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Protein

Interferon alpha-4

Gene

IFNA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-4
Short name:
IFN-alpha-4
Alternative name(s):
Interferon alpha-4B
Interferon alpha-76
Interferon alpha-M1
Gene namesi
Name:IFNA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000236637.3
HGNCiHGNC:5425 IFNA4
MIMi147564 gene
neXtProtiNX_P05014

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3441
OpenTargetsiENSG00000236637
PharmGKBiPA29664

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA4
DMDMi84029375

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001636124 – 189Interferon alpha-4Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05014
PeptideAtlasiP05014
PRIDEiP05014
ProteomicsDBi51763

PTM databases

iPTMnetiP05014
PhosphoSitePlusiP05014

Expressioni

Gene expression databases

BgeeiENSG00000236637 Expressed in 4 organ(s), highest expression level in adipose tissue
CleanExiHS_IFNA4
GenevisibleiP05014 HS

Organism-specific databases

HPAiHPA047557

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALDOAP04075-23EBI-10194381,EBI-10194102

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109664, 10 interactors
IntActiP05014, 1 interactor
STRINGi9606.ENSP00000412897

Structurei

3D structure databases

ProteinModelPortaliP05014
SMRiP05014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05014
KOiK05414
OMAiRIYFHRI
OrthoDBiEOG091G0MJ6
PhylomeDBiP05014
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05014-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF
60 70 80 90 100
SCLKDRHDFG FPEEEFDGHQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD
Length:189
Mass (Da):21,808
Last modified:May 10, 2005 - v2
Checksum:i828DF9C33ABC337F
GO

Polymorphismi

Two forms exist; alpha-4a (shown here) and alpha-4b (PubMed:9335434). They seem to be equally abundant (PubMed:9335434).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03401049H → P. Corresponds to variant dbSNP:rs201964250Ensembl.1
Natural variantiVAR_01300274A → T in alpha-4B. 3 PublicationsCorresponds to variant dbSNP:rs1062571Ensembl.1
Natural variantiVAR_013003137E → V in alpha-4B. 1 PublicationCorresponds to variant dbSNP:rs3750480Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27318 mRNA Translation: AAA52726.1
X02955 Genomic DNA Translation: CAA26701.1
AL512606 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58621.1
BC074965 mRNA Translation: AAH74965.1
BC074966 mRNA Translation: AAH74966.1
BC113640 mRNA Translation: AAI13641.1
BC113642 mRNA Translation: AAI13643.1
CCDSiCCDS6498.1
PIRiE23753 IVHU4B
I52347
RefSeqiNP_066546.1, NM_021068.2
UniGeneiHs.1510

Genome annotation databases

EnsembliENST00000421715; ENSP00000412897; ENSG00000236637
GeneIDi3441
KEGGihsa:3441
UCSCiuc003zon.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27318 mRNA Translation: AAA52726.1
X02955 Genomic DNA Translation: CAA26701.1
AL512606 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58621.1
BC074965 mRNA Translation: AAH74965.1
BC074966 mRNA Translation: AAH74966.1
BC113640 mRNA Translation: AAI13641.1
BC113642 mRNA Translation: AAI13643.1
CCDSiCCDS6498.1
PIRiE23753 IVHU4B
I52347
RefSeqiNP_066546.1, NM_021068.2
UniGeneiHs.1510

3D structure databases

ProteinModelPortaliP05014
SMRiP05014
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109664, 10 interactors
IntActiP05014, 1 interactor
STRINGi9606.ENSP00000412897

Chemistry databases

ChEMBLiCHEMBL3856161

PTM databases

iPTMnetiP05014
PhosphoSitePlusiP05014

Polymorphism and mutation databases

BioMutaiIFNA4
DMDMi84029375

Proteomic databases

PaxDbiP05014
PeptideAtlasiP05014
PRIDEiP05014
ProteomicsDBi51763

Protocols and materials databases

DNASUi3441
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421715; ENSP00000412897; ENSG00000236637
GeneIDi3441
KEGGihsa:3441
UCSCiuc003zon.3 human

Organism-specific databases

CTDi3441
DisGeNETi3441
EuPathDBiHostDB:ENSG00000236637.3
GeneCardsiIFNA4
HGNCiHGNC:5425 IFNA4
HPAiHPA047557
MIMi147564 gene
neXtProtiNX_P05014
OpenTargetsiENSG00000236637
PharmGKBiPA29664
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05014
KOiK05414
OMAiRIYFHRI
OrthoDBiEOG091G0MJ6
PhylomeDBiP05014
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

GeneWikiiIFNA4
GenomeRNAii3441
PROiPR:P05014
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000236637 Expressed in 4 organ(s), highest expression level in adipose tissue
CleanExiHS_IFNA4
GenevisibleiP05014 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNA4_HUMAN
AccessioniPrimary (citable) accession number: P05014
Secondary accession number(s): P13358, Q14CS4, Q5VV15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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