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Entry version 201 (08 May 2019)
Sequence version 4 (24 Jan 2006)
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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plasma membrane anion exchange protein of wide distribution.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425381 Bicarbonate transporters

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P04920

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.31.1.2 the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Non-erythroid band 3-like protein
Short name:
BND3L
Solute carrier family 4 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A2
Synonyms:AE2, EPB3L1, HKB3, MPB3L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11028 SLC4A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109280 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04920

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 707CytoplasmicSequence analysisAdd BLAST707
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei708 – 731HelicalSequence analysisAdd BLAST24
Transmembranei737 – 774HelicalSequence analysisAdd BLAST38
Transmembranei784 – 816HelicalSequence analysisAdd BLAST33
Transmembranei826 – 847HelicalSequence analysisAdd BLAST22
Topological domaini848 – 900ExtracellularSequence analysisAdd BLAST53
Transmembranei901 – 918HelicalSequence analysisAdd BLAST18
Topological domaini919 – 933CytoplasmicSequence analysisAdd BLAST15
Transmembranei934 – 954HelicalSequence analysisAdd BLAST21
Transmembranei988 – 1010HelicalSequence analysisAdd BLAST23
Transmembranei1036 – 1059HelicalSequence analysisAdd BLAST24
Transmembranei1091 – 1136HelicalSequence analysisAdd BLAST46
Transmembranei1163 – 1199HelicalSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6522

Open Targets

More...
OpenTargetsi
ENSG00000164889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35896

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC4A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85687559

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000792151 – 1241Anion exchange protein 2Add BLAST1241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei170PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei183PhosphothreonineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei257PhosphothreonineBy similarity1
Modified residuei274N6-methyllysineCombined sources1
Modified residuei443PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi859N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi868N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi882N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1173S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P04920

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P04920

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04920

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04920

PeptideAtlas

More...
PeptideAtlasi
P04920

PRoteomics IDEntifications database

More...
PRIDEi
P04920

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51757
51758 [P04920-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04920

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04920

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P04920

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164889 Expressed in 212 organ(s), highest expression level in body of stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P04920 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04920 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019339

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112413, 38 interactors

Protein interaction database and analysis system

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IntActi
P04920, 18 interactors

Molecular INTeraction database

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MINTi
P04920

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419412

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04920

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni708 – 1241Membrane (anion exchange)Add BLAST534

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 320Pro-richAdd BLAST316

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1172 Eukaryota
ENOG410XPHD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280683

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04920

KEGG Orthology (KO)

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KOi
K13855

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACGLFGM

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04920

TreeFam database of animal gene trees

More...
TreeFami
TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001717 Anion_exchange
IPR002978 Anion_exchange_2
IPR018241 Anion_exchange_CS
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453 PTHR11453, 1 hit
PTHR11453:SF14 PTHR11453:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00165 ANIONEXCHNGR
PR01188 ANIONEXHNGR2
PR01231 HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834 ae, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00219 ANION_EXCHANGER_1, 1 hit
PS00220 ANION_EXCHANGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: P04920-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGETPT IEEGEEDEDE ASEAEGARAL TQPSPVSTPS
160 170 180 190 200
SVQFFLQEDD SADRKAERTS PSSPAPLPHQ EATPRASKGA QAGTQVEEAE
210 220 230 240 250
AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR IGSMTGAEQA
260 270 280 290 300
LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG
310 320 330 340 350
REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE
360 370 380 390 400
EDVEEETERW GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ
410 420 430 440 450
VVEQMVISDQ IKAEDRANVL RALLLKHSHP SDEKDFSFPR NISAGSLGSL
460 470 480 490 500
LGHHHGQGAE SDPHVTEPLM GGVPETRLEV ERERELPPPA PPAGITRSKS
510 520 530 540 550
KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA VELDAVLEVP
560 570 580 590 600
VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT
610 620 630 640 650
AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL
660 670 680 690 700
EPKSAQDKAL LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF
710 720 730 740 750
RDALDPQCLA AVIFIYFAAL SPAITFGGLL GEKTQDLIGV SELIMSTALQ
760 770 780 790 800
GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS FCSSNHLEYL VGRVWIGFWL
810 820 830 840 850
VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF YKLVKIFQEH
860 870 880 890 900
PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT
910 920 930 940 950
ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV
960 970 980 990 1000
DYSIEDTYTQ KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP
1010 1020 1030 1040 1050
AILVFILIFM ETQITTLIIS KKERMLQKGS GFHLDLLLIV AMGGICALFG
1060 1070 1080 1090 1100
LPWLAAATVR SVTHANALTV MSKAVAPGDK PKIQEVKEQR VTGLLVALLV
1110 1120 1130 1140 1150
GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH LLLMPPKHHP
1160 1170 1180 1190 1200
DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR
1210 1220 1230 1240
MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V
Length:1,241
Mass (Da):137,009
Last modified:January 24, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35E32D9FC34DFB61
GO
Isoform B1 (identifier: P04920-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MTQ

