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Entry version 222 (13 Feb 2019)
Sequence version 1 (13 Aug 1987)
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Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • growth factor activity Source: UniProtKB-KW
  • hormone activity Source: BHF-UCL
  • insulin-like growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: BHF-UCL
  • integrin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P05019

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P05019

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Mechano growth factor
Short name:
MGF
Somatomedin-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGF1
Synonyms:IBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000017427.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5464 IGF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147440 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05019

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Insulin-like growth factor I deficiency (IGF1 deficiency)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
See also OMIM:608747

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi84R → E: Dominant-negative mutant, no effect on IGFR1-binding, defective in integrin-binding and the formation of ternary complex with integrins and IGFR1, defective in inducing IGF1 signaling and cell proliferation, and suppresses activation of IGF1R by insulin and tumorigenesis in vivo; when associated with E-85. 4 Publications1
Mutagenesisi85R → E: Dominant-negative mutant, no effect on IGFR1-binding, defective in integrin-binding and the formation of ternary complex with integrins and IGFR1, defective in inducing IGF1 signaling and cell proliferation, and suppresses activation of IGF1R by insulin and tumorigenesis in vivo; when associated with E-84. 4 Publications1

Keywords - Diseasei

Deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
3479

MalaCards human disease database

More...
MalaCardsi
IGF1
MIMi608747 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000017427

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
73272 Growth delay due to insulin-like growth factor type 1 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29697

Protein family/group databases

Allergome; a platform for allergen knowledge

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Allergomei
11751 Hom s IGF-1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3217394

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
IGF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124263

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001566322 – 48Add BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001566449 – 118Insulin-like growth factor IAdd BLAST70
PropeptideiPRO_0000015665119 – 195E peptideAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 961 Publication
Disulfide bondi66 ↔ 1091 Publication
Disulfide bondi95 ↔ 1001 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05019

PeptideAtlas

More...
PeptideAtlasi
P05019

PRoteomics IDEntifications database

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PRIDEi
P05019

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51765
51766 [P05019-2]
51767 [P05019-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05019

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P05019

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000017427 Expressed in 218 organ(s), highest expression level in endometrium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P05019 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P05019 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA048946

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ternary complex with IGFR1 and ITGAV:ITGB3 (PubMed:19578119). Forms a ternary complex with IGFR1 and ITGA6:ITGB4 (PubMed:22351760, PubMed:23696648).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109700, 14 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P05019

Database of interacting proteins

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DIPi
DIP-41933N
DIP-6021N

Protein interaction database and analysis system

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IntActi
P05019, 11 interactors

Molecular INTeraction database

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MINTi
P05019

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302665

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B9GNMR-A49-118[»]
1BQTNMR-A49-118[»]
1GF1model-A49-118[»]
1GZRX-ray2.00B49-118[»]
1GZYX-ray2.54B49-118[»]
1GZZX-ray2.30B49-118[»]
1H02X-ray2.00B49-118[»]
1H59X-ray2.10A49-118[»]
1IMXX-ray1.82A49-118[»]
1PMXNMR-A49-118[»]
1TGRX-ray1.42A/B49-77[»]
A/B90-110[»]
1WQJX-ray1.60I49-118[»]
2DSPX-ray2.50I49-118[»]
2DSQX-ray2.80C/I49-118[»]
2DSRX-ray2.10I49-118[»]
2GF1NMR-A49-118[»]
3GF1NMR-A49-118[»]
3LRINMR-A49-118[»]
4XSSX-ray3.00B49-118[»]
5U8QX-ray3.27B49-118[»]
6FF3X-ray2.57B49-118[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P05019

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05019

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05019

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 77BAdd BLAST29
Regioni78 – 89CAdd BLAST12
Regioni90 – 110AAdd BLAST21
Regioni111 – 118D8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ2T Eukaryota
ENOG4111MIV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233362

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006137

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05019

KEGG Orthology (KO)

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KOi
K05459

Identification of Orthologs from Complete Genome Data

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OMAi
CFQSCDL

Database of Orthologous Groups

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OrthoDBi
1644517at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P05019

TreeFam database of animal gene trees

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TreeFami
TF332820

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022341 IGF-I
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family

Pfam protein domain database

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Pfami
View protein in Pfam
PF00049 Insulin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02002 INSLNLIKEGF
PR02005 INSLNLIKEGF1
PR00276 INSULINFAMLY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00078 IlGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56994 SSF56994, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00262 INSULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P05019-1) [UniParc]FASTAAdd to basket
Also known as: IGF-IB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP
60 70 80 90 100
ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC
110 120 130 140 150
DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KTQKYQPPST NKNTKSQRRK
160 170 180 190
GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR EIGSRNAECR GKKGK
Length:195
Mass (Da):21,841
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE88A8CFBD1CD1873
GO
Isoform 2 (identifier: P05019-2) [UniParc]FASTAAdd to basket
Also known as: IGF-IA

