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Protein

Secretogranin-1

Gene

CHGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-1
Alternative name(s):
Chromogranin-B
Short name:
CgB
Secretogranin I
Short name:
SgI
Cleaved into the following 3 chains:
Gene namesi
Name:CHGB
Synonyms:SCG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000089199.9
HGNCiHGNC:1930 CHGB
MIMi118920 gene
neXtProtiNX_P05060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1114
OpenTargetsiENSG00000089199
PharmGKBiPA26462

Polymorphism and mutation databases

BioMutaiCHGB
DMDMi311033509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000000543821 – 677Secretogranin-1Add BLAST657
PeptideiPRO_0000005439440 – 513GAWK peptideAdd BLAST74
PeptideiPRO_0000432730575 – 585PE-11By similarityAdd BLAST11
PeptideiPRO_0000005440617 – 673CCB peptideAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 57
Modified residuei79PhosphothreonineCurated1
Modified residuei93PhosphoserineBy similarity1
Modified residuei99PhosphoserineSequence analysis1
Modified residuei100PhosphoserineSequence analysis1
Modified residuei130Phosphoserine; by FAM20C1 Publication1
Modified residuei149PhosphoserineCombined sources1 Publication1
Modified residuei183PhosphoserineBy similarity1
Modified residuei225Phosphoserine; by FAM20C1 Publication1
Modified residuei259PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei293PhosphoserineSequence analysis1
Modified residuei294PhosphoserineSequence analysis1
Modified residuei311PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei341SulfotyrosineBy similarity1
Modified residuei367Phosphoserine; by FAM20C1 Publication1
Modified residuei377Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei380Phosphoserine; by FAM20C1 Publication1
Modified residuei401Phosphotyrosine1 Publication1
Modified residuei405PhosphoserineCombined sources1 Publication1
Modified residuei474SulfotyrosineBy similarity1
Modified residuei533PhosphoserineSequence analysis1
Modified residuei534PhosphoserineSequence analysis1
Modified residuei566SulfotyrosineBy similarity1
Modified residuei617PhosphoserineCombined sources1
Modified residuei624SulfotyrosineBy similarity1
Modified residuei626PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1

Post-translational modificationi

Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).By similarity
O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

EPDiP05060
PaxDbiP05060
PeptideAtlasiP05060
PRIDEiP05060
ProteomicsDBi51772

PTM databases

GlyConnecti1727
iPTMnetiP05060
PhosphoSitePlusiP05060

Expressioni

Tissue specificityi

Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.1 Publication

Gene expression databases

BgeeiENSG00000089199 Expressed in 167 organ(s), highest expression level in pituitary gland
CleanExiHS_CHGB
ExpressionAtlasiP05060 baseline and differential
GenevisibleiP05060 HS

Organism-specific databases

HPAiCAB009403
HPA008759
HPA012602

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107539, 29 interactors
IntActiP05060, 36 interactors
MINTiP05060
STRINGi9606.ENSP00000368244

Structurei

3D structure databases

ProteinModelPortaliP05060
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 120O-glycosylated at one site5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi163 – 171Poly-Glu9

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVJ3 Eukaryota
ENOG410ZHMS LUCA
GeneTreeiENSGT00730000111312
HOVERGENiHBG057317
InParanoidiP05060
KOiK19991
OMAiNWGYEKR
OrthoDBiEOG091G07VF
PhylomeDBiP05060
TreeFamiTF336596

Family and domain databases

InterProiView protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin
PANTHERiPTHR10583 PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit
PRINTSiPR00659 CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05060-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA
60 70 80 90 100
PPITPECRQV LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS
110 120 130 140 150
RGEAGAPGEE DIQGPTKADT EKWAEGGGHS RERADEPQWS LYPSDSQVSE
160 170 180 190 200
EVKTRHSEKS QREDEEEEEG ENYQKGERGE DSSEEKHLEE PGETQNAFLN
210 220 230 240 250
ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG EETGSQENHP
260 270 280 290 300
QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP
310 320 330 340 350
SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG
360 370 380 390 400
VQAPEDLEWE RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG
410 420 430 440 450
YGEESEEERG LEPGKGRHHR GRGGEPRAYF MSDTREEKRF LGEGHHRVQE
460 470 480 490 500
NQMDKARRHP QGAWKELDRN YLNYGEEGAP GKWQQQGDLQ DTKENREEAR
510 520 530 540 550
FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD NMNDNFLEGE
560 570 580 590 600
EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ
610 620 630 640 650
YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE
660 670
DEKKELENLA AMDLELQKIA EKFSQRG
Length:677
Mass (Da):78,276
Last modified:November 2, 2010 - v2
Checksum:iBFDC97F7B21245B3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MT66A0A0A0MT66_HUMAN
Secretogranin-1
CHGB
289Annotation score:

Sequence cautioni

The sequence BAD92949 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24D → E in BAF82075 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04357893S → T2 PublicationsCorresponds to variant dbSNP:rs6085324Ensembl.1
Natural variantiVAR_024414117K → N. Corresponds to variant dbSNP:rs236150Ensembl.1
Natural variantiVAR_028235145D → N. Corresponds to variant dbSNP:rs6133278Ensembl.1
Natural variantiVAR_020287178R → Q2 PublicationsCorresponds to variant dbSNP:rs910122Ensembl.1
Natural variantiVAR_028236200N → H. Corresponds to variant dbSNP:rs881118Ensembl.1
Natural variantiVAR_028237232R → Q. Corresponds to variant dbSNP:rs6139873Ensembl.1
Natural variantiVAR_024415243T → A6 PublicationsCorresponds to variant dbSNP:rs236151Ensembl.1
Natural variantiVAR_024416353A → G2 PublicationsCorresponds to variant dbSNP:rs236152Ensembl.1
Natural variantiVAR_028238413P → L. Corresponds to variant dbSNP:rs742710Ensembl.1
Natural variantiVAR_022012417R → H2 PublicationsCorresponds to variant dbSNP:rs742711Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00064 mRNA Translation: CAA68271.1
AK289386 mRNA Translation: BAF82075.1
CR456726 mRNA Translation: CAG33007.1
AB209712 mRNA Translation: BAD92949.1 Different initiation.
AL035461 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10410.1
BC000375 mRNA Translation: AAH00375.1
CCDSiCCDS13092.1
PIRiA29264 CNHUB
RefSeqiNP_001810.2, NM_001819.2
UniGeneiHs.516874

Genome annotation databases

EnsembliENST00000378961; ENSP00000368244; ENSG00000089199
GeneIDi1114
KEGGihsa:1114
UCSCiuc002wmg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00064 mRNA Translation: CAA68271.1
AK289386 mRNA Translation: BAF82075.1
CR456726 mRNA Translation: CAG33007.1
AB209712 mRNA Translation: BAD92949.1 Different initiation.
AL035461 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10410.1
BC000375 mRNA Translation: AAH00375.1
CCDSiCCDS13092.1
PIRiA29264 CNHUB
RefSeqiNP_001810.2, NM_001819.2
UniGeneiHs.516874

3D structure databases

ProteinModelPortaliP05060
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107539, 29 interactors
IntActiP05060, 36 interactors
MINTiP05060
STRINGi9606.ENSP00000368244

PTM databases

GlyConnecti1727
iPTMnetiP05060
PhosphoSitePlusiP05060

Polymorphism and mutation databases

BioMutaiCHGB
DMDMi311033509

Proteomic databases

EPDiP05060
PaxDbiP05060
PeptideAtlasiP05060
PRIDEiP05060
ProteomicsDBi51772

Protocols and materials databases

DNASUi1114
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378961; ENSP00000368244; ENSG00000089199
GeneIDi1114
KEGGihsa:1114
UCSCiuc002wmg.4 human

Organism-specific databases

CTDi1114
DisGeNETi1114
EuPathDBiHostDB:ENSG00000089199.9
GeneCardsiCHGB
H-InvDBiHIX0015625
HGNCiHGNC:1930 CHGB
HPAiCAB009403
HPA008759
HPA012602
MIMi118920 gene
neXtProtiNX_P05060
OpenTargetsiENSG00000089199
PharmGKBiPA26462
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJ3 Eukaryota
ENOG410ZHMS LUCA
GeneTreeiENSGT00730000111312
HOVERGENiHBG057317
InParanoidiP05060
KOiK19991
OMAiNWGYEKR
OrthoDBiEOG091G07VF
PhylomeDBiP05060
TreeFamiTF336596

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiCHGB human
GeneWikiiSecretoneurin
GenomeRNAii1114
PROiPR:P05060
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089199 Expressed in 167 organ(s), highest expression level in pituitary gland
CleanExiHS_CHGB
ExpressionAtlasiP05060 baseline and differential
GenevisibleiP05060 HS

Family and domain databases

InterProiView protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin
PANTHERiPTHR10583 PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit
PRINTSiPR00659 CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCG1_HUMAN
AccessioniPrimary (citable) accession number: P05060
Secondary accession number(s): A8K021
, Q59EU9, Q6IBS6, Q9BQV6, Q9UC25, Q9UJA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 2, 2010
Last modified: October 10, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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