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Protein

Pertussis toxin subunit 3

Gene

ptxC

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Enzyme and pathway databases

BioCyciBPER257313:BP3787-MONOMER

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family

Names & Taxonomyi

Protein namesi
Recommended name:
Pertussis toxin subunit 3
Short name:
PTX S3
Alternative name(s):
Islet-activating protein S3
Short name:
IAP S3
Gene namesi
Name:ptxC
Ordered Locus Names:BP3787
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

Pathology & Biotechi

Keywords - Diseasei

Whooping cough

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000001936129 – 227Pertussis toxin subunit 3Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 115
Disulfide bondi148 ↔ 162
Disulfide bondi220 ↔ 227

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Pertussis toxin contains five different chains, S1-S5. They are organized into 2 functional subunits: A, composed of S1 (which is toxic) and B, containing S2, S3, S5, and two copies of S4 (B binds to the membrane receptors). Dimers of S2-S4 and S3-S4 are held together by S5.

Protein-protein interaction databases

STRINGi257313.BP3787

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04979
SMRiP04979
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04979

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000095589
KOiK11025
OMAiMYDVLRR

Family and domain databases

Gene3Di3.10.40.10, 1 hit
InterProiView protein in InterPro
IPR005138 APT_dom
IPR037015 APT_N_sf
IPR016187 CTDL_fold
IPR008992 Enterotoxin
IPR003899 ToxinB_BORPE
IPR020063 ToxinB_su2/3_C_BORPE
PfamiView protein in Pfam
PF03440 APT, 1 hit
PF02918 Pertussis_S2S3, 1 hit
PRINTSiPR01396 BORPETOXINB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD037992 Borpert_toxB, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit
SSF56436 SSF56436, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04979-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLINNKKLLH HILPILVLAL LGMRTAQAVA PGIVIPPKAL FTQQGGAYGR
60 70 80 90 100
CPNGTRALTV AELRGNAELQ TYLRQITPGW SIYGLYDGTY LGQAYGGIIK
110 120 130 140 150
DAPPGAGFIY RETFCITTIY KTGQPAADHY YSKVTATRLL ASTNSRLCAV
160 170 180 190 200
FVRDGQSVIG ACASPYEGRY RDMYDALRRL LYMIYMSGLA VRVHVSKEEQ
210 220
YYDYEDATFQ TYALTGISLC NPAASIC
Length:227
Mass (Da):24,988
Last modified:August 13, 1987 - v1
Checksum:i8E15848065BBAB7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83984.1
M13223 Genomic DNA Translation: AAA22985.1
BX640422 Genomic DNA Translation: CAE44042.1
PIRiC24394 WEBR31
RefSeqiNP_882286.1, NC_002929.2
WP_010931651.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE44042; CAE44042; BP3787
GeneIDi2665408
KEGGibpe:BP3787
PATRICifig|257313.5.peg.4091

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83984.1
M13223 Genomic DNA Translation: AAA22985.1
BX640422 Genomic DNA Translation: CAE44042.1
PIRiC24394 WEBR31
RefSeqiNP_882286.1, NC_002929.2
WP_010931651.1, NC_002929.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCPX-ray2.70C/I29-227[»]
1PRTX-ray2.90C/I32-227[»]
1PTOX-ray3.50C/I32-227[»]
ProteinModelPortaliP04979
SMRiP04979
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP3787

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE44042; CAE44042; BP3787
GeneIDi2665408
KEGGibpe:BP3787
PATRICifig|257313.5.peg.4091

Phylogenomic databases

HOGENOMiHOG000095589
KOiK11025
OMAiMYDVLRR

Enzyme and pathway databases

BioCyciBPER257313:BP3787-MONOMER

Miscellaneous databases

EvolutionaryTraceiP04979

Family and domain databases

Gene3Di3.10.40.10, 1 hit
InterProiView protein in InterPro
IPR005138 APT_dom
IPR037015 APT_N_sf
IPR016187 CTDL_fold
IPR008992 Enterotoxin
IPR003899 ToxinB_BORPE
IPR020063 ToxinB_su2/3_C_BORPE
PfamiView protein in Pfam
PF03440 APT, 1 hit
PF02918 Pertussis_S2S3, 1 hit
PRINTSiPR01396 BORPETOXINB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD037992 Borpert_toxB, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit
SSF56436 SSF56436, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOX3_BORPE
AccessioniPrimary (citable) accession number: P04979
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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