The sequence of this isoform differs from the canonical sequence as follows:
     135-195: YQPPSTNKNT...NAECRGKKGK → EVHLKNASRGSAGNKNYRM

Show »
Length:153
Mass (Da):17,026
Checksum:iC6ECD92DCA9B37BC
GO
Isoform 3 (identifier: P05019-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MGKISSLPTQLFKCCFCDFLK → MITPT
     135-195: YQPPSTNKNT...NAECRGKKGK → EVHLKNASRGSAGNKNYRM

Note: Expressed in liver.
Show »
Length:137
Mass (Da):15,177
Checksum:iBFCC0D11E32AB75D
GO
Isoform 4 (identifier: P05019-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-195: WPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK → STFEERK

Note: Gene prediction based on EST data.
Show »
Length:158
Mass (Da):17,762
Checksum:i59DB4A0437679B6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13429Q13429_HUMAN
Insulin-like growth factor I
IGF1 IGF-I
139Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA27250 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07582598R → W Found in a patient with primordial dwarfism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587779350EnsemblClinVar.1
Natural variantiVAR_056113115A → T. Corresponds to variant dbSNP:rs17884626Ensembl.1
Natural variantiVAR_013945187A → D1 PublicationCorresponds to variant dbSNP:rs6213EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0433171 – 21MGKIS…CDFLK → MITPT in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_039637135 – 195YQPPS…GKKGK → EVHLKNASRGSAGNKNYRM in isoform 2 and isoform 3. 5 PublicationsAdd BLAST61
Alternative sequenceiVSP_047399152 – 195WPKTH…GKKGK → STFEERK in isoform 4. CuratedAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X00173 mRNA Translation: CAA24998.1
X03420 Genomic DNA Translation: CAA27152.1
X03421 Genomic DNA Translation: CAA27153.1
X03422 Genomic DNA Translation: CAA27154.1
M27544 mRNA Translation: AAA52787.1
M14155
, M12659, M14153, M14154 Genomic DNA Translation: AAA52537.1
M14156
, M12659, M14153, M14154 Genomic DNA Translation: AAA52538.1
M11568 mRNA Translation: AAA52539.1
M37484 mRNA Translation: AAA52789.1
X57025 mRNA Translation: CAA40342.1
X56773 mRNA Translation: CAA40092.1
X56774 mRNA Translation: CAA40093.1
AY260957 Genomic DNA Translation: AAO74829.1
AC010202 Genomic DNA No translation available.
AC068648 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97696.1
CH471054 Genomic DNA Translation: EAW97697.1
BC148266 mRNA Translation: AAI48267.1
X03563 Genomic DNA Translation: CAA27250.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS44960.1 [P05019-3]
CCDS44961.1 [P05019-4]
CCDS9091.1 [P05019-2]

Protein sequence database of the Protein Information Resource

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PIRi
A01611 IGHU1B
A92581 IGHU1

NCBI Reference Sequences

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RefSeqi
NP_000609.1, NM_000618.4 [P05019-2]
NP_001104754.1, NM_001111284.1 [P05019-3]
NP_001104755.1, NM_001111285.2 [P05019-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.160562

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307046; ENSP00000302665; ENSG00000017427 [P05019-1]
ENST00000337514; ENSP00000337612; ENSG00000017427 [P05019-2]
ENST00000392904; ENSP00000376637; ENSG00000017427 [P05019-4]
ENST00000392905; ENSP00000376638; ENSG00000017427 [P05019-4]
ENST00000424202; ENSP00000416811; ENSG00000017427 [P05019-3]
ENST00000644491; ENSP00000494228; ENSG00000017427 [P05019-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3479

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3479

UCSC genome browser

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UCSCi
uc001tjm.2 human [P05019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

