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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions.

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciEcoCyc:EG11072-MONOMER
MetaCyc:EG11072-MONOMER
BRENDAi3.1.11.6 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:b2509, JW2493
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11072 xseA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978451 – 456Exodeoxyribonuclease 7 large subunitAdd BLAST456

Proteomic databases

PaxDbiP04994
PRIDEiP04994

Interactioni

Subunit structurei

Heterooligomer composed of two different subunits with an approximate ratio of 4 small subunits for 1 large.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
intQP761683EBI-559703,EBI-559711

Protein-protein interaction databases

BioGridi4263222, 85 interactors
DIPiDIP-11146N
IntActiP04994, 9 interactors
STRINGi316385.ECDH10B_2675

Structurei

3D structure databases

ProteinModelPortaliP04994
SMRiP04994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS Bacteria
COG1570 LUCA
HOGENOMiHOG000229265
InParanoidiP04994
KOiK03601
PhylomeDBiP04994

Family and domain databases

CDDicd04489 ExoVII_LU_OBF, 1 hit
HAMAPiMF_00378 Exonuc_7_L, 1 hit
InterProiView protein in InterPro
IPR003753 Exonuc_VII_L
IPR020579 Exonuc_VII_lsu_C
IPR025824 OB-fold_nuc-bd_dom
PANTHERiPTHR30008 PTHR30008, 1 hit
PfamiView protein in Pfam
PF02601 Exonuc_VII_L, 1 hit
PF13742 tRNA_anti_2, 1 hit
TIGRFAMsiTIGR00237 xseA, 1 hit

Sequencei

Sequence statusi: Complete.

P04994-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPSQSPAIF TVSRLNQTVR LLLEHEMGQV WISGEISNFT QPASGHWYFT
60 70 80 90 100
LKDDTAQVRC AMFRNSNRRV TFRPQHGQQV LVRANITLYE PRGDYQIIVE
110 120 130 140 150
SMQPAGEGLL QQKYEQLKAK LQAEGLFDQQ YKKPLPSPAH CVGVITSKTG
160 170 180 190 200
AALHDILHVL KRRDPSLPVI IYPAAVQGDD APGQIVRAIE LANQRNECDV
210 220 230 240 250
LIVGRGGGSL EDLWSFNDER VARAIFTSRI PVVSAVGHET DVTIADFVAD
260 270 280 290 300
LRAPTPSAAA EVVSRNQQEL LRQVQSTRQR LEMAMDYYLA NRTRRFTQIH
310 320 330 340 350
HRLQQQHPQL RLARQQTMLE RLQKRMSFAL ENQLKRTGQQ QQRLTQRLNQ
360 370 380 390 400
QNPQPKIHRA QTRIQQLEYR LAETLRAQLS ATRERFGNAV THLEAVSPLS
410 420 430 440 450
TLARGYSVTT ATDGNVLKKV KQVKAGEMLT TRLEDGWIES EVKNIQPVKK

SRKKVH
Length:456
Mass (Da):51,832
Last modified:November 1, 1997 - v2
Checksum:iA5E5B138C54A7D27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67N → S in AAA24766 (PubMed:3021756).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02599 Genomic DNA Translation: AAA24766.1
U00096 Genomic DNA Translation: AAC75562.1
AP009048 Genomic DNA Translation: BAA16396.1
PIRiD65027 NCEC7
RefSeqiNP_417004.1, NC_000913.3
WP_000937912.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75562; AAC75562; b2509
BAA16396; BAA16396; BAA16396
GeneIDi946988
KEGGiecj:JW2493
eco:b2509
PATRICifig|1411691.4.peg.4227

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02599 Genomic DNA Translation: AAA24766.1
U00096 Genomic DNA Translation: AAC75562.1
AP009048 Genomic DNA Translation: BAA16396.1
PIRiD65027 NCEC7
RefSeqiNP_417004.1, NC_000913.3
WP_000937912.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP04994
SMRiP04994
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263222, 85 interactors
DIPiDIP-11146N
IntActiP04994, 9 interactors
STRINGi316385.ECDH10B_2675

Proteomic databases

PaxDbiP04994
PRIDEiP04994

Protocols and materials databases

DNASUi946988
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75562; AAC75562; b2509
BAA16396; BAA16396; BAA16396
GeneIDi946988
KEGGiecj:JW2493
eco:b2509
PATRICifig|1411691.4.peg.4227

Organism-specific databases

EchoBASEiEB1065
EcoGeneiEG11072 xseA

Phylogenomic databases

eggNOGiENOG4105DVS Bacteria
COG1570 LUCA
HOGENOMiHOG000229265
InParanoidiP04994
KOiK03601
PhylomeDBiP04994

Enzyme and pathway databases

BioCyciEcoCyc:EG11072-MONOMER
MetaCyc:EG11072-MONOMER
BRENDAi3.1.11.6 2026

Miscellaneous databases

PROiPR:P04994

Family and domain databases

CDDicd04489 ExoVII_LU_OBF, 1 hit
HAMAPiMF_00378 Exonuc_7_L, 1 hit
InterProiView protein in InterPro
IPR003753 Exonuc_VII_L
IPR020579 Exonuc_VII_lsu_C
IPR025824 OB-fold_nuc-bd_dom
PANTHERiPTHR30008 PTHR30008, 1 hit
PfamiView protein in Pfam
PF02601 Exonuc_VII_L, 1 hit
PF13742 tRNA_anti_2, 1 hit
TIGRFAMsiTIGR00237 xseA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_ECOLI
AccessioniPrimary (citable) accession number: P04994
Secondary accession number(s): P78230
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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