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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

ATP1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.1 Publication
Involved in cell adhesion and establishing epithelial cell polarity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ATP metabolic process Source: BHF-UCL
  • cardiac muscle contraction Source: BHF-UCL
  • cell adhesion Source: UniProtKB-KW
  • cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • cellular calcium ion homeostasis Source: BHF-UCL
  • cellular potassium ion homeostasis Source: BHF-UCL
  • cellular sodium ion homeostasis Source: BHF-UCL
  • leukocyte migration Source: Reactome
  • membrane repolarization Source: BHF-UCL
  • membrane repolarization during cardiac muscle cell action potential Source: BHF-UCL
  • positive regulation of ATPase activity Source: BHF-UCL
  • positive regulation of calcium:sodium antiporter activity Source: BHF-UCL
  • positive regulation of potassium ion import Source: BHF-UCL
  • positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
  • positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
  • potassium ion import Source: BHF-UCL
  • potassium ion import across plasma membrane Source: BHF-UCL
  • protein localization to plasma membrane Source: BHF-UCL
  • protein stabilization Source: BHF-UCL
  • protein transport into plasma membrane raft Source: BHF-UCL
  • regulation of cardiac muscle contraction by calcium ion signaling Source: BHF-UCL
  • regulation of gene expression Source: BHF-UCL
  • relaxation of cardiac muscle Source: BHF-UCL
  • response to hypoxia Source: Ensembl
  • sodium ion export across plasma membrane Source: BHF-UCL

Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-210991 Basigin interactions
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases
SIGNORiP05026

Protein family/group databases

TCDBi3.A.3.1.1 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:ATP1B1
Synonyms:ATP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143153.12
HGNCiHGNC:804 ATP1B1
MIMi182330 gene
neXtProtiNX_P05026

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini63 – 303ExtracellularSequence analysisAdd BLAST241

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi481
MalaCardsiATP1B1
OpenTargetsiENSG00000143153
PharmGKBiPA66

Chemistry databases

ChEMBLiCHEMBL2095186
DrugBankiDB09479 Rubidium chloride Rb-82

Polymorphism and mutation databases

BioMutaiATP1B1
DMDMi114392

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190971 – 303Sodium/potassium-transporting ATPase subunit beta-1Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei101PhosphotyrosineBy similarity1
Disulfide bondi126 ↔ 149By similarity
Glycosylationi158N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi159 ↔ 175By similarity
Glycosylationi193N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi213 ↔ 276By similarity
Glycosylationi265N-linked (GlcNAc...) asparagine3 Publications1

Post-translational modificationi

Glutathionylated.By similarity

Keywords - PTMi

Disulfide bond, Glutathionylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP05026
MaxQBiP05026
PaxDbiP05026
PeptideAtlasiP05026
PRIDEiP05026
ProteomicsDBi51770
51771 [P05026-2]

PTM databases

iPTMnetiP05026
PhosphoSitePlusiP05026
SwissPalmiP05026

Expressioni

Tissue specificityi

Found in most tissues.

Gene expression databases

BgeeiENSG00000143153
CleanExiHS_ATP1B1
ExpressionAtlasiP05026 baseline and differential
GenevisibleiP05026 HS

Organism-specific databases

HPAiHPA012911

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1 (PubMed:22328087). Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM (PubMed:22328087). Interacts with KIRREL3 (PubMed:25902260). Interacts with OBSCN (via protein kinase domain 1) (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC4A1P027308EBI-714630,EBI-7576138

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • protein C-terminus binding Source: Ensembl
  • protein kinase binding Source: Ensembl

Protein-protein interaction databases

BioGridi106971, 76 interactors
ComplexPortaliCPX-125 Sodium:potassium-exchanging ATPase complex
IntActiP05026, 15 interactors
MINTiP05026
STRINGi9606.ENSP00000356789

Chemistry databases

BindingDBiP05026

Structurei

3D structure databases

ProteinModelPortaliP05026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 303immunoglobulin-likeAdd BLAST113

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP05026
KOiK01540
OMAiQVPQIQK
OrthoDBiEOG091G0DJ4
PhylomeDBiP05026
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR015565 Na/K_ATPase_sub_beta_chordates
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PTHR11523:SF10 PTHR11523:SF10, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05026-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF
60 70 80 90 100
IGTIQVMLLT ISEFKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA
110 120 130 140 150
YVLNIVRFLE KYKDSAQRDD MIFEDCGDVP SEPKERGDFN HERGERKVCR
160 170 180 190 200
FKLEWLGNCS GLNDETYGYK EGKPCIIIKL NRVLGFKPKP PKNESLETYP
210 220 230 240 250
VMKYNPNVLP VQCTGKRDED KDKVGNVEYF GLGNSPGFPL QYYPYYGKLL
260 270 280 290 300
QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE

VKS
Length:303
Mass (Da):35,061
Last modified:August 13, 1987 - v1
Checksum:i107D3C04394F2D11
GO
Isoform 2 (identifier: P05026-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-303: EVKS → KF

Show »
Length:301
Mass (Da):34,893
Checksum:i670C194F2D114F67
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000349300 – 303EVKS → KF in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03747 mRNA Translation: CAA27385.1
M25160, M25161 Genomic DNA Translation: AAA36352.1
U16799 mRNA Translation: AAC50132.1
BT009787 mRNA Translation: AAP88789.1
AL031726 Genomic DNA No translation available.
BC000006 mRNA Translation: AAH00006.1
X17161 Genomic DNA Translation: CAA35040.1
CCDSiCCDS1276.1 [P05026-1]
PIRiA23764 PWHUNB
RefSeqiNP_001668.1, NM_001677.3 [P05026-1]
UniGeneiHs.291196

Genome annotation databases

EnsembliENST00000367815; ENSP00000356789; ENSG00000143153 [P05026-1]
ENST00000367816; ENSP00000356790; ENSG00000143153 [P05026-1]
GeneIDi481
KEGGihsa:481
UCSCiuc001gfr.2 human [P05026-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAT1B1_HUMAN
AccessioniPrimary (citable) accession number: P05026
Secondary accession number(s): Q5TGZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 20, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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