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UniProtKB - P05045 (LEC1_VIGUC)
Protein
Seed lectin subunit I
Gene
N/A
Organism
Vigna unguiculata subsp. cylindrica (Horse gram) (Dolichos biflorus)
Status
Functioni
Metalloglycoprotein, containing Ca, Mg, Mn, and Zn and the carbohydrates galactose, glucosamine, mannose, and fucose. It agglutinates erythrocytes of blood group A1. Has a high preference for GalNAc over Gal.
GO - Molecular functioni
- mannose binding Source: UniProtKB-KW
Keywordsi
Ligand | Calcium, Lectin, Mannose-binding |
Protein family/group databases
UniLectini | P05045 |
Names & Taxonomyi
Protein namesi | Recommended name: Seed lectin subunit IShort name: SL Cleaved into the following chain: |
Organismi | Vigna unguiculata subsp. cylindrica (Horse gram) (Dolichos biflorus) |
Taxonomic identifieri | 3840 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › NPAAA clade › indigoferoid/millettioid clade › Phaseoleae › Vigna › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Add BLAST | 22 | |
ChainiPRO_0000017611 | 23 – 275 | Seed lectin subunit IAdd BLAST | 253 | |
ChainiPRO_0000017612 | 23 – 265 | Seed lectin subunit IIAdd BLAST | 243 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 136 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Subunit II may arise from subunit I by proteolytic cleavage at the C-terminal end.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 265 – 266 | Cleavage | 2 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Homotetramer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P05045 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05045 |
Family & Domainsi
Sequence similaritiesi
Belongs to the leguminous lectin family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd06899, lectin_legume_LecRK_Arcelin_ConA, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR016363, L-lectin IPR000985, Lectin_LegA_CS IPR019825, Lectin_legB_Mn/Ca_BS IPR001220, Legume_lectin_dom |
Pfami | View protein in Pfam PF00139, Lectin_legB, 1 hit |
PIRSFi | PIRSF002690, L-type_lectin_plant, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00308, LECTIN_LEGUME_ALPHA, 1 hit PS00307, LECTIN_LEGUME_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P05045-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSTVSVVL SLFLLLLTQA NSANIQSFSF KNFNSPSFIL QGDATVSSGK
60 70 80 90 100
LQLTKVKENG IPTPSSLGRA FYSSPIQIYD KSTGAVASWA TSFTVKISAP
110 120 130 140 150
SKASFADGIA FALVPVGSEP RRNGGYLGVF DSDVYNNSAQ TVAVEFDTFS
160 170 180 190 200
NSGWDPSMKH IGIDVNSIKS IATVSWDLAN GENAEILITY NAATSLLVAS
210 220 230 240 250
LVHPSRRTSY ILSERVDITN ELPEYVSVGF SATTGLSEGY IETHDVLSWS
260 270
FASKLPDDST AEPLDLASYL VRNVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 – 67 | IPTPSSL → FPLRFPS in AAA33141 (PubMed:3584113).Curated | 7 | |
Sequence conflicti | 82 | S → F in AAA33141 (PubMed:3584113).Curated | 1 | |
Sequence conflicti | 149 | F → L in AAA33141 (PubMed:3584113).Curated | 1 | |
Sequence conflicti | 199 | A → V in AAA33141 (PubMed:3584113).Curated | 1 | |
Sequence conflicti | 227 | S → G in AAA33141 (PubMed:3584113).Curated | 1 | |
Sequence conflicti | 254 | K → R in AAA33141 (PubMed:3584113).Curated | 1 | |
Sequence conflicti | 268 | S → R in AAA33141 (PubMed:3584113).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02721 mRNA Translation: AAA33141.1 M34270 Genomic DNA Translation: AAA33143.1 |
PIRi | A29572 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02721 mRNA Translation: AAA33141.1 M34270 Genomic DNA Translation: AAA33143.1 |
PIRi | A29572 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BJQ | X-ray | 2.65 | A/B/C/D/E/F/G/H | 23-275 | [»] | |
1LU1 | X-ray | 2.60 | A | 23-275 | [»] | |
1LU2 | X-ray | 2.80 | A/B | 23-275 | [»] | |
SMRi | P05045 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
Allergomei | 3011, Dol b Agglutinin |
UniLectini | P05045 |
Miscellaneous databases
EvolutionaryTracei | P05045 |
Family and domain databases
CDDi | cd06899, lectin_legume_LecRK_Arcelin_ConA, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR016363, L-lectin IPR000985, Lectin_LegA_CS IPR019825, Lectin_legB_Mn/Ca_BS IPR001220, Legume_lectin_dom |
Pfami | View protein in Pfam PF00139, Lectin_legB, 1 hit |
PIRSFi | PIRSF002690, L-type_lectin_plant, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00308, LECTIN_LEGUME_ALPHA, 1 hit PS00307, LECTIN_LEGUME_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LEC1_VIGUC | |
Accessioni | P05045Primary (citable) accession number: P05045 Secondary accession number(s): Q39666 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | July 15, 1999 | |
Last modified: | June 2, 2021 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families