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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

ATP1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3764-aspartylphosphate intermediateBy similarity1
Binding sitei487ATPBy similarity1
Metal bindingi717MagnesiumBy similarity1
Metal bindingi721MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.1.1 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:ATP1A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163399.15
HGNCiHGNC:799 ATP1A1
MIMi182310 gene
neXtProtiNX_P05023

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini6 – 87CytoplasmicSequence analysisAdd BLAST82
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 131ExtracellularSequence analysisAdd BLAST23
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 288CytoplasmicSequence analysisAdd BLAST136
Transmembranei289 – 308HelicalSequence analysisAdd BLAST20
Topological domaini309 – 320ExtracellularSequence analysisAdd BLAST12
Transmembranei321 – 338HelicalSequence analysisAdd BLAST18
Topological domaini339 – 772CytoplasmicSequence analysisAdd BLAST434
Transmembranei773 – 792HelicalSequence analysisAdd BLAST20
Topological domaini793 – 802ExtracellularSequence analysis10
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21
Topological domaini824 – 843CytoplasmicSequence analysisAdd BLAST20
Transmembranei844 – 866HelicalSequence analysisAdd BLAST23
Topological domaini867 – 918ExtracellularSequence analysisAdd BLAST52
Transmembranei919 – 938HelicalSequence analysisAdd BLAST20
Topological domaini939 – 951CytoplasmicSequence analysisAdd BLAST13
Transmembranei952 – 970HelicalSequence analysisAdd BLAST19
Topological domaini971 – 985ExtracellularSequence analysisAdd BLAST15
Transmembranei986 – 1006HelicalSequence analysisAdd BLAST21
Topological domaini1007 – 1023CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi476
OpenTargetsiENSG00000163399
Orphaneti85142 Aldosterone-producing adenoma
PharmGKBiPA62

Chemistry databases

ChEMBLiCHEMBL1807
DrugBankiDB00511 Acetyldigitoxin
DB01430 Almitrine
DB01370 Aluminium
DB01244 Bepridil
DB01158 Bretylium
DB01188 Ciclopirox
DB01078 Deslanoside
DB01119 Diazoxide
DB01396 Digitoxin
DB00390 Digoxin
DB00903 Etacrynic acid
DB00774 Hydroflumethiazide
DB01378 Magnesium
DB01092 Ouabain
DB01345 Potassium
DB09479 Rubidium chloride Rb-82
DB01021 Trichlormethiazide

Polymorphism and mutation databases

BioMutaiATP1A1
DMDMi114374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000024831 – 55
ChainiPRO_00000024846 – 1023Sodium/potassium-transporting ATPase subunit alpha-1Add BLAST1018

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei10PhosphotyrosineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei260PhosphotyrosineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei542PhosphotyrosineCombined sources1
Modified residuei661N6-succinyllysineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei675PhosphoserineBy similarity1
Modified residuei943Phosphoserine; by PKABy similarity1

Post-translational modificationi

Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05023
MaxQBiP05023
PaxDbiP05023
PeptideAtlasiP05023
PRIDEiP05023
ProteomicsDBi51768
51769 [P05023-2]

PTM databases

CarbonylDBiP05023
iPTMnetiP05023
PhosphoSitePlusiP05023
SwissPalmiP05023

Expressioni

Gene expression databases

BgeeiENSG00000163399 Expressed in 237 organ(s), highest expression level in cortex of kidney
CleanExiHS_ATP1A1
ExpressionAtlasiP05023 baseline and differential
GenevisibleiP05023 HS

Organism-specific databases

HPAiCAB018702
CAB069993

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (PubMed:21454534). Interacts with SIK1 (By similarity). Binds the HLA class II histocompatibility antigen DR1 (PubMed:1380674). Interacts with SLC35G1 and STIM1 (PubMed:22084111).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TPT1P136935EBI-358778,EBI-1783169

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106966, 128 interactors
ComplexPortaliCPX-125 Sodium:potassium-exchanging ATPase complex
DIPiDIP-38196N
IntActiP05023, 69 interactors
MINTiP05023
STRINGi9606.ENSP00000295598

Chemistry databases

BindingDBiP05023

Structurei

3D structure databases

ProteinModelPortaliP05023
SMRiP05023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 84Phosphoinositide-3 kinase bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265622
HOVERGENiHBG004298
InParanoidiP05023
KOiK01539
OMAiARIMPEQ
OrthoDBiEOG091G01BB
PhylomeDBiP05023
TreeFamiTF312838

