein in Pfam PF01271, Granin, 1 hit |
PRINTSi | PR00659, CHROMOGRANIN |
PROSITEi | View protein in PROSITE PS00422, GRANINS_1, 1 hit PS00423, GRANINS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCG1_HUMAN | |
Accessioni | P05060Primary (citable) accession number: P05060 Secondary accession number(s): A8K021 Q9UJA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 203 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families