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Protein

Glycophorin-C

Gene

GYPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei8Not glycosylated; in variant Webb antigen1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen
LigandSialic acid

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycophorin-C
Alternative name(s):
Glycoconnectin
Glycophorin-D
Short name:
GPD
Glycoprotein beta
PAS-2'
Sialoglycoprotein D
CD_antigen: CD236
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GYPC
Synonyms:GLPC, GPC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136732.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4704 GYPC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
110750 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04921

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57ExtracellularAdd BLAST57
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 81Helical; Signal-anchor for type III membrane proteinAdd BLAST24
Topological domaini82 – 128CytoplasmicAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2995

MalaCards human disease database

More...
MalaCardsi
GYPC
MIMi611162 phenotype
616089 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136732

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
288 Hereditary elliptocytosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29082

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GYPC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121407

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001490501 – 128Glycophorin-CAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3O-linked (GalNAc...) serine2 Publications1
Glycosylationi4O-linked (GalNAc...) threonine2 Publications1
Glycosylationi6O-linked (GalNAc...) serine2 Publications1
Glycosylationi8N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi9O-linked (GalNAc...) serine1 Publication1
Glycosylationi10O-linked (GalNAc...) threonine1 Publication1
Glycosylationi15O-linked (GalNAc...) serine2 Publications1
Glycosylationi24O-linked (GalNAc...) serine2 Publications1
Glycosylationi26O-linked (GalNAc...) serine2 Publications1
Glycosylationi27O-linked (GalNAc...) threonine2 Publications1
Glycosylationi28O-linked (GalNAc...) threonine2 Publications1
Glycosylationi31O-linked (GalNAc...) threonine2 Publications1
Glycosylationi32O-linked (GalNAc...) threonine2 Publications1
Glycosylationi33O-linked (GalNAc...) threonine2 Publications1
Glycosylationi42O-linked (GalNAc...) serine3 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P04921

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P04921

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04921

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04921

PeptideAtlas

More...
PeptideAtlasi
P04921

PRoteomics IDEntifications database

More...
PRIDEi
P04921

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51759
51760 [P04921-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
189

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04921

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04921

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P04921

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136732 Expressed in 214 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_GYPC

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P04921 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009445
HPA008965

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109250, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P04921

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P04921

Protein interaction database and analysis system

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IntActi
P04921, 11 interactors

Molecular INTeraction database

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MINTi
P04921

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259254

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EJYNMR-B117-126[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P04921

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04921

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04921

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycophorin-C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2G2 Eukaryota
ENOG410YT9G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049102

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112742

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094619

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04921

KEGG Orthology (KO)

More...
KOi
K06576

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRMETST

Database of Orthologous Groups

More...
OrthoDBi
1011028at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04921

TreeFam database of animal gene trees

More...
TreeFami
TF337016

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001195 Glycophorin
IPR003585 Neurexin-like

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002466 Glycophorin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00294 4.1m, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Glycophorin-C (identifier: P04921-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME
60 70 80 90 100
TSTPTIMDIV VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE
110 120
FAESADAALQ GDPALQDAGD SSRKEYFI
Length:128
Mass (Da):13,811
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9C654009A5642D5
GO
Isoform Glycophorin-D (identifier: P04921-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:107
Mass (Da):11,499
Checksum:iB7D025DEF0555290
GO
Isoform 3 (identifier: P04921-3) [UniParc]FASTAAdd to basket
Also known as: IsoGPC

The sequence of this isoform differs from the canonical sequence as follows:
     18-36: Missing.

Show »
Length:109
Mass (Da):11,910
Checksum:i226D848E8D619180
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA32093 differs from that shown. Reason: Frameshift at position 35.Curated

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

GYPC is responsible for the Gerbich blood group system (Ge) [MIMi:616089]. Ge negative individuals carry a deletion of GYPC exon 3.1 Publication
Deletion of exon 3 in GYPC results in resistance to Plasmodium falciparum invasion and protection against severe malaria [MIMi:611162].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0031938N → S Polymorphism; Webb (WB) antigen. 1 PublicationCorresponds to variant dbSNP:rs121912760EnsemblClinVar.1
Natural variantiVAR_00319414L → F Polymorphism; Duch (DH(a)) antigen. 1 PublicationCorresponds to variant dbSNP:rs121912761EnsemblClinVar.1
Natural variantiVAR_00319523A → S Polymorphism; Ahonen (AN(a)) antigen. 1 PublicationCorresponds to variant dbSNP:rs774359594Ensembl.1
Natural variantiVAR_021342124K → E1 PublicationCorresponds to variant dbSNP:rs28370000Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0017771 – 21Missing in isoform Glycophorin-D. CuratedAdd BLAST21
Alternative sequenceiVSP_05479018 – 36Missing in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M11802 mRNA Translation: AAA60023.1
M36284 mRNA Translation: AAA52625.1
X12496 mRNA Translation: CAA31016.1
M28335 mRNA Translation: AAA52574.1
X51973 mRNA Translation: CAA36235.1
AK312032 mRNA Translation: BAG34969.1
AY838876 Genomic DNA Translation: AAV80423.1
AC013474 Genomic DNA Translation: AAY14660.1
BC106051 mRNA Translation: AAI06052.1
BC104246 mRNA Translation: AAI04247.1
BC104247 mRNA Translation: AAI04248.1
X14242 Genomic DNA Translation: CAA32458.1
M29662 Genomic DNA Translation: AAA52626.1
X13890, X13892, X13893 Genomic DNA Translation: CAA32093.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2136.1 [P04921-1]
CCDS46402.1 [P04921-3]
CCDS58724.1 [P04921-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A92573 GFHUC

