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UniProtKB - P05060 (SCG1_HUMAN)

Entry version 203 (23 Feb 2022)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
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Protein

Secretogranin-1

Gene

CHGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05060

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P05060

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secretogranin-1
Alternative name(s):
Chromogranin-B
Short name:
CgB
Secretogranin I
Short name:
SgI
Cleaved into the following 3 chains:
PE-11
GAWK peptide
CCB peptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHGB
Synonyms:SCG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1930, CHGB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118920, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05060

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000089199

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1114

Open Targets

More...OpenTargetsi		ENSG00000089199

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26462

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05060, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHGB

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033509

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 202 PublicationsAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000543821 – 677Secretogranin-1Add BLAST657
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000005439440 – 513GAWK peptideAdd BLAST74
PeptideiPRO_0000432730575 – 585PE-11By similarityAdd BLAST11
PeptideiPRO_0000005440617 – 673CCB peptideAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 57
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79PhosphothreonineCurated1
Modified residuei93PhosphoserineBy similarity1
Modified residuei99PhosphoserineSequence analysis1
Modified residuei100PhosphoserineSequence analysis1
Modified residuei130Phosphoserine; by FAM20C1 Publication1
Modified residuei149PhosphoserineCombined sources1 Publication1
Modified residuei183PhosphoserineBy similarity1
Modified residuei225Phosphoserine; by FAM20C1 Publication1
Modified residuei259PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei293PhosphoserineSequence analysis1
Modified residuei294PhosphoserineSequence analysis1
Modified residuei311PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei341SulfotyrosineBy similarity1
Modified residuei367Phosphoserine; by FAM20C1 Publication1
Modified residuei377Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei380Phosphoserine; by FAM20C1 Publication1
Modified residuei401Phosphotyrosine1 Publication1
Modified residuei405PhosphoserineCombined sources1 Publication1
Modified residuei474SulfotyrosineBy similarity1
Modified residuei533PhosphoserineSequence analysis1
Modified residuei534PhosphoserineSequence analysis1
Modified residuei566SulfotyrosineBy similarity1
Modified residuei617PhosphoserineCombined sources1
Modified residuei624SulfotyrosineBy similarity1
Modified residuei626PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).By similarity
O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05060

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05060

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05060

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05060

PeptideAtlas

More...PeptideAtlasi		P05060

PRoteomics IDEntifications database

More...PRIDEi		P05060

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51772

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1727, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05060, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05060

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05060

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000089199, Expressed in pituitary gland and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P05060, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05060, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000089199, Group enriched (adrenal gland, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107539, 35 interactors

Protein interaction database and analysis system

More...IntActi		P05060, 38 interactors

Molecular INTeraction database

More...MINTi		P05060

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000368244

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05060, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 463DisorderedSequence analysisAdd BLAST400
Regioni116 – 120O-glycosylated at one site5
Regioni475 – 512DisorderedSequence analysisAdd BLAST38
Regioni622 – 653DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 98Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi114 – 138Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi149 – 163Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi172 – 192Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi204 – 261Basic and acidic residuesSequence analysisAdd BLAST58
Compositional biasi319 – 344Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi356 – 463Basic and acidic residuesSequence analysisAdd BLAST108
Compositional biasi489 – 512Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chromogranin/secretogranin protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRBF, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154206

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026095_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05060

Identification of Orthologs from Complete Genome Data

More...OMAi		WGYEKRS

Database of Orthologous Groups

More...OrthoDBi		670416at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05060

TreeFam database of animal gene trees

More...TreeFami		TF336596

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001819, Chromogranin_AB
IPR018054, Chromogranin_CS
IPR001990, Granin

