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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

ATP1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3764-aspartylphosphate intermediateBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei487ATPBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi717MagnesiumBy similarity1
Metal bindingi721MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.1.1 the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP1A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163399.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:799 ATP1A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182310 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05023

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini6 – 87CytoplasmicSequence analysisAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 131ExtracellularSequence analysisAdd BLAST23
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 288CytoplasmicSequence analysisAdd BLAST136
Transmembranei289 – 308HelicalSequence analysisAdd BLAST20
Topological domaini309 – 320ExtracellularSequence analysisAdd BLAST12
Transmembranei321 – 338HelicalSequence analysisAdd BLAST18
Topological domaini339 – 772CytoplasmicSequence analysisAdd BLAST434
Transmembranei773 – 792HelicalSequence analysisAdd BLAST20
Topological domaini793 – 802ExtracellularSequence analysis10
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21
Topological domaini824 – 843CytoplasmicSequence analysisAdd BLAST20
Transmembranei844 – 866HelicalSequence analysisAdd BLAST23
Topological domaini867 – 918ExtracellularSequence analysisAdd BLAST52
Transmembranei919 – 938HelicalSequence analysisAdd BLAST20
Topological domaini939 – 951CytoplasmicSequence analysisAdd BLAST13
Transmembranei952 – 970HelicalSequence analysisAdd BLAST19
Topological domaini971 – 985ExtracellularSequence analysisAdd BLAST15
Transmembranei986 – 1006HelicalSequence analysisAdd BLAST21
Topological domaini1007 – 1023CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease 2DD (CMT2DD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
See also OMIM:618036
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08103948L → R in CMT2DD; no effect on Na(+)-dependent currents. 1 Publication1
Natural variantiVAR_081040592I → T in CMT2DD; unknown pathological significance. 1 Publication1
Natural variantiVAR_081041597A → T in CMT2DD; unknown pathological significance. 1 Publication1
Natural variantiVAR_081042600P → A in CMT2DD; shows fewer Na(+)-dependent currents than wild-type protein. 1 Publication1
Natural variantiVAR_081043600P → T in CMT2DD; unknown pathological significance. 1 Publication1
Natural variantiVAR_081044601D → F in CMT2DD; unknown pathological significance; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_081045811D → A in CMT2DD; shows fewer Na(+)-dependent currents than wild-type protein. 1 Publication1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
476
MIMi618036 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163399

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
85142 NON RARE IN EUROPE: Aldosterone-producing adenoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA62

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1807

Drug and drug target database

More...
DrugBanki
DB00511 Acetyldigitoxin
DB01430 Almitrine
DB01370 Aluminium
DB01244 Bepridil
DB01158 Bretylium
DB01188 Ciclopirox
DB01078 Deslanoside
DB01119 Diazoxide
DB01396 Digitoxin
DB00390 Digoxin
DB00903 Etacrynic acid
DB00774 Hydroflumethiazide
DB01378 Magnesium
DB01092 Ouabain
DB01345 Potassium
DB09479 Rubidium chloride Rb-82
DB01021 Trichlormethiazide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP1A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000024831 – 55
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000024846 – 1023Sodium/potassium-transporting ATPase subunit alpha-1Add BLAST1018

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9N6-acetyllysineBy similarity1
Modified residuei10PhosphotyrosineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei260PhosphotyrosineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei542PhosphotyrosineCombined sources1
Modified residuei661N6-succinyllysineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei675PhosphoserineBy similarity1
Modified residuei943Phosphoserine; by PKABy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P05023

MaxQB - The MaxQuant DataBase

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MaxQBi
P05023

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P05023

PeptideAtlas

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PeptideAtlasi
P05023

PRoteomics IDEntifications database

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PRIDEi
P05023

ProteomicsDB human proteome resource

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ProteomicsDBi
51768
51769 [P05023-2]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P05023