Show »
Length:1,227
Mass (Da):135,606
Checksum:iBA59FBFDF46178F2
GO
Isoform 3 (identifier: P04920-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MDFLLRPQ

Note: No experimental confirmation available.
Show »
Length:1,232
Mass (Da):136,247
Checksum:iC57606D7CA9D34D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVC2C9JVC2_HUMAN
Anion exchange protein 2
SLC4A2
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J722C9J722_HUMAN
Anion exchange protein 2
SLC4A2
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9M9C9J9M9_HUMAN
Anion exchange protein 2
SLC4A2
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J459C9J459_HUMAN
Anion exchange protein 2
SLC4A2
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J035C9J035_HUMAN
Anion exchange protein 2
SLC4A2
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7R → L in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti68E → M in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti74H → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti92D → G in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti122E → V in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti157Q → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti248E → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti399Missing in CAA27556 (PubMed:3015590).Curated1
Sequence conflicti447L → V in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti450 – 475LLGHH…GGVPE → CWGITMVRGLRVTPTSPSLS WEVFLR in CAA27556 (PubMed:3015590).CuratedAdd BLAST26
Sequence conflicti485 – 486EL → DV in CAA44067 (PubMed:1562608).Curated2
Sequence conflicti485 – 486EL → DV in CAA27556 (PubMed:3015590).Curated2
Sequence conflicti571E → K in BAG58592 (PubMed:14702039).Curated1
Sequence conflicti666 – 681AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA44067 (PubMed:1562608).CuratedAdd BLAST16
Sequence conflicti666 – 681AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA27556 (PubMed:3015590).CuratedAdd BLAST16
Sequence conflicti824Q → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti824Q → R in CAA27556 (PubMed:3015590).Curated1
Sequence conflicti902L → P in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti902L → P in CAA27556 (PubMed:3015590).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02516826G → E1 PublicationCorresponds to variant dbSNP:rs2303929Ensembl.1
Natural variantiVAR_025169202E → V1 PublicationCorresponds to variant dbSNP:rs2229551Ensembl.1
Natural variantiVAR_025170311R → W1 PublicationCorresponds to variant dbSNP:rs35016052Ensembl.1
Natural variantiVAR_0251711204L → F1 PublicationCorresponds to variant dbSNP:rs34918764Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0459531 – 17MSSAP…DSFCT → MDFLLRPQ in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0004561 – 17MSSAP…DSFCT → MTQ in isoform B1. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X62137 mRNA Translation: CAA44067.1
DQ149844 Genomic DNA Translation: AAZ38724.1
AK295767 mRNA Translation: BAG58592.1
AK312699 mRNA Translation: BAG35577.1
AC010973 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54046.1
CH471173 Genomic DNA Translation: EAW54047.1
BC009386 mRNA Translation: AAH09386.1
BC009434 mRNA Translation: AAH09434.1
X03918 mRNA Translation: CAA27556.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56520.1 [P04920-3]
CCDS56521.1 [P04920-2]
CCDS5917.1 [P04920-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S21086

