UniProtKB - P04916 (RET4_RAT)
Protein
Retinol-binding protein 4
Gene
Rbp4
Organism
Rattus norvegicus (Rat)
Status
Functioni
Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (PubMed:4708098). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (By similarity).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- protein-containing complex binding Source: RGD
- retinal binding Source: UniProtKB-KW
- retinol binding Source: UniProtKB
- retinol transmembrane transporter activity Source: InterPro
GO - Biological processi
- cardiac muscle tissue development Source: RGD
- detection of light stimulus involved in visual perception Source: RGD
- embryonic organ morphogenesis Source: RGD
- embryonic retina morphogenesis in camera-type eye Source: RGD
- embryonic skeletal system development Source: RGD
- eye development Source: RGD
- female genitalia morphogenesis Source: RGD
- gluconeogenesis Source: RGD
- glucose homeostasis Source: RGD
- heart development Source: RGD
- heart trabecula formation Source: RGD
- lung development Source: RGD
- maintenance of gastrointestinal epithelium Source: RGD
- male gonad development Source: RGD
- negative regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of immunoglobulin secretion Source: RGD
- positive regulation of insulin secretion Source: RGD
- response to ethanol Source: RGD
- response to insulin Source: RGD
- response to retinoic acid Source: RGD
- retina development in camera-type eye Source: RGD
- retinal metabolic process Source: RGD
- retinol metabolic process Source: RGD
- retinol transport Source: RGD
- spermatogenesis Source: RGD
- urinary bladder development Source: RGD
- uterus development Source: RGD
- vagina development Source: RGD
- vitamin A import Source: RGD
Keywordsi
Biological process | Transport |
Ligand | Retinol-binding, Vitamin A |
Enzyme and pathway databases
Reactomei | R-RNO-2453902, The canonical retinoid cycle in rods (twilight vision) R-RNO-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Retinol-binding protein 4Alternative name(s): Plasma retinol-binding protein Short name: PRBP Short name: RBP1 Publication |
Gene namesi | Name:Rbp4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3546, Rbp4 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: UniProtKB
Other locations
- protein-containing complex Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000017970 | 19 – 201 | Retinol-binding protein 4By similarity1 PublicationAdd BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 22 ↔ 178 | By similarity | ||
Disulfide bondi | 88 ↔ 192 | By similarity | ||
Disulfide bondi | 138 ↔ 147 | By similarity | ||
Modified residuei | 139 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, MethylationProteomic databases
PaxDbi | P04916 |
PRIDEi | P04916 |
Expressioni
Tissue specificityi
Detected in blood plasma (at protein level).1 Publication
Gene expression databases
Bgeei | ENSRNOG00000015518, Expressed in liver and 22 other tissues |
ExpressionAtlasi | P04916, baseline and differential |
Genevisiblei | P04916, RN |
Interactioni
Subunit structurei
Interacts with TTR (PubMed:4708098). Interaction with TTR prevents its loss by filtration through the kidney glomeruli (Probable).
Interacts with STRA6 (By similarity).
By similarityCurated1 PublicationProtein-protein interaction databases
IntActi | P04916, 1 interactor |
STRINGi | 10116.ENSRNOP00000021055 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RXEW, Eukaryota |
GeneTreei | ENSGT00510000047107 |
HOGENOMi | CLU_094618_0_0_1 |
InParanoidi | P04916 |
OMAi | NWEMCAH |
OrthoDBi | 1631943at2759 |
PhylomeDBi | P04916 |
TreeFami | TF331445 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002449, Retinol-bd/Purpurin |
PANTHERi | PTHR11873, PTHR11873, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit PIRSF500204, RBP_purpurin, 1 hit |
PRINTSi | PR01174, RETINOLBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P04916-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP
60 70 80 90 100
EGLFLQDNII AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQRGND DHWIIDTDYD TFALQYSCRL QNLDGTCADS
160 170 180 190 200
YSFVFSRDPN GLTPETRRLV RQRQEELCLE RQYRWIEHNG YCQSRPSRNS
L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K03046, M10610 Genomic DNA Translation: AAA42018.1 M10934 mRNA Translation: AAA42020.1 |
PIRi | A92493, VART |
RefSeqi | NP_037294.1, NM_013162.1 |
Genome annotation databases
Ensembli | ENSRNOT00000021055; ENSRNOP00000021055; ENSRNOG00000015518 |
GeneIDi | 25703 |
KEGGi | rno:25703 |
UCSCi | RGD:3546, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K03046, M10610 Genomic DNA Translation: AAA42018.1 M10934 mRNA Translation: AAA42020.1 |
PIRi | A92493, VART |
RefSeqi | NP_037294.1, NM_013162.1 |
3D structure databases
SMRi | P04916 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P04916, 1 interactor |
STRINGi | 10116.ENSRNOP00000021055 |
Proteomic databases
PaxDbi | P04916 |
PRIDEi | P04916 |
Genome annotation databases
Ensembli | ENSRNOT00000021055; ENSRNOP00000021055; ENSRNOG00000015518 |
GeneIDi | 25703 |
KEGGi | rno:25703 |
UCSCi | RGD:3546, rat |
Organism-specific databases
CTDi | 5950 |
RGDi | 3546, Rbp4 |
Phylogenomic databases
eggNOGi | ENOG502RXEW, Eukaryota |
GeneTreei | ENSGT00510000047107 |
HOGENOMi | CLU_094618_0_0_1 |
InParanoidi | P04916 |
OMAi | NWEMCAH |
OrthoDBi | 1631943at2759 |
PhylomeDBi | P04916 |
TreeFami | TF331445 |
Enzyme and pathway databases
Reactomei | R-RNO-2453902, The canonical retinoid cycle in rods (twilight vision) R-RNO-975634, Retinoid metabolism and transport |
Miscellaneous databases
PROi | PR:P04916 |
Gene expression databases
Bgeei | ENSRNOG00000015518, Expressed in liver and 22 other tissues |
ExpressionAtlasi | P04916, baseline and differential |
Genevisiblei | P04916, RN |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002449, Retinol-bd/Purpurin |
PANTHERi | PTHR11873, PTHR11873, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit PIRSF500204, RBP_purpurin, 1 hit |
PRINTSi | PR01174, RETINOLBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RET4_RAT | |
Accessioni | P04916Primary (citable) accession number: P04916 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | August 13, 1987 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families