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P05023-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKGVGRDKY EPAAVSEQGD KKGKKGKKDR DMDELKKEVS MDDHKLSLDE
60 70 80 90 100
LHRKYGTDLS RGLTSARAAE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF
110 120 130 140 150
SMLLWIGAIL CFLAYSIQAA TEEEPQNDNL YLGVVLSAVV IITGCFSYYQ
160 170 180 190 200
EAKSSKIMES FKNMVPQQAL VIRNGEKMSI NAEEVVVGDL VEVKGGDRIP
210 220 230 240 250
ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR NIAFFSTNCV
260 270 280 290 300
EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV
310 320 330 340 350
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR
360 370 380 390 400
MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA
410 420 430 440 450
DTTENQSGVS FDKTSATWLA LSRIAGLCNR AVFQANQENL PILKRAVAGD
460 470 480 490 500
ASESALLKCI ELCCGSVKEM RERYAKIVEI PFNSTNKYQL SIHKNPNTSE
510 520 530 540 550
PQHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN AYLELGGLGE
560 570 580 590 600
RVLGFCHLFL PDEQFPEGFQ FDTDDVNFPI DNLCFVGLIS MIDPPRAAVP
610 620 630 640 650
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI
660 670 680 690 700
PVSQVNPRDA KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI
710 720 730 740 750
IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL
760 770 780 790 800
LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LIFIIANIPL
810 820 830 840 850
PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK TDKLVNERLI
860 870 880 890 900
SMAYGQIGMI QALGGFFTYF VILAENGFLP IHLLGLRVDW DDRWINDVED
910 920 930 940 950
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK
960 970 980 990 1000
NKILIFGLFE ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV
1010 1020
YDEVRKLIIR RRPGGWVEKE TYY
Length:1,023
Mass (Da):112,896
Last modified:August 13, 1987 - v1
Checksum:iF3C6FDE04FB3F667
GO
Isoform 2 (identifier: P05023-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     638-681: NETVEDIAAR...DMTSEQLDDI → SGPMSRGKSW...PGGIRSSSRG
     682-1023: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:681
Mass (Da):74,140
Checksum:iB74A8E7E31E975AD
GO
Isoform 3 (identifier: P05023-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:992
Mass (Da):109,550
Checksum:i6F607167FD03A23B
GO
Isoform 4 (identifier: P05023-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-4: GKG → AFK

Show »
Length:1,023
Mass (Da):113,000
Checksum:iB5B35DE0B0650011
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TC01Q5TC01_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A1
144Annotation score:
Q5TC05Q5TC05_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A1
157Annotation score:
Q5TC02Q5TC02_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A1
106Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248N → S in BAG37313 (PubMed:14702039).Curated1
Sequence conflicti323F → L in BAH11971 (PubMed:14702039).Curated1
Sequence conflicti475A → T in CAA27390 (Ref. 13) Curated1
Sequence conflicti499S → A in CAA27390 (Ref. 13) Curated1
Sequence conflicti502Q → R in CAA27390 (Ref. 13) Curated1
Sequence conflicti523L → I in CAA27390 (Ref. 13) Curated1
Sequence conflicti892D → G in BAH11971 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04837447S → I. Corresponds to variant dbSNP:rs12564026Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442421 – 31Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0473092 – 4GKG → AFK in isoform 4. 1 Publication3
Alternative sequenceiVSP_000415638 – 681NETVE…QLDDI → SGPMSRGKSWSSPATQPSSS VSWWCSGPTWSSVRPGGIRS SSRG in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_000416682 – 1023Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00099 mRNA Translation: BAA00061.1
X04297 mRNA Translation: CAA27840.1
U16798 mRNA Translation: AAC50131.1
AK295095 mRNA Translation: BAH11971.1
AK296362 mRNA Translation: BAH12332.1
AK314777 mRNA Translation: BAG37313.1
AL136376 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56644.1
BC003077 mRNA Translation: AAH03077.1
BC001330 mRNA Translation: AAH01330.1
BC050359 mRNA Translation: AAH50359.1
M30310, M30309 Genomic DNA Translation: AAA51801.1
L76938 Genomic DNA Translation: AAA92713.1
M16793 mRNA Translation: AAD56251.1
M16794 mRNA Translation: AAD56252.1
J03007 mRNA Translation: AAA51803.1
M27572 Genomic DNA Translation: AAA35573.1
M27579 Genomic DNA Translation: AAA35574.2
X03757 mRNA Translation: CAA27390.1
CCDSiCCDS53351.1 [P05023-4]
CCDS53352.1 [P05023-3]
CCDS887.1 [P05023-1]
PIRiA24414
RefSeqiNP_000692.2, NM_000701.7 [P05023-1]
NP_001153705.1, NM_001160233.1 [P05023-4]
NP_001153706.1, NM_001160234.1 [P05023-3]
XP_016856849.1, XM_017001360.1 [P05023-3]
XP_016856850.1, XM_017001361.1 [P05023-3]
UniGeneiHs.371889

