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Protein

Pertussis toxin subunit 5

Gene

ptxE

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Enzyme and pathway databases

BioCyciBPER257313:BP3786-MONOMER

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family

Names & Taxonomyi

Protein namesi
Recommended name:
Pertussis toxin subunit 5
Short name:
PTX S5
Alternative name(s):
Islet-activating protein S5
Short name:
IAP S5
Gene namesi
Name:ptxE
Ordered Locus Names:BP3786
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

Pathology & Biotechi

Keywords - Diseasei

Whooping cough

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001936435 – 133Pertussis toxin subunit 5Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 75
Disulfide bondi126 ↔ 132

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Pertussis toxin contains five different chains, S1-S5. They are organized into 2 functional subunits: A, composed of S1 (which is toxic) and B, containing S2, S3, S5, and two copies of S4 (B binds to the membrane receptors). Dimers of S2-S4 and S3-S4 are held together by S5.

Protein-protein interaction databases

STRINGi257313.BP3786

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04981
SMRiP04981
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04981

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000095591
KOiK11027
OMAiTAFMPGR

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR015356 Pertussis_toxin_subS5
PfamiView protein in Pfam
PF09276 Pertus-S5-tox, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRQAGLPLK ANPMHTIASI LLSVLGIYSP ADVAGLPTHL YKNFTVQELA
60 70 80 90 100
LKLKGKNQEF CLTAFMSGRS LVRACLSDAG HEHDTWFDTM LGFAISAYAL
110 120 130
KSRIALTVED SPYPGTPGDL LELQICPLNG YCE
Length:133
Mass (Da):14,500
Last modified:August 13, 1987 - v1
Checksum:i4DDC39CEC7D9D28D
GO

Sequence cautioni

The sequence AAA22984 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83983.1
M13223 Genomic DNA Translation: AAA22984.1 Different initiation.
BX640422 Genomic DNA Translation: CAE44041.1
PIRiE24394 WEBR51
RefSeqiNP_882285.1, NC_002929.2
WP_010931650.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE44041; CAE44041; BP3786
GeneIDi2665407
KEGGibpe:BP3786
PATRICifig|257313.5.peg.4090

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83983.1
M13223 Genomic DNA Translation: AAA22984.1 Different initiation.
BX640422 Genomic DNA Translation: CAE44041.1
PIRiE24394 WEBR51
RefSeqiNP_882285.1, NC_002929.2
WP_010931650.1, NC_002929.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCPX-ray2.70F/L35-133[»]
1PRTX-ray2.90F/L36-133[»]
1PTOX-ray3.50F/L36-133[»]
ProteinModelPortaliP04981
SMRiP04981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP3786

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE44041; CAE44041; BP3786
GeneIDi2665407
KEGGibpe:BP3786
PATRICifig|257313.5.peg.4090

Phylogenomic databases

HOGENOMiHOG000095591
KOiK11027
OMAiTAFMPGR

Enzyme and pathway databases

BioCyciBPER257313:BP3786-MONOMER

Miscellaneous databases

EvolutionaryTraceiP04981

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR015356 Pertussis_toxin_subS5
PfamiView protein in Pfam
PF09276 Pertus-S5-tox, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOX5_BORPE
AccessioniPrimary (citable) accession number: P04981
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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