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Protein

Glycophorin-C

Gene

GYPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei8Not glycosylated; in variant Webb antigen1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBlood group antigen
LigandSialic acid

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-C
Alternative name(s):
Glycoconnectin
Glycophorin-D
Short name:
GPD
Glycoprotein beta
PAS-2'
Sialoglycoprotein D
CD_antigen: CD236
Gene namesi
Name:GYPC
Synonyms:GLPC, GPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136732.14
HGNCiHGNC:4704 GYPC
MIMi110750 gene
neXtProtiNX_P04921

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularAdd BLAST57
Transmembranei58 – 81Helical; Signal-anchor for type III membrane proteinAdd BLAST24
Topological domaini82 – 128CytoplasmicAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2995
MalaCardsiGYPC
MIMi611162 phenotype
616089 phenotype
OpenTargetsiENSG00000136732
Orphaneti288 Hereditary elliptocytosis
PharmGKBiPA29082

Polymorphism and mutation databases

BioMutaiGYPC
DMDMi121407

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001490501 – 128Glycophorin-CAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3O-linked (GalNAc...) serine2 Publications1
Glycosylationi4O-linked (GalNAc...) threonine2 Publications1
Glycosylationi6O-linked (GalNAc...) serine2 Publications1
Glycosylationi8N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi9O-linked (GalNAc...) serine1 Publication1
Glycosylationi10O-linked (GalNAc...) threonine1 Publication1
Glycosylationi15O-linked (GalNAc...) serine2 Publications1
Glycosylationi24O-linked (GalNAc...) serine2 Publications1
Glycosylationi26O-linked (GalNAc...) serine2 Publications1
Glycosylationi27O-linked (GalNAc...) threonine2 Publications1
Glycosylationi28O-linked (GalNAc...) threonine2 Publications1
Glycosylationi31O-linked (GalNAc...) threonine2 Publications1
Glycosylationi32O-linked (GalNAc...) threonine2 Publications1
Glycosylationi33O-linked (GalNAc...) threonine2 Publications1
Glycosylationi42O-linked (GalNAc...) serine3 Publications1
Modified residuei104PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP04921
MaxQBiP04921
PaxDbiP04921
PeptideAtlasiP04921
PRIDEiP04921
ProteomicsDBi51759
51760 [P04921-2]

PTM databases

GlyConnecti189
iPTMnetiP04921
PhosphoSitePlusiP04921
UniCarbKBiP04921

Expressioni

Tissue specificityi

Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000136732
CleanExiHS_GYPC
GenevisibleiP04921 HS

Organism-specific databases

HPAiCAB009445
HPA008965

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPP1Q000132EBI-7797098,EBI-711788

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109250, 1 interactor
CORUMiP04921
ELMiP04921
IntActiP04921, 12 interactors
MINTiP04921
STRINGi9606.ENSP00000259254

Structurei

3D structure databases

ProteinModelPortaliP04921
SMRiP04921
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04921

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2G2 Eukaryota
ENOG410YT9G LUCA
GeneTreeiENSGT00510000049102
HOGENOMiHOG000112742
HOVERGENiHBG094619
InParanoidiP04921
KOiK06576
OMAiLRYMYRH
OrthoDBiEOG091G1481
PhylomeDBiP04921
TreeFamiTF337016

Family and domain databases

InterProiView protein in InterPro
IPR001195 Glycophorin
IPR003585 Neurexin-like
PIRSFiPIRSF002466 Glycophorin, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Glycophorin-C (identifier: P04921-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME
60 70 80 90 100
TSTPTIMDIV VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE
110 120
FAESADAALQ GDPALQDAGD SSRKEYFI
Length:128
Mass (Da):13,811
Last modified:August 13, 1987 - v1
Checksum:iC9C654009A5642D5
GO
Isoform Glycophorin-D (identifier: P04921-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:107
Mass (Da):11,499
Checksum:iB7D025DEF0555290
GO
Isoform 3 (identifier: P04921-3) [UniParc]FASTAAdd to basket
Also known as: IsoGPC

The sequence of this isoform differs from the canonical sequence as follows:
     18-36: Missing.

Show »
Length:109
Mass (Da):11,910
Checksum:i226D848E8D619180
GO

Sequence cautioni

The sequence CAA32093 differs from that shown. Reason: Frameshift at position 35.Curated

Polymorphismi

GYPC is responsible for the Gerbich blood group system (Ge) [MIMi:616089]. Ge negative individuals carry a deletion of GYPC exon 3.1 Publication
Deletion of exon 3 in GYPC results in resistance to Plasmodium falciparum invasion and protection against severe malaria [MIMi:611162].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0031938N → S Polymorphism; Webb (WB) antigen. 1 PublicationCorresponds to variant dbSNP:rs121912760EnsemblClinVar.1
Natural variantiVAR_00319414L → F Polymorphism; Duch (DH(a)) antigen. 1 PublicationCorresponds to variant dbSNP:rs121912761EnsemblClinVar.1
Natural variantiVAR_00319523A → S Polymorphism; Ahonen (AN(a)) antigen. 1 PublicationCorresponds to variant dbSNP:rs774359594Ensembl.1
Natural variantiVAR_021342124K → E1 PublicationCorresponds to variant dbSNP:rs28370000Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0017771 – 21Missing in isoform Glycophorin-D. CuratedAdd BLAST21
Alternative sequenceiVSP_05479018 – 36Missing in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11802 mRNA Translation: AAA60023.1
M36284 mRNA Translation: AAA52625.1
X12496 mRNA Translation: CAA31016.1
M28335 mRNA Translation: AAA52574.1
X51973 mRNA Translation: CAA36235.1
AK312032 mRNA Translation: BAG34969.1
AY838876 Genomic DNA Translation: AAV80423.1
AC013474 Genomic DNA Translation: AAY14660.1
BC106051 mRNA Translation: AAI06052.1
BC104246 mRNA Translation: AAI04247.1
BC104247 mRNA Translation: AAI04248.1
X14242 Genomic DNA Translation: CAA32458.1
M29662 Genomic DNA Translation: AAA52626.1
X13890, X13892, X13893 Genomic DNA Translation: CAA32093.1 Frameshift.
CCDSiCCDS2136.1 [P04921-1]
CCDS46402.1 [P04921-3]
CCDS58724.1 [P04921-2]
PIRiA92573 GFHUC
RefSeqiNP_001243513.1, NM_001256584.1 [P04921-2]
NP_002092.1, NM_002101.4 [P04921-1]
NP_058131.1, NM_016815.3 [P04921-3]
UniGeneiHs.59138

Genome annotation databases

EnsembliENST00000259254; ENSP00000259254; ENSG00000136732 [P04921-1]
ENST00000356887; ENSP00000349354; ENSG00000136732 [P04921-2]
ENST00000409836; ENSP00000386904; ENSG00000136732 [P04921-3]
GeneIDi2995
KEGGihsa:2995
UCSCiuc002tnq.5 human [P04921-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGLPC_HUMAN
AccessioniPrimary (citable) accession number: P04921
Secondary accession number(s): B2R522, Q53SV9, Q92642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 18, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

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