NIEHS-SNPs
Wikipedia

Insulin-like growth factor 1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00173 mRNA Translation: CAA24998.1
X03420 Genomic DNA Translation: CAA27152.1
X03421 Genomic DNA Translation: CAA27153.1
X03422 Genomic DNA Translation: CAA27154.1
M27544 mRNA Translation: AAA52787.1
M14155
, M12659, M14153, M14154 Genomic DNA Translation: AAA52537.1
M14156
, M12659, M14153, M14154 Genomic DNA Translation: AAA52538.1
M11568 mRNA Translation: AAA52539.1
M37484 mRNA Translation: AAA52789.1
X57025 mRNA Translation: CAA40342.1
X56773 mRNA Translation: CAA40092.1
X56774 mRNA Translation: CAA40093.1
AY260957 Genomic DNA Translation: AAO74829.1
AC010202 Genomic DNA No translation available.
AC068648 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97696.1
CH471054 Genomic DNA Translation: EAW97697.1
BC148266 mRNA Translation: AAI48267.1
X03563 Genomic DNA Translation: CAA27250.1 Sequence problems.
CCDSiCCDS44960.1 [P05019-3]
CCDS44961.1 [P05019-4]
CCDS9091.1 [P05019-2]
PIRiA01611 IGHU1B
A92581 IGHU1
RefSeqiNP_000609.1, NM_000618.4 [P05019-2]
NP_001104754.1, NM_001111284.1 [P05019-3]
NP_001104755.1, NM_001111285.2 [P05019-1]
UniGeneiHs.160562

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B9GNMR-A49-118[»]
1BQTNMR-A49-118[»]
1GF1model-A49-118[»]
1GZRX-ray2.00B49-118[»]
1GZYX-ray2.54B49-118[»]
1GZZX-ray2.30B49-118[»]
1H02X-ray2.00B49-118[»]
1H59X-ray2.10A49-118[»]
1IMXX-ray1.82A49-118[»]
1PMXNMR-A49-118[»]
1TGRX-ray1.42A/B49-77[»]
A/B90-110[»]
1WQJX-ray1.60I49-118[»]
2DSPX-ray2.50I49-118[»]
2DSQX-ray2.80C/I49-118[»]
2DSRX-ray2.10I49-118[»]
2GF1NMR-A49-118[»]
3GF1NMR-A49-118[»]
3LRINMR-A49-118[»]
4XSSX-ray3.00B49-118[»]
5U8QX-ray3.27B49-118[»]
6FF3X-ray2.57B49-118[»]
ProteinModelPortaliP05019
SMRiP05019
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109700, 14 interactors
CORUMiP05019
DIPiDIP-41933N
DIP-6021N
IntActiP05019, 11 interactors
MINTiP05019
STRINGi9606.ENSP00000302665

Chemistry databases

ChEMBLiCHEMBL3217394

Protein family/group databases

Allergomei11751 Hom s IGF-1

PTM databases

iPTMnetiP05019
PhosphoSitePlusiP05019

Polymorphism and mutation databases

BioMutaiIGF1
DMDMi124263

Proteomic databases

PaxDbiP05019
PeptideAtlasiP05019
PRIDEiP05019
ProteomicsDBi51765
51766 [P05019-2]
51767 [P05019-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3479
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307046; ENSP00000302665; ENSG00000017427 [P05019-1]
ENST00000337514; ENSP00000337612; ENSG00000017427 [P05019-2]
ENST00000392904; ENSP00000376637; ENSG00000017427 [P05019-4]
ENST00000392905; ENSP00000376638; ENSG00000017427 [P05019-4]
ENST00000424202; ENSP00000416811; ENSG00000017427 [P05019-3]
ENST00000644491; ENSP00000494228; ENSG00000017427 [P05019-2]
GeneIDi3479
KEGGihsa:3479
UCSCiuc001tjm.2 human [P05019-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3479
DisGeNETi3479
EuPathDBiHostDB:ENSG00000017427.15

GeneCards: human genes, protein and diseases

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GeneCardsi
IGF1
HGNCiHGNC:5464 IGF1
HPAiHPA048946
MalaCardsiIGF1
MIMi147440 gene
608747 phenotype
neXtProtiNX_P05019
OpenTargetsiENSG00000017427
Orphaneti73272 Growth delay due to insulin-like growth factor type 1 deficiency
PharmGKBiPA29697

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ2T Eukaryota
ENOG4111MIV LUCA
GeneTreeiENSGT00940000159081
HOGENOMiHOG000233362
HOVERGENiHBG006137
InParanoidiP05019
KOiK05459
OMAiCFQSCDL
OrthoDBi1644517at2759
PhylomeDBiP05019
TreeFamiTF332820

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
SABIO-RKiP05019
SignaLinkiP05019
SIGNORiP05019

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IGF1 human
EvolutionaryTraceiP05019

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Insulin-like_growth_factor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3479

Protein Ontology

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PROi
PR:P05019

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000017427 Expressed in 218 organ(s), highest expression level in endometrium
ExpressionAtlasiP05019 baseline and differential
GenevisibleiP05019 HS

Family and domain databases

InterProiView protein in InterPro
IPR022341 IGF-I
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR02002 INSLNLIKEGF
PR02005 INSLNLIKEGF1
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05019
Secondary accession number(s): B2RWM7
, E9PD02, P01343, Q14620
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 13, 2019
This is version 222 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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