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Protein

Clathrin light chain A

Gene

CLTA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium

Enzyme and pathway databases

ReactomeiR-BTA-177504 Retrograde neurotrophin signalling
R-BTA-190873 Gap junction degradation
R-BTA-196025 Formation of annular gap junctions
R-BTA-2132295 MHC class II antigen presentation
R-BTA-432720 Lysosome Vesicle Biogenesis
R-BTA-432722 Golgi Associated Vesicle Biogenesis
R-BTA-437239 Recycling pathway of L1
R-BTA-5099900 WNT5A-dependent internalization of FZD4
R-BTA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-BTA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-BTA-8856828 Clathrin-mediated endocytosis
R-BTA-8866427 VLDLR internalisation and degradation
R-BTA-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:CLTA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Organism-specific databases

VGNCiVGNC:27469 CLTA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057661 – 243Clathrin light chain AAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Blocked amino end (Met)1
Modified residuei100PhosphoserineBy similarity1
Modified residuei201PhosphoserineBy similarity1
Modified residuei218N6-acetyllysineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei237N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP04973
PeptideAtlasiP04973
PRIDEiP04973

Expressioni

Gene expression databases

BgeeiENSBTAG00000001137

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP04973, 2 interactors
MINTiP04973
STRINGi9913.ENSBTAP00000001518

Structurei

3D structure databases

SMRiP04973
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04973

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 157Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031 Eukaryota
ENOG4111J5K LUCA
GeneTreeiENSGT00390000010441
HOGENOMiHOG000008147
HOVERGENiHBG003386
InParanoidiP04973
KOiK04644
OMAiINHPCYR
OrthoDBiEOG091G0WEF
TreeFamiTF313162

Family and domain databases

InterProiView protein in InterPro
IPR000996 Clathrin_L-chain
PANTHERiPTHR10639 PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086 Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P04973-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGVP AGGPALGNGV AGEEDPAAAF LAQQESEIAG IENDEAFAIL
60 70 80 90 100
DGGAPGSQPH GEPPGIPDAV DGVTNGDYYQ ESNGPTDSYA AISQVDRLQS
110 120 130 140 150
EPESIRKWRE EQTERLEALD ANSRKQEAEW KEKAIKELDE WYARQDEQLQ
160 170 180 190 200
KTKANNRVAD EAFYKQPFAD VIGYVTNINH PCYSLEQAAE EAFVNDIEES
210 220 230 240
SPGTEWERVA RLCDFNPKSS KQAKDVSRMR SVLISLKQAP LVH
Length:243
Mass (Da):26,723
Last modified:August 13, 1987 - v1
Checksum:iB1967A24DC14A06F
GO
Isoform Non-brain (identifier: P04973-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-187: Missing.

Show »
Length:213
Mass (Da):23,308
Checksum:iFCF2754AC7B684DE
GO
Isoform 3 (identifier: P04973-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-187: Missing.

Show »
Length:231
Mass (Da):25,323
Checksum:i4B2F0359CECAC709
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14P → H in CAA28542 (PubMed:3821891).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001094158 – 187Missing in isoform Non-brain. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_024237176 – 187Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04849 mRNA Translation: CAA28540.1
X04851 mRNA Translation: CAA28542.1
BC118427 mRNA Translation: AAI18428.1
PIRiA26599
RefSeqiNP_776447.1, NM_174022.2 [P04973-1]
XP_005210116.1, XM_005210059.2 [P04973-3]
XP_005210119.1, XM_005210062.2 [P04973-2]
UniGeneiBt.1617

Genome annotation databases

EnsembliENSBTAT00000001518; ENSBTAP00000001518; ENSBTAG00000001137 [P04973-1]
ENSBTAT00000046425; ENSBTAP00000043729; ENSBTAG00000001137 [P04973-3]
ENSBTAT00000055956; ENSBTAP00000047748; ENSBTAG00000001137 [P04973-2]
GeneIDi281078
KEGGibta:281078

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLCA_BOVIN
AccessioniPrimary (citable) accession number: P04973
Secondary accession number(s): Q17QD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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