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Entry version 99 (29 Sep 2021)
Sequence version 2 (01 Feb 1996)
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Protein

Merozoite surface protein 1

Gene

MSP-1

Organism
Plasmodium falciparum (isolate Wellcome)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Merozoite surface protein 1
Alternative name(s):
Merozoite surface antigens
PMMSA
p195
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate Wellcome)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5848 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Malaria

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002456120 – 1618Merozoite surface protein 1Add BLAST1599
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000245621619 – 1639Removed in mature formBy similarityAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi768N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi783N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi844N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1058N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1526N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1532 ↔ 1543
Disulfide bondi1537 ↔ 1553
Disulfide bondi1555 ↔ 1566
Disulfide bondi1574 ↔ 1587
Disulfide bondi1581 ↔ 1601
Disulfide bondi1603 ↔ 1617
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1618GPI-anchor amidated serineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Merozoite surface antigen contain the sequence of 83 kDa, 42 kDa and 19 kDa antigens which are the major surface antigens of merozoites. The maturation take place during schizont.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Merozoite

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11639
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P04933

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04933

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04933

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 78DisorderedSequence analysisAdd BLAST21
Regioni94 – 122DisorderedSequence analysisAdd BLAST29
Regioni689 – 764DisorderedSequence analysisAdd BLAST76
Regioni893 – 915DisorderedSequence analysisAdd BLAST23
Regioni1199 – 1229DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi94 – 121Polar residuesSequence analysisAdd BLAST28
Compositional biasi697 – 740Polar residuesSequence analysisAdd BLAST44
Compositional biasi742 – 756Pro residuesSequence analysisAdd BLAST15

Keywords - Domaini

Repeat, Signal

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010901, MSP1_C
IPR024730, MSP1_EGF_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12946, EGF_MSP1_1, 1 hit
PF07462, MSP1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P04933-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYSLFQKEK
60 70 80 90 100
MVLNEGTSGT AVTTSTPGSK GSVASGGSGG SVASGGSVAS GGSVASGGSV
110 120 130 140 150
ASGGSGNSRR TNPSDNSSDS DAKSYADLKH RVRNYLLTIK ELKYPQLFDL
160 170 180 190 200
TNHMLTLCDN IHGFKYLIDG YEEINELLYK LNFYFDLLRA KLNDVCANDY
210 220 230 240 250
CQIPFNLKIR ANELDVLKKL VFGYRKPLDN IKDNVGKMED YIKKNKKTIE
260 270 280 290 300
NINELIEESK KTIDKNKNAT KEEEKKKLYQ AQYDLSIYNK QLEEAHNLIS
310 320 330 340 350
VLEKRIDTLK KNENIKELLD KINEIKNPPP ANSGNTPNTL LDKNKKIEEH
360 370 380 390 400
EKEIKEIAKT IKFNIDSLFT DPLELEYYLR EKNKNIDISA KVETKESTEP
410 420 430 440 450
NEYPNGVTYP LSYNDINNAL NELNSFGDLI NPFDYTKEPS KNIYTDNERK
460 470 480 490 500
KFINEIKEKI KIEKKKIESD KKSYEDRSKS LNDITKEYEK LLNEIYDSKF
510 520 530 540 550
NNNIDLTNFE KMMGKRYSYK VEKLTHHNTF ASYENSKHNL EKLTKALKYM
560 570 580 590 600
EDYSLRNIVV EKELKYYKNL ISKIENEIET LVENIKKDEE QLFEKKITKD
610 620 630 640 650
ENKPDEKILE VSDIVKVQVQ KVLLMNKIDE LKKTQLILKN VELKHNIHVP
660 670 680 690 700
NSYKQENKQE PYYLIVLKKE IDKLKVFMPK VESLINEEKK NIKTEGQSDN
710 720 730 740 750
SEPSTEGEIT GQATTKPGQQ AGSALEGDSV QAQAQEQKQA QPPVPVPVPE
760 770 780 790 800
AKAQVPTPPA PVNNKTENVS KLDYLEKLYE FLNTSYICHK YILVSHSTMN
810 820 830 840 850
EKILKQYKIT KEEESKLSSC DPLDLLFNIQ NNIPVMYSMF DSLNNSLSQL
860 870 880 890 900
FMEIYEKEMV CNLYKLKDND KIKNLLEEAK KVSTSVKTLS SSSMQPLSLT
910 920 930 940 950
PQDKPEVSAN DDTSHSTNLN NSLKLFENIL SLGKNKNIYQ ELIGQKSSEN
960 970 980 990 1000
FYEKILKDSD TFYNESFTNF VKSKADDINS LNDESKRKKL EEDINKLKKT
1010 1020 1030 1040 1050
LQLSFDLYNK YKLKLERLFD KKKTVGKYKM QIKKLTLLKE QLESKLNSLN
1060 1070 1080 1090 1100
NPKHVLQNFS VFFNKKKEAE IAETENTLEN TKILLKHYKG LVKYYNGESS
1110 1120 1130 1140 1150
PLKTLSEESI QTEDNYASLE NFKVLSKLEG KLKDNLNLEK KKLSYLSSGL
1160 1170 1180 1190 1200
HHLIAELKEV IKNKNYTGNS PSENNTDVNN ALESYKKFLP EGTDVATVVS
1210 1220 1230 1240 1250
ESGSDTLEQS QPKKPASTHV GAESNTITTS QNVDDEVDDV IIVPIFGESE
1260 1270 1280 1290 1300
EDYDDLGQVV TGEAVTPSVI DNILSKIENE YEVLYLKPLA GVYRSLKKQL
1310 1320 1330 1340 1350
ENNVMTFNVN VKDILNSRFN KRENFKNVLE SDLIPYKDLT SSNYVVKDPY
1360 1370 1380 1390 1400
KFLNKEKRDK FLSSYNYIKD SIDTDINFAN DVLGYYKILS EKYKSDLDSI
1410 1420 1430 1440 1450
KKYINDKQGE NEKYLPFLNN IETLYKTVND KIDLFVIHLE AKVLNYTYEK
1460 1470 1480 1490 1500
SNVEVKIKEL NYLKTIQDKL ADFKKNNNFV GIADLSTDYN HNNLLTKFLS
1510 1520 1530 1540 1550
TGMVFENLAK TVLSNLLDGN LQGMLNISQH QCVKKQCPQN SGCFRHLDER
1560 1570 1580 1590 1600
EECKCLLNYK QEGDKCVENP NPTCNENNGG CDADAKCTEE DSGSNGKKIT
1610 1620 1630
CECTKPDSYP LFDGIFCSSS NFLGISFLLI LMLILYSFI
Length:1,639
Mass (Da):187,619
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C255B6616C87F6E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X02919 mRNA Translation: CAA26676.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A24594
S05603

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02919 mRNA Translation: CAA26676.1
PIRiA24594
S05603

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CEJNMR-A1526-1621[»]
2FLGNMR-A1526-1573[»]
2MU7NMR-A42-61[»]
2MUENMR-A1282-1301[»]
BMRBiP04933
SMRiP04933
ModBaseiSearch...
PDBe-KBiSearch...

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P04933, 14 sequenced antibodies

Miscellaneous databases

EvolutionaryTraceiP04933

Family and domain databases

InterProiView protein in InterPro
IPR010901, MSP1_C
IPR024730, MSP1_EGF_1
PfamiView protein in Pfam
PF12946, EGF_MSP1_1, 1 hit
PF07462, MSP1_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSP1_PLAFW
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04933
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1996
Last modified: September 29, 2021
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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