The PANTHER Classification System

More...PANTHERi		PTHR10583, PTHR10583, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01271, Granin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00659, CHROMOGRANIN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00422, GRANINS_1, 1 hit
PS00423, GRANINS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05060-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA 
        60         70         80         90        100
PPITPECRQV LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS 
       110        120        130        140        150
RGEAGAPGEE DIQGPTKADT EKWAEGGGHS RERADEPQWS LYPSDSQVSE 
       160        170        180        190        200
EVKTRHSEKS QREDEEEEEG ENYQKGERGE DSSEEKHLEE PGETQNAFLN 
       210        220        230        240        250
ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG EETGSQENHP 
       260        270        280        290        300
QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP 
       310        320        330        340        350
SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG 
       360        370        380        390        400
VQAPEDLEWE RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG 
       410        420        430        440        450
YGEESEEERG LEPGKGRHHR GRGGEPRAYF MSDTREEKRF LGEGHHRVQE 
       460        470        480        490        500
NQMDKARRHP QGAWKELDRN YLNYGEEGAP GKWQQQGDLQ DTKENREEAR 
       510        520        530        540        550
FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD NMNDNFLEGE 
       560        570        580        590        600
EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ 
       610        620        630        640        650
YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE 
       660        670 
DEKKELENLA AMDLELQKIA EKFSQRG
Length:677
Mass (Da):78,276
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFDC97F7B21245B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MT66A0A0A0MT66_HUMAN
Secretogranin-1
CHGB
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92949 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24D → E in BAF82075 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04357893S → T2 PublicationsCorresponds to variant dbSNP:rs6085324Ensembl.1
Natural variantiVAR_024414117K → N. Corresponds to variant dbSNP:rs236150Ensembl.1
Natural variantiVAR_028235145D → N. Corresponds to variant dbSNP:rs6133278Ensembl.1
Natural variantiVAR_020287178R → Q2 PublicationsCorresponds to variant dbSNP:rs910122Ensembl.1
Natural variantiVAR_028236200N → H. Corresponds to variant dbSNP:rs881118Ensembl.1
Natural variantiVAR_028237232R → Q. Corresponds to variant dbSNP:rs6139873Ensembl.1
Natural variantiVAR_024415243T → A6 PublicationsCorresponds to variant dbSNP:rs236151Ensembl.1
Natural variantiVAR_024416353A → G2 PublicationsCorresponds to variant dbSNP:rs236152Ensembl.1
Natural variantiVAR_028238413P → L. Corresponds to variant dbSNP:rs742710Ensembl.1
Natural variantiVAR_022012417R → H2 PublicationsCorresponds to variant dbSNP:rs742711Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00064 mRNA Translation: CAA68271.1
AK289386 mRNA Translation: BAF82075.1
CR456726 mRNA Translation: CAG33007.1
AB209712 mRNA Translation: BAD92949.1 Different initiation.
AL035461 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10410.1
BC000375 mRNA Translation: AAH00375.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13092.1

Protein sequence database of the Protein Information Resource

More...PIRi		A29264, CNHUB

NCBI Reference Sequences

More...RefSeqi		NP_001810.2, NM_001819.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000378961; ENSP00000368244; ENSG00000089199

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1114

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1114

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000378961.9; ENSP00000368244.4; NM_001819.3; NP_001810.2

UCSC genome browser

More...UCSCi		uc002wmg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00064 mRNA Translation: CAA68271.1
AK289386 mRNA Translation: BAF82075.1
CR456726 mRNA Translation: CAG33007.1
AB209712 mRNA Translation: BAD92949.1 Different initiation.
AL035461 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10410.1
BC000375 mRNA Translation: AAH00375.1
CCDSiCCDS13092.1
PIRiA29264, CNHUB
RefSeqiNP_001810.2, NM_001819.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi107539, 35 interactors
IntActiP05060, 38 interactors
MINTiP05060
STRINGi9606.ENSP00000368244

PTM databases

GlyConnecti1727, 1 N-Linked glycan (1 site)
GlyGeniP05060, 1 site, 1 N-linked glycan (1 site)
iPTMnetiP05060
PhosphoSitePlusiP05060

Genetic variation databases

BioMutaiCHGB
DMDMi311033509

Proteomic databases

EPDiP05060
jPOSTiP05060
MassIVEiP05060
PaxDbiP05060
PeptideAtlasiP05060
PRIDEiP05060
ProteomicsDBi51772

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2170, 241 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		1114

Genome annotation databases

EnsembliENST00000378961; ENSP00000368244; ENSG00000089199
GeneIDi1114
KEGGihsa:1114
MANE-SelectiENST00000378961.9; ENSP00000368244.4; NM_001819.3; NP_001810.2
UCSCiuc002wmg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1114
DisGeNETi1114

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHGB
HGNCiHGNC:1930, CHGB
HPAiENSG00000089199, Group enriched (adrenal gland, pituitary gland)
MIMi118920, gene
neXtProtiNX_P05060
OpenTargetsiENSG00000089199
PharmGKBiPA26462
VEuPathDBiHostDB:ENSG00000089199

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRBF, Eukaryota
GeneTreeiENSGT00940000154206
HOGENOMiCLU_026095_0_0_1
InParanoidiP05060
OMAiWGYEKRS
OrthoDBi670416at2759
PhylomeDBiP05060
TreeFamiTF336596

Enzyme and pathway databases

PathwayCommonsiP05060
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation
SignaLinkiP05060

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1114, 9 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHGB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Secretoneurin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1114
PharosiP05060, Tbio

Protein Ontology

More...PROi		PR:P05060
RNActiP05060, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000089199, Expressed in pituitary gland and 183 other tissues
ExpressionAtlasiP05060, baseline and differential
GenevisibleiP05060, HS

Family and domain databases

InterProiView protein in InterPro
IPR001819, Chromogranin_AB
IPR018054, Chromogranin_CS
IPR001990, Granin
PANTHERiPTHR10583, PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271, Granin, 1 hit
PRINTSiPR00659, CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422, GRANINS_1, 1 hit
PS00423, GRANINS_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05060
Secondary accession number(s): A8K021
, Q59EU9, Q6IBS6, Q9BQV6, Q9UC25, Q9UJA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 2, 2010
Last modified: February 23, 2022
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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