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Protein

Interferon alpha-6

Gene

IFNA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-6
Short name:
IFN-alpha-6
Alternative name(s):
Interferon alpha-54
Interferon alpha-K
Short name:
LeIF K
Gene namesi
Name:IFNA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120235.4
HGNCiHGNC:5427 IFNA6
MIMi147566 gene
neXtProtiNX_P05013

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3443
OpenTargetsiENSG00000120235
PharmGKBiPA29666

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA6
DMDMi124460

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001636321 – 189Interferon alpha-6Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05013
PeptideAtlasiP05013
PRIDEiP05013
ProteomicsDBi51762

PTM databases

iPTMnetiP05013
PhosphoSitePlusiP05013

Expressioni

Gene expression databases

BgeeiENSG00000120235 Expressed in 18 organ(s), highest expression level in caudate nucleus
CleanExiHS_IFNA6
ExpressionAtlasiP05013 baseline and differential
GenevisibleiP05013 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109666, 4 interactors
IntActiP05013, 1 interactor
STRINGi9606.ENSP00000369558

Structurei

3D structure databases

ProteinModelPortaliP05013
SMRiP05013
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05013
KOiK05414
OMAiHRRTMML
PhylomeDBiP05013
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05013-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPFALLMA LVVLSCKSSC SLDCDLPQTH SLGHRRTMML LAQMRRISLF
60 70 80 90 100
SCLKDRHDFR FPQEEFDGNQ FQKAEAISVL HEVIQQTFNL FSTKDSSVAW
110 120 130 140 150
DERLLDKLYT ELYQQLNDLE ACVMQEVWVG GTPLMNEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSFSSSRN LQERLRRKE
Length:189
Mass (Da):22,141
Last modified:August 13, 1987 - v1
Checksum:i8C7F3F90F12C562E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQU8A0A0A0MQU8_HUMAN
Interferon alpha-6
IFNA6
190Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02958 Genomic DNA Translation: CAA26704.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58613.1
BC069471 mRNA Translation: AAH69471.1
BC096697 mRNA Translation: AAH96697.1
BC096710 mRNA Translation: AAH96710.1
BC096730 mRNA Translation: AAH96730.1
BC098357 mRNA Translation: AAH98357.1
CCDSiCCDS6504.1
PIRiA23753 IVHUI6
RefSeqiNP_066282.1, NM_021002.2
UniGeneiHs.533470

Genome annotation databases

EnsembliENST00000380210; ENSP00000369558; ENSG00000120235
GeneIDi3443
KEGGihsa:3443
UCSCiuc011lni.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02958 Genomic DNA Translation: CAA26704.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58613.1
BC069471 mRNA Translation: AAH69471.1
BC096697 mRNA Translation: AAH96697.1
BC096710 mRNA Translation: AAH96710.1
BC096730 mRNA Translation: AAH96730.1
BC098357 mRNA Translation: AAH98357.1
CCDSiCCDS6504.1
PIRiA23753 IVHUI6
RefSeqiNP_066282.1, NM_021002.2
UniGeneiHs.533470

3D structure databases

ProteinModelPortaliP05013
SMRiP05013
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109666, 4 interactors
IntActiP05013, 1 interactor
STRINGi9606.ENSP00000369558

Chemistry databases

ChEMBLiCHEMBL3856161

PTM databases

iPTMnetiP05013
PhosphoSitePlusiP05013

Polymorphism and mutation databases

BioMutaiIFNA6
DMDMi124460

Proteomic databases

PaxDbiP05013
PeptideAtlasiP05013
PRIDEiP05013
ProteomicsDBi51762

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380210; ENSP00000369558; ENSG00000120235
GeneIDi3443
KEGGihsa:3443
UCSCiuc011lni.3 human

Organism-specific databases

CTDi3443
DisGeNETi3443
EuPathDBiHostDB:ENSG00000120235.4
GeneCardsiIFNA6
HGNCiHGNC:5427 IFNA6
HPAiHPA047557
MIMi147566 gene
neXtProtiNX_P05013
OpenTargetsiENSG00000120235
PharmGKBiPA29666
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05013
KOiK05414
OMAiHRRTMML
PhylomeDBiP05013
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

GeneWikiiIFNA6
GenomeRNAii3443
PROiPR:P05013
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120235 Expressed in 18 organ(s), highest expression level in caudate nucleus
CleanExiHS_IFNA6
ExpressionAtlasiP05013 baseline and differential
GenevisibleiP05013 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNA6_HUMAN
AccessioniPrimary (citable) accession number: P05013
Secondary accession number(s): Q5VYQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 12, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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