NCBI Reference Sequences

More...
RefSeqi
NP_001186621.1, NM_001199692.2 [P04920-1]
NP_001186622.1, NM_001199693.1 [P04920-3]
NP_001186623.1, NM_001199694.2 [P04920-2]
NP_003031.3, NM_003040.3 [P04920-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392826; ENSP00000376571; ENSG00000164889 [P04920-3]
ENST00000413384; ENSP00000405600; ENSG00000164889 [P04920-1]
ENST00000461735; ENSP00000419164; ENSG00000164889 [P04920-2]
ENST00000485713; ENSP00000419412; ENSG00000164889 [P04920-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6522

UCSC genome browser

More...
UCSCi
uc003wit.4 human [P04920-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62137 mRNA Translation: CAA44067.1
DQ149844 Genomic DNA Translation: AAZ38724.1
AK295767 mRNA Translation: BAG58592.1
AK312699 mRNA Translation: BAG35577.1
AC010973 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54046.1
CH471173 Genomic DNA Translation: EAW54047.1
BC009386 mRNA Translation: AAH09386.1
BC009434 mRNA Translation: AAH09434.1
X03918 mRNA Translation: CAA27556.1
CCDSiCCDS56520.1 [P04920-3]
CCDS56521.1 [P04920-2]
CCDS5917.1 [P04920-1]
PIRiS21086
RefSeqiNP_001186621.1, NM_001199692.2 [P04920-1]
NP_001186622.1, NM_001199693.1 [P04920-3]
NP_001186623.1, NM_001199694.2 [P04920-2]
NP_003031.3, NM_003040.3 [P04920-1]

3D structure databases

SMRiP04920
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112413, 38 interactors
IntActiP04920, 18 interactors
MINTiP04920
STRINGi9606.ENSP00000419412

Protein family/group databases

TCDBi2.A.31.1.2 the anion exchanger (ae) family

PTM databases

iPTMnetiP04920
PhosphoSitePlusiP04920
SwissPalmiP04920

Polymorphism and mutation databases

BioMutaiSLC4A2
DMDMi85687559

Proteomic databases

EPDiP04920
jPOSTiP04920
MaxQBiP04920
PaxDbiP04920
PeptideAtlasiP04920
PRIDEiP04920
ProteomicsDBi51757
51758 [P04920-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6522
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392826; ENSP00000376571; ENSG00000164889 [P04920-3]
ENST00000413384; ENSP00000405600; ENSG00000164889 [P04920-1]
ENST00000461735; ENSP00000419164; ENSG00000164889 [P04920-2]
ENST00000485713; ENSP00000419412; ENSG00000164889 [P04920-1]
GeneIDi6522
KEGGihsa:6522
UCSCiuc003wit.4 human [P04920-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6522
DisGeNETi6522

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC4A2
HGNCiHGNC:11028 SLC4A2
HPAiHPA019339
MIMi109280 gene
neXtProtiNX_P04920
OpenTargetsiENSG00000164889
PharmGKBiPA35896

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00940000158259
HOGENOMiHOG000280683
InParanoidiP04920
KOiK13855
OMAiACGLFGM
OrthoDBi265068at2759
PhylomeDBiP04920
TreeFamiTF313630

Enzyme and pathway databases

ReactomeiR-HSA-425381 Bicarbonate transporters
SIGNORiP04920

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC4A2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC4A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6522

Protein Ontology

More...
PROi
PR:P04920

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164889 Expressed in 212 organ(s), highest expression level in body of stomach
ExpressionAtlasiP04920 baseline and differential
GenevisibleiP04920 HS

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR001717 Anion_exchange
IPR002978 Anion_exchange_2
IPR018241 Anion_exchange_CS
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PTHR11453:SF14 PTHR11453:SF14, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR00165 ANIONEXCHNGR
PR01188 ANIONEXHNGR2
PR01231 HCO3TRNSPORT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit
PROSITEiView protein in PROSITE
PS00219 ANION_EXCHANGER_1, 1 hit
PS00220 ANION_EXCHANGER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04920
Secondary accession number(s): B2R6T0
, B4DIT0, D3DX05, F8W682, Q45EY5, Q969L3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 24, 2006
Last modified: May 8, 2019
This is version 201 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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