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Protein

Interferon alpha-16

Gene

IFNA16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-16
Short name:
IFN-alpha-16
Alternative name(s):
Interferon alpha-WA
Gene namesi
Name:IFNA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147885.4
HGNCiHGNC:5421 IFNA16
MIMi147580 gene
neXtProtiNX_P05015

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3449
OpenTargetsiENSG00000147885
PharmGKBiPA29660

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA16
DMDMi124463

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000001636824 – 189Interferon alpha-16Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05015
PeptideAtlasiP05015
PRIDEiP05015
ProteomicsDBi51764
TopDownProteomicsiP05015

PTM databases

iPTMnetiP05015
PhosphoSitePlusiP05015

Expressioni

Gene expression databases

CleanExiHS_IFNA16
GenevisibleiP05015 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109672, 1 interactor
IntActiP05015, 1 interactor
MINTiP05015
STRINGi9606.ENSP00000369564

Structurei

3D structure databases

ProteinModelPortaliP05015
SMRiP05015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0U6 Eukaryota
ENOG411140H LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05015
KOiK05414
OMAiISAFHEM
OrthoDBiEOG091G0OQ3
PhylomeDBiP05015
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05015-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF
60 70 80 90 100
SCLKDRYDFG FPQEVFDGNQ FQKAQAISAF HEMIQQTFNL FSTKDSSAAW
110 120 130 140 150
DETLLDKFYI ELFQQLNDLE ACVTQEVGVE EIALMNEDSI LAVRKYFQRI
160 170 180
TLYLMGKKYS PCAWEVVRAE IMRSFSFSTN LQKGLRRKD
Length:189
Mass (Da):21,711
Last modified:August 13, 1987 - v1
Checksum:iFC8822F787F1585F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02957 Genomic DNA Translation: CAA26703.1
K02055 Genomic DNA Translation: AAA52727.1
M28585 mRNA Translation: AAA36042.1
AL512606 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58618.1
CCDSiCCDS34996.1
PIRiG23753 IVHU16
RefSeqiNP_002164.1, NM_002173.3
UniGeneiHs.56303

Genome annotation databases

EnsembliENST00000380216; ENSP00000369564; ENSG00000147885
GeneIDi3449
KEGGihsa:3449
UCSCiuc003zor.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02957 Genomic DNA Translation: CAA26703.1
K02055 Genomic DNA Translation: AAA52727.1
M28585 mRNA Translation: AAA36042.1
AL512606 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58618.1
CCDSiCCDS34996.1
PIRiG23753 IVHU16
RefSeqiNP_002164.1, NM_002173.3
UniGeneiHs.56303

3D structure databases

ProteinModelPortaliP05015
SMRiP05015
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109672, 1 interactor
IntActiP05015, 1 interactor
MINTiP05015
STRINGi9606.ENSP00000369564

Chemistry databases

ChEMBLiCHEMBL3856161

PTM databases

iPTMnetiP05015
PhosphoSitePlusiP05015

Polymorphism and mutation databases

BioMutaiIFNA16
DMDMi124463

Proteomic databases

PaxDbiP05015
PeptideAtlasiP05015
PRIDEiP05015
ProteomicsDBi51764
TopDownProteomicsiP05015

Protocols and materials databases

DNASUi3449
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380216; ENSP00000369564; ENSG00000147885
GeneIDi3449
KEGGihsa:3449
UCSCiuc003zor.1 human

Organism-specific databases

CTDi3449
DisGeNETi3449
EuPathDBiHostDB:ENSG00000147885.4
GeneCardsiIFNA16
HGNCiHGNC:5421 IFNA16
HPAiHPA047557
MIMi147580 gene
neXtProtiNX_P05015
OpenTargetsiENSG00000147885
PharmGKBiPA29660
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0U6 Eukaryota
ENOG411140H LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05015
KOiK05414
OMAiISAFHEM
OrthoDBiEOG091G0OQ3
PhylomeDBiP05015
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

GeneWikiiIFNA16
GenomeRNAii3449
PROiPR:P05015
SOURCEiSearch...

Gene expression databases

CleanExiHS_IFNA16
GenevisibleiP05015 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFN16_HUMAN
AccessioniPrimary (citable) accession number: P05015
Secondary accession number(s): Q5VV12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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