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Protein

Interferon omega-1

Gene

IFNW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

SIGNORiP05000

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon omega-1
Alternative name(s):
Interferon alpha-II-1
Gene namesi
Name:IFNW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000177047.6
HGNCiHGNC:5448 IFNW1
MIMi147553 gene
neXtProtiNX_P05000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3467
OpenTargetsiENSG00000177047
PharmGKBiPA29683

Polymorphism and mutation databases

BioMutaiIFNW1
DMDMi400061

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Or 23 in some molecules3 PublicationsAdd BLAST21
ChainiPRO_000001640822 – 195Interferon omega-1Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 1621 Publication
GlycosylationiCAR_000050101N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05000
PeptideAtlasiP05000
PRIDEiP05000
ProteomicsDBi51761

PTM databases

GlyConnecti295
UniCarbKBiP05000

Expressioni

Gene expression databases

BgeeiENSG00000177047 Expressed in 3 organ(s), highest expression level in blood
CleanExiHS_IFNW1
GenevisibleiP05000 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109689, 2 interactors
IntActiP05000, 2 interactors
STRINGi9606.ENSP00000369578

Structurei

3D structure databases

ProteinModelPortaliP05000
SMRiP05000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J975 Eukaryota
ENOG4111675 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05000
KOiK05440
OMAiRISPFLC
OrthoDBiEOG091G0TRU
PhylomeDBiP05000
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05000-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF
60 70 80 90 100
LCLKDRRDFR FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW
110 120 130 140 150
NMTLLDQLHT GLHQQLQHLE TCLLQVVGEG ESAGAISSPA LTLRRYFQGI
160 170 180 190
RVYLKEKKYS DCAWEVVRME IMKSLFLSTN MQERLRSKDR DLGSS
Length:195
Mass (Da):22,319
Last modified:July 1, 1993 - v2
Checksum:i1E4306F3487987FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 23LG → EF in AAA70091 (PubMed:8142025).Curated2
Sequence conflicti42H → M AA sequence (PubMed:7765487).Curated1
Sequence conflicti79V → A in AAA70091 (PubMed:8142025).Curated1
Sequence conflicti111G → E in AAA52724 (PubMed:2985969).Curated1
Sequence conflicti167V → D in AAA70091 (PubMed:8142025).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02002895R → S. Corresponds to variant dbSNP:rs2230055Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11003 Genomic DNA Translation: AAA52724.1
X58822 Genomic DNA Translation: CAA41626.1
AL390882 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58624.1
BC069095 mRNA Translation: AAH69095.1
BC117290 mRNA Translation: AAI17291.1
BC117292 mRNA Translation: AAI17293.1
X02669 mRNA Translation: CAA26501.1
U25670 Genomic DNA Translation: AAA70091.1
AY780805 mRNA Translation: AAV49320.1
CCDSiCCDS6496.1
PIRiA93070 IVHUII
PC2204
PC2205
RefSeqiNP_002168.1, NM_002177.2
UniGeneiHs.73010

Genome annotation databases

EnsembliENST00000380229; ENSP00000369578; ENSG00000177047
GeneIDi3467
KEGGihsa:3467
UCSCiuc003zol.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11003 Genomic DNA Translation: AAA52724.1
X58822 Genomic DNA Translation: CAA41626.1
AL390882 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58624.1
BC069095 mRNA Translation: AAH69095.1
BC117290 mRNA Translation: AAI17291.1
BC117292 mRNA Translation: AAI17293.1
X02669 mRNA Translation: CAA26501.1
U25670 Genomic DNA Translation: AAA70091.1
AY780805 mRNA Translation: AAV49320.1
CCDSiCCDS6496.1
PIRiA93070 IVHUII
PC2204
PC2205
RefSeqiNP_002168.1, NM_002177.2
UniGeneiHs.73010

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SE4X-ray3.50B22-195[»]
ProteinModelPortaliP05000
SMRiP05000
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109689, 2 interactors
IntActiP05000, 2 interactors
STRINGi9606.ENSP00000369578

PTM databases

GlyConnecti295
UniCarbKBiP05000

Polymorphism and mutation databases

BioMutaiIFNW1
DMDMi400061

Proteomic databases

PaxDbiP05000
PeptideAtlasiP05000
PRIDEiP05000
ProteomicsDBi51761

Protocols and materials databases

DNASUi3467
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380229; ENSP00000369578; ENSG00000177047
GeneIDi3467
KEGGihsa:3467
UCSCiuc003zol.2 human

Organism-specific databases

CTDi3467
DisGeNETi3467
EuPathDBiHostDB:ENSG00000177047.6
GeneCardsiIFNW1
HGNCiHGNC:5448 IFNW1
MIMi147553 gene
neXtProtiNX_P05000
OpenTargetsiENSG00000177047
PharmGKBiPA29683
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J975 Eukaryota
ENOG4111675 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP05000
KOiK05440
OMAiRISPFLC
OrthoDBiEOG091G0TRU
PhylomeDBiP05000
TreeFamiTF336177

Enzyme and pathway databases

SIGNORiP05000

Miscellaneous databases

GeneWikiiIFNW1
GenomeRNAii3467
PROiPR:P05000
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177047 Expressed in 3 organ(s), highest expression level in blood
CleanExiHS_IFNW1
GenevisibleiP05000 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNW1_HUMAN
AccessioniPrimary (citable) accession number: P05000
Secondary accession number(s): Q13168
, Q5U802, Q5VWD0, Q7M4P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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