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05023

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P05023

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P05023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163399 Expressed in 237 organ(s), highest expression level in cortex of kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_ATP1A1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P05023 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P05023 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018702
CAB069993

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (PubMed:21454534). Interacts with SIK1 (By similarity). Binds the HLA class II histocompatibility antigen DR1 (PubMed:1380674). Interacts with SLC35G1 and STIM1 (PubMed:22084111).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TPT1P136935EBI-358778,EBI-1783169

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106966, 143 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-125 Sodium:potassium-exchanging ATPase complex

Database of interacting proteins

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DIPi
DIP-38196N

Protein interaction database and analysis system

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IntActi
P05023, 70 interactors

Molecular INTeraction database

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MINTi
P05023

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295598

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P05023

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P05023

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05023

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni82 – 84Phosphoinositide-3 kinase bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0203 Eukaryota
COG0474 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154840

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000265622

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004298

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05023

KEGG Orthology (KO)

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KOi
K01539

Identification of Orthologs from Complete Genome Data

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OMAi
CFTDCAA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01BB

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05023

TreeFam database of animal gene trees

More...
TreeFami
TF312838

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02608 P-type_ATPase_Na-K_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831 Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P05023-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKGVGRDKY EPAAVSEQGD KKGKKGKKDR DMDELKKEVS MDDHKLSLDE
60 70 80 90 100
LHRKYGTDLS RGLTSARAAE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF
110 120 130 140 150
SMLLWIGAIL CFLAYSIQAA TEEEPQNDNL YLGVVLSAVV IITGCFSYYQ
160 170 180 190 200
EAKSSKIMES FKNMVPQQAL VIRNGEKMSI NAEEVVVGDL VEVKGGDRIP
210 220 230 240 250
ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR NIAFFSTNCV
260 270 280 290 300
EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV
310 320 330 340 350
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR
360 370 380 390 400
MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA
410 420 430 440 450
DTTENQSGVS FDKTSATWLA LSRIAGLCNR AVFQANQENL PILKRAVAGD
460 470 480 490 500
ASESALLKCI ELCCGSVKEM RERYAKIVEI PFNSTNKYQL SIHKNPNTSE
510 520 530 540 550
PQHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN AYLELGGLGE
560 570 580 590 600
RVLGFCHLFL PDEQFPEGFQ FDTDDVNFPI DNLCFVGLIS MIDPPRAAVP
610 620 630 640 650
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI
660 670 680 690 700
PVSQVNPRDA KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI
710 720 730 740 750
IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL
760 770 780 790 800
LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LIFIIANIPL
810 820 830 840 850
PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK TDKLVNERLI
860 870 880 890 900
SMAYGQIGMI QALGGFFTYF VILAENGFLP IHLLGLRVDW DDRWINDVED
910 920 930 940 950
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK
960 970 980 990 1000
NKILIFGLFE ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV
1010 1020
YDEVRKLIIR RRPGGWVEKE TYY
Length:1,023
Mass (Da):112,896
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3C6FDE04FB3F667
GO
Isoform 2 (identifier: P05023-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     638-681: NETVEDIAAR...DMTSEQLDDI → SGPMSRGKSW...PGGIRSSSRG
     682-1023: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:681
Mass (Da):74,140
Checksum:iB74A8E7E31E975AD
GO
Isoform 3 (identifier: P05023-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:992
Mass (Da):109,550
Checksum:i6F607167FD03A23B
GO
Isoform 4 (identifier: P05023-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-4: GKG → AFK