NCBI Reference Sequences

More...
RefSeqi
NP_001243513.1, NM_001256584.1 [P04921-2]
NP_002092.1, NM_002101.4 [P04921-1]
NP_058131.1, NM_016815.3 [P04921-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.59138

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259254; ENSP00000259254; ENSG00000136732 [P04921-1]
ENST00000356887; ENSP00000349354; ENSG00000136732 [P04921-2]
ENST00000409836; ENSP00000386904; ENSG00000136732 [P04921-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2995

UCSC genome browser

More...
UCSCi
uc002tnq.5 human [P04921-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

Glycophorin C entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11802 mRNA Translation: AAA60023.1
M36284 mRNA Translation: AAA52625.1
X12496 mRNA Translation: CAA31016.1
M28335 mRNA Translation: AAA52574.1
X51973 mRNA Translation: CAA36235.1
AK312032 mRNA Translation: BAG34969.1
AY838876 Genomic DNA Translation: AAV80423.1
AC013474 Genomic DNA Translation: AAY14660.1
BC106051 mRNA Translation: AAI06052.1
BC104246 mRNA Translation: AAI04247.1
BC104247 mRNA Translation: AAI04248.1
X14242 Genomic DNA Translation: CAA32458.1
M29662 Genomic DNA Translation: AAA52626.1
X13890, X13892, X13893 Genomic DNA Translation: CAA32093.1 Frameshift.
CCDSiCCDS2136.1 [P04921-1]
CCDS46402.1 [P04921-3]
CCDS58724.1 [P04921-2]
PIRiA92573 GFHUC
RefSeqiNP_001243513.1, NM_001256584.1 [P04921-2]
NP_002092.1, NM_002101.4 [P04921-1]
NP_058131.1, NM_016815.3 [P04921-3]
UniGeneiHs.59138

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EJYNMR-B117-126[»]
ProteinModelPortaliP04921
SMRiP04921
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109250, 1 interactor
CORUMiP04921
ELMiP04921
IntActiP04921, 11 interactors
MINTiP04921
STRINGi9606.ENSP00000259254

PTM databases

GlyConnecti189
iPTMnetiP04921
PhosphoSitePlusiP04921
UniCarbKBiP04921

Polymorphism and mutation databases

BioMutaiGYPC
DMDMi121407

Proteomic databases

EPDiP04921
jPOSTiP04921
MaxQBiP04921
PaxDbiP04921
PeptideAtlasiP04921
PRIDEiP04921
ProteomicsDBi51759
51760 [P04921-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259254; ENSP00000259254; ENSG00000136732 [P04921-1]
ENST00000356887; ENSP00000349354; ENSG00000136732 [P04921-2]
ENST00000409836; ENSP00000386904; ENSG00000136732 [P04921-3]
GeneIDi2995
KEGGihsa:2995
UCSCiuc002tnq.5 human [P04921-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2995
DisGeNETi2995
EuPathDBiHostDB:ENSG00000136732.14

GeneCards: human genes, protein and diseases

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GeneCardsi
GYPC
HGNCiHGNC:4704 GYPC
HPAiCAB009445
HPA008965
MalaCardsiGYPC
MIMi110750 gene
611162 phenotype
616089 phenotype
neXtProtiNX_P04921
OpenTargetsiENSG00000136732
Orphaneti288 Hereditary elliptocytosis
PharmGKBiPA29082

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2G2 Eukaryota
ENOG410YT9G LUCA
GeneTreeiENSGT00510000049102
HOGENOMiHOG000112742
HOVERGENiHBG094619
InParanoidiP04921
KOiK06576
OMAiGRMETST
OrthoDBi1011028at2759
PhylomeDBiP04921
TreeFamiTF337016

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GYPC human
EvolutionaryTraceiP04921

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2995

Protein Ontology

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PROi
PR:P04921

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136732 Expressed in 214 organ(s), highest expression level in blood
CleanExiHS_GYPC
GenevisibleiP04921 HS

Family and domain databases

InterProiView protein in InterPro
IPR001195 Glycophorin
IPR003585 Neurexin-like
PIRSFiPIRSF002466 Glycophorin, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLPC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04921
Secondary accession number(s): B2R522, Q53SV9, Q92642
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: January 16, 2019
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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