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Protein

Pertussis toxin subunit 2

Gene

ptxB

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Enzyme and pathway databases

BioCyciBPER257313:BP3784-MONOMER

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family

Names & Taxonomyi

Protein namesi
Recommended name:
Pertussis toxin subunit 2
Short name:
PTX S2
Alternative name(s):
Islet-activating protein S2
Short name:
IAP S2
Gene namesi
Name:ptxB
Ordered Locus Names:BP3784
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

Pathology & Biotechi

Keywords - Diseasei

Whooping cough

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000001936028 – 226Pertussis toxin subunit 2Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 114
Disulfide bondi147 ↔ 161
Disulfide bondi219 ↔ 226

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP04978

Interactioni

Subunit structurei

Pertussis toxin contains five different chains, S1-S5. They are organized into 2 functional subunits: A, composed of S1 (which is toxic) and B, containing S2, S3, S5, and two copies of S4 (B binds to the membrane receptors). Dimers of S2-S4 and S3-S4 are held together by S5.

Protein-protein interaction databases

STRINGi257313.BP3784

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04978
SMRiP04978
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04978

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000095589
KOiK11024
OMAiSPYGRCA

Family and domain databases

Gene3Di3.10.40.10, 1 hit
InterProiView protein in InterPro
IPR005138 APT_dom
IPR037015 APT_N_sf
IPR016187 CTDL_fold
IPR008992 Enterotoxin
IPR003899 ToxinB_BORPE
IPR020063 ToxinB_su2/3_C_BORPE
PfamiView protein in Pfam
PF03440 APT, 1 hit
PF02918 Pertussis_S2S3, 1 hit
PRINTSiPR01396 BORPETOXINB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD037992 Borpert_toxB, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit
SSF56436 SSF56436, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04978-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIDRKTLCH LLSVLPLALL GSHVARASTP GIVIPPQEQI TQHGGPYGRC
60 70 80 90 100
ANKTRALTVA ELRGSGDLQE YLRHVTRGWS IFALYDGTYL GGEYGGVIKD
110 120 130 140 150
GTPGGAFDLK TTFCIMTTRN TGQPATDHYY SNVTATRLLS STNSRLCAVF
160 170 180 190 200
VRSGQPVIGA CTSPYDGKYW SMYSRLRKML YLIYVAGISV RVHVSKEEQY
210 220
YDYEDATFET YALTGISICN PGSSLC
Length:226
Mass (Da):24,799
Last modified:September 19, 2003 - v2
Checksum:iEF9FAF00FB694965
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45G → S (PubMed:2873570).Curated1
Sequence conflicti45G → S (PubMed:3704651).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83981.1
M13223 Genomic DNA Translation: AAA22982.1
BX640422 Genomic DNA Translation: CAE44039.1
PIRiB24144 WEBR2P
RefSeqiNP_882283.1, NC_002929.2
WP_010931649.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE44039; CAE44039; BP3784
GeneIDi2665069
KEGGibpe:BP3784
PATRICifig|257313.5.peg.4088

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83981.1
M13223 Genomic DNA Translation: AAA22982.1
BX640422 Genomic DNA Translation: CAE44039.1
PIRiB24144 WEBR2P
RefSeqiNP_882283.1, NC_002929.2
WP_010931649.1, NC_002929.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCPX-ray2.70B/H28-226[»]
1PRTX-ray2.90B/H31-226[»]
1PTOX-ray3.50B31-226[»]
H29-226[»]
ProteinModelPortaliP04978
SMRiP04978
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP3784

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family

Proteomic databases

PRIDEiP04978

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE44039; CAE44039; BP3784
GeneIDi2665069
KEGGibpe:BP3784
PATRICifig|257313.5.peg.4088

Phylogenomic databases

HOGENOMiHOG000095589
KOiK11024
OMAiSPYGRCA

Enzyme and pathway databases

BioCyciBPER257313:BP3784-MONOMER

Miscellaneous databases

EvolutionaryTraceiP04978

Family and domain databases

Gene3Di3.10.40.10, 1 hit
InterProiView protein in InterPro
IPR005138 APT_dom
IPR037015 APT_N_sf
IPR016187 CTDL_fold
IPR008992 Enterotoxin
IPR003899 ToxinB_BORPE
IPR020063 ToxinB_su2/3_C_BORPE
PfamiView protein in Pfam
PF03440 APT, 1 hit
PF02918 Pertussis_S2S3, 1 hit
PRINTSiPR01396 BORPETOXINB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD037992 Borpert_toxB, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit
SSF56436 SSF56436, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOX2_BORPE
AccessioniPrimary (citable) accession number: P04978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: September 19, 2003
Last modified: June 20, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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