Genome annotation databases

EnsembliENST00000295598; ENSP00000295598; ENSG00000163399 [P05023-1]
ENST00000369496; ENSP00000358508; ENSG00000163399 [P05023-3]
ENST00000537345; ENSP00000445306; ENSG00000163399 [P05023-4]
GeneIDi476
KEGGihsa:476
UCSCiuc001ege.5 human [P05023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00099 mRNA Translation: BAA00061.1
X04297 mRNA Translation: CAA27840.1
U16798 mRNA Translation: AAC50131.1
AK295095 mRNA Translation: BAH11971.1
AK296362 mRNA Translation: BAH12332.1
AK314777 mRNA Translation: BAG37313.1
AL136376 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56644.1
BC003077 mRNA Translation: AAH03077.1
BC001330 mRNA Translation: AAH01330.1
BC050359 mRNA Translation: AAH50359.1
M30310, M30309 Genomic DNA Translation: AAA51801.1
L76938 Genomic DNA Translation: AAA92713.1
M16793 mRNA Translation: AAD56251.1
M16794 mRNA Translation: AAD56252.1
J03007 mRNA Translation: AAA51803.1
M27572 Genomic DNA Translation: AAA35573.1
M27579 Genomic DNA Translation: AAA35574.2
X03757 mRNA Translation: CAA27390.1
CCDSiCCDS53351.1 [P05023-4]
CCDS53352.1 [P05023-3]
CCDS887.1 [P05023-1]
PIRiA24414
RefSeqiNP_000692.2, NM_000701.7 [P05023-1]
NP_001153705.1, NM_001160233.1 [P05023-4]
NP_001153706.1, NM_001160234.1 [P05023-3]
XP_016856849.1, XM_017001360.1 [P05023-3]
XP_016856850.1, XM_017001361.1 [P05023-3]
UniGeneiHs.371889

3D structure databases

ProteinModelPortaliP05023
SMRiP05023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106966, 128 interactors
ComplexPortaliCPX-125 Sodium:potassium-exchanging ATPase complex
DIPiDIP-38196N
IntActiP05023, 69 interactors
MINTiP05023
STRINGi9606.ENSP00000295598

Chemistry databases

BindingDBiP05023
ChEMBLiCHEMBL1807
DrugBankiDB00511 Acetyldigitoxin
DB01430 Almitrine
DB01370 Aluminium
DB01244 Bepridil
DB01158 Bretylium
DB01188 Ciclopirox
DB01078 Deslanoside
DB01119 Diazoxide
DB01396 Digitoxin
DB00390 Digoxin
DB00903 Etacrynic acid
DB00774 Hydroflumethiazide
DB01378 Magnesium
DB01092 Ouabain
DB01345 Potassium
DB09479 Rubidium chloride Rb-82
DB01021 Trichlormethiazide

Protein family/group databases

TCDBi3.A.3.1.1 the p-type atpase (p-atpase) superfamily

PTM databases

CarbonylDBiP05023
iPTMnetiP05023
PhosphoSitePlusiP05023
SwissPalmiP05023

Polymorphism and mutation databases

BioMutaiATP1A1
DMDMi114374

Proteomic databases

EPDiP05023
MaxQBiP05023
PaxDbiP05023
PeptideAtlasiP05023
PRIDEiP05023
ProteomicsDBi51768
51769 [P05023-2]

Protocols and materials databases

DNASUi476
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295598; ENSP00000295598; ENSG00000163399 [P05023-1]
ENST00000369496; ENSP00000358508; ENSG00000163399 [P05023-3]
ENST00000537345; ENSP00000445306; ENSG00000163399 [P05023-4]
GeneIDi476
KEGGihsa:476
UCSCiuc001ege.5 human [P05023-1]

Organism-specific databases

CTDi476
DisGeNETi476
EuPathDBiHostDB:ENSG00000163399.15
GeneCardsiATP1A1
HGNCiHGNC:799 ATP1A1
HPAiCAB018702
CAB069993
MIMi182310 gene
neXtProtiNX_P05023
OpenTargetsiENSG00000163399
Orphaneti85142 Aldosterone-producing adenoma
PharmGKBiPA62
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265622
HOVERGENiHBG004298
InParanoidiP05023
KOiK01539
OMAiARIMPEQ
OrthoDBiEOG091G01BB
PhylomeDBiP05023
TreeFamiTF312838

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiATP1A1 human
GeneWikiiATPase,_Na%2B/K%2B_transporting,_alpha_1
GenomeRNAii476
PROiPR:P05023
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163399 Expressed in 237 organ(s), highest expression level in cortex of kidney
CleanExiHS_ATP1A1
ExpressionAtlasiP05023 baseline and differential
GenevisibleiP05023 HS

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A1_HUMAN
AccessioniPrimary (citable) accession number: P05023
Secondary accession number(s): B2RBR6
, B7Z2T5, B7Z3U6, F5H3A1, Q16689, Q6LDM4, Q9UCN1, Q9UJ20, Q9UJ21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 12, 2018
This is version 221 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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