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Protein

Serum amyloid A-3 protein

Gene

Saa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • Toll-like receptor 4 binding Source: MGI

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • cell chemotaxis Source: MGI
  • cellular response to interleukin-1 Source: MGI
  • I-kappaB phosphorylation Source: MGI
  • response to bacterium Source: MGI
  • response to stilbenoid Source: UniProtKB

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-3 protein
Gene namesi
Name:Saa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98223 Saa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000003159120 – 122Serum amyloid A-3 proteinAdd BLAST103

Proteomic databases

MaxQBiP04918
PaxDbiP04918
PRIDEiP04918

PTM databases

iPTMnetiP04918
PhosphoSitePlusiP04918

Expressioni

Tissue specificityi

Found in various tissues.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiENSMUSG00000040026
CleanExiMM_SAA3
ExpressionAtlasiP04918 baseline and differential
GenevisibleiP04918 MM

Interactioni

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • Toll-like receptor 4 binding Source: MGI

Protein-protein interaction databases

IntActiP04918, 1 interactor
MINTiP04918
STRINGi10090.ENSMUSP00000006956

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 45Combined sources25
Helixi51 – 64Combined sources14
Helixi67 – 85Combined sources19
Helixi94 – 105Combined sources12
Helixi110 – 113Combined sources4

3D structure databases

ProteinModelPortaliP04918
SMRiP04918
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP04918
KOiK17310
OMAiAYWDMRE
OrthoDBiEOG091G17YH
PhylomeDBiP04918
TreeFamiTF332544

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSIAIILC ILILGVDSQR WVQFMKEAGQ GSRDMWRAYS DMKKANWKNS
60 70 80 90 100
DKYFHARGNY DAARRGPGGA WAAKVISDAR EAVQKFTGHG AEDSRADQFA
110 120
NEWGRSGKDP NHFRPAGLPK RY
Length:122
Mass (Da):13,774
Last modified:August 13, 1987 - v1
Checksum:iB9435F82D1B0B705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57R → G in AAA40088 (PubMed:3624868).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03479 mRNA Translation: CAA27199.1
X03505, X03506, X03507 Genomic DNA Translation: CAA27219.1
BC055885 mRNA Translation: AAH55885.1
M25467 mRNA Translation: AAA37231.1
M17792 Genomic DNA Translation: AAA40088.1
CCDSiCCDS21282.1
PIRiA23521
I71950
RefSeqiNP_035445.1, NM_011315.3
UniGeneiMm.14277

Genome annotation databases

EnsembliENSMUST00000006956; ENSMUSP00000006956; ENSMUSG00000040026
GeneIDi20210
KEGGimmu:20210
UCSCiuc009gyw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSAA3_MOUSE
AccessioniPrimary (citable) accession number: P04918
Secondary accession number(s): Q62201
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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