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Protein

Glutathione S-transferase alpha-2

Gene

Gsta2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Miscellaneous

In addition to its enzymatic activity, the homodimer of Ya chains, called ligandin, binds various organic anions, xenobiotics, and azocarcinogen dyes.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

  • drug binding Source: RGD
  • glutathione binding Source: CAFA
  • glutathione transferase activity Source: CAFA

GO - Biological processi

  • aging Source: RGD
  • xenobiotic catabolic process Source: CAFA

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase alpha-2 (EC:2.5.1.18)
Alternative name(s):
GST 1b-1b
GST A2-2
Glutathione S-transferase Ya-2
Short name:
GST Ya2
Gene namesi
Name:Gsta2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2754 Gsta2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857931 – 222Glutathione S-transferase alpha-2Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-succinyllysineBy similarity1

Proteomic databases

PaxDbiP04903
PRIDEiP04903

PTM databases

CarbonylDBiP04903

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi268945, 1 interactor
STRINGi10116.ENSRNOP00000043510

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi86 – 111Combined sources26
Helixi114 – 130Combined sources17
Helixi132 – 143Combined sources12
Beta strandi146 – 149Combined sources4
Helixi155 – 171Combined sources17
Helixi172 – 175Combined sources4
Helixi179 – 189Combined sources11
Helixi192 – 198Combined sources7

3D structure databases

ProteinModelPortaliP04903
SMRiP04903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
HOGENOMiHOG000115734
HOVERGENiHBG053749
InParanoidiP04903
KOiK00799
PhylomeDBiP04903

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR003080 GST_alpha
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01266 GSTRNSFRASEA
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P04903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKPVLHYF NARGRMECIR WLLAAAGVEF EEKLIQSPED LEKLKKDGNL
60 70 80 90 100
MFDQVPMVEI DGMKLAQTRA ILNYIATKYD LYGKDMKERA LIDMYSEGIL
110 120 130 140 150
DLTEMIIQLV ICPPDQREAK TALAKDRTKN RYLPAFEKVL KSHGQDYLVG
160 170 180 190 200
NRLTRVDIHL LELLLYVEEF DASLLTSFPL LKAFKSRISS LPNVKKFLQP
210 220
GSQRKPAMDA KQIEEARKVF KF
Length:222
Mass (Da):25,559
Last modified:January 23, 2007 - v2
Checksum:iAA342417E9857A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00136 mRNA Translation: AAA41282.1
M25891 mRNA Translation: AAA41290.1
M14991
, M14986, M14987, M14988, M14989, M14990 Genomic DNA Translation: AAA41295.1
X00520 mRNA Translation: CAA25203.1
M27446 mRNA Translation: AAA41291.1
PIRiA24735
A26653
A92479 XURTG
RefSeqiNP_001010921.1, NM_001010921.1
UniGeneiRn.40574

Genome annotation databases

GeneIDi494499
KEGGirno:494499
UCSCiRGD:2754 rat

Similar proteinsi

Entry informationi

Entry nameiGSTA2_RAT
AccessioniPrimary (citable) accession number: P04903
Secondary accession number(s): Q63715
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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