Show »
Length:1,023
Mass (Da):113,000
Checksum:iB5B35DE0B0650011
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TC01Q5TC01_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TC02Q5TC02_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TC05Q5TC05_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti248N → S in BAG37313 (PubMed:14702039).Curated1
Sequence conflicti323F → L in BAH11971 (PubMed:14702039).Curated1
Sequence conflicti475A → T in CAA27390 (Ref. 13) Curated1
Sequence conflicti499S → A in CAA27390 (Ref. 13) Curated1
Sequence conflicti502Q → R in CAA27390 (Ref. 13) Curated1
Sequence conflicti523L → I in CAA27390 (Ref. 13) Curated1
Sequence conflicti892D → G in BAH11971 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04837447S → I. Corresponds to variant dbSNP:rs12564026Ensembl.1
Natural variantiVAR_08103948L → R in CMT2DD; no effect on Na(+)-dependent currents. 1 Publication1
Natural variantiVAR_081040592I → T in CMT2DD; unknown pathological significance. 1 Publication1
Natural variantiVAR_081041597A → T in CMT2DD; unknown pathological significance. 1 Publication1
Natural variantiVAR_081042600P → A in CMT2DD; shows fewer Na(+)-dependent currents than wild-type protein. 1 Publication1
Natural variantiVAR_081043600P → T in CMT2DD; unknown pathological significance. 1 Publication1
Natural variantiVAR_081044601D → F in CMT2DD; unknown pathological significance; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_081045811D → A in CMT2DD; shows fewer Na(+)-dependent currents than wild-type protein. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0442421 – 31Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0473092 – 4GKG → AFK in isoform 4. 1 Publication3
Alternative sequenceiVSP_000415638 – 681NETVE…QLDDI → SGPMSRGKSWSSPATQPSSS VSWWCSGPTWSSVRPGGIRS SSRG in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_000416682 – 1023Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D00099 mRNA Translation: BAA00061.1
X04297 mRNA Translation: CAA27840.1
U16798 mRNA Translation: AAC50131.1
AK295095 mRNA Translation: BAH11971.1
AK296362 mRNA Translation: BAH12332.1
AK314777 mRNA Translation: BAG37313.1
AL136376 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56644.1
BC003077 mRNA Translation: AAH03077.1
BC001330 mRNA Translation: AAH01330.1
BC050359 mRNA Translation: AAH50359.1
M30310, M30309 Genomic DNA Translation: AAA51801.1
L76938 Genomic DNA Translation: AAA92713.1
M16793 mRNA Translation: AAD56251.1
M16794 mRNA Translation: AAD56252.1
J03007 mRNA Translation: AAA51803.1
M27572 Genomic DNA Translation: AAA35573.1
M27579 Genomic DNA Translation: AAA35574.2
X03757 mRNA Translation: CAA27390.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53351.1 [P05023-4]
CCDS53352.1 [P05023-3]
CCDS887.1 [P05023-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A24414

NCBI Reference Sequences

More...
RefSeqi
NP_000692.2, NM_000701.7 [P05023-1]
NP_001153705.1, NM_001160233.1 [P05023-4]
NP_001153706.1, NM_001160234.1 [P05023-3]
XP_016856849.1, XM_017001360.1 [P05023-3]
XP_016856850.1, XM_017001361.1 [P05023-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.371889

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295598; ENSP00000295598; ENSG00000163399 [P05023-1]
ENST00000369496; ENSP00000358508; ENSG00000163399 [P05023-3]
ENST00000537345; ENSP00000445306; ENSG00000163399 [P05023-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
476

