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Protein

Serum amyloid A-3 protein

Gene

Saa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • Toll-like receptor 4 binding Source: MGI

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-3 protein
Gene namesi
Name:Saa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98223 Saa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000003159120 – 122Serum amyloid A-3 proteinAdd BLAST103

Proteomic databases

MaxQBiP04918
PaxDbiP04918
PRIDEiP04918

PTM databases

iPTMnetiP04918
PhosphoSitePlusiP04918

Expressioni

Tissue specificityi

Found in various tissues.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiENSMUSG00000040026 Expressed in 133 organ(s), highest expression level in epididymal fat pad
CleanExiMM_SAA3
ExpressionAtlasiP04918 baseline and differential
GenevisibleiP04918 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP04918, 1 interactor
MINTiP04918
STRINGi10090.ENSMUSP00000006956

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04918
SMRiP04918
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP04918
KOiK17310
OMAiMWRAYWD
OrthoDBiEOG091G17YH
PhylomeDBiP04918
TreeFamiTF332544

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04918-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPSIAIILC ILILGVDSQR WVQFMKEAGQ GSRDMWRAYS DMKKANWKNS
60 70 80 90 100
DKYFHARGNY DAARRGPGGA WAAKVISDAR EAVQKFTGHG AEDSRADQFA
110 120
NEWGRSGKDP NHFRPAGLPK RY
Length:122
Mass (Da):13,774
Last modified:August 13, 1987 - v1
Checksum:iB9435F82D1B0B705
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GT10A0A1B0GT10_MOUSE
Serum amyloid A-3 protein
Saa3
61Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57R → G in AAA40088 (PubMed:3624868).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03479 mRNA Translation: CAA27199.1
X03505, X03506, X03507 Genomic DNA Translation: CAA27219.1
BC055885 mRNA Translation: AAH55885.1
M25467 mRNA Translation: AAA37231.1
M17792 Genomic DNA Translation: AAA40088.1
CCDSiCCDS21282.1
PIRiA23521
I71950
RefSeqiNP_035445.1, NM_011315.3
UniGeneiMm.14277

Genome annotation databases

EnsembliENSMUST00000006956; ENSMUSP00000006956; ENSMUSG00000040026
GeneIDi20210
KEGGimmu:20210
UCSCiuc009gyw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03479 mRNA Translation: CAA27199.1
X03505, X03506, X03507 Genomic DNA Translation: CAA27219.1
BC055885 mRNA Translation: AAH55885.1
M25467 mRNA Translation: AAA37231.1
M17792 Genomic DNA Translation: AAA40088.1
CCDSiCCDS21282.1
PIRiA23521
I71950
RefSeqiNP_035445.1, NM_011315.3
UniGeneiMm.14277

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q5GX-ray2.06A/B19-122[»]
ProteinModelPortaliP04918
SMRiP04918
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04918, 1 interactor
MINTiP04918
STRINGi10090.ENSMUSP00000006956

PTM databases

iPTMnetiP04918
PhosphoSitePlusiP04918

Proteomic databases

MaxQBiP04918
PaxDbiP04918
PRIDEiP04918

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006956; ENSMUSP00000006956; ENSMUSG00000040026
GeneIDi20210
KEGGimmu:20210
UCSCiuc009gyw.1 mouse

Organism-specific databases

CTDi20210
MGIiMGI:98223 Saa3

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP04918
KOiK17310
OMAiMWRAYWD
OrthoDBiEOG091G17YH
PhylomeDBiP04918
TreeFamiTF332544

Miscellaneous databases

PROiPR:P04918
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040026 Expressed in 133 organ(s), highest expression level in epididymal fat pad
CleanExiMM_SAA3
ExpressionAtlasiP04918 baseline and differential
GenevisibleiP04918 MM

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAA3_MOUSE
AccessioniPrimary (citable) accession number: P04918
Secondary accession number(s): Q62201
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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