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:476

UCSC genome browser

More...
UCSCi
uc001ege.5 human [P05023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00099 mRNA Translation: BAA00061.1
X04297 mRNA Translation: CAA27840.1
U16798 mRNA Translation: AAC50131.1
AK295095 mRNA Translation: BAH11971.1
AK296362 mRNA Translation: BAH12332.1
AK314777 mRNA Translation: BAG37313.1
AL136376 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56644.1
BC003077 mRNA Translation: AAH03077.1
BC001330 mRNA Translation: AAH01330.1
BC050359 mRNA Translation: AAH50359.1
M30310, M30309 Genomic DNA Translation: AAA51801.1
L76938 Genomic DNA Translation: AAA92713.1
M16793 mRNA Translation: AAD56251.1
M16794 mRNA Translation: AAD56252.1
J03007 mRNA Translation: AAA51803.1
M27572 Genomic DNA Translation: AAA35573.1
M27579 Genomic DNA Translation: AAA35574.2
X03757 mRNA Translation: CAA27390.1
CCDSiCCDS53351.1 [P05023-4]
CCDS53352.1 [P05023-3]
CCDS887.1 [P05023-1]
PIRiA24414
RefSeqiNP_000692.2, NM_000701.7 [P05023-1]
NP_001153705.1, NM_001160233.1 [P05023-4]
NP_001153706.1, NM_001160234.1 [P05023-3]
XP_016856849.1, XM_017001360.1 [P05023-3]
XP_016856850.1, XM_017001361.1 [P05023-3]
UniGeneiHs.371889

3D structure databases

ProteinModelPortaliP05023
SMRiP05023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106966, 143 interactors
ComplexPortaliCPX-125 Sodium:potassium-exchanging ATPase complex
DIPiDIP-38196N
IntActiP05023, 70 interactors
MINTiP05023
STRINGi9606.ENSP00000295598

Chemistry databases

BindingDBiP05023
ChEMBLiCHEMBL1807
DrugBankiDB00511 Acetyldigitoxin
DB01430 Almitrine
DB01370 Aluminium
DB01244 Bepridil
DB01158 Bretylium
DB01188 Ciclopirox
DB01078 Deslanoside
DB01119 Diazoxide
DB01396 Digitoxin
DB00390 Digoxin
DB00903 Etacrynic acid
DB00774 Hydroflumethiazide
DB01378 Magnesium
DB01092 Ouabain
DB01345 Potassium
DB09479 Rubidium chloride Rb-82
DB01021 Trichlormethiazide

Protein family/group databases

TCDBi3.A.3.1.1 the p-type atpase (p-atpase) superfamily

PTM databases

CarbonylDBiP05023
iPTMnetiP05023
PhosphoSitePlusiP05023
SwissPalmiP05023

Polymorphism and mutation databases

BioMutaiATP1A1
DMDMi114374

Proteomic databases

EPDiP05023
MaxQBiP05023
PaxDbiP05023
PeptideAtlasiP05023
PRIDEiP05023
ProteomicsDBi51768
51769 [P05023-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
476
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295598; ENSP00000295598; ENSG00000163399 [P05023-1]
ENST00000369496; ENSP00000358508; ENSG00000163399 [P05023-3]
ENST00000537345; ENSP00000445306; ENSG00000163399 [P05023-4]
GeneIDi476
KEGGihsa:476
UCSCiuc001ege.5 human [P05023-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
476
DisGeNETi476
EuPathDBiHostDB:ENSG00000163399.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP1A1
HGNCiHGNC:799 ATP1A1
HPAiCAB018702
CAB069993
MIMi182310 gene
618036 phenotype
neXtProtiNX_P05023
OpenTargetsiENSG00000163399
Orphaneti85142 NON RARE IN EUROPE: Aldosterone-producing adenoma
PharmGKBiPA62

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00940000154840
HOGENOMiHOG000265622
HOVERGENiHBG004298
InParanoidiP05023
KOiK01539
OMAiCFTDCAA
OrthoDBiEOG091G01BB
PhylomeDBiP05023
TreeFamiTF312838

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATP1A1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATPase,_Na%2B/K%2B_transporting,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
476

Protein Ontology

More...
PROi
PR:P05023

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163399 Expressed in 237 organ(s), highest expression level in cortex of kidney
CleanExiHS_ATP1A1
ExpressionAtlasiP05023 baseline and differential
GenevisibleiP05023 HS

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT1A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05023
Secondary accession number(s): B2RBR6
, B7Z2T5, B7Z3U6, F5H3A1, Q16689, Q6LDM4, Q9UCN1, Q9UJ20, Q9UJ21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: December 5, 2018
This is version 223 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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